LST1 (leukocyte specific transcript 1)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7940
Gene name Gene Name - the full gene name approved by the HGNC.
Leukocyte specific transcript 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LST1
Synonyms (NCBI Gene) Gene synonyms aliases
B144, D6S49E, LST-1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms ha
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(19)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000902 Process Cell morphogenesis IEA
GO:0002376 Process Immune system process IEA
GO:0005737 Component Cytoplasm IDA 11478849
GO:0005794 Component Golgi apparatus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
109170 14189 ENSG00000204482
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID O00453
Protein name Leukocyte-specific transcript 1 protein (Protein B144)
Protein function Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05083 LST1 16 → 96 LST-1 protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain. {ECO:0000269|PubMed:7590964, ECO:0000269|PubMed:9367684}.
Sequence
Sequence length 97
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus N/A N/A GWAS
Show/Hide Text Mining Associations (6)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Autoimmune Diseases Associate 2477242
Breast Neoplasms Associate 30872752
COVID 19 Associate 35656698
Rubella Associate 20668555
Rupture Associate 36187340
Triple Negative Breast Neoplasms Associate 30872752