Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
80018
Gene name Gene Name - the full gene name approved by the HGNC.
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NAA25
Synonyms (NCBI Gene) Gene synonyms aliases
C12orf30, MDM20, NAP1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005228 hsa-let-7b-5p pSILAC 18668040
MIRT005259 hsa-miR-16-5p pSILAC 18668040
MIRT020629 hsa-miR-155-5p Proteomics 18668040
MIRT023442 hsa-miR-30b-5p Sequencing 20371350
MIRT005259 hsa-miR-16-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004596 Function Peptide alpha-N-acetyltransferase activity IBA 21873635
GO:0005515 Function Protein binding IPI 18570629
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005794 Component Golgi apparatus IDA
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612755 25783 ENSG00000111300
Protein
UniProt ID Q14CX7
Protein name N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)
Protein function Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression. {ECO:0000269|PubMed:1
PDB 6VP9 , 7STX , 8G0L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09797 NatB_MDM20 263 658 N-acetyltransferase B complex (NatB) non catalytic subunit Family
Sequence
MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGK
QEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLF
MAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERM
VEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYK
KLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWSPPAEGEHSLEGEVHYSAE
KAVKFIEDRITEESKSSRHLRGPHLAKLELIRRLRSQGCNDEYKLGDPEELMFQYFKKFG
DKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQQHLCVVQL
TRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKTCLKTELQFSDYYCLLAVHALIDVWR
ETGDETTVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHD
TIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFR
NRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEDLRDNRDL
NV
FFSWDPKDRDVSEEHKKLSLEEETLWLRIRSLTLRLISGLPSLNHPVEPKNSEKTAENGV
SSRIDILRLLLQQLEATLETGKRFIEKDIQYPFLGPVPTRMGGFFNSGCSQCQISSFYLV
NDIYELDTSGLEDTMEIQERIENSFKSLLDQLKDVFSKCKGDLLEVKDGNLKTHPTLLEN
LVFFVETISVILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTL
ISNVVDHIKGLETHLIALKLEELILEDTSLSPEERKFSKTVQGKVQSSYLHSLLEMGELL
KKRLETTKKLKI
Sequence length 972
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 30104761, 24262325
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
17554260, 17554300, 18978792
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
30595370, 22493691
Unknown
Disease term Disease name Evidence References Source
Coronary heart disease Coronary heart disease 21971053 ClinVar
Ischemic Stroke Ischemic Stroke GWAS
Epilepsy Epilepsy GWAS
Myocardial Infarction Myocardial Infarction GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Juvenile Associate 19565500, 20722033
Arthritis Rheumatoid Associate 20722033
Autoimmune Diseases Associate 19565500
Breast Neoplasms Associate 34018994
Crohn Disease Associate 20722033
Diabetes Mellitus Type 1 Associate 20089178, 20722033
Digestive System Neoplasms Associate 21437268
Dyslipidemias Associate 29879492
Esophageal Neoplasms Associate 28464297
Esophageal Squamous Cell Carcinoma Associate 28464297