Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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79660
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Protein phosphatase 1 regulatory subunit 3B |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
PPP1R3B |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
GL, PPP1R4, PTG |
Chromosome
Chromosome number
|
8 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
8p23.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be |
UniProt ID |
Q86XI6
|
Protein name |
Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) |
Protein function |
Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphoryla |
PDB |
2EEF
,
5ZT0
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF03370
|
CBM_21 |
127 → 233 |
Carbohydrate/starch-binding module (family 21) |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver |
Sequence |
|
Sequence length |
285 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Alzheimer disease |
Alzheimer`s Disease |
rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 View all (65 more) |
22832961 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Metabolic Syndrome |
Metabolic Syndrome |
|
|
GWAS |
Schizophrenia |
Schizophrenia |
|
|
GWAS |
Systemic lupus erythematosus |
Systemic lupus erythematosus |
|
|
GWAS |
Neuroticism |
Neuroticism |
|
|
GWAS |
Hypertension |
Hypertension |
|
|
GWAS |
Gout |
Gout |
|
|
GWAS |
Diabetes |
Diabetes |
|
|
GWAS |
Cholelithiasis |
Cholelithiasis |
|
|
GWAS |
Oligodendroglioma |
Oligodendroglioma |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Diabetes Mellitus |
Associate
|
26433129, 28334935, 30629617 |
Diabetes Mellitus Type 2 |
Associate
|
30629617, 31554886 |
Fatty Liver |
Associate
|
23416328, 32898995 |
Fatty Liver Alcoholic |
Associate
|
26845607 |
Glycogen Storage Disease |
Associate
|
33231259 |
Liver Diseases |
Associate
|
27752939 |
Mason Type Diabetes |
Associate
|
30629617 |
Melanoma |
Associate
|
23690473 |
Metabolic Syndrome |
Associate
|
33231259 |
Myocardial Infarction |
Associate
|
33231259 |
Neoplasms |
Associate
|
23690473 |
Non alcoholic Fatty Liver Disease |
Associate
|
23594525, 24785259, 26646939, 29487372, 32841307 |
Obesity |
Associate
|
27752939, 29307798, 31554886, 33553972 |
Ovarian Neoplasms |
Stimulate
|
38494731 |
Overweight |
Associate
|
27752939, 29307798 |
|