Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79838
Gene name	Transmembrane channel like 5
Gene symbol	TMC5
Synonyms (NCBI Gene)	-
Chromosome	16
Chromosome location	16p12.3

205

Show/Hide all (205)

miRTarBase ID	miRNA	Experiments	Reference
MIRT569131	hsa-miR-892c-5p	HITS-CLIP	21572407
MIRT569130	hsa-miR-506-5p	HITS-CLIP	21572407
MIRT242384	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT569129	hsa-miR-622	HITS-CLIP	21572407
MIRT569128	hsa-miR-4738-5p	HITS-CLIP	21572407
MIRT569127	hsa-miR-3605-3p	HITS-CLIP	21572407
MIRT706717	hsa-miR-3920	HITS-CLIP	21572407
MIRT242383	hsa-miR-873-3p	HITS-CLIP	21572407
MIRT569126	hsa-miR-3194-5p	HITS-CLIP	21572407
MIRT242387	hsa-miR-6832-5p	HITS-CLIP	21572407
MIRT569125	hsa-miR-1202	HITS-CLIP	21572407
MIRT569124	hsa-miR-3972	HITS-CLIP	21572407
MIRT569123	hsa-miR-5006-5p	HITS-CLIP	21572407
MIRT569131	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT569130	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT242384	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT569129	hsa-miR-622	PAR-CLIP	20371350
MIRT569128	hsa-miR-4738-5p	PAR-CLIP	20371350
MIRT569127	hsa-miR-3605-3p	PAR-CLIP	20371350
MIRT242383	hsa-miR-873-3p	PAR-CLIP	20371350
MIRT569126	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT242387	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT569125	hsa-miR-1202	PAR-CLIP	20371350
MIRT569124	hsa-miR-3972	PAR-CLIP	20371350
MIRT569123	hsa-miR-5006-5p	PAR-CLIP	20371350
MIRT242382	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT445316	hsa-miR-6771-3p	PAR-CLIP	22100165
MIRT445315	hsa-miR-4635	PAR-CLIP	22100165
MIRT445314	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445313	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT569131	hsa-miR-892c-5p	HITS-CLIP	21572407
MIRT569130	hsa-miR-506-5p	HITS-CLIP	21572407
MIRT242384	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT569129	hsa-miR-622	HITS-CLIP	21572407
MIRT569128	hsa-miR-4738-5p	HITS-CLIP	21572407
MIRT569127	hsa-miR-3605-3p	HITS-CLIP	21572407
MIRT706717	hsa-miR-3920	HITS-CLIP	21572407
MIRT242383	hsa-miR-873-3p	HITS-CLIP	21572407
MIRT569126	hsa-miR-3194-5p	HITS-CLIP	21572407
MIRT242387	hsa-miR-6832-5p	HITS-CLIP	21572407
MIRT569125	hsa-miR-1202	HITS-CLIP	21572407
MIRT569124	hsa-miR-3972	HITS-CLIP	21572407
MIRT569123	hsa-miR-5006-5p	HITS-CLIP	21572407
MIRT569131	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT569130	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT242384	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT569129	hsa-miR-622	PAR-CLIP	20371350
MIRT569128	hsa-miR-4738-5p	PAR-CLIP	20371350
MIRT569127	hsa-miR-3605-3p	PAR-CLIP	20371350
MIRT242383	hsa-miR-873-3p	PAR-CLIP	20371350
MIRT569126	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT242387	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT569125	hsa-miR-1202	PAR-CLIP	20371350
MIRT569124	hsa-miR-3972	PAR-CLIP	20371350
MIRT569123	hsa-miR-5006-5p	PAR-CLIP	20371350
MIRT242382	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT445316	hsa-miR-6771-3p	PAR-CLIP	22100165
MIRT445315	hsa-miR-4635	PAR-CLIP	22100165
MIRT445314	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445313	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT1428024	hsa-miR-1208	CLIP-seq
MIRT1428025	hsa-miR-1281	CLIP-seq
MIRT1428026	hsa-miR-129-5p	CLIP-seq
MIRT1428027	hsa-miR-1304	CLIP-seq
MIRT1428028	hsa-miR-1827	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT1428031	hsa-miR-216a	CLIP-seq
MIRT1428032	hsa-miR-3153	CLIP-seq
MIRT1428033	hsa-miR-3647-3p	CLIP-seq
MIRT1428034	hsa-miR-4252	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT1428036	hsa-miR-4282	CLIP-seq
MIRT1428037	hsa-miR-4668-5p	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT1428041	hsa-miR-4772-3p	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq
MIRT1428043	hsa-miR-513a-3p	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT1428044	hsa-miR-3908	CLIP-seq
MIRT1428045	hsa-miR-3917	CLIP-seq
MIRT1428046	hsa-miR-3942-5p	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT1428047	hsa-miR-4703-5p	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT1428048	hsa-miR-4766-3p	CLIP-seq
MIRT1428041	hsa-miR-4772-3p	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq
MIRT1428031	hsa-miR-216a	CLIP-seq
MIRT1428044	hsa-miR-3908	CLIP-seq
MIRT1428045	hsa-miR-3917	CLIP-seq
MIRT1428046	hsa-miR-3942-5p	CLIP-seq
MIRT1428036	hsa-miR-4282	CLIP-seq
MIRT1428047	hsa-miR-4703-5p	CLIP-seq
MIRT1428048	hsa-miR-4766-3p	CLIP-seq
MIRT1428043	hsa-miR-513a-3p	CLIP-seq
MIRT1428031	hsa-miR-216a	CLIP-seq
MIRT1428044	hsa-miR-3908	CLIP-seq
MIRT1428045	hsa-miR-3917	CLIP-seq
MIRT1428046	hsa-miR-3942-5p	CLIP-seq
MIRT1428047	hsa-miR-4703-5p	CLIP-seq
MIRT1428048	hsa-miR-4766-3p	CLIP-seq
MIRT2128186	hsa-miR-1285	CLIP-seq
MIRT2128187	hsa-miR-1290	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT2128188	hsa-miR-197	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT2128189	hsa-miR-3167	CLIP-seq
MIRT2128190	hsa-miR-3182	CLIP-seq
MIRT2128191	hsa-miR-3187-3p	CLIP-seq
MIRT2128192	hsa-miR-3187-5p	CLIP-seq
MIRT2128193	hsa-miR-3545-3p	CLIP-seq
MIRT2128194	hsa-miR-3663-5p	CLIP-seq
MIRT2128195	hsa-miR-378g	CLIP-seq
MIRT2128196	hsa-miR-411	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT2128197	hsa-miR-4314	CLIP-seq
MIRT2128198	hsa-miR-4435	CLIP-seq
MIRT2128199	hsa-miR-4486	CLIP-seq
MIRT2128200	hsa-miR-4659a-3p	CLIP-seq
MIRT2128201	hsa-miR-4659b-3p	CLIP-seq
MIRT2128202	hsa-miR-4680-5p	CLIP-seq
MIRT2128203	hsa-miR-4701-5p	CLIP-seq
MIRT2128204	hsa-miR-4716-5p	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT2128205	hsa-miR-4755-3p	CLIP-seq
MIRT1428041	hsa-miR-4772-3p	CLIP-seq
MIRT2128206	hsa-miR-4781-3p	CLIP-seq
MIRT2128207	hsa-miR-483-5p	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq
MIRT2128208	hsa-miR-5096	CLIP-seq
MIRT2128209	hsa-miR-548s	CLIP-seq
MIRT2128210	hsa-miR-588	CLIP-seq
MIRT2128211	hsa-miR-612	CLIP-seq
MIRT2128212	hsa-miR-876-5p	CLIP-seq
MIRT2349878	hsa-miR-4432	CLIP-seq
MIRT2349879	hsa-miR-1	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT2349880	hsa-miR-206	CLIP-seq
MIRT1428031	hsa-miR-216a	CLIP-seq
MIRT1428033	hsa-miR-3647-3p	CLIP-seq
MIRT2349881	hsa-miR-3652	CLIP-seq
MIRT2349882	hsa-miR-3673	CLIP-seq
MIRT1428044	hsa-miR-3908	CLIP-seq
MIRT1428045	hsa-miR-3917	CLIP-seq
MIRT1428046	hsa-miR-3942-5p	CLIP-seq
MIRT1428034	hsa-miR-4252	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT1428036	hsa-miR-4282	CLIP-seq
MIRT2349883	hsa-miR-4423-5p	CLIP-seq
MIRT2349884	hsa-miR-4430	CLIP-seq
MIRT1428047	hsa-miR-4703-5p	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT1428048	hsa-miR-4766-3p	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq
MIRT1428043	hsa-miR-513a-3p	CLIP-seq
MIRT2349885	hsa-miR-613	CLIP-seq
MIRT2395890	hsa-miR-143	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT1428044	hsa-miR-3908	CLIP-seq
MIRT1428045	hsa-miR-3917	CLIP-seq
MIRT2395891	hsa-miR-3919	CLIP-seq
MIRT1428046	hsa-miR-3942-5p	CLIP-seq
MIRT1428034	hsa-miR-4252	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT1428047	hsa-miR-4703-5p	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT2395892	hsa-miR-4756-3p	CLIP-seq
MIRT1428048	hsa-miR-4766-3p	CLIP-seq
MIRT2395893	hsa-miR-4770	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq
MIRT1428029	hsa-miR-1915	CLIP-seq
MIRT1428030	hsa-miR-1976	CLIP-seq
MIRT1428035	hsa-miR-4279	CLIP-seq
MIRT1428038	hsa-miR-4722-3p	CLIP-seq
MIRT1428039	hsa-miR-4726-3p	CLIP-seq
MIRT1428040	hsa-miR-4740-3p	CLIP-seq
MIRT1428042	hsa-miR-498	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0008381	Function	Mechanosensitive monoatomic ion channel activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
617197	22999	ENSG00000103534

Q6UXY8

Protein name

Transmembrane channel-like protein 5

Protein function

Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07810	TMC	724 → 830	TMC domain	Domain

Sequence

MSAYYRNNWSEEDPDYPDYSGSQNRTQGYLKTQGYPDVPGPLNNPDYPGTRSNPYSVASR
TRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHPTSLPEPDYSEFQSHPYHR
ASSRQPDYPGSQRNPDFAGSSSSGNYAGSRTHPDHFGSLEPDYPGAQSNSDHPGPRANLN
HPGSRKNLEHTSFRINPYADSLGKPDYPGADIQPNSPPFFGEPDYPSAEDNQNLPSTWRE
PDYSDAENGHDYGSSETPKMTRGVLSRTSSIQPSFRHRSDDPVGSLWGENDYPEGIEMAS
MEMANSYGHSLPGAPGSGYVNPAYVGESGPVHAYGNPPLSECDWHKSPQGQKLIASLIPM
TSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNS
LSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAK
KNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCF
FSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSEL
RQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLL
PFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALS
GEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLEL
IYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLL
FFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRN
LIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDM
EKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA

Sequence length

1006

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BLOOD COAGULATION DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	34899684	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	32148377, 40302342	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	37468683	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	34899684	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	40302342	★★★★★ ★☆☆☆☆ Found in Text Mining only

TMC5 (transmembrane channel like 5)