Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7965
Gene name	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Gene symbol	AIMP2
Synonyms (NCBI Gene)	HLD17JTV-1JTV1P38
Chromosome	7
Chromosome location	7p22.1
Summary	The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assemb

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Show/Hide all (119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016291	hsa-miR-193b-3p	Microarray	20304954
MIRT025288	hsa-miR-34a-5p	Proteomics	21566225
MIRT044033	hsa-miR-365a-3p	CLASH	23622248
MIRT037437	hsa-miR-744-5p	CLASH	23622248
MIRT1928585	hsa-miR-193a-3p	CLIP-seq
MIRT1928586	hsa-miR-193b	CLIP-seq
MIRT1928587	hsa-miR-3117-5p	CLIP-seq
MIRT1928588	hsa-miR-3176	CLIP-seq
MIRT1928589	hsa-miR-345	CLIP-seq
MIRT1928590	hsa-miR-374c	CLIP-seq
MIRT1928591	hsa-miR-3922-3p	CLIP-seq
MIRT1928592	hsa-miR-4432	CLIP-seq
MIRT1928593	hsa-miR-4522	CLIP-seq
MIRT1928594	hsa-miR-4668-3p	CLIP-seq
MIRT1928595	hsa-miR-4714-5p	CLIP-seq
MIRT1928596	hsa-miR-514	CLIP-seq
MIRT1928597	hsa-miR-514b-3p	CLIP-seq
MIRT1928598	hsa-miR-548u	CLIP-seq
MIRT1928599	hsa-miR-549	CLIP-seq
MIRT1928600	hsa-miR-655	CLIP-seq
MIRT1928585	hsa-miR-193a-3p	CLIP-seq
MIRT1928586	hsa-miR-193b	CLIP-seq
MIRT2169355	hsa-miR-300	CLIP-seq
MIRT1928587	hsa-miR-3117-5p	CLIP-seq
MIRT2169356	hsa-miR-3127-3p	CLIP-seq
MIRT2169357	hsa-miR-3140-3p	CLIP-seq
MIRT1928588	hsa-miR-3176	CLIP-seq
MIRT1928589	hsa-miR-345	CLIP-seq
MIRT1928590	hsa-miR-374c	CLIP-seq
MIRT2169358	hsa-miR-381	CLIP-seq
MIRT1928591	hsa-miR-3922-3p	CLIP-seq
MIRT1928592	hsa-miR-4432	CLIP-seq
MIRT1928593	hsa-miR-4522	CLIP-seq
MIRT1928595	hsa-miR-4714-5p	CLIP-seq
MIRT1928596	hsa-miR-514	CLIP-seq
MIRT1928597	hsa-miR-514b-3p	CLIP-seq
MIRT1928598	hsa-miR-548u	CLIP-seq
MIRT1928599	hsa-miR-549	CLIP-seq
MIRT1928600	hsa-miR-655	CLIP-seq
MIRT2443392	hsa-miR-1276	CLIP-seq
MIRT1928585	hsa-miR-193a-3p	CLIP-seq
MIRT1928586	hsa-miR-193b	CLIP-seq
MIRT2443393	hsa-miR-29a	CLIP-seq
MIRT2443394	hsa-miR-29b	CLIP-seq
MIRT2443395	hsa-miR-29c	CLIP-seq
MIRT2169355	hsa-miR-300	CLIP-seq
MIRT1928587	hsa-miR-3117-5p	CLIP-seq
MIRT2169356	hsa-miR-3127-3p	CLIP-seq
MIRT1928588	hsa-miR-3176	CLIP-seq
MIRT1928589	hsa-miR-345	CLIP-seq
MIRT2443396	hsa-miR-3663-3p	CLIP-seq
MIRT1928590	hsa-miR-374c	CLIP-seq
MIRT2169358	hsa-miR-381	CLIP-seq
MIRT1928591	hsa-miR-3922-3p	CLIP-seq
MIRT1928592	hsa-miR-4432	CLIP-seq
MIRT1928593	hsa-miR-4522	CLIP-seq
MIRT1928594	hsa-miR-4668-3p	CLIP-seq
MIRT1928595	hsa-miR-4714-5p	CLIP-seq
MIRT1928598	hsa-miR-548u	CLIP-seq
MIRT1928599	hsa-miR-549	CLIP-seq
MIRT1928600	hsa-miR-655	CLIP-seq
MIRT2443397	hsa-miR-767-5p	CLIP-seq
MIRT1928585	hsa-miR-193a-3p	CLIP-seq
MIRT1928586	hsa-miR-193b	CLIP-seq
MIRT1928587	hsa-miR-3117-5p	CLIP-seq
MIRT1928588	hsa-miR-3176	CLIP-seq
MIRT1928589	hsa-miR-345	CLIP-seq
MIRT1928591	hsa-miR-3922-3p	CLIP-seq
MIRT1928592	hsa-miR-4432	CLIP-seq
MIRT1928593	hsa-miR-4522	CLIP-seq
MIRT1928595	hsa-miR-4714-5p	CLIP-seq
MIRT1928598	hsa-miR-548u	CLIP-seq
MIRT1928599	hsa-miR-549	CLIP-seq
MIRT2443392	hsa-miR-1276	CLIP-seq
MIRT1928585	hsa-miR-193a-3p	CLIP-seq
MIRT1928586	hsa-miR-193b	CLIP-seq
MIRT2443393	hsa-miR-29a	CLIP-seq
MIRT2443394	hsa-miR-29b	CLIP-seq
MIRT2443395	hsa-miR-29c	CLIP-seq
MIRT2169355	hsa-miR-300	CLIP-seq
MIRT1928587	hsa-miR-3117-5p	CLIP-seq
MIRT2169356	hsa-miR-3127-3p	CLIP-seq
MIRT1928588	hsa-miR-3176	CLIP-seq
MIRT1928589	hsa-miR-345	CLIP-seq
MIRT2443396	hsa-miR-3663-3p	CLIP-seq
MIRT1928590	hsa-miR-374c	CLIP-seq
MIRT2169358	hsa-miR-381	CLIP-seq
MIRT1928591	hsa-miR-3922-3p	CLIP-seq
MIRT1928592	hsa-miR-4432	CLIP-seq
MIRT1928593	hsa-miR-4522	CLIP-seq
MIRT1928594	hsa-miR-4668-3p	CLIP-seq
MIRT1928595	hsa-miR-4714-5p	CLIP-seq
MIRT1928598	hsa-miR-548u	CLIP-seq
MIRT1928599	hsa-miR-549	CLIP-seq
MIRT1928600	hsa-miR-655	CLIP-seq
MIRT2443397	hsa-miR-767-5p	CLIP-seq
MIRT2443392	hsa-miR-1276	CLIP-seq
MIRT1928585	hsa-miR-193a-3p	CLIP-seq
MIRT1928586	hsa-miR-193b	CLIP-seq
MIRT2443393	hsa-miR-29a	CLIP-seq
MIRT2443394	hsa-miR-29b	CLIP-seq
MIRT2443395	hsa-miR-29c	CLIP-seq
MIRT2169355	hsa-miR-300	CLIP-seq
MIRT1928587	hsa-miR-3117-5p	CLIP-seq
MIRT2169356	hsa-miR-3127-3p	CLIP-seq
MIRT1928588	hsa-miR-3176	CLIP-seq
MIRT1928589	hsa-miR-345	CLIP-seq
MIRT2443396	hsa-miR-3663-3p	CLIP-seq
MIRT1928590	hsa-miR-374c	CLIP-seq
MIRT2169358	hsa-miR-381	CLIP-seq
MIRT1928591	hsa-miR-3922-3p	CLIP-seq
MIRT1928592	hsa-miR-4432	CLIP-seq
MIRT1928593	hsa-miR-4522	CLIP-seq
MIRT1928594	hsa-miR-4668-3p	CLIP-seq
MIRT1928595	hsa-miR-4714-5p	CLIP-seq
MIRT1928598	hsa-miR-548u	CLIP-seq
MIRT1928599	hsa-miR-549	CLIP-seq
MIRT1928600	hsa-miR-655	CLIP-seq
MIRT2443397	hsa-miR-767-5p	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 18695251, 19060904, 21044950, 21285945, 21516116, 21536907, 21900206, 21988832, 22190034, 23159739, 24212136, 24312579, 25416956, 26496610, 26871637, 27107012, 28514442, 29892012, 29997244, 31116475, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	19289464
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016567	Process	Protein ubiquitination	IEA
GO:0017101	Component	Aminoacyl-tRNA synthetase multienzyme complex	IBA
GO:0017101	Component	Aminoacyl-tRNA synthetase multienzyme complex	IDA	19131329
GO:0017101	Component	Aminoacyl-tRNA synthetase multienzyme complex	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	19131329
GO:0031398	Process	Positive regulation of protein ubiquitination	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0060090	Function	Molecular adaptor activity	IEA
GO:0060510	Process	Type II pneumocyte differentiation	IEA
GO:0065003	Process	Protein-containing complex assembly	IEA

MIM	HGNC	e!Ensembl
600859	20609	ENSG00000106305

Q13155

Protein name

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1)

Protein function

Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type

PDB

4DPG , 4YCU , 4YCW , 5A1N , 5A34 , 5A5H , 5Y6L , 6ILD , 6IY6 , 6JPV , 6K39 , 8J9S , 9DPL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16780	AIMP2_LysRS_bd	1 → 49	AIMP2 lysyl-tRNA synthetase binding domain	Domain
PF18569	Thioredoxin_16	117 → 208	Thioredoxin-like domain	Domain
PF00043	GST_C	235 → 309	Glutathione S-transferase, C-terminal domain	Domain

Sequence

MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQD
DILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALK
DIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQD
YQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIA
IFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQ
RWMRSCENLAPFNTALKLLK

Sequence length

320

Interactions

View interactions

	Reactome
			Cytosolic tRNA aminoacylation

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Leukodystrophy, hypomyelinating, 17	Pathogenic; Likely pathogenic	rs869312968, rs760123492, rs529613640, rs147658637, rs1786357576	RCV002247639 RCV003985133 RCV000656387 RCV001375046 RCV003120520
Neurodevelopmental abnormality	Likely pathogenic	rs529613640	RCV000579202

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
AIMP2-related disorder	Likely benign; Benign	rs746501522, rs145382336, rs140169208, rs145256692, rs566052179, rs767064905, rs374110509, rs1448273730, rs34525431	RCV003960879 RCV003903507 RCV003923649 RCV003963543 RCV003919210 RCV003892234 RCV003903886 RCV003914124 RCV003926256

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	33128014, 35546148
Drug Related Side Effects and Adverse Reactions	Associate	28383562
Leukemia Myeloid Acute	Associate	33128014
Lung Neoplasms	Associate	22562359, 35546148
Melanoma Cutaneous Malignant	Associate	34986671
Neoplasm Metastasis	Associate	34986671
Neoplasms	Associate	22562359, 33128014
Neoplasms	Inhibit	35546148
Nervous System Diseases	Associate	28383562
Parkinson Disease	Associate	28383562, 28972555, 31366968, 34148545
Squamous Cell Carcinoma of Head and Neck	Associate	31517839

AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2)