Gene Gene information from NCBI Gene database.
Entrez ID 80018
Gene name N-alpha-acetyltransferase 25, NatB auxiliary subunit
Gene symbol NAA25
Synonyms (NCBI Gene)
C12orf30MDM20NAP1
Chromosome 12
Chromosome location 12q24.13
Summary This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
miRNA miRNA information provided by mirtarbase database.
482
miRTarBase ID miRNA Experiments Reference
MIRT005228 hsa-let-7b-5p pSILAC 18668040
MIRT005259 hsa-miR-16-5p pSILAC 18668040
MIRT020629 hsa-miR-155-5p Proteomics 18668040
MIRT023442 hsa-miR-30b-5p Sequencing 20371350
MIRT005259 hsa-miR-16-5p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18570629, 34230638
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 18570629
GO:0005737 Component Cytoplasm IEA
GO:0005794 Component Golgi apparatus IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612755 25783 ENSG00000111300
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14CX7
Protein name N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)
Protein function Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression. {ECO:0000269|PubMed:1
PDB 6VP9 , 7STX , 8G0L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09797 NatB_MDM20 263 658 N-acetyltransferase B complex (NatB) non catalytic subunit Family
Sequence
MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGK
QEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLF
MAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERM
VEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYK
KLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWSPPAEGEHSLEGEVHYSAE
KAVKFIEDRITEESKSSRHLRGPHLAKLELIRRLRSQGCNDEYKLGDPEELMFQYFKKFG
DKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQQHLCVVQL
TRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKTCLKTELQFSDYYCLLAVHALIDVWR
ETGDETTVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHD
TIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFR
NRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEDLRDNRDL
NV
FFSWDPKDRDVSEEHKKLSLEEETLWLRIRSLTLRLISGLPSLNHPVEPKNSEKTAENGV
SSRIDILRLLLQQLEATLETGKRFIEKDIQYPFLGPVPTRMGGFFNSGCSQCQISSFYLV
NDIYELDTSGLEDTMEIQERIENSFKSLLDQLKDVFSKCKGDLLEVKDGNLKTHPTLLEN
LVFFVETISVILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTL
ISNVVDHIKGLETHLIALKLEELILEDTSLSPEERKFSKTVQGKVQSSYLHSLLEMGELL
KKRLETTKKLKI
Sequence length 972
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Thyroid cancer, nonmedullary, 1 Likely benign rs145000175 RCV005932603
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Juvenile Associate 19565500, 20722033
Arthritis Rheumatoid Associate 20722033
Autoimmune Diseases Associate 19565500
Breast Neoplasms Associate 34018994
Crohn Disease Associate 20722033
Diabetes Mellitus Type 1 Associate 20089178, 20722033
Digestive System Neoplasms Associate 21437268
Dyslipidemias Associate 29879492
Esophageal Neoplasms Associate 28464297
Esophageal Squamous Cell Carcinoma Associate 28464297