Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein
Entrez ID	7980
Gene name	Tissue factor pathway inhibitor 2
Gene symbol	TFPI2
Synonyms (NCBI Gene)	PP5REF1TFPI-2
Chromosome	7
Chromosome location	7q21.3
Summary	This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has bee

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005774	hsa-miR-616-3p	In situ hybridizationLuciferase reporter assayMicroarrayqRT-PCR	21224345
MIRT005774	hsa-miR-616-3p	Microarray	21224345
MIRT1420659	hsa-miR-15a	CLIP-seq
MIRT1420660	hsa-miR-15b	CLIP-seq
MIRT1420661	hsa-miR-16	CLIP-seq
MIRT1420662	hsa-miR-195	CLIP-seq
MIRT1420663	hsa-miR-23a	CLIP-seq
MIRT1420664	hsa-miR-23b	CLIP-seq
MIRT1420665	hsa-miR-23c	CLIP-seq
MIRT1420666	hsa-miR-3529	CLIP-seq
MIRT1420667	hsa-miR-379	CLIP-seq
MIRT1420668	hsa-miR-424	CLIP-seq
MIRT1420669	hsa-miR-4524	CLIP-seq
MIRT1420670	hsa-miR-497	CLIP-seq
MIRT1420671	hsa-miR-503	CLIP-seq
MIRT1420672	hsa-miR-646	CLIP-seq
MIRT1420659	hsa-miR-15a	CLIP-seq
MIRT1420660	hsa-miR-15b	CLIP-seq
MIRT1420661	hsa-miR-16	CLIP-seq
MIRT1420662	hsa-miR-195	CLIP-seq
MIRT1420663	hsa-miR-23a	CLIP-seq
MIRT1420664	hsa-miR-23b	CLIP-seq
MIRT1420665	hsa-miR-23c	CLIP-seq
MIRT1420666	hsa-miR-3529	CLIP-seq
MIRT1420667	hsa-miR-379	CLIP-seq
MIRT1420668	hsa-miR-424	CLIP-seq
MIRT2348326	hsa-miR-4451	CLIP-seq
MIRT1420669	hsa-miR-4524	CLIP-seq
MIRT2348327	hsa-miR-4650-3p	CLIP-seq
MIRT1420670	hsa-miR-497	CLIP-seq
MIRT1420671	hsa-miR-503	CLIP-seq
MIRT2348328	hsa-miR-522	CLIP-seq
MIRT2348329	hsa-miR-548c-3p	CLIP-seq
MIRT1420672	hsa-miR-646	CLIP-seq
MIRT1420659	hsa-miR-15a	CLIP-seq
MIRT1420660	hsa-miR-15b	CLIP-seq
MIRT1420661	hsa-miR-16	CLIP-seq
MIRT1420662	hsa-miR-195	CLIP-seq
MIRT1420663	hsa-miR-23a	CLIP-seq
MIRT1420664	hsa-miR-23b	CLIP-seq
MIRT1420665	hsa-miR-23c	CLIP-seq
MIRT2440952	hsa-miR-3163	CLIP-seq
MIRT2440953	hsa-miR-410	CLIP-seq
MIRT1420668	hsa-miR-424	CLIP-seq
MIRT1420669	hsa-miR-4524	CLIP-seq
MIRT1420670	hsa-miR-497	CLIP-seq
MIRT1420671	hsa-miR-503	CLIP-seq
MIRT1420672	hsa-miR-646	CLIP-seq
MIRT2461377	hsa-miR-3671	CLIP-seq
MIRT2461378	hsa-miR-371-5p	CLIP-seq
MIRT2461379	hsa-miR-371b-5p	CLIP-seq
MIRT2461380	hsa-miR-513c	CLIP-seq
MIRT2461381	hsa-miR-514b-5p	CLIP-seq
MIRT1420659	hsa-miR-15a	CLIP-seq
MIRT1420660	hsa-miR-15b	CLIP-seq
MIRT1420661	hsa-miR-16	CLIP-seq
MIRT1420662	hsa-miR-195	CLIP-seq
MIRT1420663	hsa-miR-23a	CLIP-seq
MIRT1420664	hsa-miR-23b	CLIP-seq
MIRT1420665	hsa-miR-23c	CLIP-seq
MIRT2440952	hsa-miR-3163	CLIP-seq
MIRT2640946	hsa-miR-3164	CLIP-seq
MIRT2640947	hsa-miR-3609	CLIP-seq
MIRT2440953	hsa-miR-410	CLIP-seq
MIRT1420668	hsa-miR-424	CLIP-seq
MIRT1420669	hsa-miR-4524	CLIP-seq
MIRT2640948	hsa-miR-4668-3p	CLIP-seq
MIRT1420670	hsa-miR-497	CLIP-seq
MIRT1420671	hsa-miR-503	CLIP-seq
MIRT2640949	hsa-miR-548ah	CLIP-seq
MIRT2348329	hsa-miR-548c-3p	CLIP-seq
MIRT2640950	hsa-miR-548t	CLIP-seq
MIRT1420672	hsa-miR-646	CLIP-seq
MIRT1420659	hsa-miR-15a	CLIP-seq
MIRT1420660	hsa-miR-15b	CLIP-seq
MIRT1420661	hsa-miR-16	CLIP-seq
MIRT1420662	hsa-miR-195	CLIP-seq
MIRT1420663	hsa-miR-23a	CLIP-seq
MIRT1420664	hsa-miR-23b	CLIP-seq
MIRT1420665	hsa-miR-23c	CLIP-seq
MIRT2440952	hsa-miR-3163	CLIP-seq
MIRT2440953	hsa-miR-410	CLIP-seq
MIRT1420668	hsa-miR-424	CLIP-seq
MIRT1420669	hsa-miR-4524	CLIP-seq
MIRT2640948	hsa-miR-4668-3p	CLIP-seq
MIRT1420670	hsa-miR-497	CLIP-seq
MIRT1420671	hsa-miR-503	CLIP-seq
MIRT2348329	hsa-miR-548c-3p	CLIP-seq
MIRT1420672	hsa-miR-646	CLIP-seq

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Transcription factor	Regulation	Reference
EGR1	Unknown	12757776
KLF6	Unknown	18053161
NFIC	Unknown	12757776
NFKB1	Unknown	12757776
SP1	Unknown	12446683

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005201	Function	Extracellular matrix structural constituent	TAS	8914837
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0007596	Process	Blood coagulation	IEA
GO:0007599	Process	Hemostasis	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0031012	Component	Extracellular matrix	TAS	8914837

MIM	HGNC	e!Ensembl
600033	11761	ENSG00000105825

P48307

Protein name

Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5)

Protein function

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

PDB

1ZR0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00014	Kunitz_BPTI	35 → 87	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
PF00014	Kunitz_BPTI	95 → 150	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
PF00014	Kunitz_BPTI	157 → 209	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Sequence

MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQS
CRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSM
TCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRY
RTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF

Sequence length

235

Interactions

View interactions

TFPI2 (tissue factor pathway inhibitor 2)