Gene Gene information from NCBI Gene database.
Entrez ID 79660
Gene name Protein phosphatase 1 regulatory subunit 3B
Gene symbol PPP1R3B
Synonyms (NCBI Gene)
GLPPP1R4PTG
Chromosome 8
Chromosome location 8p23.1
Summary This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be
miRNA miRNA information provided by mirtarbase database.
925
miRTarBase ID miRNA Experiments Reference
MIRT017328 hsa-miR-335-5p Microarray 18185580
MIRT022373 hsa-miR-124-3p Microarray 18668037
MIRT679347 hsa-miR-6858-3p HITS-CLIP 23824327
MIRT530480 hsa-miR-4676-5p HITS-CLIP 23824327
MIRT530479 hsa-miR-575 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0000164 Component Protein phosphatase type 1 complex IBA
GO:0000164 Component Protein phosphatase type 1 complex IEA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0005515 Function Protein binding IPI 15231748, 32296183, 33961781
GO:0005977 Process Glycogen metabolic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610541 14942 ENSG00000173281
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86XI6
Protein name Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)
Protein function Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphoryla
PDB 2EEF , 5ZT0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03370 CBM_21 127 233 Carbohydrate/starch-binding module (family 21) Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver
Sequence
MMAVDIEYRYNCMAPSLRQERFAFKISPKPSKPLRPCIQLSSKNEASGMVAPAVQEKKVK
KRVSFADNQGLALTMVKVFSEFDDPLDMPFNITELLDNIVSLTTAESESFVLDFSQPSAD
YLDFRNRLQADHVCLENCVLKDKAIAGTVKVQNLAFEKTVKIRMTFDTWKSYTDFPCQYV
KDTYAGSDRDTFSFDISLPEKIQSYERMEFAVYYECNGQTYWDSNRGKNYRII
RAELKST
QGMTKPHSGPDLGISFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY
Sequence length 285
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Insulin signaling pathway
Insulin resistance
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Diabetes Mellitus Associate 26433129, 28334935, 30629617
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 30629617, 31554886
★☆☆☆☆
Found in Text Mining only
Fatty Liver Associate 23416328, 32898995
★☆☆☆☆
Found in Text Mining only
Fatty Liver Alcoholic Associate 26845607
★☆☆☆☆
Found in Text Mining only
Glycogen Storage Disease Associate 33231259
★☆☆☆☆
Found in Text Mining only
Liver Diseases Associate 27752939
★☆☆☆☆
Found in Text Mining only
Mason Type Diabetes Associate 30629617
★☆☆☆☆
Found in Text Mining only
Melanoma Associate 23690473
★☆☆☆☆
Found in Text Mining only
Metabolic Syndrome Associate 33231259
★☆☆☆☆
Found in Text Mining only
Myocardial Infarction Associate 33231259
★☆☆☆☆
Found in Text Mining only