Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	79923
Gene name	Nanog homeobox
Gene symbol	NANOG
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12p13.31
Summary	The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expressio

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Show/Hide all (211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006222	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	22020437
MIRT006222	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	22020437
MIRT006228	hsa-miR-34c-5p	Luciferase reporter assayWestern blot	22020437
MIRT006229	hsa-miR-34b-3p	Luciferase reporter assayWestern blot	22020437
MIRT006222	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	22020437
MIRT006222	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	22020437
MIRT006228	hsa-miR-34c-5p	Luciferase reporter assayWestern blot	22020437
MIRT006229	hsa-miR-34b-3p	Luciferase reporter assayWestern blot	22020437
MIRT006222	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	22020437
MIRT006222	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	22020437
MIRT006228	hsa-miR-34c-5p	Luciferase reporter assayWestern blot	22020437
MIRT006229	hsa-miR-34b-3p	Luciferase reporter assayWestern blot	22020437
MIRT007216	hsa-miR-181a-3p	Luciferase reporter assay	23344176
MIRT007216	hsa-miR-181a-3p	Luciferase reporter assay	23344176
MIRT017305	hsa-miR-335-5p	Microarray	18185580
MIRT035522	hsa-miR-145-5p	Luciferase reporter assay	23541921
MIRT044412	hsa-miR-320a	CLASH	23622248
MIRT053286	hsa-miR-134-5p	ImmunohistochemistryqRT-PCRWestern blot	23467648
MIRT054183	hsa-miR-128-3p	FlowqRT-PCRWestern blot	23019226
MIRT437511	hsa-miR-302a-3p	Luciferase reporter assayqRT-PCRWestern blot	23255147
MIRT054183	hsa-miR-128-3p	Luciferase reporter assay	24903149
MIRT054183	hsa-miR-128-3p	Luciferase reporter assay	24903149
MIRT735720	hsa-miR-1252-5p	Luciferase reporter assayWestern blottingqRT-PCR	33975615
MIRT1173304	hsa-miR-1258	CLIP-seq
MIRT1173305	hsa-miR-1321	CLIP-seq
MIRT1173306	hsa-miR-1827	CLIP-seq
MIRT1173307	hsa-miR-1908	CLIP-seq
MIRT1173308	hsa-miR-2114	CLIP-seq
MIRT1173309	hsa-miR-3125	CLIP-seq
MIRT1173310	hsa-miR-3145-5p	CLIP-seq
MIRT1173311	hsa-miR-3162-5p	CLIP-seq
MIRT1173312	hsa-miR-3165	CLIP-seq
MIRT1173313	hsa-miR-3175	CLIP-seq
MIRT1173314	hsa-miR-3656	CLIP-seq
MIRT1173315	hsa-miR-3689a-3p	CLIP-seq
MIRT1173316	hsa-miR-3689c	CLIP-seq
MIRT1173317	hsa-miR-3916	CLIP-seq
MIRT1173318	hsa-miR-3929	CLIP-seq
MIRT1173319	hsa-miR-423-3p	CLIP-seq
MIRT1173320	hsa-miR-4278	CLIP-seq
MIRT1173321	hsa-miR-4419b	CLIP-seq
MIRT1173322	hsa-miR-4433	CLIP-seq
MIRT1173323	hsa-miR-4476	CLIP-seq
MIRT1173324	hsa-miR-4478	CLIP-seq
MIRT1173325	hsa-miR-4533	CLIP-seq
MIRT1173326	hsa-miR-4649-3p	CLIP-seq
MIRT1173327	hsa-miR-4722-5p	CLIP-seq
MIRT1173328	hsa-miR-4728-5p	CLIP-seq
MIRT1173329	hsa-miR-4739	CLIP-seq
MIRT1173330	hsa-miR-4756-5p	CLIP-seq
MIRT1173331	hsa-miR-4767	CLIP-seq
MIRT1173332	hsa-miR-4779	CLIP-seq
MIRT1173333	hsa-miR-485-5p	CLIP-seq
MIRT1173334	hsa-miR-508-5p	CLIP-seq
MIRT1173335	hsa-miR-513b	CLIP-seq
MIRT1173336	hsa-miR-548p	CLIP-seq
MIRT1173337	hsa-miR-566	CLIP-seq
MIRT1173338	hsa-miR-624	CLIP-seq
MIRT1173339	hsa-miR-663	CLIP-seq
MIRT1173340	hsa-miR-765	CLIP-seq
MIRT1173341	hsa-miR-940	CLIP-seq
MIRT2050227	hsa-miR-1273	CLIP-seq
MIRT1173307	hsa-miR-1908	CLIP-seq
MIRT1173308	hsa-miR-2114	CLIP-seq
MIRT1173310	hsa-miR-3145-5p	CLIP-seq
MIRT1173318	hsa-miR-3929	CLIP-seq
MIRT1173319	hsa-miR-423-3p	CLIP-seq
MIRT2050228	hsa-miR-4252	CLIP-seq
MIRT1173321	hsa-miR-4419b	CLIP-seq
MIRT1173324	hsa-miR-4478	CLIP-seq
MIRT2050229	hsa-miR-4486	CLIP-seq
MIRT2050230	hsa-miR-4649-5p	CLIP-seq
MIRT1173331	hsa-miR-4767	CLIP-seq
MIRT2050231	hsa-miR-4793-3p	CLIP-seq
MIRT1173333	hsa-miR-485-5p	CLIP-seq
MIRT1173334	hsa-miR-508-5p	CLIP-seq
MIRT1173337	hsa-miR-566	CLIP-seq
MIRT2050232	hsa-miR-661	CLIP-seq
MIRT1173339	hsa-miR-663	CLIP-seq
MIRT2050233	hsa-miR-766	CLIP-seq
MIRT2279128	hsa-miR-1207-5p	CLIP-seq
MIRT2050227	hsa-miR-1273	CLIP-seq
MIRT2279129	hsa-miR-128	CLIP-seq
MIRT1173306	hsa-miR-1827	CLIP-seq
MIRT1173308	hsa-miR-2114	CLIP-seq
MIRT2279130	hsa-miR-24	CLIP-seq
MIRT2279131	hsa-miR-2682	CLIP-seq
MIRT1173310	hsa-miR-3145-5p	CLIP-seq
MIRT1173312	hsa-miR-3165	CLIP-seq
MIRT2279132	hsa-miR-3178	CLIP-seq
MIRT1173314	hsa-miR-3656	CLIP-seq
MIRT1173318	hsa-miR-3929	CLIP-seq
MIRT1173319	hsa-miR-423-3p	CLIP-seq
MIRT2050228	hsa-miR-4252	CLIP-seq
MIRT2279133	hsa-miR-4284	CLIP-seq
MIRT2279134	hsa-miR-4327	CLIP-seq
MIRT1173321	hsa-miR-4419b	CLIP-seq
MIRT1173322	hsa-miR-4433	CLIP-seq
MIRT1173324	hsa-miR-4478	CLIP-seq
MIRT2050229	hsa-miR-4486	CLIP-seq
MIRT2279135	hsa-miR-449c	CLIP-seq
MIRT2279136	hsa-miR-451b	CLIP-seq
MIRT1173326	hsa-miR-4649-3p	CLIP-seq
MIRT2050230	hsa-miR-4649-5p	CLIP-seq
MIRT1173327	hsa-miR-4722-5p	CLIP-seq
MIRT2279137	hsa-miR-4763-3p	CLIP-seq
MIRT1173331	hsa-miR-4767	CLIP-seq
MIRT2050231	hsa-miR-4793-3p	CLIP-seq
MIRT1173333	hsa-miR-485-5p	CLIP-seq
MIRT1173334	hsa-miR-508-5p	CLIP-seq
MIRT1173335	hsa-miR-513b	CLIP-seq
MIRT1173337	hsa-miR-566	CLIP-seq
MIRT1173338	hsa-miR-624	CLIP-seq
MIRT2279138	hsa-miR-645	CLIP-seq
MIRT2050232	hsa-miR-661	CLIP-seq
MIRT2050233	hsa-miR-766	CLIP-seq
MIRT1173341	hsa-miR-940	CLIP-seq
MIRT2050227	hsa-miR-1273	CLIP-seq
MIRT2391330	hsa-miR-1468	CLIP-seq
MIRT1173306	hsa-miR-1827	CLIP-seq
MIRT1173308	hsa-miR-2114	CLIP-seq
MIRT1173310	hsa-miR-3145-5p	CLIP-seq
MIRT1173318	hsa-miR-3929	CLIP-seq
MIRT1173319	hsa-miR-423-3p	CLIP-seq
MIRT2050228	hsa-miR-4252	CLIP-seq
MIRT1173321	hsa-miR-4419b	CLIP-seq
MIRT2391331	hsa-miR-4432	CLIP-seq
MIRT1173322	hsa-miR-4433	CLIP-seq
MIRT1173324	hsa-miR-4478	CLIP-seq
MIRT2050229	hsa-miR-4486	CLIP-seq
MIRT2279136	hsa-miR-451b	CLIP-seq
MIRT1173326	hsa-miR-4649-3p	CLIP-seq
MIRT2050230	hsa-miR-4649-5p	CLIP-seq
MIRT2391332	hsa-miR-4696	CLIP-seq
MIRT2050231	hsa-miR-4793-3p	CLIP-seq
MIRT1173333	hsa-miR-485-5p	CLIP-seq
MIRT1173334	hsa-miR-508-5p	CLIP-seq
MIRT1173335	hsa-miR-513b	CLIP-seq
MIRT1173337	hsa-miR-566	CLIP-seq
MIRT1173338	hsa-miR-624	CLIP-seq
MIRT2050232	hsa-miR-661	CLIP-seq
MIRT2050233	hsa-miR-766	CLIP-seq
MIRT1173341	hsa-miR-940	CLIP-seq
MIRT1173307	hsa-miR-1908	CLIP-seq
MIRT1173308	hsa-miR-2114	CLIP-seq
MIRT1173318	hsa-miR-3929	CLIP-seq
MIRT1173319	hsa-miR-423-3p	CLIP-seq
MIRT1173321	hsa-miR-4419b	CLIP-seq
MIRT1173324	hsa-miR-4478	CLIP-seq
MIRT1173331	hsa-miR-4767	CLIP-seq
MIRT1173333	hsa-miR-485-5p	CLIP-seq
MIRT1173337	hsa-miR-566	CLIP-seq
MIRT1173339	hsa-miR-663	CLIP-seq
MIRT2050227	hsa-miR-1273	CLIP-seq
MIRT2279129	hsa-miR-128	CLIP-seq
MIRT2391330	hsa-miR-1468	CLIP-seq
MIRT1173306	hsa-miR-1827	CLIP-seq
MIRT1173307	hsa-miR-1908	CLIP-seq
MIRT1173308	hsa-miR-2114	CLIP-seq
MIRT2577310	hsa-miR-3613-3p	CLIP-seq
MIRT1173318	hsa-miR-3929	CLIP-seq
MIRT1173319	hsa-miR-423-3p	CLIP-seq
MIRT1173321	hsa-miR-4419b	CLIP-seq
MIRT2391331	hsa-miR-4432	CLIP-seq
MIRT1173324	hsa-miR-4478	CLIP-seq
MIRT2050229	hsa-miR-4486	CLIP-seq
MIRT2279136	hsa-miR-451b	CLIP-seq
MIRT1173326	hsa-miR-4649-3p	CLIP-seq
MIRT2050230	hsa-miR-4649-5p	CLIP-seq
MIRT2577311	hsa-miR-4684-5p	CLIP-seq
MIRT2391332	hsa-miR-4696	CLIP-seq
MIRT1173331	hsa-miR-4767	CLIP-seq
MIRT1173333	hsa-miR-485-5p	CLIP-seq
MIRT2577312	hsa-miR-548c-3p	CLIP-seq
MIRT1173337	hsa-miR-566	CLIP-seq
MIRT2577313	hsa-miR-607	CLIP-seq
MIRT2050232	hsa-miR-661	CLIP-seq
MIRT1173339	hsa-miR-663	CLIP-seq
MIRT2050233	hsa-miR-766	CLIP-seq
MIRT1173341	hsa-miR-940	CLIP-seq
MIRT2050227	hsa-miR-1273	CLIP-seq
MIRT2279129	hsa-miR-128	CLIP-seq
MIRT2391330	hsa-miR-1468	CLIP-seq
MIRT1173306	hsa-miR-1827	CLIP-seq
MIRT1173307	hsa-miR-1908	CLIP-seq
MIRT1173308	hsa-miR-2114	CLIP-seq
MIRT2577310	hsa-miR-3613-3p	CLIP-seq
MIRT1173318	hsa-miR-3929	CLIP-seq
MIRT1173319	hsa-miR-423-3p	CLIP-seq
MIRT2050228	hsa-miR-4252	CLIP-seq
MIRT1173321	hsa-miR-4419b	CLIP-seq
MIRT2391331	hsa-miR-4432	CLIP-seq
MIRT1173324	hsa-miR-4478	CLIP-seq
MIRT2050229	hsa-miR-4486	CLIP-seq
MIRT2279136	hsa-miR-451b	CLIP-seq
MIRT1173326	hsa-miR-4649-3p	CLIP-seq
MIRT2050230	hsa-miR-4649-5p	CLIP-seq
MIRT2577311	hsa-miR-4684-5p	CLIP-seq
MIRT2391332	hsa-miR-4696	CLIP-seq
MIRT1173327	hsa-miR-4722-5p	CLIP-seq
MIRT1173331	hsa-miR-4767	CLIP-seq
MIRT2050231	hsa-miR-4793-3p	CLIP-seq
MIRT1173333	hsa-miR-485-5p	CLIP-seq
MIRT1173334	hsa-miR-508-5p	CLIP-seq
MIRT2577312	hsa-miR-548c-3p	CLIP-seq
MIRT1173337	hsa-miR-566	CLIP-seq
MIRT2577313	hsa-miR-607	CLIP-seq
MIRT2050232	hsa-miR-661	CLIP-seq
MIRT1173339	hsa-miR-663	CLIP-seq
MIRT2050233	hsa-miR-766	CLIP-seq
MIRT1173341	hsa-miR-940	CLIP-seq

Show/Hide all (8)

Transcription factor	Regulation	Reference
CTCF	Unknown	22879976
KDM2A	Unknown	23872478
KLF4	Activation	19522013
MBD2	Repression	23255147
PBX1	Activation	19522013
POU5F1	Activation	17068183
POU5F1	Unknown	18338330
STAT3	Activation	21689689

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	25825768
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	23708658
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS
GO:0001714	Process	Endodermal cell fate specification	IDA	20713518
GO:0003677	Function	DNA binding	IDA	16153702, 19427902
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	16153702
GO:0005515	Function	Protein binding	IPI	26687479
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IC	16153702
GO:0005634	Component	Nucleus	IDA	18932205
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	20458727
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	16153702
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010468	Process	Regulation of gene expression	IMP	18388306
GO:0019827	Process	Stem cell population maintenance	IBA
GO:0019827	Process	Stem cell population maintenance	IEP	15108323
GO:0019827	Process	Stem cell population maintenance	ISS
GO:0030154	Process	Cell differentiation	IBA
GO:0030154	Process	Cell differentiation	IEP	16501172
GO:0035019	Process	Somatic stem cell population maintenance	IMP	18388306
GO:0045595	Process	Regulation of cell differentiation	IMP	16501172
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20713518
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000648	Process	Positive regulation of stem cell proliferation	IMP	16501172

MIM	HGNC	e!Ensembl
607937	20857	ENSG00000111704

Q9H9S0

Protein name

Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)

Protein function

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blo

PDB

2KT0 , 4RBO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	96 → 152	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many

Sequence

MSVDPACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDL
LIQDSPDSSTSPKGKQPTSAEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYL
SLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSS
YHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPF
YNCGEESLQSCMQFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNM
QPEDV

Sequence length

305

Interactions

View interactions

	KEGG		Reactome
	Signaling pathways regulating pluripotency of stem cells Proteoglycans in cancer		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling

NANOG (Nanog homeobox)