Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79828
Gene name Gene Name - the full gene name approved by the HGNC.
Methyltransferase 8, tRNA N3-cytidine
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
METTL8
Synonyms (NCBI Gene) Gene synonyms aliases
TIP
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q31.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT725387 hsa-miR-193a-5p HITS-CLIP 19536157
MIRT725386 hsa-miR-656-3p HITS-CLIP 19536157
MIRT725385 hsa-miR-126-5p HITS-CLIP 19536157
MIRT725384 hsa-miR-1206 HITS-CLIP 19536157
MIRT725383 hsa-miR-6853-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0008174 Function MRNA methyltransferase activity IMP 28655767
GO:0030488 Process TRNA methylation IEA
GO:0052735 Function TRNA (cytosine-3-)-methyltransferase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609525 25856 ENSG00000123600
Protein
UniProt ID Q9H825
Protein name tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-)
Protein function Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (PubMed:34774131, PubMed:35017528). N(3)-meth
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13649 Methyltransf_25 200 290 Methyltransferase domain Domain
Sequence
MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK
SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLF
I
Sequence length 291
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Woodhouse sakati syndrome Woodhouse Sakati syndrome rs1559245286, rs1314048356, rs1559289651, rs1559264135, rs761229686, rs760978794, rs1574303761, rs797045038, rs879253799, rs863224865, rs868533593, rs780493577, rs1470826074
Associations from Text Mining
Disease Name Relationship Type References
Anodontia Associate 28803425
Breast Neoplasms Associate 34063990
Colorectal Neoplasms Associate 28803425
Glioblastoma Associate 37061119
Mammary Neoplasms Animal Stimulate 34063990
Neoplasms Associate 28803425, 34063990