Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79664
Gene name	Interactor of little elongation complex ELL subunit 2
Gene symbol	ICE2
Synonyms (NCBI Gene)	BRCC1NARG2
Chromosome	15
Chromosome location	15q22.2
Summary	This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation

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Show/Hide all (107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741741	hsa-miR-8055	HITS-CLIP	23824327
MIRT741742	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT741743	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT741744	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT741745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT741746	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT741747	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT741748	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT741749	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT741750	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT741751	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT741752	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT741753	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT741754	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT741755	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741741	hsa-miR-8055	HITS-CLIP	23824327
MIRT741742	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741731	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT741732	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT741733	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT741734	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT741735	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT741736	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT741737	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT741738	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT741745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT741746	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT741739	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT741740	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT741741	hsa-miR-8055	HITS-CLIP	23824327
MIRT741742	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT741743	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT741744	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT741745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT741746	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT741747	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT742505	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT741748	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT741749	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT741750	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT741751	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT741752	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT741753	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT741754	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT741755	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT754470	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT754471	hsa-miR-3133	PAR-CLIP	22012620
MIRT754472	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT754473	hsa-miR-4803	PAR-CLIP	22012620
MIRT754474	hsa-miR-4797-3p	PAR-CLIP	22012620
MIRT754475	hsa-miR-4264	PAR-CLIP	22012620
MIRT755139	hsa-miR-1224-3p	PAR-CLIP	23592263
MIRT755140	hsa-miR-6787-3p	PAR-CLIP	23592263
MIRT755141	hsa-miR-532-3p	PAR-CLIP	23592263
MIRT755142	hsa-miR-1260a	PAR-CLIP	23592263
MIRT755143	hsa-miR-1260b	PAR-CLIP	23592263
MIRT755144	hsa-miR-6749-3p	PAR-CLIP	23592263

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000791	Component	Euchromatin	IDA	22195968, 23932780
GO:0005515	Function	Protein binding	IPI	21729782, 22195968, 23932780
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0008023	Component	Transcription elongation factor complex	IDA	23932780
GO:0008023	Component	Transcription elongation factor complex	IEA
GO:0008023	Component	Transcription elongation factor complex	IMP	22195968
GO:0015030	Component	Cajal body	IDA	23932780
GO:0016604	Component	Nuclear body	IDA
GO:0035363	Component	Histone locus body	IDA	23932780
GO:0042795	Process	SnRNA transcription by RNA polymerase II	IBA
GO:0042795	Process	SnRNA transcription by RNA polymerase II	IMP	23932780
GO:0042796	Process	SnRNA transcription by RNA polymerase III	IBA
GO:0042796	Process	SnRNA transcription by RNA polymerase III	IMP	23932780
GO:0045945	Process	Positive regulation of transcription by RNA polymerase III	IBA
GO:0045945	Process	Positive regulation of transcription by RNA polymerase III	IMP	23932780

MIM	HGNC	e!Ensembl
610835	29885	ENSG00000128915

Q659A1

Protein name

Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2)

Protein function

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10505	NARG2_C	720 → 930	NMDA receptor-regulated gene protein 2 C-terminus	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at low levels in lung and testis. {ECO:0000269|PubMed:15606750}.

Sequence

MSSKMVISEPGLNWDISPKNGLKTFFSRENYKDHSMAPSLKELRVLSNRRIGENLNASAS
SVENEPAVSSATQAKEKVKTTIGMVLLPKPRVPYPRFSRFSQREQRSYVDLLVKYAKIPA
NSKAVGINKNDYLQYLDMKKHVNEEVTEFLKFLQNSAKKCAQDYNMLSDDARLFTEKILR
ACIEQVKKYSEFYTLHEVTSLMGFFPFRVEMGLKLEKTLLALGSVKYVKTVFPSMPIKLQ
LSKDDIATIETSEQTAEAMHYDISKDPNAEKLVSRYHPQIALTSQSLFTLLNNHGPTYKE
QWEIPVCIQVIPVAGSKPVKVIYINSPLPQKKMTMRERNQIFHEVPLKFMMSKNTSVPVS
AVFMDKPEEFISEMDMSCEVNECRKIESLENLYLDFDDDVTELETFGVTTTKVSKSPSPA
STSTVPNMTDAPTAPKAGTTTVAPSAPDISANSRSLSQILMEQLQKEKQLVTGMDGGPEE
CKNKDDQGFESCEKVSNSDKPLIQDSDLKTSDALQLENSQEIETSNKNDMTIDILHADGE
RPNVLENLDNSKEKTVGSEAAKTEDTVLCSSDTDEECLIIDTECKNNSDGKTAVVGSNLS
SRPASPNSSSGQASVGNQTNTACSPEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPIS
RKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSAFQKPKGRLPYELQDYVEDTS
EYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQAC
YGVEALTESELCRLWTESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISN
LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPS
SLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETK
SSCLPAQQVETEGVAPHKRKIT

Sequence length

982

Interactions

View interactions

	Reactome
			RNA polymerase II transcribes snRNA genes

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
ICE2-related disorder	Uncertain significance; Likely benign	rs745899002, rs2505763780, rs151196206, rs199727296, rs375280679, rs199560072, rs2063906754, rs766076147, rs368391917, rs143271506, rs2505763455	RCV003419166 RCV003397681 RCV003980892 RCV003981370 RCV003933991 RCV003942117 RCV003939429 RCV003949273 RCV003947075 RCV003959103 RCV003969477
NARG2-related Intellectual disability	Uncertain significance	rs2063909740, rs999661043	RCV004799291 RCV004799292

ICE2 (interactor of little elongation complex ELL subunit 2)