Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79723
Gene name Gene Name - the full gene name approved by the HGNC.
SUV39H2 histone lysine methyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SUV39H2
Synonyms (NCBI Gene) Gene synonyms aliases
KMT1B
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p13
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT560846 hsa-miR-6768-3p PAR-CLIP 20371350
MIRT560845 hsa-miR-3156-5p PAR-CLIP 20371350
MIRT560844 hsa-miR-181a-5p PAR-CLIP 20371350
MIRT560843 hsa-miR-181b-5p PAR-CLIP 20371350
MIRT560842 hsa-miR-181c-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 21402781
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000785 Component Chromatin IDA 10949293
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding ISS
GO:0005515 Function Protein binding IPI 17474147, 23455924, 25416956, 31515488
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606503 17287 ENSG00000152455
Protein
UniProt ID Q9H5I1
Protein name Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
Protein function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,
PDB 2R3A , 6P0R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00385 Chromo 47 96 Chromo (CHRromatin Organisation MOdifier) domain Domain
PF05033 Pre-SET 145 242 Pre-SET motif Family
PF00856 SET 262 373 SET domain Family
Sequence
Sequence length 410
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Lysine degradation
Metabolic pathways
  PKMTs methylate histone lysines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Migraine Migraine Disorders rs794727411 23793025
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 24966962
Carcinoma Non Small Cell Lung Stimulate 33658396
Hepatitis C Associate 24966962
Intervertebral Disc Degeneration Associate 37605006
Intervertebral disc disease Associate 37605006
Latent Autoimmune Diabetes in Adults Associate 28396876
Neoplasms Associate 16638127, 24966962
Niemann Pick Disease Type C Associate 37605006
Purpura Thrombocytopenic Idiopathic Inhibit 24433164