Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79901
Gene name Gene Name - the full gene name approved by the HGNC.
Cytochrome b reductase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CYBRD1
Synonyms (NCBI Gene) Gene synonyms aliases
CYB561A2, DCYTB, FRRS3
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorpti
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022211 hsa-miR-124-3p Microarray 18668037
MIRT028908 hsa-miR-26b-5p Microarray 19088304
MIRT030691 hsa-miR-21-5p Microarray 18591254
MIRT049718 hsa-miR-92a-3p CLASH 23622248
MIRT044230 hsa-miR-301a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000293 Function Ferric-chelate reductase activity IDA 14499595
GO:0005515 Function Protein binding IPI 21516116, 25416956, 25910212, 32296183, 32814053
GO:0005765 Component Lysosomal membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0006879 Process Cellular iron ion homeostasis TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605745 20797 ENSG00000071967
Protein
UniProt ID Q53TN4
Protein name Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)
Protein function Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing F
PDB 5ZLE , 5ZLG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03188 Cytochrom_B561 49 185 Eukaryotic cytochrome b561 Family
Tissue specificity TISSUE SPECIFICITY: Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium. {ECO:0000269|PubMed:16510471, ECO:0000269|PubMed:17068337}.
Sequence
MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVF
IQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLH
SWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTE
KLIFS
LRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGG
TEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM
Sequence length 286
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Mineral absorption   Iron uptake and transport
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Iron overload Iron Overload 27884173 ClinVar
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Asthma Asthma GWAS
Dementia Dementia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 34397867
Asthma Associate 34022066
Carcinogenesis Associate 37632052
Carcinoma Hepatocellular Associate 37632052
Colorectal Neoplasms Associate 16641131, 23236349, 36593242
Hemochromatosis Associate 19892936, 22773607
Hepatitis C Chronic Associate 37632052
Iron Overload Associate 19673882, 35644542
Multiple Sclerosis Associate 35281467
Neoplasm Metastasis Associate 34397867, 36593242