MCTP1 (multiple C2 and transmembrane domain containing 1)

Gene

• Entrez ID: 79772
• Gene name: Multiple C2 and transmembrane domain containing 1
• Gene symbol: MCTP1
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q15

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021932	hsa-miR-128-3p	Microarray	17612493
MIRT656417	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT656417	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT656416	hsa-miR-1470	HITS-CLIP	23824327
MIRT656415	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT656414	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656413	hsa-miR-4287	HITS-CLIP	23824327
MIRT656412	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT656411	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT656410	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT656409	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT656408	hsa-miR-6505-5p	HITS-CLIP	23824327
MIRT656407	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT656406	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT656405	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT656404	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT656417	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT656417	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT656416	hsa-miR-1470	HITS-CLIP	23824327
MIRT656415	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT656414	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656413	hsa-miR-4287	HITS-CLIP	23824327
MIRT656412	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT656411	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT656410	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT656409	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT656408	hsa-miR-6505-5p	HITS-CLIP	23824327
MIRT656407	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT656406	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT656405	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT656404	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1138069	hsa-miR-4509	CLIP-seq
MIRT1138070	hsa-miR-4744	CLIP-seq
MIRT1920614	hsa-miR-3668	CLIP-seq
MIRT1920615	hsa-miR-3935	CLIP-seq
MIRT1920616	hsa-miR-552	CLIP-seq
MIRT2039206	hsa-miR-3660	CLIP-seq
MIRT2039207	hsa-miR-4526	CLIP-seq
MIRT2039208	hsa-miR-4666-3p	CLIP-seq
MIRT2390738	hsa-miR-2467-5p	CLIP-seq
MIRT2390739	hsa-miR-3188	CLIP-seq
MIRT2390740	hsa-miR-3616-3p	CLIP-seq
MIRT2390741	hsa-miR-3929	CLIP-seq
MIRT2390742	hsa-miR-3975	CLIP-seq
MIRT2390743	hsa-miR-4419b	CLIP-seq
MIRT2390744	hsa-miR-4478	CLIP-seq
MIRT2390745	hsa-miR-4649-3p	CLIP-seq
MIRT2390746	hsa-miR-4663	CLIP-seq
MIRT2390747	hsa-miR-4721	CLIP-seq
MIRT2390748	hsa-miR-485-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IDA	15528213
GO:0005544	Function	Calcium-dependent phospholipid binding	IDA	15528213
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IDA	15528213
GO:0019722	Process	Calcium-mediated signaling	NAS	15528213
GO:0030336	Process	Negative regulation of cell migration	ISS
GO:0030672	Component	Synaptic vesicle membrane	IBA	21873635
GO:0030672	Component	Synaptic vesicle membrane	ISS
GO:0045806	Process	Negative regulation of endocytosis	ISS
GO:0046928	Process	Regulation of neurotransmitter secretion	IBA	21873635
GO:0046928	Process	Regulation of neurotransmitter secretion	ISS
GO:0048168	Process	Regulation of neuronal synaptic plasticity	ISS
GO:0055037	Component	Recycling endosome	ISS
GO:1902883	Process	Negative regulation of response to oxidative stress	ISS

Other IDs

• MIM: 616296
• HGNC: 26183
• e!Ensembl: ENSG00000175471

Protein

• UniProt ID: Q6DN14
• Protein name: Multiple C2 and transmembrane domain-containing protein 1
• Protein function: Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	261 → 362	C2 domain	Domain
  PF00168	C2	470 → 571	C2 domain	Domain
  PF00168	C2	626 → 725	C2 domain	Domain
  PF08372	PRT_C	828 → 977	Plant phosphoribosyltransferase C-terminal	Family

• Sequence:

  MEPRAAAAGEPEPPAASSSFQARLWKNLQLGVGRSKGGGGGRAGGPERRTADTPSPSPPP
  PVGTGNAPARGSGAGSRWSGFKKRKQVLDRVFSSSQPNLCCSSPEPLEPGGAGRAEQGST
  LRRRIREHLLPAVKGPAAASGAAGGTPPGGRSPDSAPSSSSASSSLSSSPQPPPRGDRAR
  DEGARRQGPGAHLCHQKSSSLPGTACLEQLLEPPPPPAEPARSPAESRAPETGEEHGSSQ
  KIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKI
  IHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTL
  TLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKS
  LFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGR
  DLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDK
  DAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSL
  EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRL
  LTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK
  AYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIR
  MKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFL
  IISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVAS
  FGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDN
  NELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG

• Sequence length: 999

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Bipolar Disorder	Bipolar Disorder			GWAS
Anorexia	Anorexia			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Esophageal Neoplasms	Associate	33571139
Inflammatory Breast Neoplasms	Associate	31532791
Multiple System Atrophy	Associate	27470294
Synucleinopathies	Associate	27470294