Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	794
Gene name	Calbindin 2
Gene symbol	CALB2
Synonyms (NCBI Gene)	CAB29CAL2CR
Chromosome	16
Chromosome location	16q22.2
Summary	This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targ

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018745	hsa-miR-335-5p	Microarray	18185580
MIRT858748	hsa-miR-1231	CLIP-seq
MIRT858749	hsa-miR-1267	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT858751	hsa-miR-1293	CLIP-seq
MIRT858752	hsa-miR-2467-3p	CLIP-seq
MIRT858753	hsa-miR-298	CLIP-seq
MIRT858754	hsa-miR-30a	CLIP-seq
MIRT858755	hsa-miR-30b	CLIP-seq
MIRT858756	hsa-miR-30c	CLIP-seq
MIRT858757	hsa-miR-30d	CLIP-seq
MIRT858758	hsa-miR-30e	CLIP-seq
MIRT858759	hsa-miR-3123	CLIP-seq
MIRT858760	hsa-miR-3127-5p	CLIP-seq
MIRT858761	hsa-miR-3132	CLIP-seq
MIRT858762	hsa-miR-3144-5p	CLIP-seq
MIRT858763	hsa-miR-3162-5p	CLIP-seq
MIRT858764	hsa-miR-3170	CLIP-seq
MIRT858765	hsa-miR-342-5p	CLIP-seq
MIRT858766	hsa-miR-3529	CLIP-seq
MIRT858767	hsa-miR-3607-3p	CLIP-seq
MIRT858768	hsa-miR-3622b-5p	CLIP-seq
MIRT858769	hsa-miR-3664-5p	CLIP-seq
MIRT858770	hsa-miR-3670	CLIP-seq
MIRT858771	hsa-miR-3686	CLIP-seq
MIRT858772	hsa-miR-376c	CLIP-seq
MIRT858773	hsa-miR-379	CLIP-seq
MIRT858774	hsa-miR-3918	CLIP-seq
MIRT858775	hsa-miR-3921	CLIP-seq
MIRT858776	hsa-miR-4260	CLIP-seq
MIRT858777	hsa-miR-4288	CLIP-seq
MIRT858778	hsa-miR-4300	CLIP-seq
MIRT858779	hsa-miR-4313	CLIP-seq
MIRT858780	hsa-miR-4419a	CLIP-seq
MIRT858781	hsa-miR-4436b-3p	CLIP-seq
MIRT858782	hsa-miR-4483	CLIP-seq
MIRT858783	hsa-miR-4510	CLIP-seq
MIRT858784	hsa-miR-4520a-3p	CLIP-seq
MIRT858785	hsa-miR-4520b-3p	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858787	hsa-miR-4651	CLIP-seq
MIRT858788	hsa-miR-4653-5p	CLIP-seq
MIRT858789	hsa-miR-4664-5p	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858791	hsa-miR-4682	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858793	hsa-miR-4716-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858795	hsa-miR-4778-3p	CLIP-seq
MIRT858796	hsa-miR-485-3p	CLIP-seq
MIRT858797	hsa-miR-487a	CLIP-seq
MIRT858798	hsa-miR-490-3p	CLIP-seq
MIRT858799	hsa-miR-587	CLIP-seq
MIRT858800	hsa-miR-593	CLIP-seq
MIRT858801	hsa-miR-608	CLIP-seq
MIRT858802	hsa-miR-619	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858804	hsa-miR-627	CLIP-seq
MIRT858805	hsa-miR-632	CLIP-seq
MIRT858806	hsa-miR-9	CLIP-seq
MIRT858807	hsa-miR-920	CLIP-seq
MIRT858808	hsa-miR-922	CLIP-seq
MIRT858809	hsa-miR-924	CLIP-seq
MIRT858810	hsa-miR-939	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT858753	hsa-miR-298	CLIP-seq
MIRT858754	hsa-miR-30a	CLIP-seq
MIRT858755	hsa-miR-30b	CLIP-seq
MIRT858756	hsa-miR-30c	CLIP-seq
MIRT858757	hsa-miR-30d	CLIP-seq
MIRT858758	hsa-miR-30e	CLIP-seq
MIRT858759	hsa-miR-3123	CLIP-seq
MIRT858760	hsa-miR-3127-5p	CLIP-seq
MIRT858763	hsa-miR-3162-5p	CLIP-seq
MIRT1954962	hsa-miR-3689d	CLIP-seq
MIRT858774	hsa-miR-3918	CLIP-seq
MIRT858779	hsa-miR-4313	CLIP-seq
MIRT858781	hsa-miR-4436b-3p	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858793	hsa-miR-4716-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858808	hsa-miR-922	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT2192584	hsa-miR-22	CLIP-seq
MIRT858776	hsa-miR-4260	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858787	hsa-miR-4651	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858801	hsa-miR-608	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858770	hsa-miR-3670	CLIP-seq
MIRT858778	hsa-miR-4300	CLIP-seq
MIRT858780	hsa-miR-4419a	CLIP-seq
MIRT858783	hsa-miR-4510	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858807	hsa-miR-920	CLIP-seq

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GO ID	Ontology	Definition	Evidence
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005921	Component	Gap junction	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	ISS
GO:0030425	Component	Dendrite	IBA
GO:0030425	Component	Dendrite	IEA
GO:0032420	Component	Stereocilium	IEA
GO:0032437	Component	Cuticular plate	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043195	Component	Terminal bouton	IBA
GO:0044293	Component	Dendriole	IEA
GO:0044293	Component	Dendriole	ISS
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048167	Process	Regulation of synaptic plasticity	IEA
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	ISS
GO:0099509	Process	Regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:0099534	Function	Calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:0099534	Function	Calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	ISS
GO:0099536	Process	Synaptic signaling	IEA
GO:0099536	Process	Synaptic signaling	ISS

MIM	HGNC	e!Ensembl
114051	1435	ENSG00000172137

P22676

Protein name

Calretinin (CR) (29 kDa calbindin)

Protein function

Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways (PubMed:2001709). Predominantly expressed in

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13499	EF-hand_7	18 → 92	EF-hand domain pair	Domain
PF13499	EF-hand_7	109 → 180	EF-hand domain pair	Domain
PF13202	EF-hand_5	157 → 180	EF hand	Domain
PF13405	EF-hand_6	199 → 234	EF-hand domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Brain.

Sequence

MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
SDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYD
TDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLL
PVQENFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEMNIQQL
TNYRKSVMSLAEAGKLYRKDLEIVLCSEPPM

Sequence length

271

Interactions

View interactions

CALB2 (calbindin 2)