MOB3B (MOB kinase activator 3B)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79817
Gene name Gene Name - the full gene name approved by the HGNC.
MOB kinase activator 3B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MOB3B
Synonyms (NCBI Gene) Gene synonyms aliases
C9orf35, MOB1D, MOBKL2B
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the inte
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(57)
miRTarBase ID miRNA Experiments Reference
MIRT021972 hsa-miR-128-3p Microarray 17612493
MIRT023324 hsa-miR-122-5p Microarray 17612493
MIRT025174 hsa-miR-181a-5p Microarray 17612493
MIRT027623 hsa-miR-98-5p Microarray 19088304
MIRT442528 hsa-miR-409-3p PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 19060904, 32296183
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IBA
GO:0007165 Process Signal transduction IBA
GO:0030295 Function Protein kinase activator activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617652 23825 ENSG00000120162
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q86TA1
Protein name MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) (MOB kinase activator-like 2B)
Protein function Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03637 Mob1_phocein 35 → 207 Mob1/phocein family Family
Sequence
Sequence length 216
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis N/A N/A GWAS
Asthma Adult asthma, Asthma N/A N/A GWAS
Breast Cancer Breast cancer specific mortality in estrogen receptor negative breast cancer N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Show/Hide Text Mining Associations (6)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 23587638, 34475377
Breast Neoplasms Associate 35381768
Frontotemporal Dementia Associate 34475377, 37979250
Lymphoma Mantle Cell Associate 18984860, 20421449
Prostatic Neoplasms Associate 26130958, 28084441, 30866497
Rhabdomyosarcoma Alveolar Associate 36232302