Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79654
Gene name Gene Name - the full gene name approved by the HGNC.	HECT domain E3 ubiquitin protein ligase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HECTD3
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p34.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023327	hsa-miR-122-5p	Microarray	17612493
MIRT025780	hsa-miR-7-5p	Microarray	19073608
MIRT029557	hsa-miR-26b-5p	Microarray	19088304
MIRT041762	hsa-miR-484	CLASH	23622248
MIRT039878	hsa-miR-615-3p	CLASH	23622248
MIRT674629	hsa-miR-5693	HITS-CLIP	23824327
MIRT138483	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674628	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT674627	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT674626	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT674625	hsa-miR-4284	HITS-CLIP	23824327
MIRT674624	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT667981	hsa-miR-7977	HITS-CLIP	23824327
MIRT674623	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT667994	hsa-miR-3714	HITS-CLIP	23824327
MIRT667993	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT667992	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT667991	hsa-miR-1324	HITS-CLIP	23824327
MIRT667990	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT667989	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT667988	hsa-miR-3166	HITS-CLIP	23824327
MIRT667987	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT667986	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT667985	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT667984	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT667983	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT667982	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT667981	hsa-miR-7977	HITS-CLIP	23824327
MIRT667980	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT667979	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT667978	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT667977	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT667976	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT667975	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT667974	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT667973	hsa-miR-3689c	HITS-CLIP	23824327
MIRT667972	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT667971	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT667970	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT667969	hsa-miR-3122	HITS-CLIP	23824327
MIRT667968	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT667967	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT667966	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT455933	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT455932	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT455931	hsa-miR-219a-2-3p	PAR-CLIP	23592263
MIRT455930	hsa-miR-6087	PAR-CLIP	23592263
MIRT455929	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT455928	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT455927	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT455926	hsa-miR-4459	PAR-CLIP	23592263
MIRT727508	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT029557	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT674629	hsa-miR-5693	HITS-CLIP	23824327
MIRT138483	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674628	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT674627	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT674626	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT674625	hsa-miR-4284	HITS-CLIP	23824327
MIRT674624	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT667981	hsa-miR-7977	HITS-CLIP	23824327
MIRT674623	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT667994	hsa-miR-3714	HITS-CLIP	23824327
MIRT667993	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT667992	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT667991	hsa-miR-1324	HITS-CLIP	23824327
MIRT667990	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT667989	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT667988	hsa-miR-3166	HITS-CLIP	23824327
MIRT667987	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT667986	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT667985	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT667984	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT667983	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT667982	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT667981	hsa-miR-7977	HITS-CLIP	23824327
MIRT667980	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT667979	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT667978	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT667977	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT667976	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT667975	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT667974	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT667973	hsa-miR-3689c	HITS-CLIP	23824327
MIRT667972	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT667971	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT667970	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT667969	hsa-miR-3122	HITS-CLIP	23824327
MIRT667968	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT667967	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT667966	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT455933	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT455932	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT455931	hsa-miR-219a-2-3p	PAR-CLIP	23592263
MIRT455930	hsa-miR-6087	PAR-CLIP	23592263
MIRT455929	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT455928	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT455927	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT455926	hsa-miR-4459	PAR-CLIP	23592263
MIRT1043548	hsa-miR-1180	CLIP-seq
MIRT1043549	hsa-miR-1207-5p	CLIP-seq
MIRT1043550	hsa-miR-122	CLIP-seq
MIRT1043551	hsa-miR-1237	CLIP-seq
MIRT1043552	hsa-miR-1248	CLIP-seq
MIRT1043553	hsa-miR-125a-5p	CLIP-seq
MIRT1043554	hsa-miR-125b	CLIP-seq
MIRT1043555	hsa-miR-1275	CLIP-seq
MIRT1043556	hsa-miR-1291	CLIP-seq
MIRT1043557	hsa-miR-1297	CLIP-seq
MIRT1043558	hsa-miR-1321	CLIP-seq
MIRT1043559	hsa-miR-1909	CLIP-seq
MIRT1043560	hsa-miR-1972	CLIP-seq
MIRT1043561	hsa-miR-19a	CLIP-seq
MIRT1043562	hsa-miR-19b	CLIP-seq
MIRT1043563	hsa-miR-2110	CLIP-seq
MIRT1043564	hsa-miR-2115	CLIP-seq
MIRT1043565	hsa-miR-218	CLIP-seq
MIRT1043566	hsa-miR-26a	CLIP-seq
MIRT1043567	hsa-miR-26b	CLIP-seq
MIRT1043568	hsa-miR-3126-5p	CLIP-seq
MIRT1043569	hsa-miR-3127-3p	CLIP-seq
MIRT1043570	hsa-miR-3135b	CLIP-seq
MIRT1043571	hsa-miR-3144-5p	CLIP-seq
MIRT1043572	hsa-miR-3150a-3p	CLIP-seq
MIRT1043573	hsa-miR-3155	CLIP-seq
MIRT1043574	hsa-miR-3155b	CLIP-seq
MIRT1043575	hsa-miR-3160-3p	CLIP-seq
MIRT1043576	hsa-miR-3190	CLIP-seq
MIRT1043577	hsa-miR-3191	CLIP-seq
MIRT1043578	hsa-miR-3612	CLIP-seq
MIRT1043579	hsa-miR-3647-3p	CLIP-seq
MIRT1043580	hsa-miR-3649	CLIP-seq
MIRT1043581	hsa-miR-3652	CLIP-seq
MIRT1043582	hsa-miR-378g	CLIP-seq
MIRT1043583	hsa-miR-3928	CLIP-seq
MIRT1043584	hsa-miR-3940-5p	CLIP-seq
MIRT1043585	hsa-miR-4270	CLIP-seq
MIRT1043586	hsa-miR-4272	CLIP-seq
MIRT1043587	hsa-miR-4313	CLIP-seq
MIRT1043588	hsa-miR-4319	CLIP-seq
MIRT1043589	hsa-miR-432	CLIP-seq
MIRT1043590	hsa-miR-4419a	CLIP-seq
MIRT1043591	hsa-miR-4430	CLIP-seq
MIRT1043592	hsa-miR-4436b-3p	CLIP-seq
MIRT1043593	hsa-miR-4441	CLIP-seq
MIRT1043594	hsa-miR-4443	CLIP-seq
MIRT1043595	hsa-miR-4465	CLIP-seq
MIRT1043596	hsa-miR-4484	CLIP-seq
MIRT1043597	hsa-miR-4507	CLIP-seq
MIRT1043598	hsa-miR-4510	CLIP-seq
MIRT1043599	hsa-miR-4650-5p	CLIP-seq
MIRT1043600	hsa-miR-4652-5p	CLIP-seq
MIRT1043601	hsa-miR-4664-3p	CLIP-seq
MIRT1043602	hsa-miR-4665-5p	CLIP-seq
MIRT1043603	hsa-miR-4694-3p	CLIP-seq
MIRT1043604	hsa-miR-4699-5p	CLIP-seq
MIRT1043605	hsa-miR-4729	CLIP-seq
MIRT1043606	hsa-miR-4731-5p	CLIP-seq
MIRT1043607	hsa-miR-4739	CLIP-seq
MIRT1043608	hsa-miR-4752	CLIP-seq
MIRT1043609	hsa-miR-4756-5p	CLIP-seq
MIRT1043610	hsa-miR-4763-3p	CLIP-seq
MIRT1043611	hsa-miR-4802-5p	CLIP-seq
MIRT1043612	hsa-miR-488	CLIP-seq
MIRT1043613	hsa-miR-516a-3p	CLIP-seq
MIRT1043614	hsa-miR-544b	CLIP-seq
MIRT1043615	hsa-miR-548g	CLIP-seq
MIRT1043616	hsa-miR-562	CLIP-seq
MIRT1043617	hsa-miR-597	CLIP-seq
MIRT1043618	hsa-miR-635	CLIP-seq
MIRT1043619	hsa-miR-642a	CLIP-seq
MIRT1043620	hsa-miR-650	CLIP-seq
MIRT1043621	hsa-miR-7	CLIP-seq
MIRT1043622	hsa-miR-875-5p	CLIP-seq
MIRT1043623	hsa-miR-885-3p	CLIP-seq
MIRT1043548	hsa-miR-1180	CLIP-seq
MIRT2009409	hsa-miR-147	CLIP-seq
MIRT1043565	hsa-miR-218	CLIP-seq
MIRT1043576	hsa-miR-3190	CLIP-seq
MIRT2009410	hsa-miR-3529	CLIP-seq
MIRT2009411	hsa-miR-3672	CLIP-seq
MIRT1043582	hsa-miR-378g	CLIP-seq
MIRT2009412	hsa-miR-379	CLIP-seq
MIRT1043584	hsa-miR-3940-5p	CLIP-seq
MIRT1043586	hsa-miR-4272	CLIP-seq
MIRT2009413	hsa-miR-4451	CLIP-seq
MIRT2009414	hsa-miR-4463	CLIP-seq
MIRT1043597	hsa-miR-4507	CLIP-seq
MIRT2009415	hsa-miR-4650-3p	CLIP-seq
MIRT1043601	hsa-miR-4664-3p	CLIP-seq
MIRT1043605	hsa-miR-4729	CLIP-seq
MIRT1043606	hsa-miR-4731-5p	CLIP-seq
MIRT1043608	hsa-miR-4752	CLIP-seq
MIRT2009416	hsa-miR-599	CLIP-seq
MIRT1043621	hsa-miR-7	CLIP-seq
MIRT1043548	hsa-miR-1180	CLIP-seq
MIRT1043549	hsa-miR-1207-5p	CLIP-seq
MIRT2241787	hsa-miR-125a-3p	CLIP-seq
MIRT1043557	hsa-miR-1297	CLIP-seq
MIRT1043558	hsa-miR-1321	CLIP-seq
MIRT2241788	hsa-miR-153	CLIP-seq
MIRT1043559	hsa-miR-1909	CLIP-seq
MIRT1043560	hsa-miR-1972	CLIP-seq
MIRT1043563	hsa-miR-2110	CLIP-seq
MIRT1043565	hsa-miR-218	CLIP-seq
MIRT1043566	hsa-miR-26a	CLIP-seq
MIRT1043567	hsa-miR-26b	CLIP-seq
MIRT1043572	hsa-miR-3150a-3p	CLIP-seq
MIRT1043573	hsa-miR-3155	CLIP-seq
MIRT1043574	hsa-miR-3155b	CLIP-seq
MIRT1043576	hsa-miR-3190	CLIP-seq
MIRT2241789	hsa-miR-3665	CLIP-seq
MIRT1043582	hsa-miR-378g	CLIP-seq
MIRT2241790	hsa-miR-3914	CLIP-seq
MIRT1043583	hsa-miR-3928	CLIP-seq
MIRT1043586	hsa-miR-4272	CLIP-seq
MIRT1043590	hsa-miR-4419a	CLIP-seq
MIRT1043592	hsa-miR-4436b-3p	CLIP-seq
MIRT2241791	hsa-miR-4455	CLIP-seq
MIRT1043595	hsa-miR-4465	CLIP-seq
MIRT1043598	hsa-miR-4510	CLIP-seq
MIRT1043599	hsa-miR-4650-5p	CLIP-seq
MIRT1043601	hsa-miR-4664-3p	CLIP-seq
MIRT2241792	hsa-miR-4668-5p	CLIP-seq
MIRT1043604	hsa-miR-4699-5p	CLIP-seq
MIRT2241793	hsa-miR-4717-3p	CLIP-seq
MIRT1043605	hsa-miR-4729	CLIP-seq
MIRT1043606	hsa-miR-4731-5p	CLIP-seq
MIRT1043607	hsa-miR-4739	CLIP-seq
MIRT2241794	hsa-miR-4747-5p	CLIP-seq
MIRT1043608	hsa-miR-4752	CLIP-seq
MIRT1043609	hsa-miR-4756-5p	CLIP-seq
MIRT1043610	hsa-miR-4763-3p	CLIP-seq
MIRT1043611	hsa-miR-4802-5p	CLIP-seq
MIRT1043615	hsa-miR-548g	CLIP-seq
MIRT1043616	hsa-miR-562	CLIP-seq
MIRT1043621	hsa-miR-7	CLIP-seq
MIRT1043623	hsa-miR-885-3p	CLIP-seq
MIRT2009409	hsa-miR-147	CLIP-seq
MIRT1043572	hsa-miR-3150a-3p	CLIP-seq
MIRT2388928	hsa-miR-3175	CLIP-seq
MIRT2009410	hsa-miR-3529	CLIP-seq
MIRT2009411	hsa-miR-3672	CLIP-seq
MIRT2009412	hsa-miR-379	CLIP-seq
MIRT1043584	hsa-miR-3940-5p	CLIP-seq
MIRT2009413	hsa-miR-4451	CLIP-seq
MIRT2009414	hsa-miR-4463	CLIP-seq
MIRT1043597	hsa-miR-4507	CLIP-seq
MIRT2009415	hsa-miR-4650-3p	CLIP-seq
MIRT2388929	hsa-miR-4773	CLIP-seq
MIRT2009416	hsa-miR-599	CLIP-seq
MIRT2388930	hsa-miR-939	CLIP-seq
MIRT1043549	hsa-miR-1207-5p	CLIP-seq
MIRT1043553	hsa-miR-125a-5p	CLIP-seq
MIRT1043554	hsa-miR-125b	CLIP-seq
MIRT1043556	hsa-miR-1291	CLIP-seq
MIRT1043558	hsa-miR-1321	CLIP-seq
MIRT2241788	hsa-miR-153	CLIP-seq
MIRT1043559	hsa-miR-1909	CLIP-seq
MIRT1043568	hsa-miR-3126-5p	CLIP-seq
MIRT1043583	hsa-miR-3928	CLIP-seq
MIRT1043588	hsa-miR-4319	CLIP-seq
MIRT1043590	hsa-miR-4419a	CLIP-seq
MIRT2241791	hsa-miR-4455	CLIP-seq
MIRT1043598	hsa-miR-4510	CLIP-seq
MIRT1043607	hsa-miR-4739	CLIP-seq
MIRT1043609	hsa-miR-4756-5p	CLIP-seq
MIRT1043610	hsa-miR-4763-3p	CLIP-seq
MIRT1043614	hsa-miR-544b	CLIP-seq
MIRT1043615	hsa-miR-548g	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	18194665
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0005515	Function	Protein binding	IPI	18194665, 32296183
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019905	Function	Syntaxin binding	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	18194665
GO:0048471	Component	Perinuclear region of cytoplasm	ISS

MIM	HGNC	e!Ensembl
618638	26117	ENSG00000126107

Protein

UniProt ID

Q5T447

Protein name

E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)

Protein function

E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03256	ANAPC10	232 → 393	Anaphase-promoting complex, subunit 10 (APC10)	Family
PF00632	HECT	562 → 852	HECT-domain (ubiquitin-transferase)	Domain

Sequence

MAGPGPGAVLESPRQLLGRVRFLAEAARSLRAGRPLPAALAFVPREVLYKLYKDPAGPSR
VLLPVWEAEGLGLRVGAAGPAPGTGSGPLRAARDSIELRRGACVRTTGEELCNGHGLWVK
LTKEQLAEHLGDCGLQEGWLLVCRPAEGGARLVPIDTPNHLQRQQQLFGVDYRPVLRWEQ
VVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSV
KQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDT
TDDNFMPKRVVVYGGEGDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDG
IDVRLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDS
VLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRL
AMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQ
GGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEW
IGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDKETF
EFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQVAAMQA
GLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNF
TNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEE
KLRYAAYNCVAIDTDMSPWEE

Sequence length

861

Interactions

View interactions

	Reactome
			Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	29685151
Neoplasms	Associate	38111983

HECTD3 (HECT domain E3 ubiquitin protein ligase 3)