PGAP1 (post-GPI attachment to proteins inositol deacylase 1)

Gene

• Entrez ID: 80055
• Gene name: Post-GPI attachment to proteins inositol deacylase 1
• Gene symbol: PGAP1
• Synonyms (NCBI Gene): Bst1, ISPD3024, MRT42, NEDDSBA, SPG67
• Chromosome: 2
• Chromosome location: 2q33.1
• Summary: The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this ma

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs143038880	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs143960563	C>T	Likely-benign, likely-pathogenic	Non coding transcript variant, genic downstream transcript variant, coding sequence variant, missense variant
rs587777202	C>A,G,T	Pathogenic	Splice donor variant, genic downstream transcript variant
rs587777378	AGA>-	Pathogenic	5 prime UTR variant, inframe deletion, non coding transcript variant, coding sequence variant
rs750079325	C>T	Pathogenic	Splice donor variant
rs767774867	->TA	Pathogenic, likely-pathogenic	Genic downstream transcript variant, frameshift variant, non coding transcript variant, coding sequence variant
rs781325598	GTAT>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant
rs869025578	A>T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained, genic downstream transcript variant
rs869025579	GGA>-	Pathogenic	Inframe deletion, coding sequence variant, non coding transcript variant, 5 prime UTR variant
rs869025580	TTAGT>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant, 5 prime UTR variant
rs869025581	T>C	Pathogenic	Splice acceptor variant
rs1169608420	C>A	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant, non coding transcript variant
rs1361547443	A>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained, non coding transcript variant
rs1364192556	G>A	Likely-pathogenic	5 prime UTR variant, coding sequence variant, stop gained, non coding transcript variant
rs1410587479	G>A	Pathogenic	5 prime UTR variant, non coding transcript variant, stop gained, coding sequence variant
rs1441509615	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs1559328283	T>G	Likely-pathogenic	Splice acceptor variant, genic downstream transcript variant
rs1576086299	G>C	Likely-pathogenic	Stop gained, non coding transcript variant, genic downstream transcript variant, coding sequence variant
rs1576164991	T>A	Likely-pathogenic	Stop gained, non coding transcript variant, intron variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016203	hsa-miR-590-3p	Sequencing	20371350
MIRT529347	hsa-miR-6128	PAR-CLIP	22012620
MIRT726971	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT726970	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT726969	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT726968	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT529347	hsa-miR-6128	PAR-CLIP	22012620
MIRT1226947	hsa-miR-106a	CLIP-seq
MIRT1226948	hsa-miR-106b	CLIP-seq
MIRT1226949	hsa-miR-1193	CLIP-seq
MIRT1226950	hsa-miR-1207-3p	CLIP-seq
MIRT1226951	hsa-miR-1207-5p	CLIP-seq
MIRT1226952	hsa-miR-1255a	CLIP-seq
MIRT1226953	hsa-miR-1255b	CLIP-seq
MIRT1226954	hsa-miR-1268	CLIP-seq
MIRT1226955	hsa-miR-1268b	CLIP-seq
MIRT1226956	hsa-miR-1271	CLIP-seq
MIRT1226957	hsa-miR-1273f	CLIP-seq
MIRT1226958	hsa-miR-128	CLIP-seq
MIRT1226959	hsa-miR-1285	CLIP-seq
MIRT1226960	hsa-miR-129-5p	CLIP-seq
MIRT1226961	hsa-miR-1299	CLIP-seq
MIRT1226962	hsa-miR-130a	CLIP-seq
MIRT1226963	hsa-miR-130b	CLIP-seq
MIRT1226964	hsa-miR-135a	CLIP-seq
MIRT1226965	hsa-miR-135b	CLIP-seq
MIRT1226966	hsa-miR-143	CLIP-seq
MIRT1226967	hsa-miR-154	CLIP-seq
MIRT1226968	hsa-miR-155	CLIP-seq
MIRT1226969	hsa-miR-17	CLIP-seq
MIRT1226970	hsa-miR-181a	CLIP-seq
MIRT1226971	hsa-miR-181b	CLIP-seq
MIRT1226972	hsa-miR-181c	CLIP-seq
MIRT1226973	hsa-miR-181d	CLIP-seq
MIRT1226974	hsa-miR-182	CLIP-seq
MIRT1226975	hsa-miR-1827	CLIP-seq
MIRT1226976	hsa-miR-186	CLIP-seq
MIRT1226977	hsa-miR-1909	CLIP-seq
MIRT1226978	hsa-miR-200b	CLIP-seq
MIRT1226979	hsa-miR-200c	CLIP-seq
MIRT1226980	hsa-miR-20a	CLIP-seq
MIRT1226981	hsa-miR-20b	CLIP-seq
MIRT1226982	hsa-miR-2110	CLIP-seq
MIRT1226983	hsa-miR-2114	CLIP-seq
MIRT1226984	hsa-miR-217	CLIP-seq
MIRT1226985	hsa-miR-24	CLIP-seq
MIRT1226986	hsa-miR-2681	CLIP-seq
MIRT1226987	hsa-miR-27a	CLIP-seq
MIRT1226988	hsa-miR-27b	CLIP-seq
MIRT1226989	hsa-miR-301a	CLIP-seq
MIRT1226990	hsa-miR-301b	CLIP-seq
MIRT1226991	hsa-miR-3119	CLIP-seq
MIRT1226992	hsa-miR-3122	CLIP-seq
MIRT1226993	hsa-miR-3128	CLIP-seq
MIRT1226994	hsa-miR-3134	CLIP-seq
MIRT1226995	hsa-miR-3137	CLIP-seq
MIRT1226996	hsa-miR-3140-3p	CLIP-seq
MIRT1226997	hsa-miR-3145-3p	CLIP-seq
MIRT1226998	hsa-miR-3150a-3p	CLIP-seq
MIRT1226999	hsa-miR-3160-5p	CLIP-seq
MIRT1227000	hsa-miR-3163	CLIP-seq
MIRT1227001	hsa-miR-3175	CLIP-seq
MIRT1227002	hsa-miR-3187-5p	CLIP-seq
MIRT1227003	hsa-miR-3202	CLIP-seq
MIRT1227004	hsa-miR-323-3p	CLIP-seq
MIRT1227005	hsa-miR-326	CLIP-seq
MIRT1227006	hsa-miR-330-5p	CLIP-seq
MIRT1227007	hsa-miR-3607-3p	CLIP-seq
MIRT1227008	hsa-miR-3609	CLIP-seq
MIRT1227009	hsa-miR-3611	CLIP-seq
MIRT1227010	hsa-miR-3612	CLIP-seq
MIRT1227011	hsa-miR-3666	CLIP-seq
MIRT1227012	hsa-miR-3682-3p	CLIP-seq
MIRT1227013	hsa-miR-3682-5p	CLIP-seq
MIRT1227014	hsa-miR-3686	CLIP-seq
MIRT1227015	hsa-miR-3688-3p	CLIP-seq
MIRT1227016	hsa-miR-3689a-3p	CLIP-seq
MIRT1227017	hsa-miR-3689c	CLIP-seq
MIRT1227018	hsa-miR-369-3p	CLIP-seq
MIRT1227019	hsa-miR-374a	CLIP-seq
MIRT1227020	hsa-miR-374b	CLIP-seq
MIRT1227021	hsa-miR-377	CLIP-seq
MIRT1227022	hsa-miR-3913-5p	CLIP-seq
MIRT1227023	hsa-miR-3919	CLIP-seq
MIRT1227024	hsa-miR-3929	CLIP-seq
MIRT1227025	hsa-miR-4260	CLIP-seq
MIRT1227026	hsa-miR-4262	CLIP-seq
MIRT1227027	hsa-miR-4269	CLIP-seq
MIRT1227028	hsa-miR-4272	CLIP-seq
MIRT1227029	hsa-miR-4284	CLIP-seq
MIRT1227030	hsa-miR-429	CLIP-seq
MIRT1227031	hsa-miR-4295	CLIP-seq
MIRT1227032	hsa-miR-4419b	CLIP-seq
MIRT1227033	hsa-miR-4476	CLIP-seq
MIRT1227034	hsa-miR-4478	CLIP-seq
MIRT1227035	hsa-miR-4486	CLIP-seq
MIRT1227036	hsa-miR-4490	CLIP-seq
MIRT1227037	hsa-miR-4496	CLIP-seq
MIRT1227038	hsa-miR-4505	CLIP-seq
MIRT1227039	hsa-miR-4506	CLIP-seq
MIRT1227040	hsa-miR-4509	CLIP-seq
MIRT1227041	hsa-miR-454	CLIP-seq
MIRT1227042	hsa-miR-4633-5p	CLIP-seq
MIRT1227043	hsa-miR-4642	CLIP-seq
MIRT1227044	hsa-miR-4645-5p	CLIP-seq
MIRT1227045	hsa-miR-4649-3p	CLIP-seq
MIRT1227046	hsa-miR-4652-3p	CLIP-seq
MIRT1227047	hsa-miR-4668-3p	CLIP-seq
MIRT1227048	hsa-miR-4673	CLIP-seq
MIRT1227049	hsa-miR-4688	CLIP-seq
MIRT1227050	hsa-miR-4698	CLIP-seq
MIRT1227051	hsa-miR-4705	CLIP-seq
MIRT1227052	hsa-miR-4708-5p	CLIP-seq
MIRT1227053	hsa-miR-4711-5p	CLIP-seq
MIRT1227054	hsa-miR-4717-3p	CLIP-seq
MIRT1227055	hsa-miR-4718	CLIP-seq
MIRT1227056	hsa-miR-4719	CLIP-seq
MIRT1227057	hsa-miR-4720-5p	CLIP-seq
MIRT1227058	hsa-miR-4724-3p	CLIP-seq
MIRT1227059	hsa-miR-4728-5p	CLIP-seq
MIRT1227060	hsa-miR-4736	CLIP-seq
MIRT1227061	hsa-miR-4742-3p	CLIP-seq
MIRT1227062	hsa-miR-4744	CLIP-seq
MIRT1227063	hsa-miR-4747-5p	CLIP-seq
MIRT1227064	hsa-miR-4763-3p	CLIP-seq
MIRT1227065	hsa-miR-4770	CLIP-seq
MIRT1227066	hsa-miR-4774-5p	CLIP-seq
MIRT1227067	hsa-miR-4775	CLIP-seq
MIRT1227068	hsa-miR-4777-5p	CLIP-seq
MIRT1227069	hsa-miR-4782-5p	CLIP-seq
MIRT1227070	hsa-miR-4796-3p	CLIP-seq
MIRT1227071	hsa-miR-4799-3p	CLIP-seq
MIRT1227072	hsa-miR-4799-5p	CLIP-seq
MIRT1227073	hsa-miR-485-5p	CLIP-seq
MIRT1227074	hsa-miR-491-3p	CLIP-seq
MIRT1227075	hsa-miR-498	CLIP-seq
MIRT1227076	hsa-miR-499-3p	CLIP-seq
MIRT1227077	hsa-miR-499a-3p	CLIP-seq
MIRT1227078	hsa-miR-513a-3p	CLIP-seq
MIRT1227079	hsa-miR-516b	CLIP-seq
MIRT1227080	hsa-miR-518d-5p	CLIP-seq
MIRT1227081	hsa-miR-519b-5p	CLIP-seq
MIRT1227082	hsa-miR-519c-5p	CLIP-seq
MIRT1227083	hsa-miR-519d	CLIP-seq
MIRT1227084	hsa-miR-520c-5p	CLIP-seq
MIRT1227085	hsa-miR-520d-5p	CLIP-seq
MIRT1227086	hsa-miR-524-5p	CLIP-seq
MIRT1227087	hsa-miR-526a	CLIP-seq
MIRT1227088	hsa-miR-532-5p	CLIP-seq
MIRT1227089	hsa-miR-539	CLIP-seq
MIRT1227090	hsa-miR-543	CLIP-seq
MIRT1227091	hsa-miR-548ae	CLIP-seq
MIRT1227092	hsa-miR-548ah	CLIP-seq
MIRT1227093	hsa-miR-548aj	CLIP-seq
MIRT1227094	hsa-miR-548am	CLIP-seq
MIRT1227095	hsa-miR-548n	CLIP-seq
MIRT1227096	hsa-miR-548p	CLIP-seq
MIRT1227097	hsa-miR-548t	CLIP-seq
MIRT1227098	hsa-miR-548x	CLIP-seq
MIRT1227099	hsa-miR-561	CLIP-seq
MIRT1227100	hsa-miR-570	CLIP-seq
MIRT1227101	hsa-miR-585	CLIP-seq
MIRT1227102	hsa-miR-612	CLIP-seq
MIRT1227103	hsa-miR-629	CLIP-seq
MIRT1227104	hsa-miR-633	CLIP-seq
MIRT1227105	hsa-miR-650	CLIP-seq
MIRT1227106	hsa-miR-656	CLIP-seq
MIRT1227107	hsa-miR-765	CLIP-seq
MIRT1227108	hsa-miR-885-5p	CLIP-seq
MIRT1227109	hsa-miR-93	CLIP-seq
MIRT1227110	hsa-miR-935	CLIP-seq
MIRT1227111	hsa-miR-939	CLIP-seq
MIRT1227112	hsa-miR-940	CLIP-seq
MIRT1227113	hsa-miR-96	CLIP-seq
MIRT1226947	hsa-miR-106a	CLIP-seq
MIRT1226948	hsa-miR-106b	CLIP-seq
MIRT2066491	hsa-miR-1182	CLIP-seq
MIRT1226949	hsa-miR-1193	CLIP-seq
MIRT1226950	hsa-miR-1207-3p	CLIP-seq
MIRT2066492	hsa-miR-1238	CLIP-seq
MIRT2066493	hsa-miR-1246	CLIP-seq
MIRT1226952	hsa-miR-1255a	CLIP-seq
MIRT1226953	hsa-miR-1255b	CLIP-seq
MIRT2066494	hsa-miR-125a-3p	CLIP-seq
MIRT1226956	hsa-miR-1271	CLIP-seq
MIRT2066495	hsa-miR-1276	CLIP-seq
MIRT1226958	hsa-miR-128	CLIP-seq
MIRT2066496	hsa-miR-1283	CLIP-seq
MIRT2066497	hsa-miR-1290	CLIP-seq
MIRT1226960	hsa-miR-129-5p	CLIP-seq
MIRT1226961	hsa-miR-1299	CLIP-seq
MIRT2066498	hsa-miR-1305	CLIP-seq
MIRT1226969	hsa-miR-17	CLIP-seq
MIRT1226970	hsa-miR-181a	CLIP-seq
MIRT1226971	hsa-miR-181b	CLIP-seq
MIRT1226972	hsa-miR-181c	CLIP-seq
MIRT1226973	hsa-miR-181d	CLIP-seq
MIRT1226975	hsa-miR-1827	CLIP-seq
MIRT2066499	hsa-miR-202	CLIP-seq
MIRT2066500	hsa-miR-2054	CLIP-seq
MIRT1226980	hsa-miR-20a	CLIP-seq
MIRT1226981	hsa-miR-20b	CLIP-seq
MIRT1226983	hsa-miR-2114	CLIP-seq
MIRT2066501	hsa-miR-3065-5p	CLIP-seq
MIRT2066502	hsa-miR-3074-3p	CLIP-seq
MIRT2066503	hsa-miR-3074-5p	CLIP-seq
MIRT2066504	hsa-miR-3121-3p	CLIP-seq
MIRT2066505	hsa-miR-3124-3p	CLIP-seq
MIRT1226994	hsa-miR-3134	CLIP-seq
MIRT1226995	hsa-miR-3137	CLIP-seq
MIRT2066506	hsa-miR-3167	CLIP-seq
MIRT1227005	hsa-miR-326	CLIP-seq
MIRT1227006	hsa-miR-330-5p	CLIP-seq
MIRT2066507	hsa-miR-335	CLIP-seq
MIRT2066508	hsa-miR-340	CLIP-seq
MIRT2066509	hsa-miR-34b	CLIP-seq
MIRT1227008	hsa-miR-3609	CLIP-seq
MIRT2066510	hsa-miR-3622b-5p	CLIP-seq
MIRT2066511	hsa-miR-3658	CLIP-seq
MIRT1227015	hsa-miR-3688-3p	CLIP-seq
MIRT1227024	hsa-miR-3929	CLIP-seq
MIRT2066512	hsa-miR-3934	CLIP-seq
MIRT2066513	hsa-miR-410	CLIP-seq
MIRT2066514	hsa-miR-4257	CLIP-seq
MIRT1227026	hsa-miR-4262	CLIP-seq
MIRT1227027	hsa-miR-4269	CLIP-seq
MIRT2066515	hsa-miR-4311	CLIP-seq
MIRT1227032	hsa-miR-4419b	CLIP-seq
MIRT2066516	hsa-miR-4432	CLIP-seq
MIRT2066517	hsa-miR-4446-5p	CLIP-seq
MIRT2066518	hsa-miR-4474-5p	CLIP-seq
MIRT1227034	hsa-miR-4478	CLIP-seq
MIRT1227036	hsa-miR-4490	CLIP-seq
MIRT2066519	hsa-miR-4499	CLIP-seq
MIRT2066520	hsa-miR-4511	CLIP-seq
MIRT2066521	hsa-miR-4514	CLIP-seq
MIRT2066522	hsa-miR-4637	CLIP-seq
MIRT1227045	hsa-miR-4649-3p	CLIP-seq
MIRT2066523	hsa-miR-4662a-3p	CLIP-seq
MIRT2066524	hsa-miR-4666-3p	CLIP-seq
MIRT2066525	hsa-miR-4678	CLIP-seq
MIRT2066526	hsa-miR-4692	CLIP-seq
MIRT2066527	hsa-miR-4704-5p	CLIP-seq
MIRT1227051	hsa-miR-4705	CLIP-seq
MIRT1227053	hsa-miR-4711-5p	CLIP-seq
MIRT1227056	hsa-miR-4719	CLIP-seq
MIRT2066528	hsa-miR-4729	CLIP-seq
MIRT2066529	hsa-miR-4742-5p	CLIP-seq
MIRT2066530	hsa-miR-4762-5p	CLIP-seq
MIRT2066531	hsa-miR-4773	CLIP-seq
MIRT1227066	hsa-miR-4774-5p	CLIP-seq
MIRT1227069	hsa-miR-4782-5p	CLIP-seq
MIRT1227070	hsa-miR-4796-3p	CLIP-seq
MIRT1227073	hsa-miR-485-5p	CLIP-seq
MIRT2066532	hsa-miR-486-5p	CLIP-seq
MIRT2066533	hsa-miR-495	CLIP-seq
MIRT2066534	hsa-miR-500a	CLIP-seq
MIRT1227078	hsa-miR-513a-3p	CLIP-seq
MIRT2066535	hsa-miR-515-5p	CLIP-seq
MIRT1227079	hsa-miR-516b	CLIP-seq
MIRT2066536	hsa-miR-519a	CLIP-seq
MIRT2066537	hsa-miR-519b-3p	CLIP-seq
MIRT2066538	hsa-miR-519c-3p	CLIP-seq
MIRT1227083	hsa-miR-519d	CLIP-seq
MIRT2066539	hsa-miR-520a-5p	CLIP-seq
MIRT2066540	hsa-miR-525-5p	CLIP-seq
MIRT1227089	hsa-miR-539	CLIP-seq
MIRT2066541	hsa-miR-542-3p	CLIP-seq
MIRT1227090	hsa-miR-543	CLIP-seq
MIRT1227092	hsa-miR-548ah	CLIP-seq
MIRT2066542	hsa-miR-548l	CLIP-seq
MIRT2066543	hsa-miR-579	CLIP-seq
MIRT2066544	hsa-miR-582-5p	CLIP-seq
MIRT2066545	hsa-miR-583	CLIP-seq
MIRT2066546	hsa-miR-601	CLIP-seq
MIRT2066547	hsa-miR-603	CLIP-seq
MIRT2066548	hsa-miR-607	CLIP-seq
MIRT1227103	hsa-miR-629	CLIP-seq
MIRT1227104	hsa-miR-633	CLIP-seq
MIRT2066549	hsa-miR-645	CLIP-seq
MIRT2066550	hsa-miR-764	CLIP-seq
MIRT2066551	hsa-miR-876-5p	CLIP-seq
MIRT1227109	hsa-miR-93	CLIP-seq
MIRT1227113	hsa-miR-96	CLIP-seq
MIRT2293888	hsa-miR-103a	CLIP-seq
MIRT1226947	hsa-miR-106a	CLIP-seq
MIRT1226948	hsa-miR-106b	CLIP-seq
MIRT2293889	hsa-miR-107	CLIP-seq
MIRT1226950	hsa-miR-1207-3p	CLIP-seq
MIRT2293890	hsa-miR-1262	CLIP-seq
MIRT2293891	hsa-miR-1269	CLIP-seq
MIRT2293892	hsa-miR-1269b	CLIP-seq
MIRT1226956	hsa-miR-1271	CLIP-seq
MIRT2293893	hsa-miR-145	CLIP-seq
MIRT1226969	hsa-miR-17	CLIP-seq
MIRT1226974	hsa-miR-182	CLIP-seq
MIRT2293894	hsa-miR-1825	CLIP-seq
MIRT2293895	hsa-miR-1908	CLIP-seq
MIRT2293896	hsa-miR-194	CLIP-seq
MIRT2293897	hsa-miR-199a-5p	CLIP-seq
MIRT2293898	hsa-miR-199b-5p	CLIP-seq
MIRT1226980	hsa-miR-20a	CLIP-seq
MIRT1226981	hsa-miR-20b	CLIP-seq
MIRT1226983	hsa-miR-2114	CLIP-seq
MIRT2293899	hsa-miR-2277-3p	CLIP-seq
MIRT1226985	hsa-miR-24	CLIP-seq
MIRT1226987	hsa-miR-27a	CLIP-seq
MIRT1226988	hsa-miR-27b	CLIP-seq
MIRT1226992	hsa-miR-3122	CLIP-seq
MIRT1226995	hsa-miR-3137	CLIP-seq
MIRT2293900	hsa-miR-3138	CLIP-seq
MIRT2293901	hsa-miR-331-3p	CLIP-seq
MIRT1227008	hsa-miR-3609	CLIP-seq
MIRT1227016	hsa-miR-3689a-3p	CLIP-seq
MIRT1227017	hsa-miR-3689c	CLIP-seq
MIRT1227022	hsa-miR-3913-5p	CLIP-seq
MIRT2293902	hsa-miR-3922-5p	CLIP-seq
MIRT2293903	hsa-miR-4252	CLIP-seq
MIRT1227029	hsa-miR-4284	CLIP-seq
MIRT2293904	hsa-miR-4299	CLIP-seq
MIRT2293905	hsa-miR-4445	CLIP-seq
MIRT2293906	hsa-miR-4468	CLIP-seq
MIRT2293907	hsa-miR-4493	CLIP-seq
MIRT2066519	hsa-miR-4499	CLIP-seq
MIRT2293908	hsa-miR-4529-3p	CLIP-seq
MIRT2293909	hsa-miR-4701-3p	CLIP-seq
MIRT2066527	hsa-miR-4704-5p	CLIP-seq
MIRT1227053	hsa-miR-4711-5p	CLIP-seq
MIRT1227059	hsa-miR-4728-5p	CLIP-seq
MIRT2293910	hsa-miR-4735-5p	CLIP-seq
MIRT2293911	hsa-miR-4793-3p	CLIP-seq
MIRT1227070	hsa-miR-4796-3p	CLIP-seq
MIRT2293912	hsa-miR-508-5p	CLIP-seq
MIRT2066536	hsa-miR-519a	CLIP-seq
MIRT2066537	hsa-miR-519b-3p	CLIP-seq
MIRT2066538	hsa-miR-519c-3p	CLIP-seq
MIRT1227083	hsa-miR-519d	CLIP-seq
MIRT2066541	hsa-miR-542-3p	CLIP-seq
MIRT1227092	hsa-miR-548ah	CLIP-seq
MIRT2066543	hsa-miR-579	CLIP-seq
MIRT1227103	hsa-miR-629	CLIP-seq
MIRT2293913	hsa-miR-661	CLIP-seq
MIRT2293914	hsa-miR-663	CLIP-seq
MIRT2293915	hsa-miR-766	CLIP-seq
MIRT2293916	hsa-miR-875-3p	CLIP-seq
MIRT2293917	hsa-miR-885-3p	CLIP-seq
MIRT1227109	hsa-miR-93	CLIP-seq
MIRT1227113	hsa-miR-96	CLIP-seq
MIRT1226954	hsa-miR-1268	CLIP-seq
MIRT1226955	hsa-miR-1268b	CLIP-seq
MIRT1226975	hsa-miR-1827	CLIP-seq
MIRT2293895	hsa-miR-1908	CLIP-seq
MIRT1226983	hsa-miR-2114	CLIP-seq
MIRT1226985	hsa-miR-24	CLIP-seq
MIRT1226995	hsa-miR-3137	CLIP-seq
MIRT1227024	hsa-miR-3929	CLIP-seq
MIRT1227029	hsa-miR-4284	CLIP-seq
MIRT1227032	hsa-miR-4419b	CLIP-seq
MIRT1227034	hsa-miR-4478	CLIP-seq
MIRT1227035	hsa-miR-4486	CLIP-seq
MIRT1227038	hsa-miR-4505	CLIP-seq
MIRT1227045	hsa-miR-4649-3p	CLIP-seq
MIRT1227073	hsa-miR-485-5p	CLIP-seq
MIRT1227101	hsa-miR-585	CLIP-seq
MIRT2293914	hsa-miR-663	CLIP-seq
MIRT1226975	hsa-miR-1827	CLIP-seq
MIRT2293895	hsa-miR-1908	CLIP-seq
MIRT1226982	hsa-miR-2110	CLIP-seq
MIRT1226998	hsa-miR-3150a-3p	CLIP-seq
MIRT1227001	hsa-miR-3175	CLIP-seq
MIRT1227010	hsa-miR-3612	CLIP-seq
MIRT2456281	hsa-miR-3613-3p	CLIP-seq
MIRT2456282	hsa-miR-371-5p	CLIP-seq
MIRT2456283	hsa-miR-371b-5p	CLIP-seq
MIRT2066512	hsa-miR-3934	CLIP-seq
MIRT1227025	hsa-miR-4260	CLIP-seq
MIRT2066533	hsa-miR-495	CLIP-seq
MIRT1227105	hsa-miR-650	CLIP-seq
MIRT2293914	hsa-miR-663	CLIP-seq
MIRT1227111	hsa-miR-939	CLIP-seq
MIRT1226975	hsa-miR-1827	CLIP-seq
MIRT2293895	hsa-miR-1908	CLIP-seq
MIRT1226982	hsa-miR-2110	CLIP-seq
MIRT1226998	hsa-miR-3150a-3p	CLIP-seq
MIRT1227001	hsa-miR-3175	CLIP-seq
MIRT1227010	hsa-miR-3612	CLIP-seq
MIRT2066512	hsa-miR-3934	CLIP-seq
MIRT1227025	hsa-miR-4260	CLIP-seq
MIRT1227105	hsa-miR-650	CLIP-seq
MIRT2293914	hsa-miR-663	CLIP-seq
MIRT1227111	hsa-miR-939	CLIP-seq
MIRT2066496	hsa-miR-1283	CLIP-seq
MIRT2592015	hsa-miR-1284	CLIP-seq
MIRT1226975	hsa-miR-1827	CLIP-seq
MIRT2293895	hsa-miR-1908	CLIP-seq
MIRT1226982	hsa-miR-2110	CLIP-seq
MIRT2592016	hsa-miR-2467-3p	CLIP-seq
MIRT2592017	hsa-miR-300	CLIP-seq
MIRT2066502	hsa-miR-3074-3p	CLIP-seq
MIRT1226998	hsa-miR-3150a-3p	CLIP-seq
MIRT2592018	hsa-miR-3150a-5p	CLIP-seq
MIRT2592019	hsa-miR-3150b-5p	CLIP-seq
MIRT1227001	hsa-miR-3175	CLIP-seq
MIRT2592020	hsa-miR-337-3p	CLIP-seq
MIRT1227010	hsa-miR-3612	CLIP-seq
MIRT2456281	hsa-miR-3613-3p	CLIP-seq
MIRT2592021	hsa-miR-3662	CLIP-seq
MIRT2456282	hsa-miR-371-5p	CLIP-seq
MIRT2456283	hsa-miR-371b-5p	CLIP-seq
MIRT2592022	hsa-miR-381	CLIP-seq
MIRT2066512	hsa-miR-3934	CLIP-seq
MIRT1227025	hsa-miR-4260	CLIP-seq
MIRT2592023	hsa-miR-4659a-3p	CLIP-seq
MIRT2592024	hsa-miR-4659b-3p	CLIP-seq
MIRT2066524	hsa-miR-4666-3p	CLIP-seq
MIRT2592025	hsa-miR-4778-3p	CLIP-seq
MIRT2066533	hsa-miR-495	CLIP-seq
MIRT1227085	hsa-miR-520d-5p	CLIP-seq
MIRT1227086	hsa-miR-524-5p	CLIP-seq
MIRT2066544	hsa-miR-582-5p	CLIP-seq
MIRT1227105	hsa-miR-650	CLIP-seq
MIRT2293914	hsa-miR-663	CLIP-seq
MIRT1227111	hsa-miR-939	CLIP-seq
MIRT1226958	hsa-miR-128	CLIP-seq
MIRT2066496	hsa-miR-1283	CLIP-seq
MIRT1226975	hsa-miR-1827	CLIP-seq
MIRT1226976	hsa-miR-186	CLIP-seq
MIRT2293895	hsa-miR-1908	CLIP-seq
MIRT1226982	hsa-miR-2110	CLIP-seq
MIRT2592016	hsa-miR-2467-3p	CLIP-seq
MIRT2687714	hsa-miR-3133	CLIP-seq
MIRT1226998	hsa-miR-3150a-3p	CLIP-seq
MIRT2592018	hsa-miR-3150a-5p	CLIP-seq
MIRT2592019	hsa-miR-3150b-5p	CLIP-seq
MIRT1227001	hsa-miR-3175	CLIP-seq
MIRT1227010	hsa-miR-3612	CLIP-seq
MIRT2456281	hsa-miR-3613-3p	CLIP-seq
MIRT2066510	hsa-miR-3622b-5p	CLIP-seq
MIRT2592021	hsa-miR-3662	CLIP-seq
MIRT2687715	hsa-miR-3664-5p	CLIP-seq
MIRT2456282	hsa-miR-371-5p	CLIP-seq
MIRT2456283	hsa-miR-371b-5p	CLIP-seq
MIRT2066512	hsa-miR-3934	CLIP-seq
MIRT1227025	hsa-miR-4260	CLIP-seq
MIRT2687716	hsa-miR-4263	CLIP-seq
MIRT1227027	hsa-miR-4269	CLIP-seq
MIRT2066518	hsa-miR-4474-5p	CLIP-seq
MIRT1227040	hsa-miR-4509	CLIP-seq
MIRT2066521	hsa-miR-4514	CLIP-seq
MIRT2687717	hsa-miR-4520b-3p	CLIP-seq
MIRT2687718	hsa-miR-4522	CLIP-seq
MIRT2293908	hsa-miR-4529-3p	CLIP-seq
MIRT2687719	hsa-miR-4535	CLIP-seq
MIRT2592023	hsa-miR-4659a-3p	CLIP-seq
MIRT2592024	hsa-miR-4659b-3p	CLIP-seq
MIRT2066526	hsa-miR-4692	CLIP-seq
MIRT2066529	hsa-miR-4742-5p	CLIP-seq
MIRT1227062	hsa-miR-4744	CLIP-seq
MIRT2687720	hsa-miR-4776-5p	CLIP-seq
MIRT2592025	hsa-miR-4778-3p	CLIP-seq
MIRT1227072	hsa-miR-4799-5p	CLIP-seq
MIRT2687721	hsa-miR-492	CLIP-seq
MIRT2066533	hsa-miR-495	CLIP-seq
MIRT2687722	hsa-miR-576-5p	CLIP-seq
MIRT2066544	hsa-miR-582-5p	CLIP-seq
MIRT1227105	hsa-miR-650	CLIP-seq
MIRT2293914	hsa-miR-663	CLIP-seq
MIRT2687723	hsa-miR-889	CLIP-seq
MIRT1227111	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006506	Process	GPI anchor biosynthetic process	IBA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0009880	Process	Embryonic pattern specification	IEA
GO:0009948	Process	Anterior/posterior axis specification	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016255	Process	Attachment of GPI anchor to protein	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0016788	Function	Hydrolase activity, acting on ester bonds	TAS
GO:0021871	Process	Forebrain regionalization	IEA
GO:0050185	Function	Phosphatidylinositol deacylase activity	IBA
GO:0060322	Process	Head development	IEA
GO:0160215	Function	Deacylase activity	IDA	24784135, 38167496
GO:0160215	Function	Deacylase activity	ISS
GO:1902953	Process	Positive regulation of ER to Golgi vesicle-mediated transport	ISS

Other IDs

• MIM: 611655
• HGNC: 25712
• e!Ensembl: ENSG00000197121

Protein

• UniProt ID: Q75T13
• Protein name: GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) (hPGAP1)
• Protein function: GPI inositol-deacylase that catalyzes the remove of the acyl chain linked to the 2-OH position of inositol ring from the GPI-anchored protein (GPI-AP) in the endoplasmic reticulum (PubMed:24784135, PubMed:38167496). Initiates the post-attachment
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07819	PGAP1	82 → 302	PGAP1-like protein	Family

• Sequence:

  MFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKR
  YPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYH
  FDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLYKGQEFAPKSVAIIGHSMGGLVA
  RALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSV
  AGGFRDYQVRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFF
  DLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPAIISDLTGTSMWVLVKVSKWTYV
  AYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELL
  PTIKYLTLRLQDYPSLSHLVVYVPSVRGSKFVVDCEFFKKEKRYIQLPVTHLFSFGLSSR
  KVVLNTNGLYYNLELLNFGQIYQAFKINVVSKCSAVKEEITSIYRLHIPWSYEDSLTIAQ
  APSSTEISLKLHIAQPENNTHVALFKMYTSSDCRYEVTVKTSFSQILGQVVRFHGGALPA
  YVVSNILLAYRGQLYSLFSTGCCLEYATMLDKEAKPYKVDPFVIIIKFLLGYKWFKELWD
  VLLLPELDAVILTCQSMCFPLISLILFLFGTCTAYWSGLLSSASVRLLSSLWLALKRPSE
  LPKDIKMISPDLPFLTIVLIIVSWTTCGALAILLSYLYYVFKVVHLQASLTTFKNSQPVN
  PKHSRRSEKKSNHHKDSSIHHLRLSANDAEDSLRMHSTVINLLTWIVLLSMPSLIYWLKN
  LRYYFKLNPDPCKPLAFILIPTMAILGNTYTVSIKSSKLLKTTSQFPLPLAVGVIAFGSA
  HLYRLPCFVFIPLLLHALCNFM

• Sequence length: 922

Pathways

KEGG:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Metabolic pathways

Reactome:

Attachment of GPI anchor to uPAR

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cerebral visual impairment and intellectual disability	Pathogenic	rs869025579, rs869025580	RCV000210383 RCV000210406
Intellectual disability, autosomal recessive 42	Likely pathogenic; Pathogenic	rs755341613, rs1701868598, rs587777202, rs2125822934, rs587777378, rs1406991265, rs1703370102, rs2468726625, rs869025578, rs143038880, rs869025579, rs869025580, rs869025581, rs2468726562, rs1051067702, rs2468647366, rs2468626300, rs2469091823, rs2469098389, rs1559346318, rs1361547443, rs750079325, rs781325598, rs1410587479, rs767774867, rs1559328283, rs1576086299, rs1576164991, rs1702534679, rs756609752, rs1288514578	RCV001334245 RCV001726504 RCV001385052 RCV000087334 RCV004527538 RCV000118980 RCV002018672 RCV002761297 RCV002852964 RCV000208580 RCV000208575 RCV000208579 RCV000208582 RCV000208574 RCV003228789 RCV003448808 RCV003492886 RCV003585501 RCV003584201 RCV003584394 RCV004551155 RCV000502026 RCV000504407 RCV000545388 RCV000537324 RCV000850580 RCV000693120 RCV000986966 RCV000986968 RCV001169901 RCV001262862 RCV001263009
See cases	Likely pathogenic; Pathogenic	rs1364192556	RCV002252152

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign; Likely benign	rs6708677, rs62185645, rs73988069	RCV005924531 RCV005899892 RCV005903971
Adrenocortical carcinoma, hereditary	Benign	rs73988069	RCV005903974
Cervical cancer	Benign; Likely benign	rs62185645, rs73988069	RCV005899893 RCV005903975
Cholangiocarcinoma	Benign	rs73988069	RCV005903978
Familial cancer of breast	Likely benign; Benign	rs756037783, rs73988069	RCV005926585 RCV005903970
Gastric cancer	Benign; Likely benign	rs62185645	RCV005899894
Hereditary spastic paraplegia	Conflicting classifications of pathogenicity; Uncertain significance; Benign; Likely benign	rs570708925, rs749719250, rs147312612, rs138036688, rs186535521, rs780043187, rs142482606, rs1162811688, rs2125840414, rs753763690, rs758283563, rs768328398, rs1051067702, rs1484939132, rs1246230813, rs1038323136, rs983042203, rs1337628147, rs774987863, rs144502622, rs2125822923, rs62185645, rs138525017, rs142320636, rs149815494, rs150893861, rs35444896, rs73988069, rs139107571, rs74459402, rs201984003	RCV001847238 RCV001847245 RCV001847289 RCV001847294 RCV001847305 RCV001847334 RCV001848550 RCV001848551 RCV001848552 RCV001848553 RCV001848554 RCV001848555 RCV001848557 RCV001848558 RCV001848559 RCV001848560 RCV001848561 RCV001848562 RCV001848563 RCV001848564 RCV001848565 RCV001848872 RCV001848873 RCV001848874 RCV001848972 RCV001848971 RCV001848973 RCV001849128 RCV001847106 RCV001847093 RCV001847099
High myopia	Uncertain significance	rs747122565	RCV000785740
Intellectual disability, autosomal recessive 58	Uncertain significance	rs201002323	RCV003483668
Lung cancer	Benign; Likely benign	rs62185645, rs73988069	RCV005899896 RCV005903979
Malignant lymphoma, large B-cell, diffuse	Benign	rs332300	RCV005918710
Malignant tumor of esophagus	Benign	rs73988069	RCV005903972
Neurodevelopmental disorder	Uncertain significance	rs762049431, rs2468626295	RCV003389082 RCV003389221
Nonpapillary renal cell carcinoma	Benign	rs73988069	RCV005903973
Ovarian serous cystadenocarcinoma	Benign	rs73988069	RCV005903976
PGAP1-related disorder	Conflicting classifications of pathogenicity; Benign; Likely benign	rs138036688, rs74459402, rs139927561, rs371032957, rs200242648	RCV003931120 RCV003920426 RCV003930451 RCV003930443 RCV003903216
Thymoma	Benign	rs73988069	RCV005903977
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	rs62185645	RCV005899895
Uterine carcinosarcoma	Benign	rs332300	RCV005918711
Uveal melanoma	Benign	rs332300	RCV005918709

Associations from Text Mining
Disease Name	Relationship Type	References
Brain Diseases	Associate	24784135
Inflammation	Associate	35686740
Intellectual Disability	Associate	24784135
Nasopharyngeal Carcinoma	Associate	34261404
Osteoarthritis	Associate	35686740
Paget Disease Extramammary	Associate	34895219
Vision Disorders	Associate	26350515