DENND2D (DENN domain containing 2D)

Gene

• Entrez ID: 79961
• Gene name: DENN domain containing 2D
• Gene symbol: DENND2D
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p13.3-p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022403	hsa-miR-124-3p	Microarray	18668037
MIRT932356	hsa-miR-1225-3p	CLIP-seq
MIRT932357	hsa-miR-1233	CLIP-seq
MIRT932358	hsa-miR-2276	CLIP-seq
MIRT932359	hsa-miR-3613-3p	CLIP-seq
MIRT932360	hsa-miR-3921	CLIP-seq
MIRT932361	hsa-miR-4277	CLIP-seq
MIRT932362	hsa-miR-4303	CLIP-seq
MIRT932363	hsa-miR-4633-3p	CLIP-seq
MIRT932364	hsa-miR-4653-5p	CLIP-seq
MIRT932365	hsa-miR-4677-3p	CLIP-seq
MIRT932366	hsa-miR-4679	CLIP-seq
MIRT932367	hsa-miR-4694-3p	CLIP-seq
MIRT932368	hsa-miR-4772-3p	CLIP-seq
MIRT2211478	hsa-miR-103a	CLIP-seq
MIRT2211479	hsa-miR-107	CLIP-seq
MIRT2211480	hsa-miR-1207-5p	CLIP-seq
MIRT2211481	hsa-miR-1246	CLIP-seq
MIRT2211482	hsa-miR-127-5p	CLIP-seq
MIRT2211483	hsa-miR-1301	CLIP-seq
MIRT2211484	hsa-miR-1324	CLIP-seq
MIRT2211485	hsa-miR-1909	CLIP-seq
MIRT2211486	hsa-miR-216a	CLIP-seq
MIRT2211487	hsa-miR-3064-3p	CLIP-seq
MIRT2211488	hsa-miR-3942-5p	CLIP-seq
MIRT2211489	hsa-miR-4330	CLIP-seq
MIRT2211490	hsa-miR-4432	CLIP-seq
MIRT2211491	hsa-miR-4656	CLIP-seq
MIRT2211492	hsa-miR-4703-5p	CLIP-seq
MIRT2211493	hsa-miR-4713-3p	CLIP-seq
MIRT2211494	hsa-miR-4736	CLIP-seq
MIRT2211495	hsa-miR-4762-5p	CLIP-seq
MIRT2211496	hsa-miR-4763-3p	CLIP-seq
MIRT2211497	hsa-miR-5047	CLIP-seq
MIRT2211498	hsa-miR-619	CLIP-seq
MIRT2211499	hsa-miR-646	CLIP-seq
MIRT2515199	hsa-miR-3668	CLIP-seq
MIRT2515200	hsa-miR-4732-5p	CLIP-seq
MIRT2515201	hsa-miR-499a-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 33961781
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA

Other IDs

• MIM: 615111
• HGNC: 26192
• e!Ensembl: ENSG00000162777

Protein

• UniProt ID: Q9H6A0
• Protein name: DENN domain-containing protein 2D
• Protein function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03456	uDENN	73 → 141	uDENN domain	Domain
  PF02141	DENN	149 → 333	DENN (AEX-3) domain	Family
  PF03455	dDENN	404 → 452	dDENN domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous les
• Sequence:

  MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVV
  SLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRE
  TFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQIS
  MAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLS
  FEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVC
  CPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQ
  GINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRR
  FVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK

• Sequence length: 471

Pathways

Reactome:

RAB GEFs exchange GTP for GDP on RABs