Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	79800
Gene name	Calcium responsive transcription factor
Gene symbol	CARF
Synonyms (NCBI Gene)	ALS2CR8NYD-SP24
Chromosome	2
Chromosome location	2q33.2

106

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025457	hsa-miR-34a-5p	Proteomics	21566225
MIRT043277	hsa-miR-331-3p	CLASH	23622248
MIRT503816	hsa-miR-521	HITS-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503816	hsa-miR-521	HITS-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503816	hsa-miR-521	HITS-CLIP	23824327
MIRT503815	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT550292	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT503814	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT503813	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT503816	hsa-miR-521	PAR-CLIP	20371350
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503816	hsa-miR-521	PAR-CLIP	20371350
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT515275	hsa-miR-495-5p	PAR-CLIP	21572407
MIRT503816	hsa-miR-521	PAR-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550292	hsa-miR-153-5p	PAR-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503816	hsa-miR-521	PAR-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503816	hsa-miR-521	PAR-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515275	hsa-miR-495-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	HITS-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503816	hsa-miR-521	HITS-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503816	hsa-miR-521	HITS-CLIP	23824327
MIRT503815	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT550292	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT503814	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT503813	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT503816	hsa-miR-521	PAR-CLIP	20371350
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503816	hsa-miR-521	PAR-CLIP	20371350
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT515275	hsa-miR-495-5p	PAR-CLIP	21572407
MIRT503816	hsa-miR-521	PAR-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550292	hsa-miR-153-5p	PAR-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503816	hsa-miR-521	PAR-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503816	hsa-miR-521	PAR-CLIP	21572407
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515275	hsa-miR-495-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503816	hsa-miR-521	PAR-CLIP	23446348
MIRT503815	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503814	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503813	hsa-miR-1277-5p	PAR-CLIP	23446348

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	11832226
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001652	Component	Granular component	IEA
GO:0003677	Function	DNA binding	IDA	11832226
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0071277	Process	Cellular response to calcium ion	IDA	11832226, 22174809

MIM	HGNC	e!Ensembl
607586	14435	ENSG00000138380

Q8N187

Protein name

Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24)

Protein function

Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence. {ECO:0000269|PubMed:11832226, ECO:0000

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15299	ALS2CR8	253 → 483	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8	Family

Sequence

MEQSNDSLRVNHNDGEESKTSAQVFEHLICMDSRDSSFGQNDSPTVLPITTREANNSLIS
QNIPGPLTQTQTLSAEQFHLVDQNGQAIQYELQSLGESNAQMMIVASPTENGQVLRVIPP
TQTGMAQVIIPQGQLVDVNSPRDVPEEKPSNRNLPTVRVDTLADNTSNYILHPQTSFPLP
KKSVTGMLEEPLLGPLQPLSSNTPIWACRLRSCEKIGDSYRGYCVSETELESVLTFHKQQ
TQSVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGSRAVVMECQYGPRRKGFQLKKV
SEQESRSCQLYKATCPARIYIKKVQKFPEYRVPTDPKIDKKIIRMEQEKAFNMLKKNLVD
AGGVLRWYVQLPTQQAHQYHELETPCLTLSPSPFPVSSLEEEETAVRDENCALPSRLHPQ
VAHKIQELVSQGIEQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPTVNDIKNHIHEVQ
KSLRNGDTVYNSEIIPATLQWTTDSGNILKETMTVTFAEGNSPGESITTKVETNQTRGSL
SPEPTHLLSSLSSFQPKIFTQLQGLQLQPRYTSPDESPAVVSVNNQPSSSPSGLLDTIGS
AVMNNNSLLLGQSHSLQRDTCLTQNNSTASTMGNLPEPDQNLVAMDELVEVGDVEDTGNL
EGTVHRILLGDVQTIPIQIIDNHSALIEENPESTISVSQVKQEPKEPALSMEAKKTVDYK
KLSAT

Sequence length

725

Interactions

View interactions

CARF (calcium responsive transcription factor)