Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79739
Gene name	Tubulin tyrosine ligase like 7
Gene symbol	TTLL7
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p31.1

168

Show/Hide all (168)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049432	hsa-miR-92a-3p	CLASH	23622248
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT649932	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT447766	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT447765	hsa-miR-4426	PAR-CLIP	22100165
MIRT447764	hsa-miR-4647	PAR-CLIP	22100165
MIRT447763	hsa-miR-4662b	PAR-CLIP	22100165
MIRT447762	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT447761	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT447760	hsa-miR-24-3p	PAR-CLIP	22100165
MIRT627335	hsa-miR-1294	HITS-CLIP	27418678
MIRT627335	hsa-miR-1294	HITS-CLIP	27418678
MIRT627335	hsa-miR-1294	HITS-CLIP	27418678
MIRT627332	hsa-miR-147a	HITS-CLIP	27418678
MIRT627332	hsa-miR-147a	HITS-CLIP	27418678
MIRT627332	hsa-miR-147a	HITS-CLIP	27418678
MIRT627332	hsa-miR-147a	HITS-CLIP	27418678
MIRT627336	hsa-miR-4316	HITS-CLIP	27418678
MIRT627336	hsa-miR-4316	HITS-CLIP	27418678
MIRT627336	hsa-miR-4316	HITS-CLIP	27418678
MIRT627329	hsa-miR-4455	HITS-CLIP	27418678
MIRT627329	hsa-miR-4455	HITS-CLIP	27418678
MIRT627329	hsa-miR-4455	HITS-CLIP	27418678
MIRT627329	hsa-miR-4455	HITS-CLIP	27418678
MIRT627329	hsa-miR-4455	HITS-CLIP	27418678
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	27418678
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	27418678
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	27418678
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	27418678
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	27418678
MIRT627337	hsa-miR-4679	HITS-CLIP	27418678
MIRT627337	hsa-miR-4679	HITS-CLIP	27418678
MIRT627337	hsa-miR-4679	HITS-CLIP	27418678
MIRT627337	hsa-miR-4679	HITS-CLIP	27418678
MIRT627337	hsa-miR-4679	HITS-CLIP	27418678
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627328	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627328	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627328	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627328	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627328	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT736968	hsa-miR-4766-3p	ChIP-seqqRT-PCR	32221048
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT649932	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627338	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT627337	hsa-miR-4679	HITS-CLIP	23824327
MIRT627336	hsa-miR-4316	HITS-CLIP	23824327
MIRT627335	hsa-miR-1294	HITS-CLIP	23824327
MIRT627334	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627333	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT627332	hsa-miR-147a	HITS-CLIP	23824327
MIRT627331	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627330	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627329	hsa-miR-4455	HITS-CLIP	23824327
MIRT627328	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT447766	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT447765	hsa-miR-4426	PAR-CLIP	22100165
MIRT447764	hsa-miR-4647	PAR-CLIP	22100165
MIRT447763	hsa-miR-4662b	PAR-CLIP	22100165
MIRT447762	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT447761	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT447760	hsa-miR-24-3p	PAR-CLIP	22100165
MIRT1462495	hsa-miR-103a	CLIP-seq
MIRT1462496	hsa-miR-107	CLIP-seq
MIRT1462497	hsa-miR-1184	CLIP-seq
MIRT1462498	hsa-miR-1205	CLIP-seq
MIRT1462499	hsa-miR-3158-5p	CLIP-seq
MIRT1462500	hsa-miR-3664-5p	CLIP-seq
MIRT1462501	hsa-miR-377	CLIP-seq
MIRT1462502	hsa-miR-448	CLIP-seq
MIRT1462503	hsa-miR-455-5p	CLIP-seq
MIRT1462504	hsa-miR-4714-5p	CLIP-seq
MIRT1462505	hsa-miR-4789-3p	CLIP-seq
MIRT1462506	hsa-miR-5096	CLIP-seq
MIRT1462507	hsa-miR-545	CLIP-seq
MIRT1462508	hsa-miR-548p	CLIP-seq
MIRT2359827	hsa-miR-3662	CLIP-seq
MIRT2396470	hsa-miR-141	CLIP-seq
MIRT2396471	hsa-miR-200a	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0015631	Function	Tubulin binding	IBA
GO:0016874	Function	Ligase activity	IEA
GO:0018095	Process	Protein polyglutamylation	IDA	25959773
GO:0030154	Process	Cell differentiation	IEA
GO:0030425	Component	Dendrite	IEA
GO:0036064	Component	Ciliary basal body	IBA
GO:0042995	Component	Cell projection	IEA
GO:0043014	Function	Alpha-tubulin binding	IDA	25959773
GO:0043204	Component	Perikaryon	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048487	Function	Beta-tubulin binding	IDA	25959773
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IDA	25959773
GO:0070740	Function	Tubulin-glutamic acid ligase activity	TAS
GO:0106437	Function	Protein-glutamic acid ligase activity, initiating	IEA
GO:0106438	Function	Protein-glutamic acid ligase activity, elongating	IEA

MIM	HGNC	e!Ensembl
618813	26242	ENSG00000137941

Q6ZT98

Protein name

Tubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7)

Protein function

Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:16901895, PubMed:25959773). Mediates both A

PDB

4YLR , 4YLS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03133	TTL	84 → 388	Tubulin-tyrosine ligase family	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum. {ECO:0000269|PubMed:16901895}.

Sequence

MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEM
GFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKS
RPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLP
SQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESN
LTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVV
KTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQ
KIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR
HQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTF
LSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEI
MKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRR
SVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDACST
NSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTK
VASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQ
GLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGI
GPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL

Sequence length

887

Interactions

View interactions

	Reactome
			Carboxyterminal post-translational modifications of tubulin

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colorectal Neoplasms	Associate	32221048	★★★★★ ★☆☆☆☆ Found in Text Mining only

TTLL7 (tubulin tyrosine ligase like 7)