SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79987
Gene name Gene Name - the full gene name approved by the HGNC.
Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SVEP1
Synonyms (NCBI Gene) Gene synonyms aliases
C9orf13, CCP22, POLYDOM, SEL-OB, SELOB
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q31.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(51)
miRTarBase ID miRNA Experiments Reference
MIRT652968 hsa-miR-3156-5p HITS-CLIP 23824327
MIRT652967 hsa-miR-6888-5p HITS-CLIP 23824327
MIRT652966 hsa-miR-501-5p HITS-CLIP 23824327
MIRT652965 hsa-miR-5196-3p HITS-CLIP 23824327
MIRT652964 hsa-miR-4793-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(6)
GO ID Ontology Definition Evidence Reference
GO:0005509 Function Calcium ion binding IEA
GO:0005576 Component Extracellular region IEA
GO:0005634 Component Nucleus IDA 27892606
GO:0005737 Component Cytoplasm IDA 27892606
GO:0007155 Process Cell adhesion IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
611691 15985 ENSG00000165124
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q4LDE5
Protein name Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)
Protein function Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (By similarity
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00092 VWA 83 → 258 von Willebrand factor type A domain Domain
PF07699 Ephrin_rec_like 310 → 360 Putative ephrin-receptor like Family
PF00084 Sushi 378 → 433 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 438 → 493 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 498 → 559 Sushi repeat (SCR repeat) Domain
PF02494 HYR 560 → 642 HYR domain Domain
PF02494 HYR 643 → 722 HYR domain Domain
PF07699 Ephrin_rec_like 1005 → 1052 Putative ephrin-receptor like Family
PF07699 Ephrin_rec_like 1059 → 1106 Putative ephrin-receptor like Family
PF07699 Ephrin_rec_like 1113 → 1160 Putative ephrin-receptor like Family
PF00008 EGF 1197 → 1227 EGF-like domain Domain
PF00008 EGF 1235 → 1265 EGF-like domain Domain
PF00008 EGF 1273 → 1303 EGF-like domain Domain
PF12661 hEGF 1316 → 1337 Human growth factor-like EGF Domain
PF00008 EGF 1349 → 1379 EGF-like domain Domain
PF00008 EGF 1387 → 1417 EGF-like domain Domain
PF00354 Pentaxin 1429 → 1623 Pentaxin family Domain
PF00084 Sushi 1628 → 1685 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 1690 → 1743 Sushi repeat (SCR repeat) Domain
PF07645 EGF_CA 1745 → 1783 Calcium-binding EGF domain Domain
PF00084 Sushi 1789 → 1842 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 1847 → 1900 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 1905 → 1958 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 1963 → 2016 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2021 → 2078 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2083 → 2141 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2146 → 2199 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2204 → 2259 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2264 → 2318 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2323 → 2376 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2381 → 2435 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2440 → 2493 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2498 → 2551 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2556 → 2608 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2658 → 2712 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2717 → 2770 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2775 → 2828 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2833 → 2886 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2891 → 2944 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 2949 → 3002 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3007 → 3059 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3064 → 3117 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3122 → 3176 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3181 → 3236 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3241 → 3294 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3299 → 3352 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3357 → 3411 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 3416 → 3468 Sushi repeat (SCR repeat) Domain
PF00008 EGF 3502 → 3530 EGF-like domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in mesenchymal cells (at protein level) (PubMed:16206243). Expressed in vascular smooth muscle cells (at protein level) (PubMed:35802072). Expressed throughout the epidermis, expression is most prominent in the basal and lowe
Sequence 
MWPRLAFCCWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSR
VERLGQAFRRRVRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTAT
RVAIVTFSSKNYVVPRVDYISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQIL
LHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKE
EHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHT
GHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC
VCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILC
LPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC
QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE
MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEK
VSVHVHPAFTPPYLFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQ
VSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHI
VIKGSPCEIPFTPVNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTY
TTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDI
DCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKS
SRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKD
PMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRI
GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPK
FGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFC
LACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFN
PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG
YTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNA
VCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC
ELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVM
LDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKIT
NCPSVNDGRWHHIAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKK
GEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVK
IDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ
PLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS
PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS
SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE
LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG
LTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT
FRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFG
DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA
KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS
NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG
RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF
EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTT
EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF
GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS
TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTV
TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIY
SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM
MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ
EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN
RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKN
WDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS
GATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE
IPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSP
SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCE
HTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPL
SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKK
CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVS
CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE
TPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVP
FVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA
HVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGG
ICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC
LNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF
Sequence length 3571
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778, 28714975
Show/Hide Unknown Diseases (5)
Unknown
Disease term Disease name Evidence References Source
Coronary heart disease Coronary heart disease 23364394 ClinVar
Diabetes Diabetes GWAS
Bipolar Disorder Bipolar Disorder GWAS
Takayasu Arteritis Takayasu Arteritis GWAS
Show/Hide Text Mining Associations (31)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 37118015
Arrhythmias Cardiac Associate 27529678
Atrial Fibrillation Associate 37967346
Atrophy Associate 37118015
Bipolar Disorder Associate 27529678
Bladder Exstrophy Associate 37509153
Breast Neoplasms Associate 23317273, 39379897
Carcinogenesis Associate 39379897
Carcinoma Hepatocellular Associate 31272500
Cardiovascular Diseases Associate 40026415