Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79828
Gene name Gene Name - the full gene name approved by the HGNC.
Methyltransferase 8, tRNA N3-cytidine
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
METTL8
Synonyms (NCBI Gene) Gene synonyms aliases
TIP
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q31.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT725387 hsa-miR-193a-5p HITS-CLIP 19536157
MIRT725386 hsa-miR-656-3p HITS-CLIP 19536157
MIRT725385 hsa-miR-126-5p HITS-CLIP 19536157
MIRT725384 hsa-miR-1206 HITS-CLIP 19536157
MIRT725383 hsa-miR-6853-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IDA 34774131
GO:0005737 Component Cytoplasm IDA 34774131
GO:0005739 Component Mitochondrion IDA 34774131
GO:0005759 Component Mitochondrial matrix IDA 35017528
GO:0008033 Process TRNA processing IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609525 25856 ENSG00000123600
Protein
UniProt ID Q9H825
Protein name tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-)
Protein function Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (PubMed:34774131, PubMed:35017528). N(3)-meth
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13649 Methyltransf_25 200 290 Methyltransferase domain Domain
Sequence
MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK
SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLF
I
Sequence length 291
Interactions View interactions
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