MANEA (mannosidase endo-alpha)

Gene

• Entrez ID: 79694
• Gene name: Mannosidase endo-alpha
• Gene symbol: MANEA
• Synonyms (NCBI Gene): ENDO, hEndo
• Chromosome: 6
• Chromosome location: 6q16.1
• Summary: N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosacchar

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT456988	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT456986	hsa-miR-3125	PAR-CLIP	23592263
MIRT456987	hsa-miR-3916	PAR-CLIP	23592263
MIRT456985	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT456984	hsa-miR-548p	PAR-CLIP	23592263
MIRT456983	hsa-miR-4476	PAR-CLIP	23592263
MIRT456982	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT456981	hsa-miR-4461	PAR-CLIP	23592263
MIRT456980	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT456979	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT456978	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT456977	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT456976	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT456975	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT1127486	hsa-miR-143	CLIP-seq
MIRT1127487	hsa-miR-186	CLIP-seq
MIRT1127488	hsa-miR-27a	CLIP-seq
MIRT1127489	hsa-miR-27b	CLIP-seq
MIRT1127490	hsa-miR-3133	CLIP-seq
MIRT1127491	hsa-miR-3145-3p	CLIP-seq
MIRT1127492	hsa-miR-323-3p	CLIP-seq
MIRT1127493	hsa-miR-3674	CLIP-seq
MIRT1127494	hsa-miR-369-5p	CLIP-seq
MIRT1127495	hsa-miR-3936	CLIP-seq
MIRT1127496	hsa-miR-4330	CLIP-seq
MIRT1127497	hsa-miR-4477b	CLIP-seq
MIRT1127498	hsa-miR-4716-5p	CLIP-seq
MIRT1127499	hsa-miR-4732-5p	CLIP-seq
MIRT1127500	hsa-miR-4770	CLIP-seq
MIRT1127501	hsa-miR-4775	CLIP-seq
MIRT1127502	hsa-miR-4799-5p	CLIP-seq
MIRT1127503	hsa-miR-518d-5p	CLIP-seq
MIRT1127504	hsa-miR-519b-5p	CLIP-seq
MIRT1127505	hsa-miR-519c-5p	CLIP-seq
MIRT1127506	hsa-miR-520a-5p	CLIP-seq
MIRT1127507	hsa-miR-520c-5p	CLIP-seq
MIRT1127508	hsa-miR-525-5p	CLIP-seq
MIRT1127509	hsa-miR-526a	CLIP-seq
MIRT1127510	hsa-miR-545	CLIP-seq
MIRT1127511	hsa-miR-579	CLIP-seq
MIRT1127512	hsa-miR-587	CLIP-seq
MIRT1127513	hsa-miR-590-3p	CLIP-seq
MIRT1127514	hsa-miR-593	CLIP-seq
MIRT1127515	hsa-miR-802	CLIP-seq
MIRT2036081	hsa-miR-1323	CLIP-seq
MIRT2036082	hsa-miR-3124-3p	CLIP-seq
MIRT1127491	hsa-miR-3145-3p	CLIP-seq
MIRT2036083	hsa-miR-3180-5p	CLIP-seq
MIRT2036084	hsa-miR-371b-5p	CLIP-seq
MIRT2036085	hsa-miR-4328	CLIP-seq
MIRT2036086	hsa-miR-4719	CLIP-seq
MIRT2036087	hsa-miR-4762-5p	CLIP-seq
MIRT1127506	hsa-miR-520a-5p	CLIP-seq
MIRT1127508	hsa-miR-525-5p	CLIP-seq
MIRT2036088	hsa-miR-548ad	CLIP-seq
MIRT2036089	hsa-miR-548o	CLIP-seq
MIRT2036090	hsa-miR-888	CLIP-seq
MIRT2266409	hsa-miR-1179	CLIP-seq
MIRT2266410	hsa-miR-1184	CLIP-seq
MIRT2266411	hsa-miR-1205	CLIP-seq
MIRT2266412	hsa-miR-1252	CLIP-seq
MIRT2266413	hsa-miR-133a	CLIP-seq
MIRT2266414	hsa-miR-133b	CLIP-seq
MIRT1127488	hsa-miR-27a	CLIP-seq
MIRT1127489	hsa-miR-27b	CLIP-seq
MIRT2266415	hsa-miR-302a	CLIP-seq
MIRT2266416	hsa-miR-302b	CLIP-seq
MIRT2266417	hsa-miR-302c	CLIP-seq
MIRT2266418	hsa-miR-302d	CLIP-seq
MIRT2266419	hsa-miR-302e	CLIP-seq
MIRT2266420	hsa-miR-3074-3p	CLIP-seq
MIRT2266421	hsa-miR-3158-5p	CLIP-seq
MIRT2266422	hsa-miR-338-5p	CLIP-seq
MIRT2266423	hsa-miR-3607-3p	CLIP-seq
MIRT2266424	hsa-miR-372	CLIP-seq
MIRT2266425	hsa-miR-373	CLIP-seq
MIRT2266426	hsa-miR-3935	CLIP-seq
MIRT2266427	hsa-miR-4270	CLIP-seq
MIRT2036085	hsa-miR-4328	CLIP-seq
MIRT2266428	hsa-miR-4422	CLIP-seq
MIRT2266429	hsa-miR-4441	CLIP-seq
MIRT2266430	hsa-miR-4495	CLIP-seq
MIRT2266431	hsa-miR-4528	CLIP-seq
MIRT2266432	hsa-miR-4670-3p	CLIP-seq
MIRT2266433	hsa-miR-4690-5p	CLIP-seq
MIRT2266434	hsa-miR-514	CLIP-seq
MIRT2266435	hsa-miR-514b-3p	CLIP-seq
MIRT2266436	hsa-miR-519a	CLIP-seq
MIRT2266437	hsa-miR-519b-3p	CLIP-seq
MIRT2266438	hsa-miR-519c-3p	CLIP-seq
MIRT2266439	hsa-miR-520a-3p	CLIP-seq
MIRT2266440	hsa-miR-520b	CLIP-seq
MIRT2266441	hsa-miR-520c-3p	CLIP-seq
MIRT2266442	hsa-miR-520d-3p	CLIP-seq
MIRT2266443	hsa-miR-520e	CLIP-seq
MIRT2266444	hsa-miR-520f	CLIP-seq
MIRT1127510	hsa-miR-545	CLIP-seq
MIRT2266445	hsa-miR-944	CLIP-seq
MIRT2266412	hsa-miR-1252	CLIP-seq
MIRT1127486	hsa-miR-143	CLIP-seq
MIRT2390492	hsa-miR-3065-5p	CLIP-seq
MIRT2390493	hsa-miR-3919	CLIP-seq
MIRT2266432	hsa-miR-4670-3p	CLIP-seq
MIRT2390494	hsa-miR-4756-3p	CLIP-seq
MIRT1127500	hsa-miR-4770	CLIP-seq
MIRT2438469	hsa-miR-129-5p	CLIP-seq
MIRT2438470	hsa-miR-450b-5p	CLIP-seq
MIRT2438471	hsa-miR-507	CLIP-seq
MIRT2438472	hsa-miR-557	CLIP-seq
MIRT2438473	hsa-miR-580	CLIP-seq
MIRT2266413	hsa-miR-133a	CLIP-seq
MIRT2266414	hsa-miR-133b	CLIP-seq
MIRT2565839	hsa-miR-3163	CLIP-seq
MIRT2565840	hsa-miR-3662	CLIP-seq
MIRT1127494	hsa-miR-369-5p	CLIP-seq
MIRT2565841	hsa-miR-380	CLIP-seq
MIRT2565842	hsa-miR-3924	CLIP-seq
MIRT2266426	hsa-miR-3935	CLIP-seq
MIRT2565843	hsa-miR-4305	CLIP-seq
MIRT2565844	hsa-miR-4436a	CLIP-seq
MIRT2266430	hsa-miR-4495	CLIP-seq
MIRT2266433	hsa-miR-4690-5p	CLIP-seq
MIRT2565845	hsa-miR-4699-5p	CLIP-seq
MIRT2565846	hsa-miR-4714-5p	CLIP-seq
MIRT2565847	hsa-miR-4718	CLIP-seq
MIRT2565848	hsa-miR-4738-3p	CLIP-seq
MIRT1127501	hsa-miR-4775	CLIP-seq
MIRT2565849	hsa-miR-548c-3p	CLIP-seq
MIRT2565850	hsa-miR-603	CLIP-seq
MIRT2565851	hsa-miR-642b	CLIP-seq
MIRT1127515	hsa-miR-802	CLIP-seq
MIRT2266445	hsa-miR-944	CLIP-seq
MIRT2266413	hsa-miR-133a	CLIP-seq
MIRT2266414	hsa-miR-133b	CLIP-seq
MIRT2266426	hsa-miR-3935	CLIP-seq
MIRT2266433	hsa-miR-4690-5p	CLIP-seq
MIRT2565847	hsa-miR-4718	CLIP-seq
MIRT2565850	hsa-miR-603	CLIP-seq
MIRT2565851	hsa-miR-642b	CLIP-seq
MIRT2266445	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0004559	Function	Alpha-mannosidase activity	IBA	21873635
GO:0004569	Function	Glycoprotein endo-alpha-1,2-mannosidase activity	TAS
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 612327
• HGNC: 21072
• e!Ensembl: ENSG00000172469

Protein

• UniProt ID: Q5SRI9
• Protein name: Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin)
• PDB: 6ZDC, 6ZDF, 6ZDK, 6ZDL, 6ZFA, 6ZFN, 6ZFQ, 6ZJ1, 6ZJ5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16317	Glyco_hydro_99	98 → 448	Glycosyl hydrolase family 99	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain. {ECO:0000269|PubMed:15677381}.
• Sequence:

  MAKFRRRTCIILALFILFIFSLMMGLKMLRPNTATFGAPFGLDLLPELHQRTIHLGKNFD
  FQKSDRINSETNTKNLKSVEITMKPSKASELNLDELPPLNNYLHVFYYSWYGNPQFDGKY
  IHWNHPVLEHWDPRIAKNYPQGRHNPPDDIGSSFYPELGSYSSRDPSVIETHMRQMRSAS
  IGVLALSWYPPDVNDENGEPTDNLVPTILDKAHKYNLKVTFHIEPYSNRDDQNMYKNVKY
  IIDKYGNHPAFYRYKTKTGNALPMFYVYDSYITKPEKWANLLTTSGSRSIRNSPYDGLFI
  ALLVEEKHKYDILQSGFDGIYTYFATNGFTYGSSHQNWASLKLFCDKYNLIFIPSVGPGY
  IDTSIRPWNTQNTRNRINGKYYEIGLSAALQTRPSLISITSFNEWHEGTQIEKAVPKRTS
  NTVYLDYRPHKPGLYLELTRKWSEKYSKERATYALDRQLPVS

• Sequence length: 462

Pathways

Reactome:

N-glycan trimming and elongation in the cis-Golgi

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease term	Disease name	Evidence	References	Source
Schizophrenia	Schizophrenia			GWAS
Mental Depression	Mental Depression			GWAS
Astrocytoma	Astrocytoma			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Anxiety Disorders	Associate	24473444
Asthma	Associate	25997986
Cocaine Related Disorders	Associate	19255376
Mental Disorders	Associate	24473444
Panic Disorder	Associate	24473444
Paranoid Disorders	Associate	18438686, 19255376, 24473444
Phobia Social	Associate	24473444
Prostatic Neoplasms	Associate	37008945