Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79733
Gene name	E2F transcription factor 8
Gene symbol	E2F8
Synonyms (NCBI Gene)	E2F-8
Chromosome	11
Chromosome location	11p15.1
Summary	This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024943	hsa-miR-215-5p	Microarray	19074876
MIRT026752	hsa-miR-192-5p	Microarray	19074876
MIRT031294	hsa-miR-19b-3p	Sequencing	20371350
MIRT038639	hsa-miR-125a-3p	CLASH	23622248
MIRT507476	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT511989	hsa-miR-570-3p	HITS-CLIP	21572407
MIRT507480	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT507478	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT507477	hsa-miR-3924	HITS-CLIP	21572407
MIRT507475	hsa-miR-4528	HITS-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT507480	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT507477	hsa-miR-3924	PAR-CLIP	20371350
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT507475	hsa-miR-4528	PAR-CLIP	20371350
MIRT507474	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT507480	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT507477	hsa-miR-3924	PAR-CLIP	20371350
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT507475	hsa-miR-4528	PAR-CLIP	20371350
MIRT507474	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523948	hsa-miR-300	PAR-CLIP	21572407
MIRT523947	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT523946	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523945	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT511989	hsa-miR-570-3p	PAR-CLIP	21572407
MIRT507480	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523944	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT523943	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT523942	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT523941	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT523940	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT523939	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT523938	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT523937	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT507477	hsa-miR-3924	PAR-CLIP	21572407
MIRT507475	hsa-miR-4528	PAR-CLIP	21572407
MIRT507474	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT031294	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT548507	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT548505	hsa-miR-4475	PAR-CLIP	21572407
MIRT548506	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT548504	hsa-miR-4698	PAR-CLIP	21572407
MIRT548503	hsa-miR-1250-3p	PAR-CLIP	21572407
MIRT548502	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT548501	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT548500	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT548499	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT548498	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT548497	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT548496	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT548495	hsa-miR-1258	PAR-CLIP	21572407
MIRT548494	hsa-miR-6892-5p	PAR-CLIP	21572407
MIRT548493	hsa-miR-4423-3p	PAR-CLIP	21572407
MIRT548492	hsa-miR-6844	PAR-CLIP	21572407
MIRT548491	hsa-miR-548aw	PAR-CLIP	21572407
MIRT548490	hsa-miR-4477b	PAR-CLIP	21572407
MIRT548489	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT548488	hsa-miR-2113	PAR-CLIP	21572407
MIRT031294	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT548507	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT548505	hsa-miR-4475	PAR-CLIP	21572407
MIRT548506	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT548504	hsa-miR-4698	PAR-CLIP	21572407
MIRT548503	hsa-miR-1250-3p	PAR-CLIP	21572407
MIRT548502	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT548501	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT548500	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT548499	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT548498	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT548497	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT548496	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT548495	hsa-miR-1258	PAR-CLIP	21572407
MIRT548494	hsa-miR-6892-5p	PAR-CLIP	21572407
MIRT548493	hsa-miR-4423-3p	PAR-CLIP	21572407
MIRT548492	hsa-miR-6844	PAR-CLIP	21572407
MIRT548491	hsa-miR-548aw	PAR-CLIP	21572407
MIRT548490	hsa-miR-4477b	PAR-CLIP	21572407
MIRT548489	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT548488	hsa-miR-2113	PAR-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT507480	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT507477	hsa-miR-3924	PAR-CLIP	21572407
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT507475	hsa-miR-4528	PAR-CLIP	21572407
MIRT507474	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT523948	hsa-miR-300	PAR-CLIP	23446348
MIRT523947	hsa-miR-381-3p	PAR-CLIP	23446348
MIRT523946	hsa-miR-4666a-3p	PAR-CLIP	23446348
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT523945	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT511989	hsa-miR-570-3p	PAR-CLIP	23446348
MIRT507480	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT523944	hsa-let-7a-3p	PAR-CLIP	23446348
MIRT523943	hsa-let-7b-3p	PAR-CLIP	23446348
MIRT523942	hsa-let-7f-1-3p	PAR-CLIP	23446348
MIRT523941	hsa-miR-98-3p	PAR-CLIP	23446348
MIRT523940	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT523939	hsa-let-7f-2-3p	PAR-CLIP	23446348
MIRT523938	hsa-miR-1185-1-3p	PAR-CLIP	23446348
MIRT523937	hsa-miR-1185-2-3p	PAR-CLIP	23446348
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT507477	hsa-miR-3924	PAR-CLIP	23446348
MIRT507475	hsa-miR-4528	PAR-CLIP	23446348
MIRT507474	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT511989	hsa-miR-570-3p	PAR-CLIP	23446348
MIRT507480	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT507477	hsa-miR-3924	PAR-CLIP	23446348
MIRT507475	hsa-miR-4528	PAR-CLIP	23446348
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT507480	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT507477	hsa-miR-3924	PAR-CLIP	23446348
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT507475	hsa-miR-4528	PAR-CLIP	23446348
MIRT507474	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT548507	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT031294	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT507476	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT507480	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT523945	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT507474	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT507479	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT507476	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT511989	hsa-miR-570-3p	HITS-CLIP	21572407
MIRT507480	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT507478	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT507477	hsa-miR-3924	HITS-CLIP	21572407
MIRT507475	hsa-miR-4528	HITS-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT507480	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT507477	hsa-miR-3924	PAR-CLIP	20371350
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT507475	hsa-miR-4528	PAR-CLIP	20371350
MIRT507474	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT507480	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT507477	hsa-miR-3924	PAR-CLIP	20371350
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT507475	hsa-miR-4528	PAR-CLIP	20371350
MIRT507474	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523948	hsa-miR-300	PAR-CLIP	21572407
MIRT523947	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT523946	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523945	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT511989	hsa-miR-570-3p	PAR-CLIP	21572407
MIRT507480	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523944	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT523943	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT523942	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT523941	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT523940	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT523939	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT523938	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT523937	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT507477	hsa-miR-3924	PAR-CLIP	21572407
MIRT507475	hsa-miR-4528	PAR-CLIP	21572407
MIRT507474	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT031294	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT548507	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT548505	hsa-miR-4475	PAR-CLIP	21572407
MIRT548506	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT548504	hsa-miR-4698	PAR-CLIP	21572407
MIRT548503	hsa-miR-1250-3p	PAR-CLIP	21572407
MIRT548502	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT548501	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT548500	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT548499	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT548498	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT548497	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT548496	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT548495	hsa-miR-1258	PAR-CLIP	21572407
MIRT548494	hsa-miR-6892-5p	PAR-CLIP	21572407
MIRT548493	hsa-miR-4423-3p	PAR-CLIP	21572407
MIRT548492	hsa-miR-6844	PAR-CLIP	21572407
MIRT548491	hsa-miR-548aw	PAR-CLIP	21572407
MIRT548490	hsa-miR-4477b	PAR-CLIP	21572407
MIRT548489	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT548488	hsa-miR-2113	PAR-CLIP	21572407
MIRT031294	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT548507	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT548505	hsa-miR-4475	PAR-CLIP	21572407
MIRT548506	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT548504	hsa-miR-4698	PAR-CLIP	21572407
MIRT548503	hsa-miR-1250-3p	PAR-CLIP	21572407
MIRT548502	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT548501	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT548500	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT548499	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT548498	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT548497	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT548496	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT548495	hsa-miR-1258	PAR-CLIP	21572407
MIRT548494	hsa-miR-6892-5p	PAR-CLIP	21572407
MIRT548493	hsa-miR-4423-3p	PAR-CLIP	21572407
MIRT548492	hsa-miR-6844	PAR-CLIP	21572407
MIRT548491	hsa-miR-548aw	PAR-CLIP	21572407
MIRT548490	hsa-miR-4477b	PAR-CLIP	21572407
MIRT548489	hsa-miR-7856-5p	PAR-CLIP	21572407
MIRT548488	hsa-miR-2113	PAR-CLIP	21572407
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT507480	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT507477	hsa-miR-3924	PAR-CLIP	21572407
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT507475	hsa-miR-4528	PAR-CLIP	21572407
MIRT507474	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT523948	hsa-miR-300	PAR-CLIP	23446348
MIRT523947	hsa-miR-381-3p	PAR-CLIP	23446348
MIRT523946	hsa-miR-4666a-3p	PAR-CLIP	23446348
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT523945	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT511989	hsa-miR-570-3p	PAR-CLIP	23446348
MIRT507480	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT523944	hsa-let-7a-3p	PAR-CLIP	23446348
MIRT523943	hsa-let-7b-3p	PAR-CLIP	23446348
MIRT523942	hsa-let-7f-1-3p	PAR-CLIP	23446348
MIRT523941	hsa-miR-98-3p	PAR-CLIP	23446348
MIRT523940	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT523939	hsa-let-7f-2-3p	PAR-CLIP	23446348
MIRT523938	hsa-miR-1185-1-3p	PAR-CLIP	23446348
MIRT523937	hsa-miR-1185-2-3p	PAR-CLIP	23446348
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT507477	hsa-miR-3924	PAR-CLIP	23446348
MIRT507475	hsa-miR-4528	PAR-CLIP	23446348
MIRT507474	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT511989	hsa-miR-570-3p	PAR-CLIP	23446348
MIRT507480	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT507477	hsa-miR-3924	PAR-CLIP	23446348
MIRT507475	hsa-miR-4528	PAR-CLIP	23446348
MIRT507481	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT507480	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT507479	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT507478	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT507477	hsa-miR-3924	PAR-CLIP	23446348
MIRT507476	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT507475	hsa-miR-4528	PAR-CLIP	23446348
MIRT507474	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT951009	hsa-miR-101	CLIP-seq
MIRT951010	hsa-miR-1185	CLIP-seq
MIRT951011	hsa-miR-1224-5p	CLIP-seq
MIRT951012	hsa-miR-1246	CLIP-seq
MIRT951013	hsa-miR-1290	CLIP-seq
MIRT951014	hsa-miR-144	CLIP-seq
MIRT951015	hsa-miR-19a	CLIP-seq
MIRT951016	hsa-miR-19b	CLIP-seq
MIRT951017	hsa-miR-3167	CLIP-seq
MIRT951018	hsa-miR-3605-5p	CLIP-seq
MIRT951019	hsa-miR-3647-3p	CLIP-seq
MIRT951020	hsa-miR-3679-3p	CLIP-seq
MIRT951021	hsa-miR-3679-5p	CLIP-seq
MIRT951022	hsa-miR-377	CLIP-seq
MIRT951023	hsa-miR-3915	CLIP-seq
MIRT951024	hsa-miR-421	CLIP-seq
MIRT951025	hsa-miR-4310	CLIP-seq
MIRT951026	hsa-miR-4445	CLIP-seq
MIRT951027	hsa-miR-4446-5p	CLIP-seq
MIRT951028	hsa-miR-4670-3p	CLIP-seq
MIRT951029	hsa-miR-4684-3p	CLIP-seq
MIRT951030	hsa-miR-4689	CLIP-seq
MIRT951031	hsa-miR-4699-3p	CLIP-seq
MIRT951032	hsa-miR-499-3p	CLIP-seq
MIRT951033	hsa-miR-499a-3p	CLIP-seq
MIRT951034	hsa-miR-582-5p	CLIP-seq
MIRT951035	hsa-miR-587	CLIP-seq
MIRT951036	hsa-miR-605	CLIP-seq
MIRT951037	hsa-miR-876-5p	CLIP-seq
MIRT951038	hsa-miR-889	CLIP-seq
MIRT951009	hsa-miR-101	CLIP-seq
MIRT951014	hsa-miR-144	CLIP-seq
MIRT1981642	hsa-miR-153	CLIP-seq
MIRT1981643	hsa-miR-374c	CLIP-seq
MIRT1981644	hsa-miR-448	CLIP-seq
MIRT951031	hsa-miR-4699-3p	CLIP-seq
MIRT951034	hsa-miR-582-5p	CLIP-seq
MIRT951036	hsa-miR-605	CLIP-seq
MIRT1981645	hsa-miR-655	CLIP-seq
MIRT1981646	hsa-miR-935	CLIP-seq
MIRT1981642	hsa-miR-153	CLIP-seq
MIRT1981643	hsa-miR-374c	CLIP-seq
MIRT1981644	hsa-miR-448	CLIP-seq
MIRT951034	hsa-miR-582-5p	CLIP-seq
MIRT2216595	hsa-miR-633	CLIP-seq
MIRT1981645	hsa-miR-655	CLIP-seq
MIRT1981646	hsa-miR-935	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	16179649
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	16179649
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IDA	22903062
GO:0001217	Function	DNA-binding transcription repressor activity	IEA
GO:0001217	Function	DNA-binding transcription repressor activity	ISS
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	16179649
GO:0001890	Process	Placenta development	IEA
GO:0001890	Process	Placenta development	ISS
GO:0002040	Process	Sprouting angiogenesis	IEA
GO:0002040	Process	Sprouting angiogenesis	IMP	22903062
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IMP	22903062
GO:0005515	Function	Protein binding	IPI	18202719, 25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0010604	Process	Positive regulation of macromolecule metabolic process	IEA
GO:0032466	Process	Negative regulation of cytokinesis	IEA
GO:0032466	Process	Negative regulation of cytokinesis	ISS
GO:0032877	Process	Positive regulation of DNA endoreduplication	IEA
GO:0032877	Process	Positive regulation of DNA endoreduplication	ISS
GO:0033301	Process	Cell cycle comprising mitosis without cytokinesis	IEA
GO:0033301	Process	Cell cycle comprising mitosis without cytokinesis	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0045935	Process	Positive regulation of nucleobase-containing compound metabolic process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	22903062
GO:0048144	Process	Fibroblast proliferation	IEA
GO:0060707	Process	Trophoblast giant cell differentiation	IEA
GO:0060707	Process	Trophoblast giant cell differentiation	ISS
GO:0060718	Process	Chorionic trophoblast cell differentiation	IEA
GO:0060718	Process	Chorionic trophoblast cell differentiation	ISS
GO:0070365	Process	Hepatocyte differentiation	IEA
GO:0070365	Process	Hepatocyte differentiation	ISS
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
612047	24727	ENSG00000129173

A0AVK6

Protein name

Transcription factor E2F8 (E2F-8)

Protein function

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recogn

PDB

4YO2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02319	E2F_TDP	114 → 182	E2F/DP family winged-helix DNA-binding domain	Domain
PF02319	E2F_TDP	262 → 347	E2F/DP family winged-helix DNA-binding domain	Domain

Sequence

MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
FEGANKTSLGTLFVPQRKLEVSTEDVH

Sequence length

867

Interactions

View interactions

	Reactome
			TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs77599073	RCV005903638
Clear cell carcinoma of kidney	Benign	rs77599073	RCV005903639
Colon adenocarcinoma	Benign	rs77599073	RCV005903635
Hepatocellular carcinoma	Benign	rs77599073	RCV005903636
Malignant tumor of esophagus	Benign	rs77599073	RCV005903637
Thymoma	Benign	rs77599073	RCV005903640
Thyroid cancer, nonmedullary, 1	Benign	rs77599073	RCV005903641

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37863324
Brain Neoplasms	Stimulate	33381564
Breast Neoplasms	Associate	31733123, 35279688, 40183319
Calcinosis Cutis	Stimulate	27683099
Cap Myopathy	Associate	29453410
Carcinogenesis	Inhibit	29363506
Carcinogenesis	Associate	33499863
Carcinoma Non Small Cell Lung	Associate	30832674
Colorectal Neoplasms	Associate	30144184
Glioma	Associate	33381564
Inflammation	Associate	35563134
Lymphatic Metastasis	Associate	37863324
Melanoma	Associate	21569352
Neoplasms	Associate	29363506, 33499863, 35561310, 38149239, 40183319
Neoplasms	Inhibit	31475738
Neoplasms	Stimulate	33381564, 37863324
Ovarian Neoplasms	Associate	37635486
Prostatic Neoplasms	Associate	27683099, 39473405
Prostatic Neoplasms	Stimulate	37888771
Squamous Cell Carcinoma of Head and Neck	Associate	36855110
Stomach Neoplasms	Associate	35421138

E2F8 (E2F transcription factor 8)