DENND2D (DENN domain containing 2D)

Gene

• Entrez ID: 79961
• Gene name: DENN domain containing 2D
• Gene symbol: DENND2D
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p13.3-p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022403	hsa-miR-124-3p	Microarray	18668037
MIRT932356	hsa-miR-1225-3p	CLIP-seq
MIRT932357	hsa-miR-1233	CLIP-seq
MIRT932358	hsa-miR-2276	CLIP-seq
MIRT932359	hsa-miR-3613-3p	CLIP-seq
MIRT932360	hsa-miR-3921	CLIP-seq
MIRT932361	hsa-miR-4277	CLIP-seq
MIRT932362	hsa-miR-4303	CLIP-seq
MIRT932363	hsa-miR-4633-3p	CLIP-seq
MIRT932364	hsa-miR-4653-5p	CLIP-seq
MIRT932365	hsa-miR-4677-3p	CLIP-seq
MIRT932366	hsa-miR-4679	CLIP-seq
MIRT932367	hsa-miR-4694-3p	CLIP-seq
MIRT932368	hsa-miR-4772-3p	CLIP-seq
MIRT2211478	hsa-miR-103a	CLIP-seq
MIRT2211479	hsa-miR-107	CLIP-seq
MIRT2211480	hsa-miR-1207-5p	CLIP-seq
MIRT2211481	hsa-miR-1246	CLIP-seq
MIRT2211482	hsa-miR-127-5p	CLIP-seq
MIRT2211483	hsa-miR-1301	CLIP-seq
MIRT2211484	hsa-miR-1324	CLIP-seq
MIRT2211485	hsa-miR-1909	CLIP-seq
MIRT2211486	hsa-miR-216a	CLIP-seq
MIRT2211487	hsa-miR-3064-3p	CLIP-seq
MIRT2211488	hsa-miR-3942-5p	CLIP-seq
MIRT2211489	hsa-miR-4330	CLIP-seq
MIRT2211490	hsa-miR-4432	CLIP-seq
MIRT2211491	hsa-miR-4656	CLIP-seq
MIRT2211492	hsa-miR-4703-5p	CLIP-seq
MIRT2211493	hsa-miR-4713-3p	CLIP-seq
MIRT2211494	hsa-miR-4736	CLIP-seq
MIRT2211495	hsa-miR-4762-5p	CLIP-seq
MIRT2211496	hsa-miR-4763-3p	CLIP-seq
MIRT2211497	hsa-miR-5047	CLIP-seq
MIRT2211498	hsa-miR-619	CLIP-seq
MIRT2211499	hsa-miR-646	CLIP-seq
MIRT2515199	hsa-miR-3668	CLIP-seq
MIRT2515200	hsa-miR-4732-5p	CLIP-seq
MIRT2515201	hsa-miR-499a-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0050790	Process	Regulation of catalytic activity	IEA

Other IDs

• MIM: 615111
• HGNC: 26192
• e!Ensembl: ENSG00000162777

Protein

• UniProt ID: Q9H6A0
• Protein name: DENN domain-containing protein 2D
• Protein function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03456	uDENN	73 → 141	uDENN domain	Domain
  PF02141	DENN	149 → 333	DENN (AEX-3) domain	Family
  PF03455	dDENN	404 → 452	dDENN domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous les
• Sequence:

  MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVV
  SLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRE
  TFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQIS
  MAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLS
  FEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVC
  CPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQ
  GINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRR
  FVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK

• Sequence length: 471

Pathways

Reactome:

RAB GEFs exchange GTP for GDP on RABs

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		30804561	ClinVar
Psoriasis	Psoriasis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	24098497
Carcinoma Non Small Cell Lung	Associate	26783084
Colorectal Neoplasms	Associate	35523764
Neoplasm Metastasis	Associate	26783084
Neoplasm Metastasis	Inhibit	35523764
Non ST Elevated Myocardial Infarction	Associate	26509668