CALB1 (calbindin 1)

Gene

• Entrez ID: 793
• Gene name: Calbindin 1
• Gene symbol: CALB1
• Synonyms (NCBI Gene): CALB, D-28K
• Chromosome: 8
• Chromosome location: 8q21.3
• Summary: The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding doma

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT858716	hsa-miR-1302	CLIP-seq
MIRT858717	hsa-miR-181a	CLIP-seq
MIRT858718	hsa-miR-181b	CLIP-seq
MIRT858719	hsa-miR-181c	CLIP-seq
MIRT858720	hsa-miR-181d	CLIP-seq
MIRT858721	hsa-miR-1912	CLIP-seq
MIRT858722	hsa-miR-2113	CLIP-seq
MIRT858723	hsa-miR-23a	CLIP-seq
MIRT858724	hsa-miR-23b	CLIP-seq
MIRT858725	hsa-miR-23c	CLIP-seq
MIRT858726	hsa-miR-3121-3p	CLIP-seq
MIRT858727	hsa-miR-3144-5p	CLIP-seq
MIRT858728	hsa-miR-3168	CLIP-seq
MIRT858729	hsa-miR-3191	CLIP-seq
MIRT858730	hsa-miR-3668	CLIP-seq
MIRT858731	hsa-miR-3924	CLIP-seq
MIRT858732	hsa-miR-4262	CLIP-seq
MIRT858733	hsa-miR-4265	CLIP-seq
MIRT858734	hsa-miR-4277	CLIP-seq
MIRT858735	hsa-miR-4296	CLIP-seq
MIRT858736	hsa-miR-4298	CLIP-seq
MIRT858737	hsa-miR-4322	CLIP-seq
MIRT858738	hsa-miR-4648	CLIP-seq
MIRT858739	hsa-miR-4652-5p	CLIP-seq
MIRT858740	hsa-miR-4654	CLIP-seq
MIRT858741	hsa-miR-4717-3p	CLIP-seq
MIRT858742	hsa-miR-4769-5p	CLIP-seq
MIRT858743	hsa-miR-4789-5p	CLIP-seq
MIRT858744	hsa-miR-4802-3p	CLIP-seq
MIRT858745	hsa-miR-498	CLIP-seq
MIRT858746	hsa-miR-513a-3p	CLIP-seq
MIRT858747	hsa-miR-642b	CLIP-seq
MIRT2192581	hsa-miR-4731-3p	CLIP-seq
MIRT2192582	hsa-miR-4801	CLIP-seq
MIRT2192583	hsa-miR-548n	CLIP-seq
MIRT2385485	hsa-miR-3201	CLIP-seq
MIRT2385486	hsa-miR-4305	CLIP-seq
MIRT2385487	hsa-miR-4733-3p	CLIP-seq
MIRT2385488	hsa-miR-4791	CLIP-seq
MIRT2385489	hsa-miR-656	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
VDR	Activation	1317496

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005499	Function	Vitamin D binding	IEA
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IDA	30289411
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	IMP	18359862
GO:0005515	Function	Protein binding	IPI	16763551, 20098747, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	16928804
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007611	Process	Learning or memory	IEA
GO:0007614	Process	Short-term memory	IMP	22796338
GO:0007616	Process	Long-term memory	IMP	22796338
GO:0007626	Process	Locomotory behavior	IEA
GO:0008270	Function	Zinc ion binding	IMP	18359862
GO:0010842	Process	Retina layer formation	IEA
GO:0010996	Process	Response to auditory stimulus	IEA
GO:0030424	Component	Axon	IDA	22796338
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IBA
GO:0030425	Component	Dendrite	IDA	22796338
GO:0030425	Component	Dendrite	IEA
GO:0032420	Component	Stereocilium	IEA
GO:0032437	Component	Cuticular plate	IEA
GO:0035502	Process	Metanephric part of ureteric bud development	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043025	Component	Neuronal cell body	IDA	22796338
GO:0043025	Component	Neuronal cell body	IEA
GO:0043195	Component	Terminal bouton	IBA
GO:0044305	Component	Calyx of Held	IEA
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048167	Process	Regulation of synaptic plasticity	IEA
GO:0055074	Process	Calcium ion homeostasis	IEA
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0072205	Process	Metanephric collecting duct development	IEA
GO:0072221	Process	Metanephric distal convoluted tubule development	IEA
GO:0072286	Process	Metanephric connecting tubule development	IEA
GO:0090102	Process	Cochlea development	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099509	Process	Regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:0099523	Component	Presynaptic cytosol	IEA
GO:0099524	Component	Postsynaptic cytosol	IEA
GO:0099534	Function	Calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0099567	Function	Calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration	IEA

Other IDs

• MIM: 114050
• HGNC: 1434
• e!Ensembl: ENSG00000104327

Protein

• UniProt ID: P05937
• Protein name: Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type)
• Protein function: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
• PDB: 6FIE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13499	EF-hand_7	101 → 171	EF-hand domain pair	Domain
  PF00036	EF-hand_1	190 → 218	EF hand	Domain

• Sequence:

  MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKT
  FVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIET
  EELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLK
  FQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMA
  LSDGGKLYRTDLALILCAGDN

• Sequence length: 261

Pathways

KEGG:

Endocrine and other factor-regulated calcium reabsorption

Reactome:

Amyloid fiber formation