Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	79823
Gene name	Calmodulin-lysine N-methyltransferase
Gene symbol	CAMKMT
Synonyms (NCBI Gene)	C2orf34CLNMTCaM KMTCamKMT
Chromosome	2
Chromosome location	2p21
Summary	This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]

102

Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030210	hsa-miR-26b-5p	Microarray	19088304
MIRT860541	hsa-miR-1226	CLIP-seq
MIRT860542	hsa-miR-1286	CLIP-seq
MIRT860543	hsa-miR-1296	CLIP-seq
MIRT860544	hsa-miR-1297	CLIP-seq
MIRT860545	hsa-miR-1324	CLIP-seq
MIRT860546	hsa-miR-197	CLIP-seq
MIRT860547	hsa-miR-21	CLIP-seq
MIRT860548	hsa-miR-224	CLIP-seq
MIRT860549	hsa-miR-26a	CLIP-seq
MIRT860550	hsa-miR-26b	CLIP-seq
MIRT860551	hsa-miR-2909	CLIP-seq
MIRT860552	hsa-miR-375	CLIP-seq
MIRT860553	hsa-miR-4436b-3p	CLIP-seq
MIRT860554	hsa-miR-4465	CLIP-seq
MIRT860555	hsa-miR-4514	CLIP-seq
MIRT860556	hsa-miR-4643	CLIP-seq
MIRT860557	hsa-miR-466	CLIP-seq
MIRT860558	hsa-miR-4692	CLIP-seq
MIRT860559	hsa-miR-4733-3p	CLIP-seq
MIRT860560	hsa-miR-4761-3p	CLIP-seq
MIRT860561	hsa-miR-4789-3p	CLIP-seq
MIRT860562	hsa-miR-4789-5p	CLIP-seq
MIRT860563	hsa-miR-590-5p	CLIP-seq
MIRT860564	hsa-miR-759	CLIP-seq
MIRT860541	hsa-miR-1226	CLIP-seq
MIRT860544	hsa-miR-1297	CLIP-seq
MIRT860545	hsa-miR-1324	CLIP-seq
MIRT860546	hsa-miR-197	CLIP-seq
MIRT860547	hsa-miR-21	CLIP-seq
MIRT860548	hsa-miR-224	CLIP-seq
MIRT860549	hsa-miR-26a	CLIP-seq
MIRT860550	hsa-miR-26b	CLIP-seq
MIRT860552	hsa-miR-375	CLIP-seq
MIRT860554	hsa-miR-4465	CLIP-seq
MIRT860555	hsa-miR-4514	CLIP-seq
MIRT860558	hsa-miR-4692	CLIP-seq
MIRT860559	hsa-miR-4733-3p	CLIP-seq
MIRT860562	hsa-miR-4789-5p	CLIP-seq
MIRT860563	hsa-miR-590-5p	CLIP-seq
MIRT860541	hsa-miR-1226	CLIP-seq
MIRT860544	hsa-miR-1297	CLIP-seq
MIRT860545	hsa-miR-1324	CLIP-seq
MIRT860546	hsa-miR-197	CLIP-seq
MIRT860547	hsa-miR-21	CLIP-seq
MIRT860548	hsa-miR-224	CLIP-seq
MIRT860549	hsa-miR-26a	CLIP-seq
MIRT860550	hsa-miR-26b	CLIP-seq
MIRT860554	hsa-miR-4465	CLIP-seq
MIRT860555	hsa-miR-4514	CLIP-seq
MIRT860556	hsa-miR-4643	CLIP-seq
MIRT860557	hsa-miR-466	CLIP-seq
MIRT860558	hsa-miR-4692	CLIP-seq
MIRT860559	hsa-miR-4733-3p	CLIP-seq
MIRT860561	hsa-miR-4789-3p	CLIP-seq
MIRT860562	hsa-miR-4789-5p	CLIP-seq
MIRT860563	hsa-miR-590-5p	CLIP-seq
MIRT860542	hsa-miR-1286	CLIP-seq
MIRT860543	hsa-miR-1296	CLIP-seq
MIRT2496188	hsa-miR-185	CLIP-seq
MIRT2496189	hsa-miR-1908	CLIP-seq
MIRT860547	hsa-miR-21	CLIP-seq
MIRT860551	hsa-miR-2909	CLIP-seq
MIRT2496190	hsa-miR-3135b	CLIP-seq
MIRT2496191	hsa-miR-3616-3p	CLIP-seq
MIRT2496192	hsa-miR-4300	CLIP-seq
MIRT2496193	hsa-miR-4306	CLIP-seq
MIRT2496194	hsa-miR-4419a	CLIP-seq
MIRT860553	hsa-miR-4436b-3p	CLIP-seq
MIRT2496195	hsa-miR-4487	CLIP-seq
MIRT2496196	hsa-miR-4510	CLIP-seq
MIRT860555	hsa-miR-4514	CLIP-seq
MIRT860556	hsa-miR-4643	CLIP-seq
MIRT2496197	hsa-miR-4644	CLIP-seq
MIRT860557	hsa-miR-466	CLIP-seq
MIRT860558	hsa-miR-4692	CLIP-seq
MIRT2496198	hsa-miR-4706	CLIP-seq
MIRT2496199	hsa-miR-4728-5p	CLIP-seq
MIRT2496200	hsa-miR-4749-5p	CLIP-seq
MIRT860560	hsa-miR-4761-3p	CLIP-seq
MIRT860561	hsa-miR-4789-3p	CLIP-seq
MIRT860562	hsa-miR-4789-5p	CLIP-seq
MIRT2496201	hsa-miR-548u	CLIP-seq
MIRT2496202	hsa-miR-583	CLIP-seq
MIRT860563	hsa-miR-590-5p	CLIP-seq
MIRT2496203	hsa-miR-663	CLIP-seq
MIRT860564	hsa-miR-759	CLIP-seq
MIRT2496204	hsa-miR-920	CLIP-seq
MIRT860542	hsa-miR-1286	CLIP-seq
MIRT860543	hsa-miR-1296	CLIP-seq
MIRT860547	hsa-miR-21	CLIP-seq
MIRT860551	hsa-miR-2909	CLIP-seq
MIRT860553	hsa-miR-4436b-3p	CLIP-seq
MIRT860555	hsa-miR-4514	CLIP-seq
MIRT860556	hsa-miR-4643	CLIP-seq
MIRT860557	hsa-miR-466	CLIP-seq
MIRT860558	hsa-miR-4692	CLIP-seq
MIRT860560	hsa-miR-4761-3p	CLIP-seq
MIRT860561	hsa-miR-4789-3p	CLIP-seq
MIRT860562	hsa-miR-4789-5p	CLIP-seq
MIRT2496201	hsa-miR-548u	CLIP-seq
MIRT860563	hsa-miR-590-5p	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	23349634
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007005	Process	Mitochondrion organization	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018025	Function	Calmodulin-lysine N-methyltransferase activity	IBA
GO:0018025	Function	Calmodulin-lysine N-methyltransferase activity	IEA
GO:0018025	Function	Calmodulin-lysine N-methyltransferase activity	TAS
GO:0022400	Process	Regulation of opsin-mediated signaling pathway	TAS
GO:0031072	Function	Heat shock protein binding	IPI	23349634
GO:0032259	Process	Methylation	IEA
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0032991	Component	Protein-containing complex	IEA

MIM	HGNC	e!Ensembl
609559	26276	ENSG00000143919

Q7Z624

Protein name

Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60)

Protein function

Catalyzes the trimethylation of 'Lys-116' in calmodulin.

PDB

4PWY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10294	Methyltransf_16	110 → 278	Lysine methyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is expressed in brain, liver, muscle colon and lung. Isoform 2 is expressed in colon, testis, kidney and brain. Isoform 1 and isoform 2 are expressed in normal lymphoblastoid cells but not in lymphoblastoid cells from patient

Sequence

MESRVADAGTGETARAAGGSPAVGCTTRGPVVSAPLGAARWKLLRQVLKQKHLDDCLRHV
SVRRFESFNLFSVTEGKERETEEEVGAWVQYTSIFCPEYSISLRHNSGSLNVEDVLTSFD
NTGNVCIWPSEEVLAYYCLKHNNIFRALAVCELGGGMTCLAGLMVAISADVKEVLLTDGN
EKAIRNVQDIITRNQKAGVFKTQKISSCVLRWDNETDVSQLEGHFDIVMCADCLFLDQYR
ASLVDAIKRLLQPRGKAMVFAPRRGNTLNQFCNLAEKAGFCIQRHENYDEHISNFHSKLK
KENPDIYEENLHYPLLLILTKHG

Sequence length

323

Interactions

View interactions

	KEGG		Reactome
	Lysine degradation Metabolic pathways		Inactivation, recovery and regulation of the phototransduction cascade Protein methylation

CAMKMT (calmodulin-lysine N-methyltransferase)