ARHGAP28 (Rho GTPase activating protein 28)

Gene

• Entrez ID: 79822
• Gene name: Rho GTPase activating protein 28
• Gene symbol: ARHGAP28
• Synonyms (NCBI Gene): -
• Chromosome: 18
• Chromosome location: 18p11.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022171	hsa-miR-124-3p	Microarray	18668037
MIRT026097	hsa-miR-196a-5p	Sequencing	20371350
MIRT027425	hsa-miR-98-5p	Microarray	19088304
MIRT794367	hsa-miR-124	CLIP-seq
MIRT794368	hsa-miR-3161	CLIP-seq
MIRT794369	hsa-miR-3714	CLIP-seq
MIRT794370	hsa-miR-3910	CLIP-seq
MIRT794371	hsa-miR-433	CLIP-seq
MIRT794372	hsa-miR-506	CLIP-seq
MIRT794373	hsa-miR-548l	CLIP-seq
MIRT794374	hsa-miR-548n	CLIP-seq
MIRT794375	hsa-miR-548t	CLIP-seq
MIRT1545482	hsa-let-7a	CLIP-seq
MIRT1545483	hsa-let-7b	CLIP-seq
MIRT1545484	hsa-let-7c	CLIP-seq
MIRT1545485	hsa-let-7d	CLIP-seq
MIRT1545486	hsa-let-7e	CLIP-seq
MIRT1545487	hsa-let-7f	CLIP-seq
MIRT1545488	hsa-let-7g	CLIP-seq
MIRT1545489	hsa-let-7i	CLIP-seq
MIRT1545490	hsa-miR-1183	CLIP-seq
MIRT1545491	hsa-miR-1294	CLIP-seq
MIRT1545492	hsa-miR-196a	CLIP-seq
MIRT1545493	hsa-miR-196b	CLIP-seq
MIRT1545494	hsa-miR-202	CLIP-seq
MIRT1545495	hsa-miR-4446-5p	CLIP-seq
MIRT1545496	hsa-miR-4458	CLIP-seq
MIRT1545497	hsa-miR-4500	CLIP-seq
MIRT1545498	hsa-miR-548an	CLIP-seq
MIRT1545499	hsa-miR-579	CLIP-seq
MIRT1545500	hsa-miR-664	CLIP-seq
MIRT1545501	hsa-miR-98	CLIP-seq
MIRT1934430	hsa-miR-144	CLIP-seq
MIRT1934431	hsa-miR-3662	CLIP-seq
MIRT1545495	hsa-miR-4446-5p	CLIP-seq
MIRT1934432	hsa-miR-4796-5p	CLIP-seq
MIRT1934433	hsa-miR-548a-5p	CLIP-seq
MIRT1934434	hsa-miR-548ab	CLIP-seq
MIRT1934435	hsa-miR-548ak	CLIP-seq
MIRT1934436	hsa-miR-548b-5p	CLIP-seq
MIRT1934437	hsa-miR-548c-5p	CLIP-seq
MIRT1934438	hsa-miR-548d-5p	CLIP-seq
MIRT1934439	hsa-miR-548h	CLIP-seq
MIRT1934440	hsa-miR-548i	CLIP-seq
MIRT1934441	hsa-miR-548j	CLIP-seq
MIRT1934442	hsa-miR-548k	CLIP-seq
MIRT794373	hsa-miR-548l	CLIP-seq
MIRT1934443	hsa-miR-548w	CLIP-seq
MIRT1934444	hsa-miR-548y	CLIP-seq
MIRT1934445	hsa-miR-559	CLIP-seq
MIRT1545499	hsa-miR-579	CLIP-seq
MIRT2174233	hsa-miR-1258	CLIP-seq
MIRT2174234	hsa-miR-3065-3p	CLIP-seq
MIRT2174235	hsa-miR-425	CLIP-seq
MIRT2174236	hsa-miR-4422	CLIP-seq
MIRT2174237	hsa-miR-4496	CLIP-seq
MIRT2174238	hsa-miR-4760-5p	CLIP-seq
MIRT2174239	hsa-miR-495	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IBA	21873635
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051497	Process	Negative regulation of stress fiber assembly	IBA	21873635
GO:1904425	Process	Negative regulation of GTP binding	IBA	21873635

Other IDs

• MIM: 610592
• HGNC: 25509
• e!Ensembl: ENSG00000088756

Protein

• UniProt ID: Q9P2N2
• Protein name: Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28)
• Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	399 → 552	RhoGAP domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle. {ECO:0000269|PubMed:10718198}.
• Sequence:

  MEVEDSGGVVLTAYHSYARAQPPNAESRCAPRAAASHPLSRKSIPRCRRINRMLSNESLH
  PPAFSRSNSEASVDSASMEDFWREIESIKDSSMGGQEEPPPAEVTPVDEGELEAEWLQDV
  GLSTLISGDEEEDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDKQSIRDVRDIFGVSES
  PPRDTCGNHTNQLDGTKEERELPRVIKTSGSMPDDASLNSTTLSDASQDKEGSFAVPRSD
  SVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVTEAL
  KRNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGI
  QLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIF
  RLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFI
  SLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMA
  PNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQ
  LPSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLN
  NQTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAE
  WVIKPQQSS

• Sequence length: 729

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Unknown
Disease term	Disease name	Evidence	References	Source
Endometriosis	Endometriosis		20864642	ClinVar
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Drug Hypersensitivity	Associate	33768542