Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79733
Gene name Gene Name - the full gene name approved by the HGNC.
E2F transcription factor 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
E2F8
Synonyms (NCBI Gene) Gene synonyms aliases
E2F-8
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the pro
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024943 hsa-miR-215-5p Microarray 19074876
MIRT026752 hsa-miR-192-5p Microarray 19074876
MIRT031294 hsa-miR-19b-3p Sequencing 20371350
MIRT038639 hsa-miR-125a-3p CLASH 23622248
MIRT507476 hsa-miR-1277-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 16179649
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 16179649
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612047 24727 ENSG00000129173
Protein
UniProt ID A0AVK6
Protein name Transcription factor E2F8 (E2F-8)
Protein function Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recogn
PDB 4YO2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02319 E2F_TDP 114 182 E2F/DP family winged-helix DNA-binding domain Domain
PF02319 E2F_TDP 262 347 E2F/DP family winged-helix DNA-binding domain Domain
Sequence
MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
HG
RHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTG
PEISPNTSGSSPV
IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
FEGANKTSLGTLFVPQRKLEVSTEDVH
Sequence length 867
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
29754146
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37863324
Brain Neoplasms Stimulate 33381564
Breast Neoplasms Associate 31733123, 35279688, 40183319
Calcinosis Cutis Stimulate 27683099
Cap Myopathy Associate 29453410
Carcinogenesis Inhibit 29363506
Carcinogenesis Associate 33499863
Carcinoma Non Small Cell Lung Associate 30832674
Colorectal Neoplasms Associate 30144184
Glioma Associate 33381564