Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	799
Gene name	Calcitonin receptor
Gene symbol	CALCR
Synonyms (NCBI Gene)	CRTCT-RCTRCTR1
Chromosome	7
Chromosome location	7q21.3
Summary	This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating oste

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1801197	A>G	Risk-factor	Missense variant, coding sequence variant

Show/Hide all (66)

miRTarBase ID	miRNA	Experiments	Reference
MIRT438265	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT438265	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT485747	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT485746	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT485745	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT485744	hsa-miR-8063	PAR-CLIP	23592263
MIRT485743	hsa-miR-4698	PAR-CLIP	23592263
MIRT485742	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT485741	hsa-miR-4424	PAR-CLIP	23592263
MIRT485740	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT485739	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT485741	hsa-miR-4424	PAR-CLIP	27292025
MIRT485746	hsa-miR-4668-3p	PAR-CLIP	27292025
MIRT485743	hsa-miR-4698	PAR-CLIP	27292025
MIRT485742	hsa-miR-4735-5p	PAR-CLIP	27292025
MIRT485745	hsa-miR-4760-3p	PAR-CLIP	27292025
MIRT485740	hsa-miR-520a-5p	PAR-CLIP	27292025
MIRT485739	hsa-miR-525-5p	PAR-CLIP	27292025
MIRT485744	hsa-miR-8063	PAR-CLIP	27292025
MIRT485747	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT485746	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT485745	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT485744	hsa-miR-8063	PAR-CLIP	23592263
MIRT485743	hsa-miR-4698	PAR-CLIP	23592263
MIRT485742	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT485741	hsa-miR-4424	PAR-CLIP	23592263
MIRT485740	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT485739	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT858937	hsa-miR-330-3p	CLIP-seq
MIRT858938	hsa-miR-33a	CLIP-seq
MIRT858939	hsa-miR-33b	CLIP-seq
MIRT858940	hsa-miR-4422	CLIP-seq
MIRT858941	hsa-miR-450b-5p	CLIP-seq
MIRT858942	hsa-miR-507	CLIP-seq
MIRT858943	hsa-miR-513a-3p	CLIP-seq
MIRT858944	hsa-miR-557	CLIP-seq
MIRT858945	hsa-miR-1255a	CLIP-seq
MIRT858946	hsa-miR-1255b	CLIP-seq
MIRT858947	hsa-miR-1910	CLIP-seq
MIRT858948	hsa-miR-3134	CLIP-seq
MIRT858949	hsa-miR-3690	CLIP-seq
MIRT858950	hsa-miR-4254	CLIP-seq
MIRT858951	hsa-miR-4534	CLIP-seq
MIRT858952	hsa-miR-4653-3p	CLIP-seq
MIRT1954982	hsa-miR-340	CLIP-seq
MIRT858949	hsa-miR-3690	CLIP-seq
MIRT858950	hsa-miR-4254	CLIP-seq
MIRT1954983	hsa-miR-4328	CLIP-seq
MIRT858952	hsa-miR-4653-3p	CLIP-seq
MIRT2192690	hsa-miR-1245	CLIP-seq
MIRT2192691	hsa-miR-1343	CLIP-seq
MIRT2192692	hsa-miR-2392	CLIP-seq
MIRT2192693	hsa-miR-24	CLIP-seq
MIRT2192694	hsa-miR-3192	CLIP-seq
MIRT2192695	hsa-miR-3198	CLIP-seq
MIRT2192696	hsa-miR-3605-5p	CLIP-seq
MIRT2192697	hsa-miR-3689a-3p	CLIP-seq
MIRT2192698	hsa-miR-3689c	CLIP-seq
MIRT2192699	hsa-miR-4276	CLIP-seq
MIRT2192700	hsa-miR-4284	CLIP-seq
MIRT2192701	hsa-miR-4309	CLIP-seq
MIRT2192702	hsa-miR-4434	CLIP-seq
MIRT2192703	hsa-miR-4516	CLIP-seq
MIRT2192704	hsa-miR-4531	CLIP-seq
MIRT858951	hsa-miR-4534	CLIP-seq
MIRT2192705	hsa-miR-4728-5p	CLIP-seq

Show/Hide all (58)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0001540	Function	Amyloid-beta binding	IDA	22500019
GO:0001635	Function	Calcitonin gene-related peptide receptor activity	IDA	38603770
GO:0001635	Function	Calcitonin gene-related peptide receptor activity	IPI	14722252
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004948	Function	Calcitonin receptor activity	IBA
GO:0004948	Function	Calcitonin receptor activity	IDA	7588285, 35324283
GO:0004948	Function	Calcitonin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	7588285, 14722252, 22500019
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	7588285, 7619207
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17110384
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	7619207, 14722252, 15563840, 35324283, 38603770
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	22500019
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	NAS	1331173
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	8078488
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0010628	Process	Positive regulation of gene expression	IGI	22500019
GO:0016020	Component	Membrane	IEA
GO:0030279	Process	Negative regulation of ossification	IEA
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0030424	Component	Axon	IBA
GO:0032841	Function	Calcitonin binding	IDA	15563840
GO:0032841	Function	Calcitonin binding	IDA	7769107, 8078488
GO:0032841	Function	Calcitonin binding	IPI	7588285, 8078488, 15563840
GO:0043488	Process	Regulation of mRNA stability	IEA
GO:0050850	Process	Positive regulation of calcium-mediated signaling	IGI	22500019
GO:0051384	Process	Response to glucocorticoid	IDA	11250927
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI	22500019
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IGI	22500019
GO:0097642	Function	Calcitonin family receptor activity	IDA	35324283
GO:0097643	Function	Amylin receptor activity	IDA	35324283
GO:0097643	Function	Amylin receptor activity	IGI	22500019
GO:0097643	Function	Amylin receptor activity	IPI	14722252
GO:0097646	Process	Calcitonin family receptor signaling pathway	IDA	35324283
GO:0097647	Process	Amylin receptor signaling pathway	IDA	14722252, 35324283
GO:0097647	Process	Amylin receptor signaling pathway	IGI	22500019
GO:0141163	Process	Positive regulation of cAMP/PKA signal transduction	IGI	22500019
GO:0150056	Component	Amylin receptor complex 1	IDA	22500019
GO:0150057	Component	Amylin receptor complex 2	IDA	22500019
GO:0150058	Component	Amylin receptor complex 3	IDA	22500019
GO:0150059	Process	Amylin receptor 1 signaling pathway	IDA	35324283, 38603770
GO:0150060	Process	Amylin receptor 2 signaling pathway	IDA	35324283
GO:0150061	Process	Amylin receptor 3 signaling pathway	IDA	35324283
GO:1904645	Process	Response to amyloid-beta	IGI	22500019
GO:1990408	Process	Calcitonin gene-related peptide receptor signaling pathway	IDA	7588285, 7769107

MIM	HGNC	e!Ensembl
114131	1440	ENSG00000004948

P30988

Protein name

Calcitonin receptor (CT-R)

Protein function

G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). CALCR interacts with receptor-activity-modifying proteins R

PDB

5II0 , 5UZ7 , 6NIY , 6PFO , 6PGQ , 7TYF , 7TYH , 7TYI , 7TYL , 7TYN , 7TYO , 7TYW , 7TYX , 7TYY , 7TZF , 8F0J , 8F0K , 8F2A , 8F2B , 9AUC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02793	HRM	69 → 137	Hormone receptor domain	Family
PF00002	7tm_2	145 → 387	7 transmembrane receptor (Secretin family)	Family

Sequence

MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQ
QLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK
HPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQR
VTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCE
GIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFP
WRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRR
PSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA

Sequence length

474

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling Osteoclast differentiation		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15	Benign	rs1801197	RCV000019203
CALCR-related disorder	Benign; Likely benign	rs2301680, rs143764918, rs780870954, rs142016257, rs140388547, rs147503225, rs1801197, rs142718250	RCV003984063 RCV003909228 RCV003897391 RCV003931690 RCV003961448 RCV003937085 RCV003974841 RCV003910579
Colon adenocarcinoma	Benign	rs10269878	RCV005922356
Lung cancer	Benign	rs10269878	RCV005922357

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	40486872
Bone Diseases	Associate	26895962, 29084126
Bone Resorption	Associate	10620070
Breast Neoplasms	Associate	6309149
Calcinosis Cutis	Associate	23820954
Carcinoma Squamous Cell	Associate	28177435
Cholangiocarcinoma	Associate	36142453
Creatine deficiency X linked	Associate	28049948, 38104212
Diabetes Mellitus	Associate	26895962, 28614667
Endocarditis	Associate	28659664
Fluorosis Dental	Associate	25402775
Glioblastoma	Associate	30777055
Hereditary pancreatitis	Associate	37603299
Intervertebral Disc Degeneration	Inhibit	28433710
Juvenile osteoporosis	Associate	24522475
Kidney Calculi	Associate	36088585
Leukemia Myeloid	Associate	8543584
Lung Neoplasms	Associate	37891619
Macular Degeneration	Inhibit	32454166
Metabolic Syndrome	Associate	30858448
Methylmalonic Aciduria due to Methylmalonyl CoA Mutase Deficiency	Associate	40486872
Mouth Neoplasms	Associate	29496061
Myotonic Dystrophy	Associate	37354016
Nasopharyngeal Carcinoma	Associate	28216622
Neoplasms	Associate	16222118, 29496061, 36380062
Neoplasms Bone Tissue	Associate	36834780
Osteoarthritis	Associate	10703936
Osteoporosis	Associate	28614667
Ovarian Neoplasms	Associate	1331173
Prostatic Neoplasms	Associate	16222118, 19001380, 23820954
Prostatitis	Associate	16222118, 23820954
Pyruvate Carboxylase Deficiency Disease	Associate	23820954

CALCR (calcitonin receptor)