GCC1 (GRIP and coiled-coil domain containing 1)

Gene

• Entrez ID: 79571
• Gene name: GRIP and coiled-coil domain containing 1
• Gene symbol: GCC1
• Synonyms (NCBI Gene): GCC1P, GCC88
• Chromosome: 7
• Chromosome location: 7q32.1
• Summary: The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompa

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025007	hsa-miR-183-5p	Sequencing	20371350
MIRT027226	hsa-miR-103a-3p	Sequencing	20371350
MIRT031853	hsa-miR-16-5p	Sequencing	20371350
MIRT657923	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT657922	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT657921	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT657920	hsa-miR-3158-5p	HITS-CLIP	23824327
MIRT657919	hsa-miR-1184	HITS-CLIP	23824327
MIRT657918	hsa-miR-1205	HITS-CLIP	23824327
MIRT657917	hsa-miR-17-3p	HITS-CLIP	23824327
MIRT027226	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT657916	hsa-miR-107	HITS-CLIP	23824327
MIRT657915	hsa-miR-626	HITS-CLIP	23824327
MIRT657914	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT657913	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT657912	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT220298	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT657911	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT657910	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT567464	hsa-miR-583	PAR-CLIP	20371350
MIRT567463	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567462	hsa-miR-665	PAR-CLIP	20371350
MIRT567461	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT567460	hsa-miR-1260a	PAR-CLIP	20371350
MIRT567459	hsa-miR-1260b	PAR-CLIP	20371350
MIRT567458	hsa-miR-3156-3p	PAR-CLIP	20371350
MIRT657923	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT657922	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT657921	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT657920	hsa-miR-3158-5p	HITS-CLIP	23824327
MIRT657919	hsa-miR-1184	HITS-CLIP	23824327
MIRT657918	hsa-miR-1205	HITS-CLIP	23824327
MIRT657917	hsa-miR-17-3p	HITS-CLIP	23824327
MIRT027226	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT657916	hsa-miR-107	HITS-CLIP	23824327
MIRT657915	hsa-miR-626	HITS-CLIP	23824327
MIRT657914	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT657913	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT657912	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT220298	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT657911	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT657910	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT567464	hsa-miR-583	PAR-CLIP	20371350
MIRT567463	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567462	hsa-miR-665	PAR-CLIP	20371350
MIRT567461	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT567460	hsa-miR-1260a	PAR-CLIP	20371350
MIRT567459	hsa-miR-1260b	PAR-CLIP	20371350
MIRT567458	hsa-miR-3156-3p	PAR-CLIP	20371350
MIRT1014282	hsa-miR-103a	CLIP-seq
MIRT1014283	hsa-miR-1251	CLIP-seq
MIRT1014284	hsa-miR-1252	CLIP-seq
MIRT1014285	hsa-miR-1256	CLIP-seq
MIRT1014286	hsa-miR-1296	CLIP-seq
MIRT1014287	hsa-miR-15a	CLIP-seq
MIRT1014288	hsa-miR-15b	CLIP-seq
MIRT1014289	hsa-miR-16	CLIP-seq
MIRT1014290	hsa-miR-186	CLIP-seq
MIRT1014291	hsa-miR-1913	CLIP-seq
MIRT1014292	hsa-miR-195	CLIP-seq
MIRT1014293	hsa-miR-3133	CLIP-seq
MIRT1014294	hsa-miR-3189-5p	CLIP-seq
MIRT1014295	hsa-miR-324-3p	CLIP-seq
MIRT1014296	hsa-miR-3675-3p	CLIP-seq
MIRT1014297	hsa-miR-3915	CLIP-seq
MIRT1014298	hsa-miR-3928	CLIP-seq
MIRT1014299	hsa-miR-424	CLIP-seq
MIRT1014300	hsa-miR-4310	CLIP-seq
MIRT1014301	hsa-miR-4422	CLIP-seq
MIRT1014302	hsa-miR-4512	CLIP-seq
MIRT1014303	hsa-miR-4521	CLIP-seq
MIRT1014304	hsa-miR-4662a-3p	CLIP-seq
MIRT1014305	hsa-miR-4682	CLIP-seq
MIRT1014306	hsa-miR-4726-3p	CLIP-seq
MIRT1014307	hsa-miR-4738-3p	CLIP-seq
MIRT1014308	hsa-miR-4758-3p	CLIP-seq
MIRT1014309	hsa-miR-497	CLIP-seq
MIRT1014310	hsa-miR-548p	CLIP-seq
MIRT1014284	hsa-miR-1252	CLIP-seq
MIRT1549177	hsa-miR-1285	CLIP-seq
MIRT1014290	hsa-miR-186	CLIP-seq
MIRT1014293	hsa-miR-3133	CLIP-seq
MIRT1549178	hsa-miR-3187-5p	CLIP-seq
MIRT1014307	hsa-miR-4738-3p	CLIP-seq
MIRT1549179	hsa-miR-612	CLIP-seq
MIRT1549177	hsa-miR-1285	CLIP-seq
MIRT2000388	hsa-miR-132	CLIP-seq
MIRT2000389	hsa-miR-145	CLIP-seq
MIRT2000390	hsa-miR-194	CLIP-seq
MIRT2000391	hsa-miR-212	CLIP-seq
MIRT2000392	hsa-miR-2355-5p	CLIP-seq
MIRT1549178	hsa-miR-3187-5p	CLIP-seq
MIRT2000393	hsa-miR-3677-5p	CLIP-seq
MIRT2000394	hsa-miR-3926	CLIP-seq
MIRT2000395	hsa-miR-4269	CLIP-seq
MIRT2000396	hsa-miR-4460	CLIP-seq
MIRT2000397	hsa-miR-4645-5p	CLIP-seq
MIRT2000398	hsa-miR-4673	CLIP-seq
MIRT2000399	hsa-miR-4727-3p	CLIP-seq
MIRT2000400	hsa-miR-548s	CLIP-seq
MIRT1549179	hsa-miR-612	CLIP-seq
MIRT2000401	hsa-miR-802	CLIP-seq
MIRT1014282	hsa-miR-103a	CLIP-seq
MIRT2233867	hsa-miR-1178	CLIP-seq
MIRT2233868	hsa-miR-1183	CLIP-seq
MIRT2233869	hsa-miR-1193	CLIP-seq
MIRT2233870	hsa-miR-1208	CLIP-seq
MIRT1014283	hsa-miR-1251	CLIP-seq
MIRT1014285	hsa-miR-1256	CLIP-seq
MIRT2233871	hsa-miR-1260	CLIP-seq
MIRT2233872	hsa-miR-1264	CLIP-seq
MIRT2233873	hsa-miR-1265	CLIP-seq
MIRT2233874	hsa-miR-128	CLIP-seq
MIRT1549177	hsa-miR-1285	CLIP-seq
MIRT2233875	hsa-miR-129-3p	CLIP-seq
MIRT2233876	hsa-miR-1302	CLIP-seq
MIRT2000392	hsa-miR-2355-5p	CLIP-seq
MIRT2233877	hsa-miR-2392	CLIP-seq
MIRT2233878	hsa-miR-3122	CLIP-seq
MIRT2233879	hsa-miR-3180-5p	CLIP-seq
MIRT2233880	hsa-miR-3183	CLIP-seq
MIRT2233881	hsa-miR-3185	CLIP-seq
MIRT1549178	hsa-miR-3187-5p	CLIP-seq
MIRT2233882	hsa-miR-3189-3p	CLIP-seq
MIRT2233883	hsa-miR-3199	CLIP-seq
MIRT2233884	hsa-miR-3646	CLIP-seq
MIRT2233885	hsa-miR-3680	CLIP-seq
MIRT2233886	hsa-miR-3681	CLIP-seq
MIRT2233887	hsa-miR-3913-5p	CLIP-seq
MIRT2233888	hsa-miR-3935	CLIP-seq
MIRT2233889	hsa-miR-4298	CLIP-seq
MIRT2233890	hsa-miR-4494	CLIP-seq
MIRT2233891	hsa-miR-4520b-3p	CLIP-seq
MIRT2233892	hsa-miR-4529-3p	CLIP-seq
MIRT2000397	hsa-miR-4645-5p	CLIP-seq
MIRT2000398	hsa-miR-4673	CLIP-seq
MIRT2233893	hsa-miR-4687-5p	CLIP-seq
MIRT2233894	hsa-miR-4723-3p	CLIP-seq
MIRT2233895	hsa-miR-4742-5p	CLIP-seq
MIRT2233896	hsa-miR-4776-5p	CLIP-seq
MIRT2233897	hsa-miR-520a-5p	CLIP-seq
MIRT2233898	hsa-miR-525-5p	CLIP-seq
MIRT2233899	hsa-miR-544	CLIP-seq
MIRT2233900	hsa-miR-577	CLIP-seq
MIRT1549179	hsa-miR-612	CLIP-seq
MIRT2233901	hsa-miR-668	CLIP-seq
MIRT2233902	hsa-miR-767-3p	CLIP-seq
MIRT2537814	hsa-miR-1266	CLIP-seq
MIRT2537815	hsa-miR-154	CLIP-seq
MIRT2537816	hsa-miR-1972	CLIP-seq
MIRT2537817	hsa-miR-216a	CLIP-seq
MIRT2537818	hsa-miR-3664-3p	CLIP-seq
MIRT2000395	hsa-miR-4269	CLIP-seq
MIRT2537819	hsa-miR-4514	CLIP-seq
MIRT2537820	hsa-miR-4518	CLIP-seq
MIRT2537821	hsa-miR-4650-5p	CLIP-seq
MIRT2537822	hsa-miR-4692	CLIP-seq
MIRT2233895	hsa-miR-4742-5p	CLIP-seq
MIRT2537814	hsa-miR-1266	CLIP-seq
MIRT2537815	hsa-miR-154	CLIP-seq
MIRT2537816	hsa-miR-1972	CLIP-seq
MIRT2537817	hsa-miR-216a	CLIP-seq
MIRT2537818	hsa-miR-3664-3p	CLIP-seq
MIRT2000395	hsa-miR-4269	CLIP-seq
MIRT2537819	hsa-miR-4514	CLIP-seq
MIRT2537820	hsa-miR-4518	CLIP-seq
MIRT2537821	hsa-miR-4650-5p	CLIP-seq
MIRT2537822	hsa-miR-4692	CLIP-seq
MIRT2233895	hsa-miR-4742-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000138	Component	Golgi trans cisterna	ISS
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 21516116, 25416956, 29892012, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016020	Component	Membrane	IEA
GO:0031267	Function	Small GTPase binding	ISS

Other IDs

• MIM: 607418
• HGNC: 19095
• e!Ensembl: ENSG00000179562

Protein

• UniProt ID: Q96CN9
• Protein name: GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1)
• Protein function: Probably involved in maintaining Golgi structure.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01465	GRIP	717 → 760	GRIP domain	Family

• Sequence:

  MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLS
  VSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDR
  PARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKS
  RMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQ
  SDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVE
  ELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEE
  QRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS
  HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALY
  YQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEE
  LEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKD
  LELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQL
  ARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANL
  EYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR

• Sequence length: 775

Pathways

Reactome:

Retrograde transport at the Trans-Golgi-Network