Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	79812
Gene name	Multimerin 2
Gene symbol	MMRN2
Synonyms (NCBI Gene)	EMILIN-3EMILIN3ENDOGLYX-1
Chromosome	10
Chromosome location	10q23.2
Summary	This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transfor

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miRTarBase ID	miRNA	Experiments
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT1153538	hsa-miR-1261	CLIP-seq
MIRT1153539	hsa-miR-1290	CLIP-seq
MIRT1153540	hsa-miR-1324	CLIP-seq
MIRT1153541	hsa-miR-142-5p	CLIP-seq
MIRT1153542	hsa-miR-2681	CLIP-seq
MIRT1153543	hsa-miR-3125	CLIP-seq
MIRT1153544	hsa-miR-3136-5p	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT1153546	hsa-miR-3160-5p	CLIP-seq
MIRT1153547	hsa-miR-3166	CLIP-seq
MIRT1153548	hsa-miR-3174	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153550	hsa-miR-3184	CLIP-seq
MIRT1153551	hsa-miR-3187-3p	CLIP-seq
MIRT1153552	hsa-miR-340	CLIP-seq
MIRT1153553	hsa-miR-3606	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153556	hsa-miR-3680	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT1153558	hsa-miR-3916	CLIP-seq
MIRT1153559	hsa-miR-3926	CLIP-seq
MIRT1153560	hsa-miR-3928	CLIP-seq
MIRT1153561	hsa-miR-409-3p	CLIP-seq
MIRT1153562	hsa-miR-423-5p	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT1153564	hsa-miR-4435	CLIP-seq
MIRT1153565	hsa-miR-4439	CLIP-seq
MIRT1153566	hsa-miR-4450	CLIP-seq
MIRT1153567	hsa-miR-4473	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT1153569	hsa-miR-4513	CLIP-seq
MIRT1153570	hsa-miR-4525	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153573	hsa-miR-4701-5p	CLIP-seq
MIRT1153574	hsa-miR-4709-3p	CLIP-seq
MIRT1153575	hsa-miR-4716-3p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT1153578	hsa-miR-4738-3p	CLIP-seq
MIRT1153579	hsa-miR-4744	CLIP-seq
MIRT1153580	hsa-miR-4778-3p	CLIP-seq
MIRT1153581	hsa-miR-4781-3p	CLIP-seq
MIRT1153582	hsa-miR-512-3p	CLIP-seq
MIRT1153583	hsa-miR-520f	CLIP-seq
MIRT1153584	hsa-miR-548s	CLIP-seq
MIRT1153585	hsa-miR-582-5p	CLIP-seq
MIRT1153586	hsa-miR-583	CLIP-seq
MIRT1153587	hsa-miR-588	CLIP-seq
MIRT1153588	hsa-miR-624	CLIP-seq
MIRT1153589	hsa-miR-921	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq
MIRT1921272	hsa-miR-4493	CLIP-seq
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT2043937	hsa-miR-146a	CLIP-seq
MIRT2043938	hsa-miR-146b-5p	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT2043939	hsa-miR-3163	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153551	hsa-miR-3187-3p	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT2043940	hsa-miR-4434	CLIP-seq
MIRT1153564	hsa-miR-4435	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT2043941	hsa-miR-4516	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT2043942	hsa-miR-4668-3p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153573	hsa-miR-4701-5p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT1153584	hsa-miR-548s	CLIP-seq
MIRT1153587	hsa-miR-588	CLIP-seq
MIRT2043943	hsa-miR-589	CLIP-seq
MIRT2043944	hsa-miR-873	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT2273341	hsa-miR-1275	CLIP-seq
MIRT2273342	hsa-miR-136	CLIP-seq
MIRT1153541	hsa-miR-142-5p	CLIP-seq
MIRT2043937	hsa-miR-146a	CLIP-seq
MIRT2043938	hsa-miR-146b-5p	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153552	hsa-miR-340	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153556	hsa-miR-3680	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT2273343	hsa-miR-377	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT2273344	hsa-miR-4457	CLIP-seq
MIRT2273345	hsa-miR-4496	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT1153570	hsa-miR-4525	CLIP-seq
MIRT2273346	hsa-miR-4540	CLIP-seq
MIRT2273347	hsa-miR-4665-5p	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT2273348	hsa-miR-4723-5p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT2273349	hsa-miR-4773	CLIP-seq
MIRT2273350	hsa-miR-5096	CLIP-seq
MIRT2273351	hsa-miR-513b	CLIP-seq
MIRT2273352	hsa-miR-543	CLIP-seq
MIRT1153586	hsa-miR-583	CLIP-seq
MIRT2043943	hsa-miR-589	CLIP-seq
MIRT1153588	hsa-miR-624	CLIP-seq
MIRT2273353	hsa-miR-625	CLIP-seq
MIRT2043944	hsa-miR-873	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT1153566	hsa-miR-4450	CLIP-seq
MIRT2273345	hsa-miR-4496	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT2043944	hsa-miR-873	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT2454324	hsa-miR-1243	CLIP-seq
MIRT1153538	hsa-miR-1261	CLIP-seq
MIRT2273341	hsa-miR-1275	CLIP-seq
MIRT1153540	hsa-miR-1324	CLIP-seq
MIRT1153541	hsa-miR-142-5p	CLIP-seq
MIRT1153542	hsa-miR-2681	CLIP-seq
MIRT1153543	hsa-miR-3125	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT1153547	hsa-miR-3166	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153552	hsa-miR-340	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT2454325	hsa-miR-3914	CLIP-seq
MIRT1153558	hsa-miR-3916	CLIP-seq
MIRT1153560	hsa-miR-3928	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT2273344	hsa-miR-4457	CLIP-seq
MIRT2454326	hsa-miR-4463	CLIP-seq
MIRT1921272	hsa-miR-4493	CLIP-seq
MIRT2273345	hsa-miR-4496	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT1153570	hsa-miR-4525	CLIP-seq
MIRT2273347	hsa-miR-4665-5p	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153574	hsa-miR-4709-3p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT2273348	hsa-miR-4723-5p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT2273349	hsa-miR-4773	CLIP-seq
MIRT2273351	hsa-miR-513b	CLIP-seq
MIRT1153586	hsa-miR-583	CLIP-seq
MIRT2273353	hsa-miR-625	CLIP-seq
MIRT2043944	hsa-miR-873	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT2043944	hsa-miR-873	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT2454324	hsa-miR-1243	CLIP-seq
MIRT1153538	hsa-miR-1261	CLIP-seq
MIRT1153540	hsa-miR-1324	CLIP-seq
MIRT1153543	hsa-miR-3125	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT1153547	hsa-miR-3166	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT2454325	hsa-miR-3914	CLIP-seq
MIRT1153558	hsa-miR-3916	CLIP-seq
MIRT1153560	hsa-miR-3928	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT2454326	hsa-miR-4463	CLIP-seq
MIRT2273345	hsa-miR-4496	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153574	hsa-miR-4709-3p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT2043944	hsa-miR-873	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq
MIRT1153537	hsa-miR-1208	CLIP-seq
MIRT2454324	hsa-miR-1243	CLIP-seq
MIRT1153538	hsa-miR-1261	CLIP-seq
MIRT1153540	hsa-miR-1324	CLIP-seq
MIRT1153541	hsa-miR-142-5p	CLIP-seq
MIRT1153543	hsa-miR-3125	CLIP-seq
MIRT1153545	hsa-miR-3150a-3p	CLIP-seq
MIRT1153547	hsa-miR-3166	CLIP-seq
MIRT1153549	hsa-miR-3175	CLIP-seq
MIRT1153552	hsa-miR-340	CLIP-seq
MIRT1153554	hsa-miR-3652	CLIP-seq
MIRT1153555	hsa-miR-3664-3p	CLIP-seq
MIRT1153557	hsa-miR-3692	CLIP-seq
MIRT2454325	hsa-miR-3914	CLIP-seq
MIRT1153558	hsa-miR-3916	CLIP-seq
MIRT1153560	hsa-miR-3928	CLIP-seq
MIRT1153563	hsa-miR-4430	CLIP-seq
MIRT2454326	hsa-miR-4463	CLIP-seq
MIRT2273345	hsa-miR-4496	CLIP-seq
MIRT1153568	hsa-miR-4505	CLIP-seq
MIRT1153571	hsa-miR-4667-5p	CLIP-seq
MIRT1153572	hsa-miR-4700-5p	CLIP-seq
MIRT1153574	hsa-miR-4709-3p	CLIP-seq
MIRT1153576	hsa-miR-4717-3p	CLIP-seq
MIRT1153577	hsa-miR-4731-5p	CLIP-seq
MIRT2043944	hsa-miR-873	CLIP-seq
MIRT1153590	hsa-miR-939	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IDA	28671670, 29763414
GO:0001525	Process	Angiogenesis	IDA	31138217
GO:0001525	Process	Angiogenesis	IEA
GO:0002042	Process	Cell migration involved in sprouting angiogenesis	IEA
GO:0005201	Function	Extracellular matrix structural constituent	RCA	23979707, 28675934
GO:0005515	Function	Protein binding	IPI	22020326, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005604	Component	Basement membrane	IEA
GO:0005615	Component	Extracellular space	IDA	11559704
GO:0007155	Process	Cell adhesion	NAS	22020326
GO:0007165	Process	Signal transduction	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	22020326
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0030336	Process	Negative regulation of cell migration	IDA	22020326
GO:0030948	Process	Negative regulation of vascular endothelial growth factor receptor signaling pathway	IBA
GO:0030948	Process	Negative regulation of vascular endothelial growth factor receptor signaling pathway	IDA	22020326
GO:0031012	Component	Extracellular matrix	HDA	23979707, 28675934
GO:0031012	Component	Extracellular matrix	IEA
GO:0048018	Function	Receptor ligand activity	IDA	28671670
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IBA
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IDA	22020326
GO:1900426	Process	Positive regulation of defense response to bacterium	IEA
GO:1900426	Process	Positive regulation of defense response to bacterium	ISO
GO:1903588	Process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	25745997
GO:1903588	Process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA
GO:1905278	Process	Positive regulation of epithelial tube formation	IDA	25745997
GO:1905332	Process	Positive regulation of morphogenesis of an epithelium	IDA	25745997
GO:1990972	Component	Multimerin complex	ISS

MIM	HGNC	e!Ensembl
608925	19888	ENSG00000173269

Q9H8L6

Protein name

Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit)

Protein function

Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel (PubMed:28435016). Affects several essential steps in angiogenesis including endothelial cell prol

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07546	EMI	55 → 127	EMI domain	Domain
PF00386	C1q	827 → 946	C1q domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Endothelium. {ECO:0000269|PubMed:11559704}.

Sequence

MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPY
PMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWR
CCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHL
LGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVH
FSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQEN
TQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGA
GARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD
ETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG
GHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV
DAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALL
EDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAA
RVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAG
AGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRK
GKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQ
TVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTT
GQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT

Sequence length

949

Interactions

View interactions

MMRN2 (multimerin 2)