Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79605
Gene name Gene Name - the full gene name approved by the HGNC.	PiggyBac transposable element derived 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PGBD5
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q42.13
Summary Summary of gene provided in NCBI Entrez Gene.	The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to

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miRTarBase ID	miRNA	Experiments	Reference
MIRT633544	hsa-miR-335-5p	HITS-CLIP	23824327
MIRT633543	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT633542	hsa-miR-5693	HITS-CLIP	23824327
MIRT633541	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT633540	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT633539	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633538	hsa-miR-3135b	HITS-CLIP	23824327
MIRT633537	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT633536	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT633535	hsa-miR-4284	HITS-CLIP	23824327
MIRT633534	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633533	hsa-miR-3652	HITS-CLIP	23824327
MIRT633532	hsa-miR-4430	HITS-CLIP	23824327
MIRT633531	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT633530	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633529	hsa-miR-5698	HITS-CLIP	23824327
MIRT633544	hsa-miR-335-5p	HITS-CLIP	23824327
MIRT633543	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT633542	hsa-miR-5693	HITS-CLIP	23824327
MIRT633541	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT633540	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT633539	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633538	hsa-miR-3135b	HITS-CLIP	23824327
MIRT633537	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT633536	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT633535	hsa-miR-4284	HITS-CLIP	23824327
MIRT633534	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633533	hsa-miR-3652	HITS-CLIP	23824327
MIRT633532	hsa-miR-4430	HITS-CLIP	23824327
MIRT633531	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT633530	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633529	hsa-miR-5698	HITS-CLIP	23824327
MIRT1227239	hsa-miR-105	CLIP-seq
MIRT1227240	hsa-miR-106a	CLIP-seq
MIRT1227241	hsa-miR-106b	CLIP-seq
MIRT1227242	hsa-miR-1287	CLIP-seq
MIRT1227243	hsa-miR-136	CLIP-seq
MIRT1227244	hsa-miR-1470	CLIP-seq
MIRT1227245	hsa-miR-17	CLIP-seq
MIRT1227246	hsa-miR-1827	CLIP-seq
MIRT1227247	hsa-miR-1915	CLIP-seq
MIRT1227248	hsa-miR-20a	CLIP-seq
MIRT1227249	hsa-miR-20b	CLIP-seq
MIRT1227250	hsa-miR-302a	CLIP-seq
MIRT1227251	hsa-miR-302b	CLIP-seq
MIRT1227252	hsa-miR-302c	CLIP-seq
MIRT1227253	hsa-miR-302d	CLIP-seq
MIRT1227254	hsa-miR-302e	CLIP-seq
MIRT1227255	hsa-miR-3120-3p	CLIP-seq
MIRT1227256	hsa-miR-3160-5p	CLIP-seq
MIRT1227257	hsa-miR-324-5p	CLIP-seq
MIRT1227258	hsa-miR-329	CLIP-seq
MIRT1227259	hsa-miR-3622b-5p	CLIP-seq
MIRT1227260	hsa-miR-362-3p	CLIP-seq
MIRT1227261	hsa-miR-3680	CLIP-seq
MIRT1227262	hsa-miR-372	CLIP-seq
MIRT1227263	hsa-miR-373	CLIP-seq
MIRT1227264	hsa-miR-3941	CLIP-seq
MIRT1227265	hsa-miR-3978	CLIP-seq
MIRT1227266	hsa-miR-4514	CLIP-seq
MIRT1227267	hsa-miR-4536	CLIP-seq
MIRT1227268	hsa-miR-4645-5p	CLIP-seq
MIRT1227269	hsa-miR-4667-3p	CLIP-seq
MIRT1227270	hsa-miR-4673	CLIP-seq
MIRT1227271	hsa-miR-4692	CLIP-seq
MIRT1227272	hsa-miR-4716-5p	CLIP-seq
MIRT1227273	hsa-miR-4720-5p	CLIP-seq
MIRT1227274	hsa-miR-4726-3p	CLIP-seq
MIRT1227275	hsa-miR-4755-3p	CLIP-seq
MIRT1227276	hsa-miR-4799-3p	CLIP-seq
MIRT1227277	hsa-miR-515-5p	CLIP-seq
MIRT1227278	hsa-miR-519d	CLIP-seq
MIRT1227279	hsa-miR-520a-3p	CLIP-seq
MIRT1227280	hsa-miR-520b	CLIP-seq
MIRT1227281	hsa-miR-520c-3p	CLIP-seq
MIRT1227282	hsa-miR-520d-3p	CLIP-seq
MIRT1227283	hsa-miR-520e	CLIP-seq
MIRT1227284	hsa-miR-520f	CLIP-seq
MIRT1227285	hsa-miR-548c-3p	CLIP-seq
MIRT1227286	hsa-miR-548n	CLIP-seq
MIRT1227287	hsa-miR-548t	CLIP-seq
MIRT1227288	hsa-miR-603	CLIP-seq
MIRT1227289	hsa-miR-609	CLIP-seq
MIRT1227290	hsa-miR-668	CLIP-seq
MIRT1227291	hsa-miR-93	CLIP-seq
MIRT2066571	hsa-miR-1264	CLIP-seq
MIRT2066572	hsa-miR-1297	CLIP-seq
MIRT1227244	hsa-miR-1470	CLIP-seq
MIRT2066573	hsa-miR-1909	CLIP-seq
MIRT1227247	hsa-miR-1915	CLIP-seq
MIRT2066574	hsa-miR-205	CLIP-seq
MIRT2066575	hsa-miR-2115	CLIP-seq
MIRT2066576	hsa-miR-26a	CLIP-seq
MIRT2066577	hsa-miR-26b	CLIP-seq
MIRT2066578	hsa-miR-3125	CLIP-seq
MIRT1227257	hsa-miR-324-5p	CLIP-seq
MIRT2066579	hsa-miR-3622a-3p	CLIP-seq
MIRT2066580	hsa-miR-3622b-3p	CLIP-seq
MIRT2066581	hsa-miR-3916	CLIP-seq
MIRT2066582	hsa-miR-3977	CLIP-seq
MIRT2066583	hsa-miR-4421	CLIP-seq
MIRT2066584	hsa-miR-4465	CLIP-seq
MIRT1227266	hsa-miR-4514	CLIP-seq
MIRT1227268	hsa-miR-4645-5p	CLIP-seq
MIRT1227269	hsa-miR-4667-3p	CLIP-seq
MIRT1227270	hsa-miR-4673	CLIP-seq
MIRT1227271	hsa-miR-4692	CLIP-seq
MIRT1227274	hsa-miR-4726-3p	CLIP-seq
MIRT2066585	hsa-miR-4793-5p	CLIP-seq
MIRT2066586	hsa-miR-516a-3p	CLIP-seq
MIRT2294123	hsa-miR-1226	CLIP-seq
MIRT2066578	hsa-miR-3125	CLIP-seq
MIRT1227258	hsa-miR-329	CLIP-seq
MIRT1227260	hsa-miR-362-3p	CLIP-seq
MIRT2066581	hsa-miR-3916	CLIP-seq
MIRT1227264	hsa-miR-3941	CLIP-seq
MIRT1227288	hsa-miR-603	CLIP-seq
MIRT1227240	hsa-miR-106a	CLIP-seq
MIRT1227241	hsa-miR-106b	CLIP-seq
MIRT1227245	hsa-miR-17	CLIP-seq
MIRT1227248	hsa-miR-20a	CLIP-seq
MIRT1227249	hsa-miR-20b	CLIP-seq
MIRT2392442	hsa-miR-3153	CLIP-seq
MIRT2392443	hsa-miR-371b-3p	CLIP-seq
MIRT1227278	hsa-miR-519d	CLIP-seq
MIRT1227291	hsa-miR-93	CLIP-seq
MIRT2066571	hsa-miR-1264	CLIP-seq
MIRT2066572	hsa-miR-1297	CLIP-seq
MIRT2066576	hsa-miR-26a	CLIP-seq
MIRT2066577	hsa-miR-26b	CLIP-seq
MIRT2456286	hsa-miR-3545-3p	CLIP-seq
MIRT2066584	hsa-miR-4465	CLIP-seq
MIRT2456287	hsa-miR-4635	CLIP-seq
MIRT2066571	hsa-miR-1264	CLIP-seq
MIRT2066572	hsa-miR-1297	CLIP-seq
MIRT2066576	hsa-miR-26a	CLIP-seq
MIRT2066577	hsa-miR-26b	CLIP-seq
MIRT2456286	hsa-miR-3545-3p	CLIP-seq
MIRT2066584	hsa-miR-4465	CLIP-seq
MIRT2456287	hsa-miR-4635	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004519	Function	Endonuclease activity	IEA
GO:0004803	Function	Transposase activity	IBA	21873635
GO:0004803	Function	Transposase activity	IDA	26406119
GO:0004803	Function	Transposase activity	IMP	27491780
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0090305	Process	Nucleic acid phosphodiester bond hydrolysis	IEA
GO:0098038	Process	Non-replicative transposition, DNA-mediated	IBA	21873635
GO:0098038	Process	Non-replicative transposition, DNA-mediated	IMP	26406119

MIM	HGNC	e!Ensembl
616791	19405	ENSG00000177614

Protein

UniProt ID

Q8N414

Protein name

PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5)

Protein function

Transposase that mediates sequence-specific genomic rearrangements (PubMed:26406119, PubMed:28504702). Can induce genomic rearrangements that inactivate the HPRT1 gene (PubMed:27491780). {ECO:0000269|PubMed:26406119, ECO:0000269|PubMed:27491780,

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13843	DDE_Tnp_1_7	121 → 487	Transposase IS4	Domain

Sequence

MAEGGGGARRRAPALLEAARARYESLHISDDVFGESGPDSGGNPFYSTSAASRSSSAASS
DDEREPPGPPGAAPPPPRAPDAQEPEEDEAGAGWSAALRDRPPPRFEDTGGPTRKMPPSA
SAVDFFQLFVPDNVLKNMVVQTNMYAKKFQERFGSDGAWVEVTLTEMKAFLGYMISTSIS
HCESVLSIWSGGFYSNRSLALVMSQARFEKILKYFHVVAFRSSQTTHGLYKVQPFLDSLQ
NSFDSAFRPSQTQVLHEPLIDEDPVFIATCTERELRKRKKRKFSLWVRQCSSTGFIIQIY
VHLKEGGGPDGLDALKNKPQLHSMVARSLCRNAAGKNYIIFTGPSITSLTLFEEFEKQGI
YCCGLLRARKSDCTGLPLSMLTNPATPPARGQYQIKMKGNMSLICWYNKGHFRFLTNAYS
PVQQGVIIKRKSGEIPCPLAVEAFAAHLSYICRYDDKYSKYFISHKPNKTWQQVFWFAIS
IAINNAYILYKMSDAYHVKRYSRAQFGERLVRELLGLEDASPTH

Sequence length

524

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Metabolic Syndrome	Metabolic Syndrome		GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.	GWAS, CBGDA

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Thyroid Cancer Papillary	Associate	36211409

PGBD5 (piggyBac transposable element derived 5)