CALCB (calcitonin related polypeptide beta)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
797
Gene name Gene Name - the full gene name approved by the HGNC.
Calcitonin related polypeptide beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CALCB
Synonyms (NCBI Gene) Gene synonyms aliases
CALC2, CGRP-II, CGRP2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.2
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
miRTarBase ID miRNA Experiments Reference
MIRT027442 hsa-miR-98-5p Microarray 19088304
MIRT1954971 hsa-miR-183 CLIP-seq
MIRT1954972 hsa-miR-338-5p CLIP-seq
MIRT2192585 hsa-miR-4528 CLIP-seq
MIRT2192586 hsa-miR-4795-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IDA 1318039
GO:0005179 Function Hormone activity IEA
GO:0005184 Function Neuropeptide hormone activity TAS 2985435
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
114160 1438 ENSG00000175868
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P10092
Protein name Calcitonin gene-related peptide 2 (CGRP2) (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
Protein function CALCB/CGRP2 is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in t
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP 1 → 123 Calcitonin / CGRP / IAPP family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in spinal cord, pituitary and thalamus. {ECO:0000269|PubMed:3492492}.
Sequence
Sequence length 127
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling
Vascular smooth muscle contraction 		  G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diverticulitis Diverticulitis N/A N/A GWAS
Show/Hide Text Mining Associations (11)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Allanson Pantzar McLeod syndrome Associate 24240197
Autoimmune Pancreatitis Associate 28151472
Carcinoma Adenoid Cystic Associate 34234876
Compartment Syndromes Associate 24240197
Diabetes Mellitus Type 2 Associate 36368953
Heart Failure Associate 2346957
Migraine Disorders Associate 33155547
Neoplasms Associate 2269360
Paralyses Familial Periodic Associate 24240197
Raynaud Disease Associate 29698501