ZNF668 (zinc finger protein 668)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 79759
Gene name Zinc finger protein 668
Gene symbol ZNF668
Synonyms (NCBI Gene)
NEDGEF
Chromosome 16
Chromosome location 16p11.2
miRNA miRNA information provided by mirtarbase database.
3
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (3)
miRTarBase ID miRNA Experiments Reference
MIRT047905 hsa-miR-30c-5p CLASH 23622248
MIRT1534505 hsa-miR-4305 CLIP-seq
MIRT1534506 hsa-miR-4704-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (11)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
617103 25821 ENSG00000167394
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96K58
Protein name Zinc finger protein 668
Protein function May be involved in transcriptional regulation. May play a role in DNA repair process.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 84 → 106 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 112 → 134 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 140 → 162 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 168 → 190 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 224 → 246 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 252 → 274 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 280 → 302 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 308 → 330 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 336 → 358 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 364 → 386 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 392 → 414 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 516 → 538 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 544 → 566 Zinc finger, C2H2 type Domain
PF13894 zf-C2H2_4 572 → 595 Domain
Sequence 
MEVEAAEARSPAPGYKRSGRRYKCVSCTKTFPNAPRAARHAATHGPADCSEEVAEVKPKP
ETEAKAEEASGEKVSGSAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRR
FMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYACADCGKSFADP
SVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLT
CHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQR
AHEGVKPYHCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSG
QRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAA
GVPPAQELVVGLALPVGVAGESSAAPAAGAGLGDPPAGLLGLPPESGGVMATQWQVVGMT
VEHVECQDAGVREAPGPLEGAGEAGGEEADEKPPQFVCRECKETFSTMTLLRRHERSHPE
LRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPMGT
PTPLEPLVALLGMPEEGPA
Sequence length 619
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
19
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (6)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Failure to thrive Pathogenic rs1178162893, rs2143756208 RCV001542807
RCV001542806
marked facial dysmorphism Pathogenic rs1178162893, rs2143756208 RCV001542807
RCV001542806
Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies Pathogenic rs1178162893, rs2143756208 RCV003222336
RCV003222335
Profound global developmental delay Pathogenic rs1178162893, rs2143756208 RCV001542807
RCV001542806
Show/Hide Unknown Diseases (4)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Benign rs2303223 RCV005920695
Myoepithelial tumor Uncertain significance rs2544017047 RCV002463958
Uveal melanoma Benign rs2303223 RCV005920696
ZNF668-related disorder Likely benign; Benign rs1205256532, rs140466221, rs61750978, rs2288003, rs74720434 RCV003899384
RCV003911679
RCV003939327
RCV003936838
RCV003916253
Show/Hide Text Mining Associations (8)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Inhibit 21852383, 37240013
Breast Neoplasms Associate 23777805
HAIR AN syndrome Associate 23777805
Melanoma Associate 21343389
Neoplasms Inhibit 21852383, 23777805, 37240013
Neoplasms Associate 32859265
Syndrome Associate 26633546
Urinary Bladder Neoplasms Associate 37240013