Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
79661
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Nei like DNA glycosylase 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
NEIL1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
FPG1, NEI1, hFPG1 |
Chromosome
Chromosome number
|
15 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
15q24.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Mul |
UniProt ID |
Q96FI4
|
Protein name |
Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) |
Protein function |
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fap |
PDB |
1TDH
,
4NRV
,
5ITQ
,
5ITR
,
5ITT
,
5ITU
,
5ITX
,
5ITY
,
6LWA
,
6LWB
,
6LWC
,
6LWD
,
6LWF
,
6LWG
,
6LWH
,
6LWI
,
6LWJ
,
6LWK
,
6LWL
,
6LWM
,
6LWN
,
6LWO
,
6LWP
,
6LWQ
,
6LWR
,
7TMX
,
8FTJ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01149
|
Fapy_DNA_glyco |
1 → 123 |
Formamidopyrimidine-DNA glycosylase N-terminal domain |
Domain |
PF09292
|
Neil1-DNA_bind |
252 → 290 |
Endonuclease VIII-like 1, DNA bind |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11904416}. |
Sequence |
|
Sequence length |
390 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Hyperinsulinism |
Hyperinsulinism |
rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180 View all (23 more) |
16446448 |
Hyperlipidemia |
Hyperlipidemia |
rs118204057, rs118204060, rs118204062, rs1563569634, rs118204069, rs118204070, rs118204071, rs1566946168, rs1064797075 |
21285402 |
Metabolic syndrome |
Metabolic Syndrome X |
rs367643250, rs587777380, rs777736953 |
16446448, 17389588 |
Obesity |
Obesity |
rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs193922650, rs193922685, rs193922687, rs751160202, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829 View all (27 more) |
16446448, 21285402 |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Alzheimer Disease |
Associate
|
31415677 |
Bipolar Disorder |
Associate
|
29626765 |
Breast Neoplasms |
Associate
|
39199284 |
Carcinogenesis |
Associate
|
18594018, 19443904, 32198476 |
Carcinoma Hepatocellular |
Associate
|
31100703, 37517321 |
Cerebral Infarction |
Associate
|
27763529 |
Cholangiocarcinoma |
Associate
|
19443904 |
Cholangitis Sclerosing |
Associate
|
19443904 |
Colorectal Neoplasms |
Associate
|
28161934, 32312920, 32685496 |
Dengue |
Associate
|
35154111 |
Depressive Disorder |
Inhibit
|
36148566 |
Drug Related Side Effects and Adverse Reactions |
Associate
|
24022861 |
Esophageal Neoplasms |
Associate
|
24022861, 34105905 |
Esophageal Squamous Cell Carcinoma |
Associate
|
24022861, 36708047 |
Fuchs' Endothelial Dystrophy |
Associate
|
26388025 |
Hepatitis C |
Associate
|
20074151 |
Inflammation |
Associate
|
37517321 |
Leukemia Radiation Induced |
Associate
|
24022861 |
Liver Diseases |
Associate
|
20074151 |
Lung Neoplasms |
Associate
|
34105905 |
Mast Cell Activation Disorders |
Associate
|
36708047 |
Neoplasms |
Associate
|
19443904, 27042257, 37240218 |
Neoplasms Radiation Induced |
Associate
|
24022861 |
Non alcoholic Fatty Liver Disease |
Associate
|
37511066 |
Oropharyngeal Neoplasms |
Associate
|
18594018 |
Radiation Pneumonitis |
Associate
|
24022861, 34105905 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
18594018 |
Stroke |
Associate
|
27763529 |
Virus Diseases |
Associate
|
37517321 |
|