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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q86UP3 |
| Protein name |
Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) |
| Protein function |
May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. |
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF12874 |
zf-met |
699 → 723 |
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Domain |
| PF00096 |
zf-C2H2 |
1548 → 1572 |
Zinc finger, C2H2 type |
Domain |
| PF00046 |
Homeodomain |
2085 → 2141 |
Homeodomain |
Domain |
| PF00046 |
Homeodomain |
2182 → 2238 |
Homeodomain |
Domain |
| PF00046 |
Homeodomain |
2561 → 2617 |
Homeodomain |
Domain |
| PF00046 |
Homeodomain |
2885 → 2941 |
Homeodomain |
Domain |
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| Tissue specificity |
TISSUE SPECIFICITY: Expressed in brain, skeletal muscle and liver. Very low expression in stomach. |
| Sequence |
METCDSPPISRQENGQSTSKLCGTTQLDNEVPEKVAGMEPDRENSSTDDNLKTDERKSEA LLGFSVENAAATQVTSAKEIPCNECATSFPSLQKYMEHHCPNARLPVLKDDNESEISELE DSDVENLTGEIVYQPDGSAYIIEDSKESGQNAQTGANSKLFSTAMFLDSLASAGEKSDQS ASAPMSFYPQIINTFHIASSLGKPFTADQAFPNTSALAGVGPVLHSFRVYDLRHKREKDY LTSDGSAKNSCVSKDVPNNVDLSKFDGCVSDGKRKPVLMCFLCKLSFGYIRSFVTHAVHD HRMTLNDEEQKLLSNKCVSAIIQGIGKDKEPLISFLEPKKSTSVYPHFSTTNLIGPDPTF RGLWSAFHVENGDSLPAGFAFLKGSASTSSSAEQPLGITQMPKAEVNLGGLSSLVVNTPI TSVSLSHSSSESSKMSESKDQENNCERPKESNVLHPNGECPVKSEPTEPGDEDEEDAYSN ELDDEEVLGELTDSIGNKDFPLLNQSISPLSSSVLKFIEKGTSSSSATVSDDTEKKKQTA AVRASGSVASNYGISGKDFADASASKDSATAAHPSEIARGDEDSSATPHQHGFTPSTPGT PGPGGDGSPGSGIECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLE AHMKEKHPEPGGSCVYCKTGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQS DKHLNNVQNLQNGNGEQVFGHSAPAPNTSLSGCGTPSPSKPKQKPTWRCEVCDYETNVAR NLRIHMTSEKHMHNMMLLQQNMKQIQHNLHLGLAPAEAELYQYYLAQNIGLTGMKLENPA DPQLMINPFQLDPATAAALAPGLGELSPYISDPALKLFQCAVCNKFTSDSLEALSVHVSS ERSLPEEEWRAVIGDIYQCKLCNYNTQLKANFQLHCKTDKHMQKYQLVAHIKEGGKSNEW RLKCIAIGNPVHLKCNACDYYTNSVDKLRLHTTNHRHEAALKLYKHLQKQEGAVNPESCY YYCAVCDYTTKVKLNLVQHVRSVKHQQTEGLRKLQLHQQGLAPEEDNLSEIFFVKDCPPN ELETASLGARTCDDDLTEQHEEAEGAIKPTAVAEDDEKDTSERDNSEGKNSNKDSVSVAG GTQPLLLAKEEDVATKRSKPTEDNKFCHEQFYQCPYCNYNSRDQSRIQMHVLSQHSVQPV ICCPLCQDVLSNKMHLQLHLTHLHSVSPDCVEKLLMTVPVPDVMMPNSMLLPAAASEKSE RDTPAAVTAEGSGKYSGESPMDDKSMAGLEDSKANVEVKNEEQKPTKEPLEVSEWNKNSS KDVKIPDTLQDQLNEQQKRQPLSVSDRHVYKYRCNHCSLAFKTMQKLQIHSQYHAIRAAT MCNLCQRSFRTFQALKKHLEAGHPELSEAELQQLYASLPVNGELWAESETMSQDDHGLEQ EMEREYEVDHEGKASPVGSDSSSIPDDMGSEPKRTLPFRKGPNFTMEKFLDPSRPYKCTV CKESFTQKNILLVHYNSVSHLHKLKKVLQEASSPVPQETNSNTDNKPYKCSICNVAYSQS STLEIHMRSVLHQTKARAAKLEPSGHVAGGHSIAANVNSPGQGMLDSMSLAAVNSKDTHL DAKELNKKQTPDLISAQPAHHPPQSPAQIQMQLQHELQQQAAFFQPQFLNPAFLPHFPMT PEALLQFQQPQFLFPFYIPGTEFSLGPDLGLPGSATFGMPGMTGMAGSLLEDLKQQIQTQ HHVGQTQLQILQQQAQQYQATQPQLQPQKQQQQPPPPQQQQQQQASKLLKQEQSNIVSAD CQIMKDVPSYKEAEDISEKPEKPKQEFISEGEGLKEGKDTKKQKSLEPSIPPPRIASGAR GNAAKALLENFGFELVIQYNENRQKVQKKGKSGEGENTDKLECGTCGKLFSNVLILKSHQ EHVHGQFFPYAALEKFARQYREAYDKLYPISPSSPETPPPPPPPPPLPPAPPQPSSMGPV KIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPPSAPPQVQLPVSLDLPLFPSIMMQP VQHPALPPQLALQLPQMDALSADLTQLCQQQLGLDPNFLRHSQFKRPRTRITDDQLKILR AYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITVLED IRIDPQPTSLEHYKSDASFSKRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNL PTRVIVVWFQNARQKARKSYENQAETKDNEKRELTNERYIRTSNMQYQCKKCNVVFPRIF DLITHQKKQCYKDEDDDAQDESQTEDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGS GTSTPLIPSPKPEPEKTSPKPEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQ PQPQPQPPKQPQLIGRPPSASQTPVPSSPLQISMTSLQNSLPPQLLQYQCDQCTVAFPTL ELWQEHQHMHFLAAQNQFLHSPFLERPMDMPYMIFDPNNPLMTGQLLGSSLTQMPPQASS SHTTAPTTVAASLKRKLDDKEDNNCSEKEGGNSGEDQHRDKRLRTTITPEQLEILYEKYL LDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFK AKSALESHIRSRHWNEGKQAGYSLPPSPLISTEDGGESPQKYIYFDYPSLPLTKIDLSSE NELASTVSTPVSKTAELSPKNLLSPSSFKAECSEDVENLNAPPAEAGYDQNKTDFDETSS INTAISDATTGDEGNTEMESTTGSSGDVKPALSPKEPKTLDTLPKPATTPTTEVCDDKFL FSLTSPSIHFNDKDGDHDQSFYITDDPDDNADRSETSSIADPSSPNPFGSSNPFKSKSND RPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEK KFKINIGKPFMINQGGTEGTKPECTLCGVKYSARLSIRDHIFSKQHISKVRETVGSQLDR EKDYLAPTTVRQLMAQQELDRIKKASDVLGLTVQQPGMMDSSSLHGISLPTAYPGLPGLP PVLLPGMNGPSSLPGFPQNSNISAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPP PPPPSSSLSGQQTEQQNKESEKKQTKPNKVKKIKEEELEATKPEKHPKKEEKISSALSVL GKVVGETHVDPIQLQALQNAIAGDPASFIGGQFLPYFIPGFASYFTPQLPGTVQGGYFPP VCGMESLFPYGPTMPQTLAGLSPGALLQQYQQYQQNLQESLQKQQKQQQEQQQKPVQAKT SKVESDQPQNSNDASETKEDKSTATESTKEEPQLESKSADFSDTYVVPFVKYEFICRKCQ MMFTDEDAAVNHQKSFCYFGQPLIDPQETVLRVPVSKYQCLACDVAISGNEALSQHLQSS LHKEKTIKQAMRNAKEHVRLLPHSVCSPNPNTTSTSQSAASSNNTYPHLSCFSMKSWPNI LFQASARRAASPPSSPPSLSLPSTVTSSLCSTSGVQTSLPTESCSDESDSELSQKLEDLD NSLEVKAKPASGLDGNFNSIRMDMFSV
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| Sequence length |
3567 |
| Interactions |
View interactions |
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| Phenotype Name |
Clinical Significance |
dbSNP ID |
RCV Accession |
| Acute myeloid leukemia |
Benign; Likely benign |
rs73239807 |
RCV005907539 |
| Clear cell carcinoma of kidney |
Benign |
rs183665267 |
RCV005938701 |
| Malignant tumor of esophagus |
Benign; Likely benign |
rs73239807 |
RCV005907540 |
| Ptosis, hereditary congenital, 1 |
Benign; Uncertain significance; Likely benign |
rs16939357, rs2733733, rs374480311, rs2536196890, rs759934471, rs752252508, rs372128559, rs139920573 |
RCV002243445 RCV002245264 RCV005052023 RCV003140490 RCV003139399 RCV003447808 RCV003456331 RCV002505409 |
| Uterine corpus endometrial carcinoma |
Benign; Likely benign |
rs183665267, rs73239807 |
RCV005938702 RCV005907541 |
| ZFHX4-related disorder |
Conflicting classifications of pathogenicity; Uncertain significance; Benign; Likely benign |
rs201352165, rs144576583, rs2536198946, rs754039043, rs762294446, rs56261025, rs376831938, rs376628513, rs372113584, rs762275106, rs113906809, rs867093271, rs373343766, rs562503838, rs769631578, rs111531604, rs2728455, rs61729527, rs150644855, rs116855615, rs751341224, rs754911207, rs376251060, rs540974936, rs371571217, rs148979629, rs778804692, rs775936557, rs73690865, rs145665241, rs2536398064, rs373464374, rs78600602, rs191596643, rs769233887, rs371578848, rs751723912, rs374283630, rs183665267, rs200099866, rs750690709, rs562547549, rs751120939, rs371012847, rs188120644, rs1164496766, rs370547889, rs375245954, rs541217165, rs61729535, rs779394582, rs137874063, rs28376707, rs144357822, rs146028915, rs191883247, rs189444720 View all (42 more) |
RCV003936677 RCV003906627 RCV003429088 RCV003404533 RCV003420956 RCV003939027 RCV003939028 RCV003980947 RCV003929180 RCV003897343 RCV003919820 RCV003921898 RCV003929637 RCV003931865 RCV003981465 RCV003974169 RCV003982466 RCV003914225 RCV003916838 RCV003979360 RCV003973934 RCV003979421 RCV003899546 RCV003909695 RCV003933893 RCV003941990 RCV003952000 RCV003961684 RCV003961726 RCV003961739 RCV003961774 RCV003927059 RCV003941632 RCV003951629 RCV003914586 RCV003932327 RCV003924369 RCV003937164 RCV003969324 RCV003922075 RCV003922193 RCV003924269 RCV003932026 RCV003934235 RCV003934283 RCV003942284 RCV003976976 RCV003977014 RCV003957271 RCV003963811 RCV003978933 RCV003966760 RCV003966773 RCV003970860 RCV003955941 RCV003975655 RCV003932957 RCV003950522 |
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