Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79603
Gene name Gene Name - the full gene name approved by the HGNC.	Ceramide synthase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CERS4
Synonyms (NCBI Gene) Gene synonyms aliases	LASS4, Trh1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.2

Show/Hide all(186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021339	hsa-miR-9-5p	Microarray	17612493
MIRT712701	hsa-miR-512-3p	HITS-CLIP	19536157
MIRT712700	hsa-miR-4501	HITS-CLIP	19536157
MIRT712699	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT712698	hsa-miR-1909-5p	HITS-CLIP	19536157
MIRT712697	hsa-miR-1537-5p	HITS-CLIP	19536157
MIRT712696	hsa-miR-4718	HITS-CLIP	19536157
MIRT712695	hsa-miR-4999-5p	HITS-CLIP	19536157
MIRT712694	hsa-miR-630	HITS-CLIP	19536157
MIRT712693	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT708419	hsa-miR-660-5p	HITS-CLIP	19536157
MIRT708418	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT708417	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT708416	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT708415	hsa-miR-6879-3p	HITS-CLIP	19536157
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23313552
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23313552
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT661273	hsa-miR-1273f	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT642543	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT642542	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT642541	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT642540	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT642535	hsa-miR-134-5p	HITS-CLIP	23824327
MIRT642534	hsa-miR-3118	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT642532	hsa-miR-498	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT617213	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617211	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT494883	hsa-miR-362-5p	PAR-CLIP	23708386
MIRT494882	hsa-miR-500b-5p	PAR-CLIP	23708386
MIRT494881	hsa-miR-6841-3p	PAR-CLIP	23708386
MIRT494880	hsa-miR-1915-5p	PAR-CLIP	23708386
MIRT494879	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT494878	hsa-miR-502-5p	PAR-CLIP	23708386
MIRT494877	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT494876	hsa-miR-3692-3p	PAR-CLIP	23708386
MIRT661273	hsa-miR-1273f	HITS-CLIP	27418678
MIRT617209	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT642531	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT642530	hsa-miR-4770	HITS-CLIP	27418678
MIRT642529	hsa-miR-6088	HITS-CLIP	27418678
MIRT617210	hsa-miR-8055	HITS-CLIP	27418678
MIRT712701	hsa-miR-512-3p	HITS-CLIP	19536157
MIRT712700	hsa-miR-4501	HITS-CLIP	19536157
MIRT712699	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT712698	hsa-miR-1909-5p	HITS-CLIP	19536157
MIRT712697	hsa-miR-1537-5p	HITS-CLIP	19536157
MIRT712696	hsa-miR-4718	HITS-CLIP	19536157
MIRT712695	hsa-miR-4999-5p	HITS-CLIP	19536157
MIRT712694	hsa-miR-630	HITS-CLIP	19536157
MIRT712693	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT708419	hsa-miR-660-5p	HITS-CLIP	19536157
MIRT708418	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT708417	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT708416	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT708415	hsa-miR-6879-3p	HITS-CLIP	19536157
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23313552
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23313552
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT661273	hsa-miR-1273f	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT642543	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT642542	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT642541	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT642540	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT642535	hsa-miR-134-5p	HITS-CLIP	23824327
MIRT642534	hsa-miR-3118	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT642532	hsa-miR-498	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT617213	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617211	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT494883	hsa-miR-362-5p	PAR-CLIP	23708386
MIRT494882	hsa-miR-500b-5p	PAR-CLIP	23708386
MIRT494881	hsa-miR-6841-3p	PAR-CLIP	23708386
MIRT494880	hsa-miR-1915-5p	PAR-CLIP	23708386
MIRT494879	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT494878	hsa-miR-502-5p	PAR-CLIP	23708386
MIRT494877	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT494876	hsa-miR-3692-3p	PAR-CLIP	23708386
MIRT2465082	hsa-miR-1972	CLIP-seq
MIRT2465083	hsa-miR-361-3p	CLIP-seq
MIRT2465084	hsa-miR-3943	CLIP-seq
MIRT2465085	hsa-miR-4283	CLIP-seq
MIRT2465086	hsa-miR-4489	CLIP-seq
MIRT2465087	hsa-miR-4717-5p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:0016410	Function	N-acyltransferase activity	IBA	21873635
GO:0030148	Process	Sphingolipid biosynthetic process	TAS
GO:0046513	Process	Ceramide biosynthetic process	IBA	21873635
GO:0046513	Process	Ceramide biosynthetic process	IDA	17977534, 29632068
GO:0050291	Function	Sphingosine N-acyltransferase activity	IBA	21873635
GO:0050291	Function	Sphingosine N-acyltransferase activity	IDA	17977534, 29632068

MIM	HGNC	e!Ensembl
615334	23747	ENSG00000090661

Protein

UniProt ID

Q9HA82

Protein name

Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24)

Protein function

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	71 → 127	Homeodomain	Domain
PF03798	TRAM_LAG1_CLN8	132 → 325	TLC domain	Domain

Sequence

MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI
GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR
RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY
WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD
SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF
GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL
QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT

Sequence length

394

Interactions

View interactions

	KEGG		Reactome
	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway		Sphingolipid de novo biosynthesis

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	29545352

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Gout	Gout	GWAS
Alzheimer disease	Alzheimer disease	GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute erythroleukemia	Stimulate	37885013
Breast Neoplasms	Stimulate	37885013
Carcinoma Non Small Cell Lung	Associate	37453674
Cardiovascular Diseases	Associate	37298446
Colorectal Neoplasms	Associate	37728516, 37758931
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	37728516
Coronary Artery Disease	Associate	37298446
Endometrial Neoplasms	Associate	37728516
Heart Valve Diseases	Associate	37298446
Machado Joseph Disease	Associate	34871736
Neoplasm Invasiveness	Associate	37758931
Neoplasms	Associate	37885013

CERS4 (ceramide synthase 4)