Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	799
Gene name Gene Name - the full gene name approved by the HGNC.	Calcitonin receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CALCR
Synonyms (NCBI Gene) Gene synonyms aliases	CRT, CT-R, CTR, CTR1
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating oste

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1801197	A>G	Risk-factor	Missense variant, coding sequence variant

Show/Hide all(66)

miRTarBase ID	miRNA	Experiments	Reference
MIRT438265	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT438265	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT485747	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT485746	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT485745	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT485744	hsa-miR-8063	PAR-CLIP	23592263
MIRT485743	hsa-miR-4698	PAR-CLIP	23592263
MIRT485742	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT485741	hsa-miR-4424	PAR-CLIP	23592263
MIRT485740	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT485739	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT485741	hsa-miR-4424	PAR-CLIP	27292025
MIRT485746	hsa-miR-4668-3p	PAR-CLIP	27292025
MIRT485743	hsa-miR-4698	PAR-CLIP	27292025
MIRT485742	hsa-miR-4735-5p	PAR-CLIP	27292025
MIRT485745	hsa-miR-4760-3p	PAR-CLIP	27292025
MIRT485740	hsa-miR-520a-5p	PAR-CLIP	27292025
MIRT485739	hsa-miR-525-5p	PAR-CLIP	27292025
MIRT485744	hsa-miR-8063	PAR-CLIP	27292025
MIRT485747	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT485746	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT485745	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT485744	hsa-miR-8063	PAR-CLIP	23592263
MIRT485743	hsa-miR-4698	PAR-CLIP	23592263
MIRT485742	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT485741	hsa-miR-4424	PAR-CLIP	23592263
MIRT485740	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT485739	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT858937	hsa-miR-330-3p	CLIP-seq
MIRT858938	hsa-miR-33a	CLIP-seq
MIRT858939	hsa-miR-33b	CLIP-seq
MIRT858940	hsa-miR-4422	CLIP-seq
MIRT858941	hsa-miR-450b-5p	CLIP-seq
MIRT858942	hsa-miR-507	CLIP-seq
MIRT858943	hsa-miR-513a-3p	CLIP-seq
MIRT858944	hsa-miR-557	CLIP-seq
MIRT858945	hsa-miR-1255a	CLIP-seq
MIRT858946	hsa-miR-1255b	CLIP-seq
MIRT858947	hsa-miR-1910	CLIP-seq
MIRT858948	hsa-miR-3134	CLIP-seq
MIRT858949	hsa-miR-3690	CLIP-seq
MIRT858950	hsa-miR-4254	CLIP-seq
MIRT858951	hsa-miR-4534	CLIP-seq
MIRT858952	hsa-miR-4653-3p	CLIP-seq
MIRT1954982	hsa-miR-340	CLIP-seq
MIRT858949	hsa-miR-3690	CLIP-seq
MIRT858950	hsa-miR-4254	CLIP-seq
MIRT1954983	hsa-miR-4328	CLIP-seq
MIRT858952	hsa-miR-4653-3p	CLIP-seq
MIRT2192690	hsa-miR-1245	CLIP-seq
MIRT2192691	hsa-miR-1343	CLIP-seq
MIRT2192692	hsa-miR-2392	CLIP-seq
MIRT2192693	hsa-miR-24	CLIP-seq
MIRT2192694	hsa-miR-3192	CLIP-seq
MIRT2192695	hsa-miR-3198	CLIP-seq
MIRT2192696	hsa-miR-3605-5p	CLIP-seq
MIRT2192697	hsa-miR-3689a-3p	CLIP-seq
MIRT2192698	hsa-miR-3689c	CLIP-seq
MIRT2192699	hsa-miR-4276	CLIP-seq
MIRT2192700	hsa-miR-4284	CLIP-seq
MIRT2192701	hsa-miR-4309	CLIP-seq
MIRT2192702	hsa-miR-4434	CLIP-seq
MIRT2192703	hsa-miR-4516	CLIP-seq
MIRT2192704	hsa-miR-4531	CLIP-seq
MIRT858951	hsa-miR-4534	CLIP-seq
MIRT2192705	hsa-miR-4728-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IC	22500019
GO:0001635	Function	Calcitonin gene-related peptide receptor activity	IPI	14722252
GO:0004948	Function	Calcitonin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	7588285, 14722252
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	NAS	7588285
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	7619207, 14722252, 15563840
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	22500019
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	NAS	1331173
GO:0007190	Process	Activation of adenylate cyclase activity	IDA	15563840
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0008528	Function	G protein-coupled peptide receptor activity	IBA	21873635
GO:0010628	Process	Positive regulation of gene expression	IGI	22500019
GO:0010739	Process	Positive regulation of protein kinase A signaling	IGI	22500019
GO:0010942	Process	Positive regulation of cell death	IGI	22500019
GO:0030424	Component	Axon	IBA	21873635
GO:0032841	Function	Calcitonin binding	IDA	8078488
GO:0032841	Function	Calcitonin binding	IDA	15563840
GO:0032841	Function	Calcitonin binding	IPI	15563840
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IGI	22500019
GO:0038041	Process	Cross-receptor inhibition within G protein-coupled receptor heterodimer	IPI	14722252
GO:0051384	Process	Response to glucocorticoid	IDA	11250927
GO:0051897	Process	Positive regulation of protein kinase B signaling	IGI	22500019
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IGI	22500019
GO:0097643	Function	Amylin receptor activity	IBA	21873635
GO:0097643	Function	Amylin receptor activity	IGI	22500019
GO:0097643	Function	Amylin receptor activity	IPI	14722252
GO:0097647	Process	Amylin receptor signaling pathway	IDA	14722252
GO:0097647	Process	Amylin receptor signaling pathway	IGI	22500019
GO:0150056	Component	Amylin receptor complex 1	IDA	22500019
GO:0150057	Component	Amylin receptor complex 2	IDA	22500019
GO:0150058	Component	Amylin receptor complex 3	IDA	22500019
GO:1904645	Process	Response to amyloid-beta	IGI	22500019
GO:1905665	Process	Positive regulation of calcium ion import across plasma membrane	IGI	22500019

MIM	HGNC	e!Ensembl
114131	1440	ENSG00000004948

Protein

UniProt ID

P30988

Protein name

Calcitonin receptor (CT-R)

Protein function

G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). CALCR interacts with receptor-activity-modifying proteins R

PDB

5II0 , 5UZ7 , 6NIY , 6PFO , 6PGQ , 7TYF , 7TYH , 7TYI , 7TYL , 7TYN , 7TYO , 7TYW , 7TYX , 7TYY , 7TZF , 8F0J , 8F0K , 8F2A , 8F2B , 9AUC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02793	HRM	69 → 137	Hormone receptor domain	Family
PF00002	7tm_2	145 → 387	7 transmembrane receptor (Secretin family)	Family

Sequence

MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQ
QLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK
HPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQR
VTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCE
GIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFP
WRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRR
PSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA

Sequence length

474

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling Osteoclast differentiation		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Hypercalcemia	Hypercalcemia	rs876657376, rs387907322, rs777676129, rs387907323, rs114368325, rs6068812, rs387907324, rs777947329, rs201304511, rs769409705, rs200095793, rs876661338, rs1554095500, rs139763321, rs774432244, rs781367354 View all (1 more)	18627265
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Diabetes	Diabetes			GWAS

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	40486872
Bone Diseases	Associate	26895962, 29084126
Bone Resorption	Associate	10620070
Breast Neoplasms	Associate	6309149
Calcinosis Cutis	Associate	23820954
Carcinoma Squamous Cell	Associate	28177435
Cholangiocarcinoma	Associate	36142453
Creatine deficiency X linked	Associate	28049948, 38104212
Diabetes Mellitus	Associate	26895962, 28614667
Endocarditis	Associate	28659664
Fluorosis Dental	Associate	25402775
Glioblastoma	Associate	30777055
Hereditary pancreatitis	Associate	37603299
Intervertebral Disc Degeneration	Inhibit	28433710
Juvenile osteoporosis	Associate	24522475
Kidney Calculi	Associate	36088585
Leukemia Myeloid	Associate	8543584
Lung Neoplasms	Associate	37891619
Macular Degeneration	Inhibit	32454166
Metabolic Syndrome	Associate	30858448
Methylmalonic Aciduria due to Methylmalonyl CoA Mutase Deficiency	Associate	40486872
Mouth Neoplasms	Associate	29496061
Myotonic Dystrophy	Associate	37354016
Nasopharyngeal Carcinoma	Associate	28216622
Neoplasms	Associate	16222118, 29496061, 36380062
Neoplasms Bone Tissue	Associate	36834780
Osteoarthritis	Associate	10703936
Osteoporosis	Associate	28614667
Ovarian Neoplasms	Associate	1331173
Prostatic Neoplasms	Associate	16222118, 19001380, 23820954
Prostatitis	Associate	16222118, 23820954
Pyruvate Carboxylase Deficiency Disease	Associate	23820954

CALCR (calcitonin receptor)