FRMD1 (FERM domain containing 1)

Gene

• Entrez ID: 79981
• Gene name: FERM domain containing 1
• Gene symbol: FRMD1
• Synonyms (NCBI Gene): bA164L23.1
• Chromosome: 6
• Chromosome location: 6q27

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019083	hsa-miR-335-5p	Microarray	18185580
MIRT1004453	hsa-miR-1262	CLIP-seq
MIRT1004454	hsa-miR-1265	CLIP-seq
MIRT1004455	hsa-miR-1266	CLIP-seq
MIRT1004456	hsa-miR-1285	CLIP-seq
MIRT1004457	hsa-miR-2392	CLIP-seq
MIRT1004458	hsa-miR-296-5p	CLIP-seq
MIRT1004459	hsa-miR-3187-5p	CLIP-seq
MIRT1004460	hsa-miR-378g	CLIP-seq
MIRT1004461	hsa-miR-4438	CLIP-seq
MIRT1004462	hsa-miR-4486	CLIP-seq
MIRT1004463	hsa-miR-4518	CLIP-seq
MIRT1004464	hsa-miR-4701-3p	CLIP-seq
MIRT1004465	hsa-miR-4749-3p	CLIP-seq
MIRT1004466	hsa-miR-542-3p	CLIP-seq
MIRT1004467	hsa-miR-592	CLIP-seq
MIRT1004468	hsa-miR-597	CLIP-seq
MIRT1004469	hsa-miR-612	CLIP-seq
MIRT2231422	hsa-miR-4475	CLIP-seq
MIRT2388210	hsa-miR-150	CLIP-seq
MIRT2388211	hsa-miR-4713-5p	CLIP-seq
MIRT2388212	hsa-miR-4768-5p	CLIP-seq
MIRT2388213	hsa-miR-532-3p	CLIP-seq
MIRT1004467	hsa-miR-592	CLIP-seq
MIRT1004468	hsa-miR-597	CLIP-seq
MIRT2388214	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0035332	Process	Positive regulation of hippo signaling	IBA
GO:0098592	Component	Cytoplasmic side of apical plasma membrane	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N878
• Protein name: FERM domain-containing protein 1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09379	FERM_N	58 → 120	FERM N-terminal domain	Domain
  PF00373	FERM_M	148 → 264	FERM central domain	Domain

• Sequence:

  MAVPPRGRGIDPARTNPDTFPPSGARCMEPSPERPACSQQEPTLGMDAMASEHRDVLVLL
  PSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSK
  DWKKERNEGNEKPRAPFVAFLRVQHYVENGRVISDHRARHLYYCHLKERVLRSQCAHREE
  AYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDYILRHMPTLHRERQGL
  SPKEAMLCFIQEACRLEDVPVHFFRLHKDKKEGRPTVILGLALRGVHIYQGKKLEIQLDG
  LPAAQKLVYYTGCTWRSRHLLHLLRASHQLHLRVRPTLQQLRQREEAEEKQHYRESYISD
  ELELDLASRSFPGSGVSSQHCPHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLE
  VHGLHEKEPSSSPRTSRSHPSTRGDSQATRQEPCTQVRTRGQSAEAVHQIQEMTAGVSEE
  QHSHGLDDMQLHQLALHPAPTSLSHTFHRALDCRLAGPCETRATLPSKRSSNCLALDLFG
  EAPPQEFVV

• Sequence length: 549

Pathways

KEGG:

Hippo signaling pathway
Hippo signaling pathway - multiple species

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Distal myopathy with posterior leg and anterior hand involvement	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Leukemia Lymphoma Adult T Cell	Associate	34446027	★☆☆☆☆ Found in Text Mining only
Paraparesis Tropical Spastic	Associate	34446027	★☆☆☆☆ Found in Text Mining only