Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79822
Gene name Gene Name - the full gene name approved by the HGNC.	Rho GTPase activating protein 28
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARHGAP28
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18p11.31

Show/Hide all(58)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022171	hsa-miR-124-3p	Microarray	18668037
MIRT026097	hsa-miR-196a-5p	Sequencing	20371350
MIRT027425	hsa-miR-98-5p	Microarray	19088304
MIRT794367	hsa-miR-124	CLIP-seq
MIRT794368	hsa-miR-3161	CLIP-seq
MIRT794369	hsa-miR-3714	CLIP-seq
MIRT794370	hsa-miR-3910	CLIP-seq
MIRT794371	hsa-miR-433	CLIP-seq
MIRT794372	hsa-miR-506	CLIP-seq
MIRT794373	hsa-miR-548l	CLIP-seq
MIRT794374	hsa-miR-548n	CLIP-seq
MIRT794375	hsa-miR-548t	CLIP-seq
MIRT1545482	hsa-let-7a	CLIP-seq
MIRT1545483	hsa-let-7b	CLIP-seq
MIRT1545484	hsa-let-7c	CLIP-seq
MIRT1545485	hsa-let-7d	CLIP-seq
MIRT1545486	hsa-let-7e	CLIP-seq
MIRT1545487	hsa-let-7f	CLIP-seq
MIRT1545488	hsa-let-7g	CLIP-seq
MIRT1545489	hsa-let-7i	CLIP-seq
MIRT1545490	hsa-miR-1183	CLIP-seq
MIRT1545491	hsa-miR-1294	CLIP-seq
MIRT1545492	hsa-miR-196a	CLIP-seq
MIRT1545493	hsa-miR-196b	CLIP-seq
MIRT1545494	hsa-miR-202	CLIP-seq
MIRT1545495	hsa-miR-4446-5p	CLIP-seq
MIRT1545496	hsa-miR-4458	CLIP-seq
MIRT1545497	hsa-miR-4500	CLIP-seq
MIRT1545498	hsa-miR-548an	CLIP-seq
MIRT1545499	hsa-miR-579	CLIP-seq
MIRT1545500	hsa-miR-664	CLIP-seq
MIRT1545501	hsa-miR-98	CLIP-seq
MIRT1934430	hsa-miR-144	CLIP-seq
MIRT1934431	hsa-miR-3662	CLIP-seq
MIRT1545495	hsa-miR-4446-5p	CLIP-seq
MIRT1934432	hsa-miR-4796-5p	CLIP-seq
MIRT1934433	hsa-miR-548a-5p	CLIP-seq
MIRT1934434	hsa-miR-548ab	CLIP-seq
MIRT1934435	hsa-miR-548ak	CLIP-seq
MIRT1934436	hsa-miR-548b-5p	CLIP-seq
MIRT1934437	hsa-miR-548c-5p	CLIP-seq
MIRT1934438	hsa-miR-548d-5p	CLIP-seq
MIRT1934439	hsa-miR-548h	CLIP-seq
MIRT1934440	hsa-miR-548i	CLIP-seq
MIRT1934441	hsa-miR-548j	CLIP-seq
MIRT1934442	hsa-miR-548k	CLIP-seq
MIRT794373	hsa-miR-548l	CLIP-seq
MIRT1934443	hsa-miR-548w	CLIP-seq
MIRT1934444	hsa-miR-548y	CLIP-seq
MIRT1934445	hsa-miR-559	CLIP-seq
MIRT1545499	hsa-miR-579	CLIP-seq
MIRT2174233	hsa-miR-1258	CLIP-seq
MIRT2174234	hsa-miR-3065-3p	CLIP-seq
MIRT2174235	hsa-miR-425	CLIP-seq
MIRT2174236	hsa-miR-4422	CLIP-seq
MIRT2174237	hsa-miR-4496	CLIP-seq
MIRT2174238	hsa-miR-4760-5p	CLIP-seq
MIRT2174239	hsa-miR-495	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030833	Process	Regulation of actin filament polymerization	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051497	Process	Negative regulation of stress fiber assembly	IBA
GO:0051497	Process	Negative regulation of stress fiber assembly	IEA

MIM	HGNC	e!Ensembl
610592	25509	ENSG00000088756

Protein

UniProt ID

Q9P2N2

Protein name

Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28)

Protein function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00620	RhoGAP	399 → 552	RhoGAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle. {ECO:0000269|PubMed:10718198}.

Sequence

MEVEDSGGVVLTAYHSYARAQPPNAESRCAPRAAASHPLSRKSIPRCRRINRMLSNESLH
PPAFSRSNSEASVDSASMEDFWREIESIKDSSMGGQEEPPPAEVTPVDEGELEAEWLQDV
GLSTLISGDEEEDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDKQSIRDVRDIFGVSES
PPRDTCGNHTNQLDGTKEERELPRVIKTSGSMPDDASLNSTTLSDASQDKEGSFAVPRSD
SVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVTEAL
KRNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGI
QLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIF
RLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFI
SLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMA
PNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQ
LPSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLN
NQTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAE
WVIKPQQSS

Sequence length

729

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Drug Hypersensitivity	Associate	33768542

ARHGAP28 (Rho GTPase activating protein 28)