Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7922
Gene name	Solute carrier family 39 member 7
Gene symbol	SLC39A7
Synonyms (NCBI Gene)	AGM9D6S115ED6S2244EH2-KE4HKE4KE4RING5ZIP7
Chromosome	6
Chromosome location	6p21.32
Summary	The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of

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Show/Hide all (225)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019558	hsa-miR-340-5p	Sequencing	20371350
MIRT022098	hsa-miR-128-3p	Sequencing	20371350
MIRT036341	hsa-miR-1229-3p	CLASH	23622248
MIRT550644	hsa-miR-3163	PAR-CLIP	21572407
MIRT022098	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT317521	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT317523	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT317524	hsa-miR-3689a-5p	PAR-CLIP	21572407
MIRT317525	hsa-miR-3689b-5p	PAR-CLIP	21572407
MIRT317526	hsa-miR-3689e	PAR-CLIP	21572407
MIRT317527	hsa-miR-3689f	PAR-CLIP	21572407
MIRT550643	hsa-miR-6715b-3p	PAR-CLIP	21572407
MIRT550644	hsa-miR-3163	PAR-CLIP	21572407
MIRT022098	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT317521	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT317523	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT317524	hsa-miR-3689a-5p	PAR-CLIP	21572407
MIRT317525	hsa-miR-3689b-5p	PAR-CLIP	21572407
MIRT317526	hsa-miR-3689e	PAR-CLIP	21572407
MIRT317527	hsa-miR-3689f	PAR-CLIP	21572407
MIRT550643	hsa-miR-6715b-3p	PAR-CLIP	21572407
MIRT1363666	hsa-miR-1180	CLIP-seq
MIRT1363667	hsa-miR-1197	CLIP-seq
MIRT1363668	hsa-miR-1270	CLIP-seq
MIRT1363669	hsa-miR-128	CLIP-seq
MIRT1363670	hsa-miR-146a	CLIP-seq
MIRT1363671	hsa-miR-146b-5p	CLIP-seq
MIRT1363672	hsa-miR-150	CLIP-seq
MIRT1363673	hsa-miR-1914	CLIP-seq
MIRT1363674	hsa-miR-1972	CLIP-seq
MIRT1363675	hsa-miR-34b	CLIP-seq
MIRT1363676	hsa-miR-3689b	CLIP-seq
MIRT1363677	hsa-miR-409-5p	CLIP-seq
MIRT1363678	hsa-miR-432	CLIP-seq
MIRT1363679	hsa-miR-4434	CLIP-seq
MIRT1363680	hsa-miR-4436a	CLIP-seq
MIRT1363681	hsa-miR-4516	CLIP-seq
MIRT1363682	hsa-miR-4531	CLIP-seq
MIRT1363683	hsa-miR-4650-5p	CLIP-seq
MIRT1363684	hsa-miR-4664-3p	CLIP-seq
MIRT1363685	hsa-miR-4705	CLIP-seq
MIRT1363686	hsa-miR-483-3p	CLIP-seq
MIRT1363687	hsa-miR-548c-3p	CLIP-seq
MIRT1363688	hsa-miR-580	CLIP-seq
MIRT1363689	hsa-miR-620	CLIP-seq
MIRT1363690	hsa-miR-659	CLIP-seq
MIRT1363691	hsa-miR-671-3p	CLIP-seq
MIRT1363692	hsa-miR-891b	CLIP-seq
MIRT1363669	hsa-miR-128	CLIP-seq
MIRT2107863	hsa-miR-129-3p	CLIP-seq
MIRT1363676	hsa-miR-3689b	CLIP-seq
MIRT2107864	hsa-miR-4493	CLIP-seq
MIRT2107865	hsa-miR-4635	CLIP-seq
MIRT2107866	hsa-miR-4732-3p	CLIP-seq
MIRT2107867	hsa-miR-4780	CLIP-seq
MIRT2107868	hsa-miR-521	CLIP-seq
MIRT2331648	hsa-miR-1224-3p	CLIP-seq
MIRT2331649	hsa-miR-1229	CLIP-seq
MIRT2331650	hsa-miR-125a-5p	CLIP-seq
MIRT2331651	hsa-miR-125b	CLIP-seq
MIRT2331652	hsa-miR-1260	CLIP-seq
MIRT2331653	hsa-miR-1260b	CLIP-seq
MIRT2331654	hsa-miR-1271	CLIP-seq
MIRT2331655	hsa-miR-1280	CLIP-seq
MIRT1363672	hsa-miR-150	CLIP-seq
MIRT2331656	hsa-miR-182	CLIP-seq
MIRT2331657	hsa-miR-198	CLIP-seq
MIRT2331658	hsa-miR-2964a-5p	CLIP-seq
MIRT2331659	hsa-miR-296-5p	CLIP-seq
MIRT2331660	hsa-miR-3121-5p	CLIP-seq
MIRT2331661	hsa-miR-3176	CLIP-seq
MIRT2331662	hsa-miR-3183	CLIP-seq
MIRT2331663	hsa-miR-3663-5p	CLIP-seq
MIRT2331664	hsa-miR-3667-3p	CLIP-seq
MIRT2331665	hsa-miR-3918	CLIP-seq
MIRT2331666	hsa-miR-3922-3p	CLIP-seq
MIRT2331667	hsa-miR-4281	CLIP-seq
MIRT2331668	hsa-miR-4292	CLIP-seq
MIRT2331669	hsa-miR-4308	CLIP-seq
MIRT2331670	hsa-miR-4319	CLIP-seq
MIRT2331671	hsa-miR-4435	CLIP-seq
MIRT2331672	hsa-miR-4522	CLIP-seq
MIRT2331673	hsa-miR-4685-5p	CLIP-seq
MIRT1363685	hsa-miR-4705	CLIP-seq
MIRT2331674	hsa-miR-4713-5p	CLIP-seq
MIRT2331675	hsa-miR-4723-3p	CLIP-seq
MIRT2107866	hsa-miR-4732-3p	CLIP-seq
MIRT2331676	hsa-miR-4757-5p	CLIP-seq
MIRT2331677	hsa-miR-4786-3p	CLIP-seq
MIRT2107868	hsa-miR-521	CLIP-seq
MIRT2331678	hsa-miR-532-3p	CLIP-seq
MIRT1363688	hsa-miR-580	CLIP-seq
MIRT2331679	hsa-miR-642a	CLIP-seq
MIRT2331680	hsa-miR-665	CLIP-seq
MIRT2331681	hsa-miR-670	CLIP-seq
MIRT2331682	hsa-miR-96	CLIP-seq
MIRT2331661	hsa-miR-3176	CLIP-seq
MIRT2331666	hsa-miR-3922-3p	CLIP-seq
MIRT2331667	hsa-miR-4281	CLIP-seq
MIRT2331676	hsa-miR-4757-5p	CLIP-seq
MIRT2331679	hsa-miR-642a	CLIP-seq
MIRT2626207	hsa-miR-1202	CLIP-seq
MIRT2331649	hsa-miR-1229	CLIP-seq
MIRT2331654	hsa-miR-1271	CLIP-seq
MIRT2107863	hsa-miR-129-3p	CLIP-seq
MIRT2626208	hsa-miR-139-5p	CLIP-seq
MIRT1363672	hsa-miR-150	CLIP-seq
MIRT2331656	hsa-miR-182	CLIP-seq
MIRT2626209	hsa-miR-1915	CLIP-seq
MIRT2331658	hsa-miR-2964a-5p	CLIP-seq
MIRT2331659	hsa-miR-296-5p	CLIP-seq
MIRT2331660	hsa-miR-3121-5p	CLIP-seq
MIRT2331661	hsa-miR-3176	CLIP-seq
MIRT2626210	hsa-miR-3194-5p	CLIP-seq
MIRT2626211	hsa-miR-3607-3p	CLIP-seq
MIRT2626212	hsa-miR-365	CLIP-seq
MIRT2626213	hsa-miR-3661	CLIP-seq
MIRT2331664	hsa-miR-3667-3p	CLIP-seq
MIRT2626214	hsa-miR-3686	CLIP-seq
MIRT2331665	hsa-miR-3918	CLIP-seq
MIRT2331666	hsa-miR-3922-3p	CLIP-seq
MIRT2626215	hsa-miR-3972	CLIP-seq
MIRT2626216	hsa-miR-3973	CLIP-seq
MIRT2626217	hsa-miR-4254	CLIP-seq
MIRT2626218	hsa-miR-4278	CLIP-seq
MIRT2331667	hsa-miR-4281	CLIP-seq
MIRT2331668	hsa-miR-4292	CLIP-seq
MIRT2331669	hsa-miR-4308	CLIP-seq
MIRT2626219	hsa-miR-4432	CLIP-seq
MIRT2331671	hsa-miR-4435	CLIP-seq
MIRT2107864	hsa-miR-4493	CLIP-seq
MIRT2107865	hsa-miR-4635	CLIP-seq
MIRT2626220	hsa-miR-4653-3p	CLIP-seq
MIRT2331673	hsa-miR-4685-5p	CLIP-seq
MIRT2331674	hsa-miR-4713-5p	CLIP-seq
MIRT2626221	hsa-miR-4726-3p	CLIP-seq
MIRT2107866	hsa-miR-4732-3p	CLIP-seq
MIRT2331676	hsa-miR-4757-5p	CLIP-seq
MIRT2107867	hsa-miR-4780	CLIP-seq
MIRT2626222	hsa-miR-499-5p	CLIP-seq
MIRT2107868	hsa-miR-521	CLIP-seq
MIRT2331678	hsa-miR-532-3p	CLIP-seq
MIRT2626223	hsa-miR-548a-5p	CLIP-seq
MIRT2626224	hsa-miR-548ab	CLIP-seq
MIRT2626225	hsa-miR-548ak	CLIP-seq
MIRT2626226	hsa-miR-548b-5p	CLIP-seq
MIRT2626227	hsa-miR-548c-5p	CLIP-seq
MIRT2626228	hsa-miR-548d-5p	CLIP-seq
MIRT2626229	hsa-miR-548h	CLIP-seq
MIRT2626230	hsa-miR-548i	CLIP-seq
MIRT2626231	hsa-miR-548j	CLIP-seq
MIRT2626232	hsa-miR-548v	CLIP-seq
MIRT2626233	hsa-miR-548w	CLIP-seq
MIRT2626234	hsa-miR-548y	CLIP-seq
MIRT2626235	hsa-miR-559	CLIP-seq
MIRT2626236	hsa-miR-582-5p	CLIP-seq
MIRT2626237	hsa-miR-619	CLIP-seq
MIRT2626238	hsa-miR-631	CLIP-seq
MIRT2331679	hsa-miR-642a	CLIP-seq
MIRT2626239	hsa-miR-766	CLIP-seq
MIRT2331682	hsa-miR-96	CLIP-seq
MIRT2626207	hsa-miR-1202	CLIP-seq
MIRT2331649	hsa-miR-1229	CLIP-seq
MIRT2331654	hsa-miR-1271	CLIP-seq
MIRT2107863	hsa-miR-129-3p	CLIP-seq
MIRT2626208	hsa-miR-139-5p	CLIP-seq
MIRT1363672	hsa-miR-150	CLIP-seq
MIRT2331656	hsa-miR-182	CLIP-seq
MIRT2626209	hsa-miR-1915	CLIP-seq
MIRT2331658	hsa-miR-2964a-5p	CLIP-seq
MIRT2331659	hsa-miR-296-5p	CLIP-seq
MIRT2331660	hsa-miR-3121-5p	CLIP-seq
MIRT2691207	hsa-miR-3132	CLIP-seq
MIRT2331661	hsa-miR-3176	CLIP-seq
MIRT2626210	hsa-miR-3194-5p	CLIP-seq
MIRT2626211	hsa-miR-3607-3p	CLIP-seq
MIRT2626212	hsa-miR-365	CLIP-seq
MIRT2626213	hsa-miR-3661	CLIP-seq
MIRT2331664	hsa-miR-3667-3p	CLIP-seq
MIRT2626214	hsa-miR-3686	CLIP-seq
MIRT2331665	hsa-miR-3918	CLIP-seq
MIRT2331666	hsa-miR-3922-3p	CLIP-seq
MIRT2626215	hsa-miR-3972	CLIP-seq
MIRT2626216	hsa-miR-3973	CLIP-seq
MIRT2626217	hsa-miR-4254	CLIP-seq
MIRT2626218	hsa-miR-4278	CLIP-seq
MIRT2331667	hsa-miR-4281	CLIP-seq
MIRT2331668	hsa-miR-4292	CLIP-seq
MIRT2331669	hsa-miR-4308	CLIP-seq
MIRT2626219	hsa-miR-4432	CLIP-seq
MIRT2331671	hsa-miR-4435	CLIP-seq
MIRT2691208	hsa-miR-4451	CLIP-seq
MIRT2691209	hsa-miR-4464	CLIP-seq
MIRT2107864	hsa-miR-4493	CLIP-seq
MIRT2107865	hsa-miR-4635	CLIP-seq
MIRT2626220	hsa-miR-4653-3p	CLIP-seq
MIRT2331673	hsa-miR-4685-5p	CLIP-seq
MIRT2331674	hsa-miR-4713-5p	CLIP-seq
MIRT2626221	hsa-miR-4726-3p	CLIP-seq
MIRT2107866	hsa-miR-4732-3p	CLIP-seq
MIRT2691210	hsa-miR-4748	CLIP-seq
MIRT2331676	hsa-miR-4757-5p	CLIP-seq
MIRT2107867	hsa-miR-4780	CLIP-seq
MIRT2626222	hsa-miR-499-5p	CLIP-seq
MIRT2107868	hsa-miR-521	CLIP-seq
MIRT2331678	hsa-miR-532-3p	CLIP-seq
MIRT2626223	hsa-miR-548a-5p	CLIP-seq
MIRT2626224	hsa-miR-548ab	CLIP-seq
MIRT2626225	hsa-miR-548ak	CLIP-seq
MIRT2626226	hsa-miR-548b-5p	CLIP-seq
MIRT2626227	hsa-miR-548c-5p	CLIP-seq
MIRT2626228	hsa-miR-548d-5p	CLIP-seq
MIRT2626229	hsa-miR-548h	CLIP-seq
MIRT2626230	hsa-miR-548i	CLIP-seq
MIRT2626231	hsa-miR-548j	CLIP-seq
MIRT2626232	hsa-miR-548v	CLIP-seq
MIRT2626233	hsa-miR-548w	CLIP-seq
MIRT2626234	hsa-miR-548y	CLIP-seq
MIRT2626235	hsa-miR-559	CLIP-seq
MIRT2626236	hsa-miR-582-5p	CLIP-seq
MIRT2626237	hsa-miR-619	CLIP-seq
MIRT2626238	hsa-miR-631	CLIP-seq
MIRT2331679	hsa-miR-642a	CLIP-seq
MIRT2626239	hsa-miR-766	CLIP-seq
MIRT2331682	hsa-miR-96	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005385	Function	Zinc ion transmembrane transporter activity	IBA
GO:0005385	Function	Zinc ion transmembrane transporter activity	IDA	14525538
GO:0005385	Function	Zinc ion transmembrane transporter activity	IEA
GO:0005385	Function	Zinc ion transmembrane transporter activity	IMP	30718914
GO:0005385	Function	Zinc ion transmembrane transporter activity	TAS
GO:0005515	Function	Protein binding	IPI	22317921, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA	14525538, 30718914
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	29980658
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006829	Process	Zinc ion transport	IEA
GO:0006882	Process	Intracellular zinc ion homeostasis	IBA
GO:0006882	Process	Intracellular zinc ion homeostasis	IMP	29980658
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8812499
GO:0030001	Process	Metal ion transport	IEA
GO:0030183	Process	B cell differentiation	IEA
GO:0030183	Process	B cell differentiation	IMP	30718914
GO:0046873	Function	Metal ion transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0071577	Process	Zinc ion transmembrane transport	IBA
GO:0071577	Process	Zinc ion transmembrane transport	IDA	14525538
GO:0071577	Process	Zinc ion transmembrane transport	IEA
GO:0071577	Process	Zinc ion transmembrane transport	TAS
GO:0098773	Process	Skin epidermis development	IEA
GO:0110075	Process	Regulation of ferroptosis	IMP	33608508

MIM	HGNC	e!Ensembl
601416	4927	ENSG00000112473

Q92504

Protein name

Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)

Protein function

Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653, PubMed:29980658). Acts as a gatekeeper

PDB

8GZE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02535	Zip	132 → 466	ZIP Zinc transporter	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14525538, ECO:0000269|PubMed:15705588}.

Sequence

MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSH
AHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGES
GAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGL
LGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHV
KGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGP
VRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEV
PHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVL
PFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE

Sequence length

469

Interactions

View interactions

	KEGG		Reactome
	Alzheimer disease Parkinson disease		Zinc influx into cells by the SLC39 gene family

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Agammaglobulinemia 9, autosomal recessive	Pathogenic; Likely pathogenic	rs771311186, rs1170038377, rs201790479, rs563866464, rs1026743380	RCV001810391 RCV001810392 RCV001810393 RCV002271714 RCV003990822

Show/Hide Unknown Diseases (21)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Uncertain significance	rs758514072	RCV005930402
Cholangiocarcinoma	Benign	rs41266701	RCV005914097
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	rs41266701	RCV005914100
Clear cell carcinoma of kidney	Benign	rs11538810	RCV005902628
Colon adenocarcinoma	Uncertain significance; Benign	rs201645740, rs11538810	RCV005924270 RCV005902624
Familial pancreatic carcinoma	Benign	rs41266701	RCV005914093
Gastric cancer	Uncertain significance	rs201645740	RCV005924271
Germ cell tumor of testis	Benign	rs41266701	RCV005914098
Hepatocellular carcinoma	Benign	rs41266701, rs11538810	RCV005914089 RCV005902625
Lung cancer	-; Benign	rs966007186, rs11538810	RCV005931768 RCV005902630
Malignant lymphoma, large B-cell, diffuse	Benign	rs41266701	RCV005914094
Malignant tumor of esophagus	Benign	rs11538810	RCV005902626
Melanoma	Uncertain significance	rs201645740	RCV005924272
Nonpapillary renal cell carcinoma	Benign	rs41266701, rs11538810	RCV005914090 RCV005902627
Ovarian cancer	Benign	rs41266701	RCV005914091
Ovarian serous cystadenocarcinoma	Benign	rs11538810	RCV005902629
SLC39A7-related disorder	Benign	rs200100279	RCV003933449
Thymoma	Benign	rs41266701	RCV005914096
Uterine carcinosarcoma	Benign	rs41266701	RCV005914095
Uterine corpus endometrial carcinoma	Benign	rs41266701	RCV005914099
Uveal melanoma	Benign	rs41266701	RCV005914092

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	33535184
Asthma	Associate	32645059
Breast Neoplasms	Associate	31483418, 32744318, 35864548
Carcinogenesis	Associate	28981607
Carcinoma Squamous Cell	Associate	33535184
Colorectal Neoplasms	Associate	28981607
Immunoglobulin G4 Related Disease	Associate	33832415
Inflammation	Associate	33832415
Neoplasms	Associate	32109290
Smoke Inhalation Injury	Associate	33535184
Stomach Neoplasms	Associate	32109290
Triple Negative Breast Neoplasms	Associate	36142814
Zinc Deficiency Neonatal due to Low Breast Milk Zinc	Associate	32645059

SLC39A7 (solute carrier family 39 member 7)