IRX1 (iroquois homeobox 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 79192
Gene name Iroquois homeobox 1
Gene symbol IRX1
Synonyms (NCBI Gene)
IRX-5IRXA1
Chromosome 5
Chromosome location 5p15.33
Summary This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head an
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (8)
miRTarBase ID miRNA Experiments Reference
MIRT1072254 hsa-miR-3153 CLIP-seq
MIRT1072255 hsa-miR-4311 CLIP-seq
MIRT1072256 hsa-miR-4731-3p CLIP-seq
MIRT1072257 hsa-miR-4801 CLIP-seq
MIRT1072258 hsa-miR-625 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (20)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 20440264
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606197 14358 ENSG00000170549
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P78414
Protein name Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05920 Homeobox_KN 145 → 184 Homeobox KN domain Family
Sequence 
MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
LGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPY
GQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
ARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQ
SNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPG
AAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPS
HGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAP
GALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
Sequence length 480
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
IRX1-related disorder Uncertain significance; Likely benign; Benign rs1223077677, rs61741521, rs200644003, rs844154, rs61746094, rs141212131, rs373622269, rs61743903, rs6884950, rs150332848 RCV003402601
RCV003907164
RCV003919574
RCV003974388
RCV003979607
RCV003911805
RCV003951437
RCV003903164
RCV003903165
RCV003930536
Show/Hide Text Mining Associations (21)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Juvenile Associate 26815016
Arthritis Rheumatoid Associate 23456299, 26815016
Carcinoma Ductal Associate 33667646
Carcinoma Non Small Cell Lung Associate 33859751
Down Syndrome Associate 38513239
Emanuel syndrome Associate 27175594
Graves Ophthalmopathy Associate 32908802
Keloid Associate 35047146
Leukemia Associate 27175594
Leukemia Myeloid Acute Associate 33219204, 35328612