ZNF385D (zinc finger protein 385D)

Gene

• Entrez ID: 79750
• Gene name: Zinc finger protein 385D
• Gene symbol: ZNF385D
• Synonyms (NCBI Gene): ZNF659
• Chromosome: 3
• Chromosome location: 3p24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT714750	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT648956	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT648957	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT714749	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT648955	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT714748	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT714747	hsa-miR-623	HITS-CLIP	19536157
MIRT714746	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT714745	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT648954	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT714744	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT714743	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT648953	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT648952	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT648951	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT648956	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648957	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648955	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT648954	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT648953	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648952	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648951	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT714750	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT648956	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT648957	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT714749	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT648955	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT714748	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT714747	hsa-miR-623	HITS-CLIP	19536157
MIRT714746	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT714745	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT648954	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT714744	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT714743	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT648953	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT648952	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT648951	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT648956	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648957	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648955	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT648954	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT648953	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648952	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648951	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT1523650	hsa-miR-1224-3p	CLIP-seq
MIRT1523651	hsa-miR-1260	CLIP-seq
MIRT1523652	hsa-miR-1260b	CLIP-seq
MIRT1523653	hsa-miR-1280	CLIP-seq
MIRT1523654	hsa-miR-1470	CLIP-seq
MIRT1523655	hsa-miR-4469	CLIP-seq
MIRT1523656	hsa-miR-4667-3p	CLIP-seq
MIRT1523657	hsa-miR-532-3p	CLIP-seq
MIRT1523650	hsa-miR-1224-3p	CLIP-seq
MIRT1523651	hsa-miR-1260	CLIP-seq
MIRT1523652	hsa-miR-1260b	CLIP-seq
MIRT1523653	hsa-miR-1280	CLIP-seq
MIRT1523654	hsa-miR-1470	CLIP-seq
MIRT1523655	hsa-miR-4469	CLIP-seq
MIRT1523656	hsa-miR-4667-3p	CLIP-seq
MIRT1523657	hsa-miR-532-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA	21873635
GO:0008270	Function	Zinc ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 621200
• HGNC: 26191
• e!Ensembl: ENSG00000151789

Protein

• UniProt ID: Q9H6B1
• Protein name: Zinc finger protein 385D (Zinc finger protein 659)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12874	zf-met	80 → 104		Domain
  PF12874	zf-met	204 → 228		Domain
  PF12874	zf-met	267 → 291		Domain

• Sequence:

  MRNIMYFGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQ
  KAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLKALEAMKNKQKS
  VTAKDSAKTTFTSITTNTINTSSDKTDGTAGTPAISTTTTVEIRKSSVMTTEITSKVEKS
  PTTATGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGT
  IKAFPRAGVKGKGPVNKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPP
  KPKYSPYNKLQKTAHPLGVKLVFSKEPSKPLAPRILPNPLAAAAAAAAVAVSSPFSLRTA
  PAATLFQTSALPPALLRPAPGPIRTAHTPVLFAPY

• Sequence length: 395

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	31095341

Unknown
Disease term	Disease name	Evidence	References	Source
Attention Deficit Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder			GWAS
Bipolar Disorder	Bipolar Disorder			GWAS
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).		GWAS, CBGDA
Metabolic Syndrome	Metabolic Syndrome			GWAS
Moyamoya Disease	Moyamoya Disease			GWAS
Schizophrenia	Schizophrenia			GWAS
Astrocytoma	Astrocytoma			GWAS
Diabetes	Diabetes			GWAS
Atrial Fibrillation	Atrial Fibrillation			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Bipolar Disorder	Associate	24387768
Carcinoma Hepatocellular	Associate	31322274
Dyslexia Acquired	Associate	24024963
Language Disorders	Associate	24024963
Mental Disorders	Associate	39674387