Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79723
Gene name Gene Name - the full gene name approved by the HGNC.	SUV39H2 histone lysine methyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SUV39H2
Synonyms (NCBI Gene) Gene synonyms aliases	KMT1B
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p13

Show/Hide all(233)

miRTarBase ID	miRNA	Experiments	Reference
MIRT560846	hsa-miR-6768-3p	PAR-CLIP	20371350
MIRT560845	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT560844	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT560843	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT560842	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT560841	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT560839	hsa-miR-4262	PAR-CLIP	20371350
MIRT560840	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT560838	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT560837	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT560836	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT560846	hsa-miR-6768-3p	PAR-CLIP	20371350
MIRT560845	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT560844	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT560843	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT560842	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT560841	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT560839	hsa-miR-4262	PAR-CLIP	20371350
MIRT560840	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT560838	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT560837	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT560836	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT560846	hsa-miR-6768-3p	PAR-CLIP	20371350
MIRT560845	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT560844	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT560843	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT560842	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT560841	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT560839	hsa-miR-4262	PAR-CLIP	20371350
MIRT560840	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT560838	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT560837	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT560836	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT560846	hsa-miR-6768-3p	PAR-CLIP	20371350
MIRT560845	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT560844	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT560843	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT560842	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT560841	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT560839	hsa-miR-4262	PAR-CLIP	20371350
MIRT560840	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT560838	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT560837	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT560836	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT1404211	hsa-miR-1200	CLIP-seq
MIRT1404212	hsa-miR-3074-3p	CLIP-seq
MIRT1404213	hsa-miR-3074-5p	CLIP-seq
MIRT1404214	hsa-miR-3130-5p	CLIP-seq
MIRT1404215	hsa-miR-3140-5p	CLIP-seq
MIRT1404216	hsa-miR-374a	CLIP-seq
MIRT1404217	hsa-miR-374b	CLIP-seq
MIRT1404218	hsa-miR-4482	CLIP-seq
MIRT1404219	hsa-miR-4712-3p	CLIP-seq
MIRT1404220	hsa-miR-4786-5p	CLIP-seq
MIRT1404221	hsa-miR-548p	CLIP-seq
MIRT1404222	hsa-miR-622	CLIP-seq
MIRT1404223	hsa-miR-656	CLIP-seq
MIRT1404224	hsa-miR-769-5p	CLIP-seq
MIRT1404225	hsa-miR-103b	CLIP-seq
MIRT1404211	hsa-miR-1200	CLIP-seq
MIRT1404226	hsa-miR-1227	CLIP-seq
MIRT1404227	hsa-miR-1254	CLIP-seq
MIRT1404228	hsa-miR-1271	CLIP-seq
MIRT1404229	hsa-miR-1304	CLIP-seq
MIRT1404230	hsa-miR-133a	CLIP-seq
MIRT1404231	hsa-miR-133b	CLIP-seq
MIRT1404232	hsa-miR-144	CLIP-seq
MIRT1404233	hsa-miR-182	CLIP-seq
MIRT1404234	hsa-miR-183	CLIP-seq
MIRT1404235	hsa-miR-200b	CLIP-seq
MIRT1404236	hsa-miR-200c	CLIP-seq
MIRT1404237	hsa-miR-2053	CLIP-seq
MIRT1404238	hsa-miR-24	CLIP-seq
MIRT1404239	hsa-miR-300	CLIP-seq
MIRT1404240	hsa-miR-30a	CLIP-seq
MIRT1404241	hsa-miR-30b	CLIP-seq
MIRT1404242	hsa-miR-30c	CLIP-seq
MIRT1404243	hsa-miR-30d	CLIP-seq
MIRT1404244	hsa-miR-30e	CLIP-seq
MIRT1404245	hsa-miR-31	CLIP-seq
MIRT1404246	hsa-miR-3116	CLIP-seq
MIRT1404247	hsa-miR-3163	CLIP-seq
MIRT1404248	hsa-miR-3187-3p	CLIP-seq
MIRT1404249	hsa-miR-3199	CLIP-seq
MIRT1404250	hsa-miR-323-3p	CLIP-seq
MIRT1404251	hsa-miR-330-3p	CLIP-seq
MIRT1404252	hsa-miR-331-5p	CLIP-seq
MIRT1404253	hsa-miR-361-5p	CLIP-seq
MIRT1404254	hsa-miR-3671	CLIP-seq
MIRT1404255	hsa-miR-371-5p	CLIP-seq
MIRT1404256	hsa-miR-371b-5p	CLIP-seq
MIRT1404257	hsa-miR-374c	CLIP-seq
MIRT1404258	hsa-miR-381	CLIP-seq
MIRT1404259	hsa-miR-382	CLIP-seq
MIRT1404260	hsa-miR-3908	CLIP-seq
MIRT1404261	hsa-miR-3926	CLIP-seq
MIRT1404262	hsa-miR-3942-3p	CLIP-seq
MIRT1404263	hsa-miR-3942-5p	CLIP-seq
MIRT1404264	hsa-miR-4254	CLIP-seq
MIRT1404265	hsa-miR-4257	CLIP-seq
MIRT1404266	hsa-miR-4269	CLIP-seq
MIRT1404267	hsa-miR-4282	CLIP-seq
MIRT1404268	hsa-miR-4284	CLIP-seq
MIRT1404269	hsa-miR-429	CLIP-seq
MIRT1404270	hsa-miR-431	CLIP-seq
MIRT1404271	hsa-miR-4315	CLIP-seq
MIRT1404272	hsa-miR-4324	CLIP-seq
MIRT1404273	hsa-miR-4435	CLIP-seq
MIRT1404274	hsa-miR-4438	CLIP-seq
MIRT1404275	hsa-miR-4470	CLIP-seq
MIRT1404276	hsa-miR-4480	CLIP-seq
MIRT1404277	hsa-miR-4495	CLIP-seq
MIRT1404278	hsa-miR-4514	CLIP-seq
MIRT1404279	hsa-miR-4635	CLIP-seq
MIRT1404280	hsa-miR-4640-3p	CLIP-seq
MIRT1404281	hsa-miR-4670-3p	CLIP-seq
MIRT1404282	hsa-miR-4692	CLIP-seq
MIRT1404283	hsa-miR-4701-5p	CLIP-seq
MIRT1404284	hsa-miR-4703-5p	CLIP-seq
MIRT1404285	hsa-miR-4715-3p	CLIP-seq
MIRT1404286	hsa-miR-4742-5p	CLIP-seq
MIRT1404287	hsa-miR-4760-3p	CLIP-seq
MIRT1404288	hsa-miR-4766-3p	CLIP-seq
MIRT1404289	hsa-miR-4772-3p	CLIP-seq
MIRT1404290	hsa-miR-4804-3p	CLIP-seq
MIRT1404291	hsa-miR-494	CLIP-seq
MIRT1404292	hsa-miR-5095	CLIP-seq
MIRT1404293	hsa-miR-544b	CLIP-seq
MIRT1404294	hsa-miR-548c-3p	CLIP-seq
MIRT1404295	hsa-miR-548s	CLIP-seq
MIRT1404296	hsa-miR-556-5p	CLIP-seq
MIRT1404297	hsa-miR-569	CLIP-seq
MIRT1404298	hsa-miR-570	CLIP-seq
MIRT1404299	hsa-miR-588	CLIP-seq
MIRT1404300	hsa-miR-603	CLIP-seq
MIRT1404301	hsa-miR-607	CLIP-seq
MIRT1404302	hsa-miR-655	CLIP-seq
MIRT1404223	hsa-miR-656	CLIP-seq
MIRT1404303	hsa-miR-96	CLIP-seq
MIRT1404220	hsa-miR-4786-5p	CLIP-seq
MIRT1404224	hsa-miR-769-5p	CLIP-seq
MIRT1404211	hsa-miR-1200	CLIP-seq
MIRT1404272	hsa-miR-4324	CLIP-seq
MIRT1404293	hsa-miR-544b	CLIP-seq
MIRT1404211	hsa-miR-1200	CLIP-seq
MIRT2343182	hsa-miR-1297	CLIP-seq
MIRT2343183	hsa-miR-1976	CLIP-seq
MIRT2343184	hsa-miR-26a	CLIP-seq
MIRT2343185	hsa-miR-26b	CLIP-seq
MIRT1404240	hsa-miR-30a	CLIP-seq
MIRT1404241	hsa-miR-30b	CLIP-seq
MIRT1404242	hsa-miR-30c	CLIP-seq
MIRT1404243	hsa-miR-30d	CLIP-seq
MIRT1404244	hsa-miR-30e	CLIP-seq
MIRT1404249	hsa-miR-3199	CLIP-seq
MIRT2343186	hsa-miR-337-3p	CLIP-seq
MIRT2343187	hsa-miR-3663-5p	CLIP-seq
MIRT2343188	hsa-miR-3934	CLIP-seq
MIRT2343189	hsa-miR-4279	CLIP-seq
MIRT1404272	hsa-miR-4324	CLIP-seq
MIRT1404273	hsa-miR-4435	CLIP-seq
MIRT1404274	hsa-miR-4438	CLIP-seq
MIRT2343190	hsa-miR-4465	CLIP-seq
MIRT1404277	hsa-miR-4495	CLIP-seq
MIRT2343191	hsa-miR-450b-3p	CLIP-seq
MIRT1404279	hsa-miR-4635	CLIP-seq
MIRT2343192	hsa-miR-4650-5p	CLIP-seq
MIRT2343193	hsa-miR-4713-3p	CLIP-seq
MIRT2343194	hsa-miR-4722-3p	CLIP-seq
MIRT2343195	hsa-miR-4735-5p	CLIP-seq
MIRT2343196	hsa-miR-4755-3p	CLIP-seq
MIRT2343197	hsa-miR-4775	CLIP-seq
MIRT1404292	hsa-miR-5095	CLIP-seq
MIRT2343198	hsa-miR-512-3p	CLIP-seq
MIRT2343199	hsa-miR-513a-5p	CLIP-seq
MIRT1404293	hsa-miR-544b	CLIP-seq
MIRT2343200	hsa-miR-552	CLIP-seq
MIRT2343201	hsa-miR-590-3p	CLIP-seq
MIRT2343202	hsa-miR-638	CLIP-seq
MIRT2343203	hsa-miR-769-3p	CLIP-seq
MIRT1404211	hsa-miR-1200	CLIP-seq
MIRT1404226	hsa-miR-1227	CLIP-seq
MIRT2343182	hsa-miR-1297	CLIP-seq
MIRT2343183	hsa-miR-1976	CLIP-seq
MIRT2343184	hsa-miR-26a	CLIP-seq
MIRT2343185	hsa-miR-26b	CLIP-seq
MIRT1404249	hsa-miR-3199	CLIP-seq
MIRT2343189	hsa-miR-4279	CLIP-seq
MIRT1404272	hsa-miR-4324	CLIP-seq
MIRT1404274	hsa-miR-4438	CLIP-seq
MIRT2433745	hsa-miR-4452	CLIP-seq
MIRT2343190	hsa-miR-4465	CLIP-seq
MIRT2433746	hsa-miR-4680-3p	CLIP-seq
MIRT2343194	hsa-miR-4722-3p	CLIP-seq
MIRT1404292	hsa-miR-5095	CLIP-seq
MIRT1404293	hsa-miR-544b	CLIP-seq
MIRT1404285	hsa-miR-4715-3p	CLIP-seq
MIRT2637021	hsa-miR-1183	CLIP-seq
MIRT1404226	hsa-miR-1227	CLIP-seq
MIRT2637022	hsa-miR-1281	CLIP-seq
MIRT2343182	hsa-miR-1297	CLIP-seq
MIRT2637023	hsa-miR-199a-3p	CLIP-seq
MIRT2637024	hsa-miR-199b-3p	CLIP-seq
MIRT2343184	hsa-miR-26a	CLIP-seq
MIRT2343185	hsa-miR-26b	CLIP-seq
MIRT2637025	hsa-miR-3129-5p	CLIP-seq
MIRT1404215	hsa-miR-3140-5p	CLIP-seq
MIRT2637026	hsa-miR-3149	CLIP-seq
MIRT1404249	hsa-miR-3199	CLIP-seq
MIRT2637027	hsa-miR-3935	CLIP-seq
MIRT1404274	hsa-miR-4438	CLIP-seq
MIRT2433745	hsa-miR-4452	CLIP-seq
MIRT2343190	hsa-miR-4465	CLIP-seq
MIRT2433746	hsa-miR-4680-3p	CLIP-seq
MIRT1404285	hsa-miR-4715-3p	CLIP-seq
MIRT2343195	hsa-miR-4735-5p	CLIP-seq
MIRT2343197	hsa-miR-4775	CLIP-seq
MIRT1404292	hsa-miR-5095	CLIP-seq
MIRT1404221	hsa-miR-548p	CLIP-seq
MIRT2343201	hsa-miR-590-3p	CLIP-seq
MIRT2637028	hsa-miR-936	CLIP-seq
MIRT2637021	hsa-miR-1183	CLIP-seq
MIRT1404226	hsa-miR-1227	CLIP-seq
MIRT2637026	hsa-miR-3149	CLIP-seq
MIRT1404249	hsa-miR-3199	CLIP-seq
MIRT2637027	hsa-miR-3935	CLIP-seq
MIRT1404274	hsa-miR-4438	CLIP-seq
MIRT1404285	hsa-miR-4715-3p	CLIP-seq
MIRT2343195	hsa-miR-4735-5p	CLIP-seq
MIRT2343197	hsa-miR-4775	CLIP-seq
MIRT1404292	hsa-miR-5095	CLIP-seq
MIRT1404221	hsa-miR-548p	CLIP-seq
MIRT2343201	hsa-miR-590-3p	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	21402781
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000785	Component	Chromatin	IDA	10949293
GO:0000785	Component	Chromatin	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	ISS
GO:0005515	Function	Protein binding	IPI	17474147, 23455924, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	30111536
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006325	Process	Chromatin organization	IMP	10949293
GO:0006338	Process	Chromatin remodeling	IDA	10949293
GO:0007623	Process	Circadian rhythm	ISS
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008270	Function	Zinc ion binding	IDA	20084102
GO:0008270	Function	Zinc ion binding	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0032259	Process	Methylation	IEA
GO:0042054	Function	Histone methyltransferase activity	IEA
GO:0044725	Process	Epigenetic programming in the zygotic pronuclei	IDA	30111536
GO:0044725	Process	Epigenetic programming in the zygotic pronuclei	IEA
GO:0045814	Process	Negative regulation of gene expression, epigenetic	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0046974	Function	Histone H3K9 methyltransferase activity	IBA
GO:0046974	Function	Histone H3K9 methyltransferase activity	IDA	10949293
GO:0046974	Function	Histone H3K9 methyltransferase activity	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0071456	Process	Cellular response to hypoxia	IDA	21402781
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0140938	Function	Histone H3 methyltransferase activity	TAS
GO:0140949	Function	Histone H3K9 trimethyltransferase activity	IEA
GO:1904047	Function	S-adenosyl-L-methionine binding	IDA	20084102
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	30111536

MIM	HGNC	e!Ensembl
606503	17287	ENSG00000152455

Protein

UniProt ID

Q9H5I1

Protein name

Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)

Protein function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,

PDB

2R3A , 6P0R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00385	Chromo	47 → 96	Chromo (CHRromatin Organisation MOdifier) domain	Domain
PF05033	Pre-SET	145 → 242	Pre-SET motif	Family
PF00856	SET	262 → 373	SET domain	Family

Sequence

MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN

Sequence length

410

Interactions

View interactions

	KEGG		Reactome
	Lysine degradation Metabolic pathways		PKMTs methylate histone lysines

SUV39H2 (SUV39H2 histone lysine methyltransferase)