MANEA (mannosidase endo-alpha)

Gene

• Entrez ID: 79694
• Gene name: Mannosidase endo-alpha
• Gene symbol: MANEA
• Synonyms (NCBI Gene): ENDO, hEndo
• Chromosome: 6
• Chromosome location: 6q16.1
• Summary: N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosacchar

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT1127486	hsa-miR-143	CLIP-seq
MIRT1127487	hsa-miR-186	CLIP-seq
MIRT1127488	hsa-miR-27a	CLIP-seq
MIRT1127489	hsa-miR-27b	CLIP-seq
MIRT1127490	hsa-miR-3133	CLIP-seq
MIRT1127491	hsa-miR-3145-3p	CLIP-seq
MIRT1127492	hsa-miR-323-3p	CLIP-seq
MIRT1127493	hsa-miR-3674	CLIP-seq
MIRT1127494	hsa-miR-369-5p	CLIP-seq
MIRT1127495	hsa-miR-3936	CLIP-seq
MIRT1127496	hsa-miR-4330	CLIP-seq
MIRT1127497	hsa-miR-4477b	CLIP-seq
MIRT1127498	hsa-miR-4716-5p	CLIP-seq
MIRT1127499	hsa-miR-4732-5p	CLIP-seq
MIRT1127500	hsa-miR-4770	CLIP-seq
MIRT1127501	hsa-miR-4775	CLIP-seq
MIRT1127502	hsa-miR-4799-5p	CLIP-seq
MIRT1127503	hsa-miR-518d-5p	CLIP-seq
MIRT1127504	hsa-miR-519b-5p	CLIP-seq
MIRT1127505	hsa-miR-519c-5p	CLIP-seq
MIRT1127506	hsa-miR-520a-5p	CLIP-seq
MIRT1127507	hsa-miR-520c-5p	CLIP-seq
MIRT1127508	hsa-miR-525-5p	CLIP-seq
MIRT1127509	hsa-miR-526a	CLIP-seq
MIRT1127510	hsa-miR-545	CLIP-seq
MIRT1127511	hsa-miR-579	CLIP-seq
MIRT1127512	hsa-miR-587	CLIP-seq
MIRT1127513	hsa-miR-590-3p	CLIP-seq
MIRT1127514	hsa-miR-593	CLIP-seq
MIRT1127515	hsa-miR-802	CLIP-seq
MIRT2036081	hsa-miR-1323	CLIP-seq
MIRT2036082	hsa-miR-3124-3p	CLIP-seq
MIRT1127491	hsa-miR-3145-3p	CLIP-seq
MIRT2036083	hsa-miR-3180-5p	CLIP-seq
MIRT2036084	hsa-miR-371b-5p	CLIP-seq
MIRT2036085	hsa-miR-4328	CLIP-seq
MIRT2036086	hsa-miR-4719	CLIP-seq
MIRT2036087	hsa-miR-4762-5p	CLIP-seq
MIRT1127506	hsa-miR-520a-5p	CLIP-seq
MIRT1127508	hsa-miR-525-5p	CLIP-seq
MIRT2036088	hsa-miR-548ad	CLIP-seq
MIRT2036089	hsa-miR-548o	CLIP-seq
MIRT2036090	hsa-miR-888	CLIP-seq
MIRT2266409	hsa-miR-1179	CLIP-seq
MIRT2266410	hsa-miR-1184	CLIP-seq
MIRT2266411	hsa-miR-1205	CLIP-seq
MIRT2266412	hsa-miR-1252	CLIP-seq
MIRT2266413	hsa-miR-133a	CLIP-seq
MIRT2266414	hsa-miR-133b	CLIP-seq
MIRT1127488	hsa-miR-27a	CLIP-seq
MIRT1127489	hsa-miR-27b	CLIP-seq
MIRT2266415	hsa-miR-302a	CLIP-seq
MIRT2266416	hsa-miR-302b	CLIP-seq
MIRT2266417	hsa-miR-302c	CLIP-seq
MIRT2266418	hsa-miR-302d	CLIP-seq
MIRT2266419	hsa-miR-302e	CLIP-seq
MIRT2266420	hsa-miR-3074-3p	CLIP-seq
MIRT2266421	hsa-miR-3158-5p	CLIP-seq
MIRT2266422	hsa-miR-338-5p	CLIP-seq
MIRT2266423	hsa-miR-3607-3p	CLIP-seq
MIRT2266424	hsa-miR-372	CLIP-seq
MIRT2266425	hsa-miR-373	CLIP-seq
MIRT2266426	hsa-miR-3935	CLIP-seq
MIRT2266427	hsa-miR-4270	CLIP-seq
MIRT2036085	hsa-miR-4328	CLIP-seq
MIRT2266428	hsa-miR-4422	CLIP-seq
MIRT2266429	hsa-miR-4441	CLIP-seq
MIRT2266430	hsa-miR-4495	CLIP-seq
MIRT2266431	hsa-miR-4528	CLIP-seq
MIRT2266432	hsa-miR-4670-3p	CLIP-seq
MIRT2266433	hsa-miR-4690-5p	CLIP-seq
MIRT2266434	hsa-miR-514	CLIP-seq
MIRT2266435	hsa-miR-514b-3p	CLIP-seq
MIRT2266436	hsa-miR-519a	CLIP-seq
MIRT2266437	hsa-miR-519b-3p	CLIP-seq
MIRT2266438	hsa-miR-519c-3p	CLIP-seq
MIRT2266439	hsa-miR-520a-3p	CLIP-seq
MIRT2266440	hsa-miR-520b	CLIP-seq
MIRT2266441	hsa-miR-520c-3p	CLIP-seq
MIRT2266442	hsa-miR-520d-3p	CLIP-seq
MIRT2266443	hsa-miR-520e	CLIP-seq
MIRT2266444	hsa-miR-520f	CLIP-seq
MIRT1127510	hsa-miR-545	CLIP-seq
MIRT2266445	hsa-miR-944	CLIP-seq
MIRT2266412	hsa-miR-1252	CLIP-seq
MIRT1127486	hsa-miR-143	CLIP-seq
MIRT2390492	hsa-miR-3065-5p	CLIP-seq
MIRT2390493	hsa-miR-3919	CLIP-seq
MIRT2266432	hsa-miR-4670-3p	CLIP-seq
MIRT2390494	hsa-miR-4756-3p	CLIP-seq
MIRT1127500	hsa-miR-4770	CLIP-seq
MIRT2438469	hsa-miR-129-5p	CLIP-seq
MIRT2438470	hsa-miR-450b-5p	CLIP-seq
MIRT2438471	hsa-miR-507	CLIP-seq
MIRT2438472	hsa-miR-557	CLIP-seq
MIRT2438473	hsa-miR-580	CLIP-seq
MIRT2266413	hsa-miR-133a	CLIP-seq
MIRT2266414	hsa-miR-133b	CLIP-seq
MIRT2565839	hsa-miR-3163	CLIP-seq
MIRT2565840	hsa-miR-3662	CLIP-seq
MIRT1127494	hsa-miR-369-5p	CLIP-seq
MIRT2565841	hsa-miR-380	CLIP-seq
MIRT2565842	hsa-miR-3924	CLIP-seq
MIRT2266426	hsa-miR-3935	CLIP-seq
MIRT2565843	hsa-miR-4305	CLIP-seq
MIRT2565844	hsa-miR-4436a	CLIP-seq
MIRT2266430	hsa-miR-4495	CLIP-seq
MIRT2266433	hsa-miR-4690-5p	CLIP-seq
MIRT2565845	hsa-miR-4699-5p	CLIP-seq
MIRT2565846	hsa-miR-4714-5p	CLIP-seq
MIRT2565847	hsa-miR-4718	CLIP-seq
MIRT2565848	hsa-miR-4738-3p	CLIP-seq
MIRT1127501	hsa-miR-4775	CLIP-seq
MIRT2565849	hsa-miR-548c-3p	CLIP-seq
MIRT2565850	hsa-miR-603	CLIP-seq
MIRT2565851	hsa-miR-642b	CLIP-seq
MIRT1127515	hsa-miR-802	CLIP-seq
MIRT2266445	hsa-miR-944	CLIP-seq
MIRT2266413	hsa-miR-133a	CLIP-seq
MIRT2266414	hsa-miR-133b	CLIP-seq
MIRT2266426	hsa-miR-3935	CLIP-seq
MIRT2266433	hsa-miR-4690-5p	CLIP-seq
MIRT2565847	hsa-miR-4718	CLIP-seq
MIRT2565850	hsa-miR-603	CLIP-seq
MIRT2565851	hsa-miR-642b	CLIP-seq
MIRT2266445	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IDA	15760709
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0004559	Function	Alpha-mannosidase activity	IBA
GO:0004559	Function	Alpha-mannosidase activity	IEA
GO:0004569	Function	Glycoprotein endo-alpha-1,2-mannosidase activity	IDA	15760709
GO:0004569	Function	Glycoprotein endo-alpha-1,2-mannosidase activity	IEA
GO:0004569	Function	Glycoprotein endo-alpha-1,2-mannosidase activity	TAS
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA

Other IDs

• MIM: 612327
• HGNC: 21072
• e!Ensembl: ENSG00000172469

Protein

• UniProt ID: Q5SRI9
• Protein name: Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin)
• PDB: 6ZDC, 6ZDF, 6ZDK, 6ZDL, 6ZFA, 6ZFN, 6ZFQ, 6ZJ1, 6ZJ5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16317	Glyco_hydro_99	98 → 448	Glycosyl hydrolase family 99	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain. {ECO:0000269|PubMed:15677381}.
• Sequence:

  MAKFRRRTCIILALFILFIFSLMMGLKMLRPNTATFGAPFGLDLLPELHQRTIHLGKNFD
  FQKSDRINSETNTKNLKSVEITMKPSKASELNLDELPPLNNYLHVFYYSWYGNPQFDGKY
  IHWNHPVLEHWDPRIAKNYPQGRHNPPDDIGSSFYPELGSYSSRDPSVIETHMRQMRSAS
  IGVLALSWYPPDVNDENGEPTDNLVPTILDKAHKYNLKVTFHIEPYSNRDDQNMYKNVKY
  IIDKYGNHPAFYRYKTKTGNALPMFYVYDSYITKPEKWANLLTTSGSRSIRNSPYDGLFI
  ALLVEEKHKYDILQSGFDGIYTYFATNGFTYGSSHQNWASLKLFCDKYNLIFIPSVGPGY
  IDTSIRPWNTQNTRNRINGKYYEIGLSAALQTRPSLISITSFNEWHEGTQIEKAVPKRTS
  NTVYLDYRPHKPGLYLELTRKWSEKYSKERATYALDRQLPVS

• Sequence length: 462

Pathways

Reactome:

N-glycan trimming and elongation in the cis-Golgi