Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	79611
Gene name	Acyl-CoA synthetase short chain family member 3
Gene symbol	ACSS3
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12q21.31

131

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017832	hsa-miR-335-5p	Microarray	18185580
MIRT539516	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT539515	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT539514	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT539513	hsa-miR-23c	PAR-CLIP	22012620
MIRT539512	hsa-miR-7849-3p	PAR-CLIP	22012620
MIRT539511	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT539510	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT539509	hsa-miR-4480	PAR-CLIP	22012620
MIRT539508	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT539507	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT539506	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT539505	hsa-miR-507	PAR-CLIP	22012620
MIRT539504	hsa-miR-557	PAR-CLIP	22012620
MIRT539503	hsa-miR-3680-3p	PAR-CLIP	22012620
MIRT539516	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT539515	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT539514	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT539513	hsa-miR-23c	PAR-CLIP	22012620
MIRT539512	hsa-miR-7849-3p	PAR-CLIP	22012620
MIRT539511	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT539510	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT539509	hsa-miR-4480	PAR-CLIP	22012620
MIRT539508	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT539507	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT539506	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT539505	hsa-miR-507	PAR-CLIP	22012620
MIRT539504	hsa-miR-557	PAR-CLIP	22012620
MIRT539503	hsa-miR-3680-3p	PAR-CLIP	22012620
MIRT763724	hsa-miR-1273f	CLIP-seq
MIRT763725	hsa-miR-1289	CLIP-seq
MIRT763726	hsa-miR-1323	CLIP-seq
MIRT763727	hsa-miR-143	CLIP-seq
MIRT763728	hsa-miR-2052	CLIP-seq
MIRT763729	hsa-miR-3198	CLIP-seq
MIRT763730	hsa-miR-3664-5p	CLIP-seq
MIRT763731	hsa-miR-4294	CLIP-seq
MIRT763732	hsa-miR-4309	CLIP-seq
MIRT763733	hsa-miR-4534	CLIP-seq
MIRT763734	hsa-miR-4708-5p	CLIP-seq
MIRT763735	hsa-miR-4714-5p	CLIP-seq
MIRT763736	hsa-miR-4770	CLIP-seq
MIRT763737	hsa-miR-548o	CLIP-seq
MIRT763738	hsa-miR-550b	CLIP-seq
MIRT763739	hsa-miR-924	CLIP-seq
MIRT1925104	hsa-miR-197	CLIP-seq
MIRT1925105	hsa-miR-24	CLIP-seq
MIRT1925106	hsa-miR-3155	CLIP-seq
MIRT1925107	hsa-miR-3155b	CLIP-seq
MIRT1925108	hsa-miR-3187-3p	CLIP-seq
MIRT1925109	hsa-miR-4284	CLIP-seq
MIRT1925110	hsa-miR-4435	CLIP-seq
MIRT1925111	hsa-miR-4701-5p	CLIP-seq
MIRT1925112	hsa-miR-4716-5p	CLIP-seq
MIRT1925113	hsa-miR-4755-3p	CLIP-seq
MIRT1925114	hsa-miR-4772-3p	CLIP-seq
MIRT1925115	hsa-miR-4781-3p	CLIP-seq
MIRT1925116	hsa-miR-484	CLIP-seq
MIRT1925117	hsa-miR-5096	CLIP-seq
MIRT1925118	hsa-miR-548s	CLIP-seq
MIRT1925119	hsa-miR-548v	CLIP-seq
MIRT1925120	hsa-miR-588	CLIP-seq
MIRT1925121	hsa-miR-630	CLIP-seq
MIRT1925122	hsa-miR-643	CLIP-seq
MIRT2166622	hsa-miR-106a	CLIP-seq
MIRT2166623	hsa-miR-106b	CLIP-seq
MIRT2166624	hsa-miR-150	CLIP-seq
MIRT2166625	hsa-miR-17	CLIP-seq
MIRT2166626	hsa-miR-20a	CLIP-seq
MIRT2166627	hsa-miR-20b	CLIP-seq
MIRT2166628	hsa-miR-23a	CLIP-seq
MIRT2166629	hsa-miR-23b	CLIP-seq
MIRT2166630	hsa-miR-4258	CLIP-seq
MIRT2166631	hsa-miR-4763-5p	CLIP-seq
MIRT2166632	hsa-miR-519d	CLIP-seq
MIRT2166633	hsa-miR-520g	CLIP-seq
MIRT2166634	hsa-miR-520h	CLIP-seq
MIRT2166635	hsa-miR-579	CLIP-seq
MIRT2166636	hsa-miR-93	CLIP-seq
MIRT2469045	hsa-miR-1275	CLIP-seq
MIRT2469046	hsa-miR-1297	CLIP-seq
MIRT2469047	hsa-miR-199a-3p	CLIP-seq
MIRT2469048	hsa-miR-199b-3p	CLIP-seq
MIRT1925105	hsa-miR-24	CLIP-seq
MIRT2469049	hsa-miR-26a	CLIP-seq
MIRT2469050	hsa-miR-26b	CLIP-seq
MIRT2469051	hsa-miR-3129-5p	CLIP-seq
MIRT2469052	hsa-miR-3135b	CLIP-seq
MIRT2469053	hsa-miR-3149	CLIP-seq
MIRT2469054	hsa-miR-3652	CLIP-seq
MIRT2166630	hsa-miR-4258	CLIP-seq
MIRT2469055	hsa-miR-4272	CLIP-seq
MIRT2469056	hsa-miR-4279	CLIP-seq
MIRT1925109	hsa-miR-4284	CLIP-seq
MIRT2469057	hsa-miR-4430	CLIP-seq
MIRT2469058	hsa-miR-4447	CLIP-seq
MIRT2469059	hsa-miR-4465	CLIP-seq
MIRT2469060	hsa-miR-4471	CLIP-seq
MIRT2469061	hsa-miR-4472	CLIP-seq
MIRT2469062	hsa-miR-4525	CLIP-seq
MIRT2469063	hsa-miR-4665-5p	CLIP-seq
MIRT1925112	hsa-miR-4716-5p	CLIP-seq
MIRT2469064	hsa-miR-4723-5p	CLIP-seq
MIRT1925114	hsa-miR-4772-3p	CLIP-seq
MIRT2469065	hsa-miR-502-5p	CLIP-seq
MIRT2469066	hsa-miR-577	CLIP-seq
MIRT2469067	hsa-miR-625	CLIP-seq
MIRT1925121	hsa-miR-630	CLIP-seq
MIRT1925122	hsa-miR-643	CLIP-seq
MIRT2469068	hsa-miR-936	CLIP-seq
MIRT2469045	hsa-miR-1275	CLIP-seq
MIRT2469046	hsa-miR-1297	CLIP-seq
MIRT1925105	hsa-miR-24	CLIP-seq
MIRT2469049	hsa-miR-26a	CLIP-seq
MIRT2469050	hsa-miR-26b	CLIP-seq
MIRT2469053	hsa-miR-3149	CLIP-seq
MIRT2674335	hsa-miR-3152-5p	CLIP-seq
MIRT2166630	hsa-miR-4258	CLIP-seq
MIRT2469055	hsa-miR-4272	CLIP-seq
MIRT2469056	hsa-miR-4279	CLIP-seq
MIRT1925109	hsa-miR-4284	CLIP-seq
MIRT2469059	hsa-miR-4465	CLIP-seq
MIRT2469060	hsa-miR-4471	CLIP-seq
MIRT2469062	hsa-miR-4525	CLIP-seq
MIRT2469063	hsa-miR-4665-5p	CLIP-seq
MIRT2469064	hsa-miR-4723-5p	CLIP-seq
MIRT1925114	hsa-miR-4772-3p	CLIP-seq
MIRT2469065	hsa-miR-502-5p	CLIP-seq
MIRT2469067	hsa-miR-625	CLIP-seq
MIRT1925121	hsa-miR-630	CLIP-seq
MIRT1925122	hsa-miR-643	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003987	Function	Acetate-CoA ligase activity	IEA
GO:0003987	Function	Acetate-CoA ligase activity	ISS
GO:0003987	Function	Acetate-CoA ligase activity	TAS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IBA
GO:0005759	Component	Mitochondrial matrix	IDA	28003429
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0031956	Function	Medium-chain fatty acid-CoA ligase activity	IEA
GO:0031956	Function	Medium-chain fatty acid-CoA ligase activity	ISS
GO:0046951	Process	Ketone body biosynthetic process	TAS
GO:0050218	Function	Propionate-CoA ligase activity	IBA
GO:0050218	Function	Propionate-CoA ligase activity	IDA	28003429
GO:0050218	Function	Propionate-CoA ligase activity	IEA

MIM	HGNC	e!Ensembl
614356	24723	ENSG00000111058

Q9H6R3

Protein name

Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 3) (Acyl-CoA synthetase short-chain family member 3) (Propionate--CoA ligase) (EC 6.2.1.17)

Protein function

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate (PubMed:28003429). Can utilize acetate and butyrate with a much lower affinity (By similarity). {ECO:0000250|UniProtKB:A0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16177	ACAS_N	62 → 116	Acetyl-coenzyme A synthetase N-terminus	Family
PF00501	AMP-binding	117 → 562	AMP-binding enzyme	Family
PF13193	AMP-binding_C	570 → 649	AMP-binding enzyme C-terminal domain	Domain

Sequence

MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGS
EYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRH
IENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQ
AMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEE
ALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTS
GTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGN
TTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKT
LFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVP
GYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDA
GYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLA
LCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVN
GKPYKITSTIEDPSIFGHVEEMLKQA

Sequence length

686

Interactions

View interactions

	KEGG		Reactome
	Propanoate metabolism Metabolic pathways		Synthesis of Ketone Bodies

ACSS3 (acyl-CoA synthetase short chain family member 3)