WWC2 (WW and C2 domain containing 2)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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80014 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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WW and C2 domain containing 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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WWC2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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BOMB |
Chromosome
Chromosome number
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4 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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4q35.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C- |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | Q6AWC2 | |||||||||||||||
Protein name | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | |||||||||||||||
Protein function | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional a | |||||||||||||||
Family and domains |
Pfam
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Sequence |
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Sequence length | 1192 | |||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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