Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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79827
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
CXADR like cell adhesion molecule |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
CLMP |
Synonyms (NCBI Gene)
Gene synonyms aliases
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ACAM, ASAM, CSBM, CSBS |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
|
CSBS |
Chromosome
Chromosome number
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11 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q24.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte matur |
UniProt ID |
Q9H6B4
|
Protein name |
CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein) |
Protein function |
May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. {ECO:0000269|PubMed:14573622, ECO:0000269|PubMed:15563274, ECO:0000269|PubMed |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF07686
|
V-set |
18 → 129 |
Immunoglobulin V-set domain |
Domain |
PF13895
|
Ig_2 |
129 → 225 |
Immunoglobulin domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney |
Sequence |
|
Sequence length |
373 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Hypotrichosis |
Hypotrichosis |
rs121434306, rs121434307, rs121434308, rs121434309, rs1325804776, rs267606775, rs786200875, rs1568062215, rs267606776, rs1462595806, rs267606777, rs267606659, rs2147483647, rs559648418, rs121917819, rs121917820, rs387906382, rs267606867, rs267606868, rs267606869, rs201868115, rs587776925, rs587777527, rs587777545, rs766783183, rs879255262, rs201249971, rs768448663, rs1566212378, rs1249530918, rs1260995701, rs1569039353, rs1827030121 View all (18 more) |
|
Intestinal pseudoobstruction |
Intestinal Pseudo-Obstruction |
rs587776966, rs765907815 |
22155368, 27352967 |
Lipodystrophy |
Lipodystrophy |
rs553668, rs766817317 |
|
Visceral myopathy |
Visceral Myopathy |
rs587777383, rs587777384, rs587777385, rs78001248, rs587777386, rs587777387, rs587777388, rs786205435, rs587777870, rs730880256, rs797044959, rs864309490, rs864309491, rs768290597, rs864309492, rs777696417, rs1553787823, rs1057516046, rs1553787619, rs1553396458, rs1596904322, rs1573468797, rs1573461481, rs1573462811, rs757905857, rs1680192455 View all (11 more) |
|
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Breast Cancer |
Breast Cancer |
Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients |
|
GWAS, CBGDA |
Colorectal Cancer |
Colorectal Cancer |
In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. |
|
GWAS, CBGDA |
Oligodendroglioma |
Oligodendroglioma |
|
|
GWAS |
Glioblastoma |
Glioblastoma |
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 |
|
GWAS, CBGDA |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Colitis Ulcerative |
Associate
|
33793617 |
Colorectal Neoplasms |
Associate
|
32859214 |
Dermatitis Allergic Contact |
Inhibit
|
31783056 |
Inflammation |
Associate
|
33793617 |
Inflammation |
Stimulate
|
36241608 |
Intestinal Pseudo Obstruction |
Associate
|
23037936 |
Multiple Sclerosis |
Associate
|
36241608 |
Neuroinflammatory Diseases |
Associate
|
36241608 |
Pancreatic Neoplasms |
Associate
|
37588985 |
|