Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79812
Gene name Gene Name - the full gene name approved by the HGNC.
Multimerin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MMRN2
Synonyms (NCBI Gene) Gene synonyms aliases
EMILIN-3, EMILIN3, ENDOGLYX-1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transfor
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1153537 hsa-miR-1208 CLIP-seq
MIRT1153538 hsa-miR-1261 CLIP-seq
MIRT1153539 hsa-miR-1290 CLIP-seq
MIRT1153540 hsa-miR-1324 CLIP-seq
MIRT1153541 hsa-miR-142-5p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002042 Process Cell migration involved in sprouting angiogenesis IEA
GO:0005201 Function Extracellular matrix structural constituent RCA 23979707, 28675934
GO:0005515 Function Protein binding IPI 22020326, 32296183
GO:0005604 Component Basement membrane IEA
GO:0005615 Component Extracellular space IDA 11559704
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608925 19888 ENSG00000173269
Protein
UniProt ID Q9H8L6
Protein name Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit)
Protein function Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel (PubMed:28435016). Affects several essential steps in angiogenesis including endothelial cell prol
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07546 EMI 55 127 EMI domain Domain
PF00386 C1q 827 946 C1q domain Domain
Tissue specificity TISSUE SPECIFICITY: Endothelium. {ECO:0000269|PubMed:11559704}.
Sequence
MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPY
PMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWR
CCPGYTG
PNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHL
LGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVH
FSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQEN
TQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGA
GARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD
ETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG
GHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV
DAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALL
EDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAA
RVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAG
AGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRK
GKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQ
TVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTT
GQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLM
FKT
Sequence length 949
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30419062
Breast Neoplasms Associate 26544852
Carcinoma Renal Cell Associate 33761933
Lung Neoplasms Associate 30419062
Neoplasm Metastasis Associate 18327805
Neoplasms Associate 18327805, 28435016, 30544909
Stomach Neoplasms Inhibit 30544909