Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
800
Gene name Gene Name - the full gene name approved by the HGNC.
Caldesmon 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CALD1
Synonyms (NCBI Gene) Gene synonyms aliases
CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22, h-CD
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomy
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023307 hsa-miR-122-5p Proteomics 21750653
MIRT025321 hsa-miR-34a-5p Proteomics 21566225
MIRT025321 hsa-miR-34a-5p Proteomics 21566225
MIRT030858 hsa-miR-21-5p Microarray 18591254
MIRT051318 hsa-miR-15a-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
NR3C1 Activation 18772142
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IEA
GO:0003779 Function Actin binding IBA
GO:0003779 Function Actin binding IEA
GO:0003779 Function Actin binding TAS 1555769
GO:0005515 Function Protein binding IPI 21044950, 30021884, 35271311
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
114213 1441 ENSG00000122786
Protein
UniProt ID Q05682
Protein name Caldesmon (CDM)
Protein function Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases th
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02029 Caldesmon 31 299 Caldesmon Disordered
PF02029 Caldesmon 296 780 Caldesmon Disordered
Tissue specificity TISSUE SPECIFICITY: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal
Sequence
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ
EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI
EAEEK
AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK
EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE
KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS
FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR
RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE
KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS
SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN
VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE

KQSVDKVTSPTKV
Sequence length 793
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Vascular smooth muscle contraction   Smooth Muscle Contraction
<