Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79706
Gene name	PRKR interacting protein 1
Gene symbol	PRKRIP1
Synonyms (NCBI Gene)	C114KRBOX3
Chromosome	7
Chromosome location	7q22.1

106

Show/Hide all (106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT036381	hsa-miR-1229-3p	CLASH	23622248
MIRT720792	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT720791	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT720790	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT720789	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT720788	hsa-miR-520a-5p	HITS-CLIP	19536157
MIRT720787	hsa-miR-525-5p	HITS-CLIP	19536157
MIRT720786	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT720785	hsa-miR-1260a	HITS-CLIP	19536157
MIRT720784	hsa-miR-1260b	HITS-CLIP	19536157
MIRT720783	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT720782	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT720792	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT720791	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT720790	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT720789	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT720788	hsa-miR-520a-5p	HITS-CLIP	19536157
MIRT720787	hsa-miR-525-5p	HITS-CLIP	19536157
MIRT720786	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT720785	hsa-miR-1260a	HITS-CLIP	19536157
MIRT720784	hsa-miR-1260b	HITS-CLIP	19536157
MIRT720783	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT720782	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT1263684	hsa-miR-1182	CLIP-seq
MIRT1263685	hsa-miR-1296	CLIP-seq
MIRT1263686	hsa-miR-204	CLIP-seq
MIRT1263687	hsa-miR-211	CLIP-seq
MIRT1263688	hsa-miR-221	CLIP-seq
MIRT1263689	hsa-miR-222	CLIP-seq
MIRT1263690	hsa-miR-24	CLIP-seq
MIRT1263691	hsa-miR-2909	CLIP-seq
MIRT1263692	hsa-miR-296-5p	CLIP-seq
MIRT1263693	hsa-miR-3158-3p	CLIP-seq
MIRT1263694	hsa-miR-3179	CLIP-seq
MIRT1263695	hsa-miR-3184	CLIP-seq
MIRT1263696	hsa-miR-3649	CLIP-seq
MIRT1263697	hsa-miR-3662	CLIP-seq
MIRT1263698	hsa-miR-3665	CLIP-seq
MIRT1263699	hsa-miR-3919	CLIP-seq
MIRT1263700	hsa-miR-423-5p	CLIP-seq
MIRT1263701	hsa-miR-4253	CLIP-seq
MIRT1263702	hsa-miR-4297	CLIP-seq
MIRT1263703	hsa-miR-4314	CLIP-seq
MIRT1263704	hsa-miR-4437	CLIP-seq
MIRT1263705	hsa-miR-4446-3p	CLIP-seq
MIRT1263706	hsa-miR-4446-5p	CLIP-seq
MIRT1263707	hsa-miR-4475	CLIP-seq
MIRT1263708	hsa-miR-4704-5p	CLIP-seq
MIRT1263709	hsa-miR-4726-3p	CLIP-seq
MIRT1263710	hsa-miR-4729	CLIP-seq
MIRT1263711	hsa-miR-4755-5p	CLIP-seq
MIRT1263712	hsa-miR-4756-3p	CLIP-seq
MIRT1263713	hsa-miR-4761-3p	CLIP-seq
MIRT1263714	hsa-miR-548v	CLIP-seq
MIRT1263715	hsa-miR-623	CLIP-seq
MIRT1263716	hsa-miR-629	CLIP-seq
MIRT1263717	hsa-miR-657	CLIP-seq
MIRT1263718	hsa-miR-661	CLIP-seq
MIRT1263719	hsa-miR-720	CLIP-seq
MIRT1263720	hsa-miR-764	CLIP-seq
MIRT1263721	hsa-miR-942	CLIP-seq
MIRT2077604	hsa-miR-122	CLIP-seq
MIRT2077605	hsa-miR-1260	CLIP-seq
MIRT2077606	hsa-miR-1307	CLIP-seq
MIRT2077607	hsa-miR-149	CLIP-seq
MIRT2077608	hsa-miR-1915	CLIP-seq
MIRT2077609	hsa-miR-1976	CLIP-seq
MIRT2077610	hsa-miR-3174	CLIP-seq
MIRT2077611	hsa-miR-339-5p	CLIP-seq
MIRT2077612	hsa-miR-4268	CLIP-seq
MIRT2077613	hsa-miR-4301	CLIP-seq
MIRT2077614	hsa-miR-4481	CLIP-seq
MIRT2077615	hsa-miR-4638-5p	CLIP-seq
MIRT2077616	hsa-miR-4668-3p	CLIP-seq
MIRT1263709	hsa-miR-4726-3p	CLIP-seq
MIRT2077617	hsa-miR-4745-5p	CLIP-seq
MIRT2077618	hsa-miR-4757-5p	CLIP-seq
MIRT2077619	hsa-miR-4758-5p	CLIP-seq
MIRT2077620	hsa-miR-593	CLIP-seq
MIRT2077621	hsa-miR-605	CLIP-seq
MIRT1263688	hsa-miR-221	CLIP-seq
MIRT1263689	hsa-miR-222	CLIP-seq
MIRT1263690	hsa-miR-24	CLIP-seq
MIRT1263699	hsa-miR-3919	CLIP-seq
MIRT1263704	hsa-miR-4437	CLIP-seq
MIRT2304151	hsa-miR-4649-3p	CLIP-seq
MIRT1263712	hsa-miR-4756-3p	CLIP-seq
MIRT1263714	hsa-miR-548v	CLIP-seq
MIRT1263709	hsa-miR-4726-3p	CLIP-seq
MIRT1263684	hsa-miR-1182	CLIP-seq
MIRT2457187	hsa-miR-1323	CLIP-seq
MIRT1263686	hsa-miR-204	CLIP-seq
MIRT1263687	hsa-miR-211	CLIP-seq
MIRT2457188	hsa-miR-371b-5p	CLIP-seq
MIRT2457189	hsa-miR-4323	CLIP-seq
MIRT1263706	hsa-miR-4446-5p	CLIP-seq
MIRT2457190	hsa-miR-4529-5p	CLIP-seq
MIRT2304151	hsa-miR-4649-3p	CLIP-seq
MIRT1263709	hsa-miR-4726-3p	CLIP-seq
MIRT1263711	hsa-miR-4755-5p	CLIP-seq
MIRT2457191	hsa-miR-4758-3p	CLIP-seq
MIRT2457192	hsa-miR-548aa	CLIP-seq
MIRT2457193	hsa-miR-548o	CLIP-seq
MIRT1263715	hsa-miR-623	CLIP-seq
MIRT1263719	hsa-miR-720	CLIP-seq
MIRT2457194	hsa-miR-888	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003014	Process	Renal system process	IDA	21183621
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	ISS
GO:0004860	Function	Protein kinase inhibitor activity	IBA
GO:0004860	Function	Protein kinase inhibitor activity	IEA
GO:0004860	Function	Protein kinase inhibitor activity	ISS
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	ISS
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
617458	21894	ENSG00000128563

Q9H875

Protein name

PRKR-interacting protein 1

Protein function

Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:30705154). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000269|PubMed:28502770, ECO:00002

PDB

5XJC , 6ICZ , 6QDV , 7W5A , 7W5B , 8C6J , 9FMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06658	DUF1168	42 → 178	Protein of unknown function (DUF1168)	Family

Sequence

MASPAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPP
PEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAA
EEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPSF
TMGR

Sequence length

184

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PRKRIP1 (PRKR interacting protein 1)