Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79664
Gene name Gene Name - the full gene name approved by the HGNC.	Interactor of little elongation complex ELL subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ICE2
Synonyms (NCBI Gene) Gene synonyms aliases	BRCC1, NARG2
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation

Show/Hide all(107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741741	hsa-miR-8055	HITS-CLIP	23824327
MIRT741742	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT741743	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT741744	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT741745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT741746	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT741747	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT741748	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT741749	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT741750	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT741751	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT741752	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT741753	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT741754	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT741755	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741741	hsa-miR-8055	HITS-CLIP	23824327
MIRT741742	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT741746	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741741	hsa-miR-8055	HITS-CLIP	23824327
MIRT741742	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT741743	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT741744	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT741745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT741746	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT741747	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT742505	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT741748	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT741749	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT741750	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT741751	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT741752	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT741753	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT741754	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT741755	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT754470	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT754471	hsa-miR-3133	PAR-CLIP	22012620
MIRT754472	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT754473	hsa-miR-4803	PAR-CLIP	22012620
MIRT754474	hsa-miR-4797-3p	PAR-CLIP	22012620
MIRT754475	hsa-miR-4264	PAR-CLIP	22012620
MIRT755139	hsa-miR-1224-3p	PAR-CLIP	23592263
MIRT755140	hsa-miR-6787-3p	PAR-CLIP	23592263
MIRT755141	hsa-miR-532-3p	PAR-CLIP	23592263
MIRT755142	hsa-miR-1260a	PAR-CLIP	23592263
MIRT755143	hsa-miR-1260b	PAR-CLIP	23592263
MIRT755144	hsa-miR-6749-3p	PAR-CLIP	23592263

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22195968, 23932780
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0008023	Component	Transcription elongation factor complex	IDA	23932780
GO:0008023	Component	Transcription elongation factor complex	IMP	22195968
GO:0015030	Component	Cajal body	IDA	23932780
GO:0016604	Component	Nuclear body	IDA
GO:0035327	Component	Transcriptionally active chromatin	IDA	22195968, 23932780
GO:0035363	Component	Histone locus body	IDA	23932780
GO:0042795	Process	SnRNA transcription by RNA polymerase II	IBA	21873635
GO:0042795	Process	SnRNA transcription by RNA polymerase II	IMP	23932780
GO:0042795	Process	SnRNA transcription by RNA polymerase II	TAS
GO:0042796	Process	SnRNA transcription by RNA polymerase III	IBA	21873635
GO:0042796	Process	SnRNA transcription by RNA polymerase III	IMP	23932780
GO:0045945	Process	Positive regulation of transcription by RNA polymerase III	IBA	21873635
GO:0045945	Process	Positive regulation of transcription by RNA polymerase III	IMP	23932780

MIM	HGNC	e!Ensembl
610835	29885	ENSG00000128915

Protein

UniProt ID

Q659A1

Protein name

Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2)

Protein function

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10505	NARG2_C	720 → 930	NMDA receptor-regulated gene protein 2 C-terminus	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at low levels in lung and testis. {ECO:0000269|PubMed:15606750}.

Sequence

MSSKMVISEPGLNWDISPKNGLKTFFSRENYKDHSMAPSLKELRVLSNRRIGENLNASAS
SVENEPAVSSATQAKEKVKTTIGMVLLPKPRVPYPRFSRFSQREQRSYVDLLVKYAKIPA
NSKAVGINKNDYLQYLDMKKHVNEEVTEFLKFLQNSAKKCAQDYNMLSDDARLFTEKILR
ACIEQVKKYSEFYTLHEVTSLMGFFPFRVEMGLKLEKTLLALGSVKYVKTVFPSMPIKLQ
LSKDDIATIETSEQTAEAMHYDISKDPNAEKLVSRYHPQIALTSQSLFTLLNNHGPTYKE
QWEIPVCIQVIPVAGSKPVKVIYINSPLPQKKMTMRERNQIFHEVPLKFMMSKNTSVPVS
AVFMDKPEEFISEMDMSCEVNECRKIESLENLYLDFDDDVTELETFGVTTTKVSKSPSPA
STSTVPNMTDAPTAPKAGTTTVAPSAPDISANSRSLSQILMEQLQKEKQLVTGMDGGPEE
CKNKDDQGFESCEKVSNSDKPLIQDSDLKTSDALQLENSQEIETSNKNDMTIDILHADGE
RPNVLENLDNSKEKTVGSEAAKTEDTVLCSSDTDEECLIIDTECKNNSDGKTAVVGSNLS
SRPASPNSSSGQASVGNQTNTACSPEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPIS
RKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSAFQKPKGRLPYELQDYVEDTS
EYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQAC
YGVEALTESELCRLWTESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISN
LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPS
SLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETK
SSCLPAQQVETEGVAPHKRKIT

Sequence length

982

Interactions

View interactions

	Reactome
			RNA polymerase II transcribes snRNA genes

ICE2 (interactor of little elongation complex ELL subunit 2)