Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	794
Gene name Gene Name - the full gene name approved by the HGNC.	Calbindin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CALB2
Synonyms (NCBI Gene) Gene synonyms aliases	CAB29, CAL2, CR
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targ

Show/Hide all(100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018745	hsa-miR-335-5p	Microarray	18185580
MIRT858748	hsa-miR-1231	CLIP-seq
MIRT858749	hsa-miR-1267	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT858751	hsa-miR-1293	CLIP-seq
MIRT858752	hsa-miR-2467-3p	CLIP-seq
MIRT858753	hsa-miR-298	CLIP-seq
MIRT858754	hsa-miR-30a	CLIP-seq
MIRT858755	hsa-miR-30b	CLIP-seq
MIRT858756	hsa-miR-30c	CLIP-seq
MIRT858757	hsa-miR-30d	CLIP-seq
MIRT858758	hsa-miR-30e	CLIP-seq
MIRT858759	hsa-miR-3123	CLIP-seq
MIRT858760	hsa-miR-3127-5p	CLIP-seq
MIRT858761	hsa-miR-3132	CLIP-seq
MIRT858762	hsa-miR-3144-5p	CLIP-seq
MIRT858763	hsa-miR-3162-5p	CLIP-seq
MIRT858764	hsa-miR-3170	CLIP-seq
MIRT858765	hsa-miR-342-5p	CLIP-seq
MIRT858766	hsa-miR-3529	CLIP-seq
MIRT858767	hsa-miR-3607-3p	CLIP-seq
MIRT858768	hsa-miR-3622b-5p	CLIP-seq
MIRT858769	hsa-miR-3664-5p	CLIP-seq
MIRT858770	hsa-miR-3670	CLIP-seq
MIRT858771	hsa-miR-3686	CLIP-seq
MIRT858772	hsa-miR-376c	CLIP-seq
MIRT858773	hsa-miR-379	CLIP-seq
MIRT858774	hsa-miR-3918	CLIP-seq
MIRT858775	hsa-miR-3921	CLIP-seq
MIRT858776	hsa-miR-4260	CLIP-seq
MIRT858777	hsa-miR-4288	CLIP-seq
MIRT858778	hsa-miR-4300	CLIP-seq
MIRT858779	hsa-miR-4313	CLIP-seq
MIRT858780	hsa-miR-4419a	CLIP-seq
MIRT858781	hsa-miR-4436b-3p	CLIP-seq
MIRT858782	hsa-miR-4483	CLIP-seq
MIRT858783	hsa-miR-4510	CLIP-seq
MIRT858784	hsa-miR-4520a-3p	CLIP-seq
MIRT858785	hsa-miR-4520b-3p	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858787	hsa-miR-4651	CLIP-seq
MIRT858788	hsa-miR-4653-5p	CLIP-seq
MIRT858789	hsa-miR-4664-5p	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858791	hsa-miR-4682	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858793	hsa-miR-4716-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858795	hsa-miR-4778-3p	CLIP-seq
MIRT858796	hsa-miR-485-3p	CLIP-seq
MIRT858797	hsa-miR-487a	CLIP-seq
MIRT858798	hsa-miR-490-3p	CLIP-seq
MIRT858799	hsa-miR-587	CLIP-seq
MIRT858800	hsa-miR-593	CLIP-seq
MIRT858801	hsa-miR-608	CLIP-seq
MIRT858802	hsa-miR-619	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858804	hsa-miR-627	CLIP-seq
MIRT858805	hsa-miR-632	CLIP-seq
MIRT858806	hsa-miR-9	CLIP-seq
MIRT858807	hsa-miR-920	CLIP-seq
MIRT858808	hsa-miR-922	CLIP-seq
MIRT858809	hsa-miR-924	CLIP-seq
MIRT858810	hsa-miR-939	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT858753	hsa-miR-298	CLIP-seq
MIRT858754	hsa-miR-30a	CLIP-seq
MIRT858755	hsa-miR-30b	CLIP-seq
MIRT858756	hsa-miR-30c	CLIP-seq
MIRT858757	hsa-miR-30d	CLIP-seq
MIRT858758	hsa-miR-30e	CLIP-seq
MIRT858759	hsa-miR-3123	CLIP-seq
MIRT858760	hsa-miR-3127-5p	CLIP-seq
MIRT858763	hsa-miR-3162-5p	CLIP-seq
MIRT1954962	hsa-miR-3689d	CLIP-seq
MIRT858774	hsa-miR-3918	CLIP-seq
MIRT858779	hsa-miR-4313	CLIP-seq
MIRT858781	hsa-miR-4436b-3p	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858793	hsa-miR-4716-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858808	hsa-miR-922	CLIP-seq
MIRT858750	hsa-miR-1275	CLIP-seq
MIRT2192584	hsa-miR-22	CLIP-seq
MIRT858776	hsa-miR-4260	CLIP-seq
MIRT858786	hsa-miR-4525	CLIP-seq
MIRT858787	hsa-miR-4651	CLIP-seq
MIRT858790	hsa-miR-4665-5p	CLIP-seq
MIRT858794	hsa-miR-4723-5p	CLIP-seq
MIRT858801	hsa-miR-608	CLIP-seq
MIRT858803	hsa-miR-625	CLIP-seq
MIRT858770	hsa-miR-3670	CLIP-seq
MIRT858778	hsa-miR-4300	CLIP-seq
MIRT858780	hsa-miR-4419a	CLIP-seq
MIRT858783	hsa-miR-4510	CLIP-seq
MIRT858792	hsa-miR-4711-5p	CLIP-seq
MIRT858807	hsa-miR-920	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005921	Component	Gap junction	IEA
GO:0030425	Component	Dendrite	IBA	21873635
GO:0032420	Component	Stereocilium	IEA
GO:0032437	Component	Cuticular plate	IEA
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043195	Component	Terminal bouton	IBA	21873635
GO:0045202	Component	Synapse	IBA	21873635
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0097060	Component	Synaptic membrane	IEA
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0099509	Process	Regulation of presynaptic cytosolic calcium ion concentration	IBA	21873635
GO:0099534	Function	Calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:1900271	Process	Regulation of long-term synaptic potentiation	IBA	21873635

MIM	HGNC	e!Ensembl
114051	1435	ENSG00000172137

Protein

UniProt ID

P22676

Protein name

Calretinin (CR) (29 kDa calbindin)

Protein function

Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways (PubMed:2001709). Predominantly expressed in

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13499	EF-hand_7	18 → 92	EF-hand domain pair	Domain
PF13499	EF-hand_7	109 → 180	EF-hand domain pair	Domain
PF13202	EF-hand_5	157 → 180	EF hand	Domain
PF13405	EF-hand_6	199 → 234	EF-hand domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Brain.

Sequence

MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
SDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYD
TDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLL
PVQENFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEMNIQQL
TNYRKSVMSLAEAGKLYRKDLEIVLCSEPPM

Sequence length

271

Interactions

View interactions

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, Familial	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733 View all (171 more)	11796754
Lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic	rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048	11796754
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	26198764

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Bipolar Disorder	Bipolar Disorder	GWAS
Neuroticism	Neuroticism	GWAS

Show/Hide Text Mining Associations (69)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	15736446
Adenocarcinoma Mucinous	Associate	27062033
Adenocarcinoma of Lung	Associate	29327712
Adenomatoid Tumor	Associate	19543245
Alzheimer Disease	Associate	24028428
Atrial Fibrillation	Associate	29940585
Azoospermia	Associate	38193226
Breast Neoplasms	Associate	24322014
Carcinogenesis	Associate	18214032, 19435792, 31671889
Carcinoma	Associate	24262018
Carcinoma	Stimulate	33432559
Carcinoma Basal Cell	Associate	24262018
Carcinoma Ductal Breast	Associate	24262018
Carcinoma Medullary	Associate	24437456
Carcinoma Pancreatic Ductal	Associate	33432559, 35963640
Carcinoma Papillary	Associate	29785016
Carcinoma Renal Cell	Associate	12610103, 17361207
Carcinoma Renal Cell	Inhibit	35417384
Carcinoma Squamous Cell	Associate	16415794
Cognition Disorders	Associate	30549027
Colitis Ulcerative	Associate	33600772
Colonic Neoplasms	Associate	18214032, 8898855
Colorectal Neoplasms	Associate	18214032, 21629658, 27062033, 37664836
Coronary Artery Disease	Associate	40026415
Cysts	Associate	29197096
Desmoid disease hereditary	Associate	22531174
Down Syndrome	Associate	29509279, 35623352
Drug Related Side Effects and Adverse Reactions	Inhibit	19435792
Endodermal Sinus Tumor	Associate	26076062
Fasciitis	Associate	22531174
Fibromatosis Aggressive	Associate	22531174
Focal Cortical Dysplasia	Associate	34301297
Focal cortical dysplasia of Taylor	Associate	34301297
Gastrointestinal Stromal Tumors	Associate	12610103
Glomerulosclerosis Focal Segmental	Stimulate	28158993
Granulosa Cell Tumor	Associate	26076062
Granulosa cell tumor of the ovary	Associate	12610103
Hirschsprung Disease	Inhibit	15220363
Hirschsprung Disease	Associate	24294384, 28139502
Histiocytoma Benign Fibrous	Associate	22531174
Histiocytoma Malignant Fibrous	Associate	22531174
Holoprosencephaly	Associate	19234067
Inflammation	Stimulate	37664836
Leiomyosarcoma	Associate	12610103
Leukoencephalopathies	Associate	16776375
Lymphoma Non Hodgkin	Associate	32533757
Malformations of Cortical Development	Associate	30549027
Mesothelioma	Associate	11570906, 15736446, 16056246, 16415794, 16554731, 17361207, 19435792, 23041828, 26848772
Mesothelioma Malignant	Associate	12194995, 15736446, 16206294, 17361207, 18098206, 22011651, 22531174, 28922567, 30545133, 31671889, 32727552, 33432559, 36557076, 38038422, 38203360, 38280040 View all (1 more)
Mesothelioma Malignant	Stimulate	25400801
Myelodysplastic Syndromes	Associate	32929772
Myxoma	Associate	14633612
Necrosis	Associate	16206294
Neoplasm Metastasis	Associate	15736446, 20190734, 32533757
Neoplasms	Associate	16206294, 17106529, 19028702, 22531174, 23011824, 24594996, 28544176, 32533757, 32727552, 32929772, 33534223, 35963640, 36335378, 36813116, 37406360, 37584555, 37664836 View all (2 more)
Neoplasms Cystic Mucinous and Serous	Associate	16056246, 32880620
Nephrosis Lipoid	Associate	28158993
Non Muscle Invasive Bladder Neoplasms	Associate	27626805
Oligospermia	Stimulate	38193226
Ovarian Neoplasms	Associate	23011824
Pancreatic Neoplasms	Associate	33432559
Parkinson Disease	Associate	36952070, 40715263
Pelvic Inflammatory Disease	Associate	20190734
Peritoneal Diseases	Associate	33432559
Pleural Effusion Malignant	Associate	18098206
Poroma	Associate	24322014
Sarcoma	Associate	12946229, 17361207
Sarcoma Synovial	Associate	11411458, 17106529
Solitary Fibrous Tumors	Associate	22531174

CALB2 (calbindin 2)