Gene Gene information from NCBI Gene database.
Entrez ID 79811
Gene name SAFB like transcription modulator
Gene symbol SLTM
Synonyms (NCBI Gene)
Met
Chromosome 15
Chromosome location 15q22.1
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs1401798992 G>C,T Likely-pathogenic Downstream transcript variant, non coding transcript variant, coding sequence variant, missense variant, genic downstream transcript variant
miRNA miRNA information provided by mirtarbase database.
214
miRTarBase ID miRNA Experiments Reference
MIRT021156 hsa-miR-186-5p Sequencing 20371350
MIRT1370164 hsa-miR-101 CLIP-seq
MIRT1370165 hsa-miR-105 CLIP-seq
MIRT1370166 hsa-miR-1237 CLIP-seq
MIRT1370167 hsa-miR-1250 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620992 20709 ENSG00000137776
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NWH9
Protein name SAFB-like transcription modulator (Modulator of estrogen-induced transcription)
Protein function When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02037 SAP 22 56 SAP domain Family
PF00076 RRM_1 386 456 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Sequence
MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG
GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN
DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED
DTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMN
ANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKD
SKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLIS
VEKVKGDPSKKEMKKENDEKSSSR
SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI
KKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERL
QRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQ
EKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRE
SDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVER
PERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD
TSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSG
SGFKPFKGGPPRRF
Sequence length 1034
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Jeune thoracic dystrophy Likely pathogenic rs1401798992 RCV000755166
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASPERGER SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Abnormalities Drug Induced Associate 25087088
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Associate 15720819, 17062664, 18349821, 18379349, 19096300, 22042947, 22052229, 22198430, 22450065, 23449277, 25886066, 26183759, 26315110, 27080983, 27300295
View all (17 more)
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Clear Cell Associate 21478826, 21983935
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Mucinous Associate 32840168
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Associate 16327494
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 18093943, 19096300, 20150826, 22975805, 25079552, 25886066, 25922291, 25971939, 26066407, 26098749, 26416301, 26791794, 26845116, 27060149, 27151654
View all (39 more)
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Stimulate 19817696
★☆☆☆☆
Found in Text Mining only
Adenoma Associate 34801057
★☆☆☆☆
Found in Text Mining only
Adenoma Pleomorphic Associate 33838468
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Associate 28141798
★☆☆☆☆
Found in Text Mining only