Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7982
Gene name Gene Name - the full gene name approved by the HGNC.	Suppression of tumorigenicity 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ST7
Synonyms (NCBI Gene) Gene synonyms aliases	ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q31.2
Summary Summary of gene provided in NCBI Entrez Gene.	The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutation

Show/Hide all(103)

miRTarBase ID	miRNA	Experiments
MIRT1393806	hsa-miR-1273f	CLIP-seq
MIRT1393807	hsa-miR-1294	CLIP-seq
MIRT1393808	hsa-miR-3656	CLIP-seq
MIRT1393809	hsa-miR-3960	CLIP-seq
MIRT1393810	hsa-miR-4710	CLIP-seq
MIRT1393811	hsa-miR-885-3p	CLIP-seq
MIRT1393812	hsa-miR-124	CLIP-seq
MIRT1393813	hsa-miR-19a	CLIP-seq
MIRT1393814	hsa-miR-19b	CLIP-seq
MIRT1393815	hsa-miR-4708-3p	CLIP-seq
MIRT1393816	hsa-miR-4729	CLIP-seq
MIRT1393817	hsa-miR-506	CLIP-seq
MIRT1393818	hsa-miR-518a-5p	CLIP-seq
MIRT1393819	hsa-miR-527	CLIP-seq
MIRT1393820	hsa-miR-556-5p	CLIP-seq
MIRT1393821	hsa-miR-570	CLIP-seq
MIRT1393813	hsa-miR-19a	CLIP-seq
MIRT1393814	hsa-miR-19b	CLIP-seq
MIRT2395262	hsa-miR-3179	CLIP-seq
MIRT2395263	hsa-miR-4761-3p	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634122	hsa-miR-1180	CLIP-seq
MIRT2634123	hsa-miR-1193	CLIP-seq
MIRT2634124	hsa-miR-186	CLIP-seq
MIRT2634125	hsa-miR-299-3p	CLIP-seq
MIRT2634126	hsa-miR-3133	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634127	hsa-miR-3151	CLIP-seq
MIRT2634128	hsa-miR-3163	CLIP-seq
MIRT2634129	hsa-miR-3165	CLIP-seq
MIRT2634130	hsa-miR-3175	CLIP-seq
MIRT2634131	hsa-miR-3202	CLIP-seq
MIRT2634132	hsa-miR-320a	CLIP-seq
MIRT2634133	hsa-miR-320b	CLIP-seq
MIRT2634134	hsa-miR-320c	CLIP-seq
MIRT2634135	hsa-miR-320d	CLIP-seq
MIRT2634136	hsa-miR-3611	CLIP-seq
MIRT2634137	hsa-miR-3691-5p	CLIP-seq
MIRT2634138	hsa-miR-411	CLIP-seq
MIRT2634139	hsa-miR-4429	CLIP-seq
MIRT2634140	hsa-miR-4446-3p	CLIP-seq
MIRT2634141	hsa-miR-4447	CLIP-seq
MIRT2634142	hsa-miR-4472	CLIP-seq
MIRT2634143	hsa-miR-4493	CLIP-seq
MIRT2634144	hsa-miR-4511	CLIP-seq
MIRT2634145	hsa-miR-4533	CLIP-seq
MIRT2634146	hsa-miR-4651	CLIP-seq
MIRT2634147	hsa-miR-4664-3p	CLIP-seq
MIRT2634148	hsa-miR-4709-3p	CLIP-seq
MIRT2634149	hsa-miR-4730	CLIP-seq
MIRT2634150	hsa-miR-4764-5p	CLIP-seq
MIRT2634151	hsa-miR-491-5p	CLIP-seq
MIRT2634152	hsa-miR-496	CLIP-seq
MIRT2634153	hsa-miR-512-5p	CLIP-seq
MIRT2634154	hsa-miR-608	CLIP-seq
MIRT2634155	hsa-miR-658	CLIP-seq
MIRT2634156	hsa-miR-939	CLIP-seq
MIRT2634122	hsa-miR-1180	CLIP-seq
MIRT2634123	hsa-miR-1193	CLIP-seq
MIRT2692133	hsa-miR-1255a	CLIP-seq
MIRT2692134	hsa-miR-1255b	CLIP-seq
MIRT2692135	hsa-miR-1293	CLIP-seq
MIRT2634124	hsa-miR-186	CLIP-seq
MIRT2634125	hsa-miR-299-3p	CLIP-seq
MIRT2692136	hsa-miR-3120-3p	CLIP-seq
MIRT2634126	hsa-miR-3133	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634127	hsa-miR-3151	CLIP-seq
MIRT2634128	hsa-miR-3163	CLIP-seq
MIRT2634129	hsa-miR-3165	CLIP-seq
MIRT2634130	hsa-miR-3175	CLIP-seq
MIRT2395262	hsa-miR-3179	CLIP-seq
MIRT2634131	hsa-miR-3202	CLIP-seq
MIRT2634132	hsa-miR-320a	CLIP-seq
MIRT2634133	hsa-miR-320b	CLIP-seq
MIRT2634134	hsa-miR-320c	CLIP-seq
MIRT2634135	hsa-miR-320d	CLIP-seq
MIRT2634136	hsa-miR-3611	CLIP-seq
MIRT2692137	hsa-miR-3681	CLIP-seq
MIRT2634137	hsa-miR-3691-5p	CLIP-seq
MIRT2634138	hsa-miR-411	CLIP-seq
MIRT2634139	hsa-miR-4429	CLIP-seq
MIRT2634140	hsa-miR-4446-3p	CLIP-seq
MIRT2634141	hsa-miR-4447	CLIP-seq
MIRT2692138	hsa-miR-4468	CLIP-seq
MIRT2634142	hsa-miR-4472	CLIP-seq
MIRT2692139	hsa-miR-4483	CLIP-seq
MIRT2634143	hsa-miR-4493	CLIP-seq
MIRT2634144	hsa-miR-4511	CLIP-seq
MIRT2634145	hsa-miR-4533	CLIP-seq
MIRT2692140	hsa-miR-4645-3p	CLIP-seq
MIRT2634146	hsa-miR-4651	CLIP-seq
MIRT2634147	hsa-miR-4664-3p	CLIP-seq
MIRT2634148	hsa-miR-4709-3p	CLIP-seq
MIRT2395263	hsa-miR-4761-3p	CLIP-seq
MIRT2634150	hsa-miR-4764-5p	CLIP-seq
MIRT2634151	hsa-miR-491-5p	CLIP-seq
MIRT2634152	hsa-miR-496	CLIP-seq
MIRT2634153	hsa-miR-512-5p	CLIP-seq
MIRT2692141	hsa-miR-542-3p	CLIP-seq
MIRT2692142	hsa-miR-545	CLIP-seq
MIRT2634154	hsa-miR-608	CLIP-seq
MIRT2634156	hsa-miR-939	CLIP-seq

Show/Hide all(3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016021	Component	Integral component of membrane	IEA
GO:0030198	Process	Extracellular matrix organization	NAS	16474848
GO:0045595	Process	Regulation of cell differentiation	NAS	16474848

MIM	HGNC	e!Ensembl
600833	11351	ENSG00000004866

Protein

UniProt ID

Q9NRC1

Protein name

Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG)

Protein function

May act as a tumor suppressor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04184	ST7	17 → 562	ST7 protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in heart, liver and pancreas. {ECO:0000269|PubMed:10889047, ECO:0000269|PubMed:11279520}.

Sequence

MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTP
KFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSN
GDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDS
DHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCAT
AYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKR
RLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDD
ISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYL
LEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKG
HLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELM
GVFAKAMIDIFCSAEFRDWNCKSIFMRVEDELEIPPAPQSQHFQN

Sequence length

585

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Developmental And Epileptic Encephalopathy	genetic developmental and epileptic encephalopathy	GenCC
Inflammatory Bowel Disease	Inflammatory Bowel Disease	GWAS
Ulcerative colitis	Ulcerative colitis	GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	12107844, 12799635, 23875900
Carcinogenesis	Associate	12107844
Colitis Associated Neoplasms	Associate	31972160
Colorectal Neoplasms	Associate	32140074
Dysentery	Associate	34030712
Esophageal Neoplasms	Associate	35704638
Neoplasms	Associate	14669308, 17627275, 23875900
Neoplasms	Inhibit	33793053
Neuralgia	Associate	36855217
Pancreatic Neoplasms	Associate	33793053
Prostatic Neoplasms	Associate	37008945
Stomach Neoplasms	Associate	14669308, 20626849

ST7 (suppression of tumorigenicity 7)