IPO4 (importin 4)

Gene

• Entrez ID: 79711
• Gene name: Importin 4
• Gene symbol: IPO4
• Synonyms (NCBI Gene): Imp4
• Chromosome: 14
• Chromosome location: 14q12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001620	hsa-let-7b-5p	pSILAC	18668040
MIRT001450	hsa-miR-16-5p	pSILAC	18668040
MIRT001450	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT001620	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT001620	hsa-let-7b-5p	CLASH	23622248
MIRT048945	hsa-miR-92a-3p	CLASH	23622248
MIRT048945	hsa-miR-92a-3p	CLASH	23622248
MIRT041255	hsa-miR-193b-3p	CLASH	23622248
MIRT037189	hsa-miR-877-3p	CLASH	23622248
MIRT036612	hsa-miR-940	CLASH	23622248
MIRT1068739	hsa-miR-498	CLIP-seq
MIRT1068740	hsa-miR-570	CLIP-seq
MIRT2016712	hsa-miR-124	CLIP-seq
MIRT2016713	hsa-miR-1266	CLIP-seq
MIRT2016714	hsa-miR-1285	CLIP-seq
MIRT2016715	hsa-miR-146b-3p	CLIP-seq
MIRT2016716	hsa-miR-149	CLIP-seq
MIRT2016717	hsa-miR-1587	CLIP-seq
MIRT2016718	hsa-miR-3151	CLIP-seq
MIRT2016719	hsa-miR-3155	CLIP-seq
MIRT2016720	hsa-miR-3155b	CLIP-seq
MIRT2016721	hsa-miR-3187-5p	CLIP-seq
MIRT2016722	hsa-miR-323-5p	CLIP-seq
MIRT2016723	hsa-miR-3545-3p	CLIP-seq
MIRT2016724	hsa-miR-3714	CLIP-seq
MIRT2016725	hsa-miR-378g	CLIP-seq
MIRT2016726	hsa-miR-3910	CLIP-seq
MIRT2016727	hsa-miR-4270	CLIP-seq
MIRT2016728	hsa-miR-4283	CLIP-seq
MIRT2016729	hsa-miR-4441	CLIP-seq
MIRT2016730	hsa-miR-4489	CLIP-seq
MIRT2016731	hsa-miR-4492	CLIP-seq
MIRT2016732	hsa-miR-4498	CLIP-seq
MIRT2016733	hsa-miR-4506	CLIP-seq
MIRT2016734	hsa-miR-4518	CLIP-seq
MIRT2016735	hsa-miR-4539	CLIP-seq
MIRT2016736	hsa-miR-4656	CLIP-seq
MIRT2016737	hsa-miR-4675	CLIP-seq
MIRT2016738	hsa-miR-4724-5p	CLIP-seq
MIRT2016739	hsa-miR-4741	CLIP-seq
MIRT2016740	hsa-miR-4753-5p	CLIP-seq
MIRT2016741	hsa-miR-484	CLIP-seq
MIRT2016742	hsa-miR-506	CLIP-seq
MIRT2016743	hsa-miR-612	CLIP-seq
MIRT2016744	hsa-miR-661	CLIP-seq
MIRT2016745	hsa-miR-762	CLIP-seq
MIRT2248805	hsa-miR-101	CLIP-seq
MIRT2248806	hsa-miR-1272	CLIP-seq
MIRT2248807	hsa-miR-1322	CLIP-seq
MIRT2248808	hsa-miR-144	CLIP-seq
MIRT2248809	hsa-miR-194	CLIP-seq
MIRT2248810	hsa-miR-2964a-5p	CLIP-seq
MIRT2016724	hsa-miR-3714	CLIP-seq
MIRT2248811	hsa-miR-579	CLIP-seq
MIRT2248812	hsa-miR-582-5p	CLIP-seq
MIRT2016712	hsa-miR-124	CLIP-seq
MIRT2016724	hsa-miR-3714	CLIP-seq
MIRT2016726	hsa-miR-3910	CLIP-seq
MIRT2016731	hsa-miR-4492	CLIP-seq
MIRT2016732	hsa-miR-4498	CLIP-seq
MIRT2016742	hsa-miR-506	CLIP-seq
MIRT2016745	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	14718166
GO:0005515	Function	Protein binding	IPI	17616579, 20805509, 22022502, 25959826, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006335	Process	DNA replication-dependent nucleosome assembly	IDA	14718166
GO:0006336	Process	DNA replication-independent nucleosome assembly	IDA	14718166
GO:0006606	Process	Protein import into nucleus	IBA	21873635
GO:0006606	Process	Protein import into nucleus	IDA	11823430
GO:0008139	Function	Nuclear localization sequence binding	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0061608	Function	Nuclear import signal receptor activity	IBA	21873635

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TEX9
• Protein name: Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)
• Protein function: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo s
• PDB: 5XAH, 5XBK, 7UNK, 8DYO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03810	IBN_N	24 → 90	Importin-beta N-terminal domain	Family
  PF02985	HEAT	395 → 425	HEAT repeat	Repeat
  PF13513	HEAT_EZ	913 → 968		Repeat

• Sequence:

  MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL
  TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL
  QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS
  LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT
  PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA
  AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA
  LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ
  FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL
  MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV
  QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG
  LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI
  SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA
  LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR
  SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP
  ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL
  LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN
  ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA
  PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL
  S

• Sequence length: 1081

Pathways

KEGG:

Nucleocytoplasmic transport

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772

Associations from Text Mining
Disease Name	Relationship Type	References
Degloving Injuries	Associate	38013320