Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79949
Gene name Gene Name - the full gene name approved by the HGNC.	Pleckstrin homology domain containing S1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLEKHS1
Synonyms (NCBI Gene) Gene synonyms aliases	C10orf81, HEL185
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q25.3

Show/Hide all(139)

miRTarBase ID	miRNA	Experiments	Reference
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23313552
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23313552
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23313552
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23313552
MIRT671932	hsa-miR-3666	HITS-CLIP	23313552
MIRT671931	hsa-miR-4295	HITS-CLIP	23313552
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23313552
MIRT693712	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT671927	hsa-miR-3135b	HITS-CLIP	23313552
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT671923	hsa-miR-4284	HITS-CLIP	23313552
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT671921	hsa-miR-3652	HITS-CLIP	23313552
MIRT671920	hsa-miR-4430	HITS-CLIP	23313552
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23313552
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23313552
MIRT693711	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT693709	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT693710	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT671916	hsa-miR-8057	HITS-CLIP	23313552
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23313552
MIRT693708	hsa-miR-670-3p	HITS-CLIP	23313552
MIRT693707	hsa-miR-1238-3p	HITS-CLIP	23313552
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT671932	hsa-miR-3666	HITS-CLIP	23824327
MIRT671931	hsa-miR-4295	HITS-CLIP	23824327
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT671929	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT671928	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671927	hsa-miR-3135b	HITS-CLIP	23824327
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT671923	hsa-miR-4284	HITS-CLIP	23824327
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671921	hsa-miR-3652	HITS-CLIP	23824327
MIRT671920	hsa-miR-4430	HITS-CLIP	23824327
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT671916	hsa-miR-8057	HITS-CLIP	23824327
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT516892	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516891	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516889	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516888	hsa-miR-3149	PAR-CLIP	23446348
MIRT671917	hsa-miR-106a-3p	PAR-CLIP	27292025
MIRT671925	hsa-miR-122-5p	PAR-CLIP	27292025
MIRT693707	hsa-miR-1238-3p	PAR-CLIP	27292025
MIRT671936	hsa-miR-130a-3p	PAR-CLIP	27292025
MIRT671935	hsa-miR-130b-3p	PAR-CLIP	27292025
MIRT671922	hsa-miR-24-3p	PAR-CLIP	27292025
MIRT671934	hsa-miR-301a-3p	PAR-CLIP	27292025
MIRT671933	hsa-miR-301b-3p	PAR-CLIP	27292025
MIRT671927	hsa-miR-3135b	PAR-CLIP	27292025
MIRT671924	hsa-miR-3622b-5p	PAR-CLIP	27292025
MIRT671921	hsa-miR-3652	PAR-CLIP	27292025
MIRT671932	hsa-miR-3666	PAR-CLIP	27292025
MIRT671923	hsa-miR-4284	PAR-CLIP	27292025
MIRT671931	hsa-miR-4295	PAR-CLIP	27292025
MIRT671918	hsa-miR-4423-5p	PAR-CLIP	27292025
MIRT671920	hsa-miR-4430	PAR-CLIP	27292025
MIRT671930	hsa-miR-454-3p	PAR-CLIP	27292025
MIRT671926	hsa-miR-504-3p	PAR-CLIP	27292025
MIRT671937	hsa-miR-5197-5p	PAR-CLIP	27292025
MIRT671919	hsa-miR-6501-5p	PAR-CLIP	27292025
MIRT693708	hsa-miR-670-3p	PAR-CLIP	27292025
MIRT693709	hsa-miR-6780a-3p	PAR-CLIP	27292025
MIRT693710	hsa-miR-6881-3p	PAR-CLIP	27292025
MIRT693711	hsa-miR-7111-3p	PAR-CLIP	27292025
MIRT671915	hsa-miR-744-3p	PAR-CLIP	27292025
MIRT671916	hsa-miR-8057	PAR-CLIP	27292025
MIRT693712	hsa-miR-877-3p	PAR-CLIP	27292025
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23313552
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23313552
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23313552
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23313552
MIRT671932	hsa-miR-3666	HITS-CLIP	23313552
MIRT671931	hsa-miR-4295	HITS-CLIP	23313552
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23313552
MIRT693712	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT671927	hsa-miR-3135b	HITS-CLIP	23313552
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT671923	hsa-miR-4284	HITS-CLIP	23313552
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT671921	hsa-miR-3652	HITS-CLIP	23313552
MIRT671920	hsa-miR-4430	HITS-CLIP	23313552
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23313552
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23313552
MIRT693711	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT693709	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT693710	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT671916	hsa-miR-8057	HITS-CLIP	23313552
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23313552
MIRT693708	hsa-miR-670-3p	HITS-CLIP	23313552
MIRT693707	hsa-miR-1238-3p	HITS-CLIP	23313552
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT671932	hsa-miR-3666	HITS-CLIP	23824327
MIRT671931	hsa-miR-4295	HITS-CLIP	23824327
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT671929	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT671928	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671927	hsa-miR-3135b	HITS-CLIP	23824327
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT671923	hsa-miR-4284	HITS-CLIP	23824327
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671921	hsa-miR-3652	HITS-CLIP	23824327
MIRT671920	hsa-miR-4430	HITS-CLIP	23824327
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT671916	hsa-miR-8057	HITS-CLIP	23824327
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT516892	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516891	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516889	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516888	hsa-miR-3149	PAR-CLIP	23446348

Show/Hide all(1)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25814554

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q5SXH7

Protein name

Pleckstrin homology domain-containing family S member 1 (PH domain-containing family S member 1) (Epididymis luminal protein 185) (hEL185)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	15 → 127	PH domain	Domain

Sequence

MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHH
HRGSIEIDQNSSVEVGISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDW
VSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKHL
MEQSSPGFRQTHLQDLSEATQDVKEENHYLTPRSVLLELDNIIASSDSGESIETDGPDQV
SGRIECHYEPMESSFFKETSHESVDSSKEEPQTLPETQDGDLHLQEQGSGIDWCLSPADV
EAQTTNDQKGNIPDESQVEKLNVFLSPPDVINYLALTEATGRICVSQWEGPPRLGCIFCH
GDHLLAVNDLKPQSLEEVSLFLTRSIQKEDSFRILSYQVAFGEGTELRDRAPGFRTSDRH
DVAKRACMESDWCRDSKTAPSTNLCLSFLFCKIMTNDGAGCWIIK

Sequence length

465

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	31828095
Neoplasms	Associate	25261935
Personality Disorders	Associate	33450964
Prostatic Neoplasms	Associate	33450964
Stomach Neoplasms	Associate	32878427, 35446856, 37978443
Urinary Bladder Neoplasms	Associate	30578357, 36658180

PLEKHS1 (pleckstrin homology domain containing S1)