Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79923
Gene name Gene Name - the full gene name approved by the HGNC.
Nanog homeobox
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NANOG
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expressio
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006222 hsa-miR-34a-5p Luciferase reporter assay, Western blot 22020437
MIRT006222 hsa-miR-34a-5p Luciferase reporter assay, Western blot 22020437
MIRT006228 hsa-miR-34c-5p Luciferase reporter assay, Western blot 22020437
MIRT006229 hsa-miR-34b-3p Luciferase reporter assay, Western blot 22020437
MIRT006222 hsa-miR-34a-5p Luciferase reporter assay, Western blot 22020437
Transcription factors
Transcription factor Regulation Reference
CTCF Unknown 22879976
KDM2A Unknown 23872478
KLF4 Activation 19522013
MBD2 Repression 23255147
PBX1 Activation 19522013
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 25825768
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 23708658
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607937 20857 ENSG00000111704
Protein
UniProt ID Q9H9S0
Protein name Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)
Protein function Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blo
PDB 2KT0 , 4RBO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00046 Homeodomain 96 152 Homeodomain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many
Sequence
MSVDPACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDL
LIQDSPDSSTSPKGKQPTSAEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYL
SLQQMQELSNILNLSYKQVKTWFQNQRMKSKR
WQKNNWPKNSNGVTQKASAPTYPSLYSS
YHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPF
YNCGEESLQSCMQFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNM
QPEDV
Sequence length 305
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Signaling pathways regulating pluripotency of stem cells
Proteoglycans in cancer
  POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Neoplasm Neoplasms, Germ Cell and Embryonal, Neoplasms, Embryonal and Mixed rs137854562, rs137854565, rs137854568, rs137854574, rs121434220, rs121909218, rs121909222, rs587776667, rs606231169, rs587776701, rs121913388, rs137852578, rs137852216, rs121912651, rs28934575
View all (247 more)
16168501
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 27285762, 27540973, 37461005
Adenocarcinoma of Lung Associate 27285762
Adjustment Disorders Associate 35186145
Alzheimer Disease Inhibit 32580970
Ameloblastoma Associate 36655039
Bone Diseases Associate 16331882
Breast Neoplasms Associate 16228988, 19633292, 25127259, 25405855, 27001847, 27981531, 28422735, 30220190, 30845764, 30906504, 31853860, 32427827, 33233699, 34592152, 36142823
View all (1 more)
Calcinosis Cutis Associate 32169072
Carcinogenesis Associate 18419830, 23708493, 35008480, 37461005, 39986058
Carcinoma Embryonal Associate 16206293, 17314394, 19876845, 22963770, 25464862, 27803193, 35008480