Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
801
Gene name Gene Name - the full gene name approved by the HGNC.
Calmodulin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CALM1
Synonyms (NCBI Gene) Gene synonyms aliases
CALML2, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, PHKD1, caM
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024054 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT024054 hsa-miR-1-3p Proteomics 18668040
MIRT053626 hsa-let-7f-5p Microarray 22942087
MIRT191943 hsa-miR-495-5p PAR-CLIP 20371350
MIRT507913 hsa-miR-382-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IEA
GO:0000922 Component Spindle pole IDA 16760425
GO:0000922 Component Spindle pole IEA
GO:0002027 Process Regulation of heart rate IEA
GO:0002027 Process Regulation of heart rate IMP 23040497
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
114180 1442 ENSG00000198668
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Apelin signaling pathway
C-type lectin receptor signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Dopaminergic synapse
Olfactory transduction
Phototransduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
Salivary secretion
Gastric acid secretion
Alzheimer disease
Parkinson disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Alcoholism
Pertussis
Tuberculosis
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Glioma
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  CaMK IV-mediated phosphorylation of CREB
Calmodulin induced events
Cam-PDE 1 activation
Platelet degranulation
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
PKA activation
Synthesis of IP3 and IP4 in the cytosol
Calcineurin activates NFAT
eNOS activation
Inactivation, recovery and regulation of the phototransduction cascade
Stimuli-sensing channels
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Smooth Muscle Contraction
Activation of Ca-permeable Kainate Receptor
Uptake and function of anthrax toxins
VEGFR2 mediated vascular permeability
Phase 0 - rapid depolarisation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Glycogen breakdown (glycogenolysis)
Protein methylation
Extra-nuclear estrogen signaling
Ion transport by P-type ATPases
Activation of RAC1 downstream of NMDARs
Long-term potentiation
Signaling downstream of RAS mutants
FCGR3A-mediated IL10 synthesis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Catecholaminergic Polymorphic Ventricular Tachycardia Catecholaminergic polymorphic ventricular tachycardia 1, catecholaminergic polymorphic ventricular tachycardia rs267607276, rs267607277 N/A
Long QT Syndrome long qt syndrome 14 rs730882252, rs199744595, rs730882253 N/A
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 34818353
Adenocarcinoma of Lung Associate 38213773
Alzheimer Disease Associate 23333870, 36530083
Alzheimer Disease Inhibit 35216403
Arrhythmias Cardiac Associate 15316014, 19265034, 23040497, 23388215, 24917665, 27374306, 28087622, 30348784, 30384889, 30944319, 31072926, 31170290, 31230402, 31454269, 32012279
View all (8 more)
Arrhythmogenic Right Ventricular Dysplasia Associate 27927985, 31454269, 36693454
Arthritis Rheumatoid Inhibit 11181651
Arthritis Rheumatoid Associate 15539412, 23333870
Astrocytoma Associate 18297103
Ataxia Associate 27632770