CALCA (calcitonin related polypeptide alpha)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 796
Gene name Calcitonin related polypeptide alpha
Gene symbol CALCA
Synonyms (NCBI Gene)
CALC1CGRPCGRP-ICGRP-alphaCGRP1CTKCPCT
Chromosome 11
Chromosome location 11p15.2
Summary This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation
miRNA miRNA information provided by mirtarbase database.
13
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (13)
miRTarBase ID miRNA Experiments Reference
MIRT858811 hsa-miR-1297 CLIP-seq
MIRT858812 hsa-miR-26a CLIP-seq
MIRT858813 hsa-miR-26b CLIP-seq
MIRT858814 hsa-miR-409-5p CLIP-seq
MIRT858815 hsa-miR-4465 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
71
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (71)
GO ID Ontology Definition Evidence Reference
GO:0001878 Process Response to yeast IDA 18603306
GO:0001935 Process Endothelial cell proliferation IDA 17267696
GO:0001944 Process Vasculature development IDA 17267696
GO:0001976 Process Nervous system process involved in regulation of systemic arterial blood pressure IDA 10642343
GO:0002031 Process G protein-coupled receptor internalization IDA 10882736
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
114130 1437 ENSG00000110680
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01258
Protein name Calcitonin [Cleaved into: Calcitonin (CT); Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)]
Protein function [Calcitonin]: Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin re
PDB 2JXZ , 7TYH , 7TYO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP 1 → 121 Calcitonin / CGRP / IAPP family Family
Sequence
Sequence length 141
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P06881
Protein name Calcitonin gene-related peptide 1 (CGRP1) (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
Protein function CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. I
PDB 6E3Y , 7KNU , 9AUC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP 1 → 124 Calcitonin / CGRP / IAPP family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in spinal cord. {ECO:0000269|PubMed:3492492}.
Sequence
Sequence length 128
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling
Vascular smooth muscle contraction 		  G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Amyloid fiber formation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Calcitonin polymorphism Benign rs2494521104 RCV000019204
Show/Hide Text Mining Associations (226)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Pain Associate 37126606
Acro Osteolysis Associate 27141814
Acute Kidney Injury Associate 36385130
Adenomyosis Associate 33602248
amyloidosis IX Associate 19445625
Angina Pectoris Variant Associate 40442685
Anxiety Associate 37676055
Aortic Stenosis Supravalvular Associate 3164411
Arthralgia Associate 27751171
Arthritis Associate 25578529