Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79875
Gene name Gene Name - the full gene name approved by the HGNC.
Thrombospondin type 1 domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
THSD4
Synonyms (NCBI Gene) Gene synonyms aliases
AAT12, ADAMTSL-6, ADAMTSL6, FVSY9334, PRO34005
Disease Acronyms (UniProt) Disease acronyms from UniProt database
AAT12
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q23
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018224 hsa-miR-335-5p Microarray 18185580
MIRT483740 hsa-miR-4438 PAR-CLIP 23592263
MIRT483738 hsa-miR-4308 PAR-CLIP 23592263
MIRT483739 hsa-miR-4292 PAR-CLIP 23592263
MIRT483737 hsa-miR-6791-5p PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001527 Component Microfibril IEA
GO:0004222 Function Metalloendopeptidase activity IBA 21873635
GO:0005201 Function Extracellular matrix structural constituent RCA 23979707, 25037231
GO:0006508 Process Proteolysis IEA
GO:0030198 Process Extracellular matrix organization IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
614476 25835 ENSG00000187720
Protein
UniProt ID Q6ZMP0
Protein name Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6)
Protein function Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory t
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00090 TSP_1 57 94 Thrombospondin type 1 domain Domain
PF05986 ADAM_spacer1 412 528 ADAM-TS Spacer 1 Family
PF19030 TSP1_ADAMTS 621 676 Domain
PF19030 TSP1_ADAMTS 680 736 Domain
PF19030 TSP1_ADAMTS 739 793 Domain
PF19030 TSP1_ADAMTS 797 850 Domain
PF19030 TSP1_ADAMTS 856 912 Domain
PF19030 TSP1_ADAMTS 916 967 Domain
PF08686 PLAC 975 1005 PLAC (protease and lacunin) domain Domain
Sequence
MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWG
PWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPG
APARAFADHVVSAVRTSVPLHRSRDE
TPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT
DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEA
PIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAYRQYKL
CNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQ
AEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKH
ALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGT
MFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIM
GTNAISPQVPPH
RRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPH
RPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDS
SMKPTPEEEPCNIFPC
PAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ
HLEKPETTSTCQLKIC
SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKL
RPNDIENCDMGPC
AKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA
EATPCDNGPC
TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK
PPSQQSCHLKPC
GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERE
SCNPQDC
VPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANRQTGFLGSR
Sequence length 1018
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  TGF-beta signaling pathway   Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
26830138
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
17463246
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 28166215, 30804561 ClinVar
Aortic Aneurysm aortic aneurysm, familial thoracic 12 GenCC
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Aortic Aneurysm Associate 34968759
Asthma Associate 32119686, 35368043
Autism Spectrum Disorder Associate 34069769
Breast Neoplasms Associate 33910530
Hemangioblastoma Associate 28742274
Lung Diseases Interstitial Associate 40076669
Neoplasms Associate 25410484
Osteoporosis Associate 22957024
Post Acute COVID 19 Syndrome Associate 40076669
Pregnancy Interstitial Associate 40076669